MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile.
Identifieur interne : 000859 ( PubMed/Checkpoint ); précédent : 000858; suivant : 000860MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile.
Auteurs : Waleed H. Mahallawi [Arabie saoudite] ; Omar F. Khabour [Jordanie] ; Qibo Zhang [Royaume-Uni] ; Hatim M. Makhdoum [Arabie saoudite] ; Bandar A. Suliman [Arabie saoudite]Source :
- Cytokine [ 1096-0023 ] ; 2018.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Cellules Th17 (métabolisme), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Cytokines (), Cytokines (métabolisme), Cytokines (sang), Humains, Infections à coronavirus (immunologie), Infections à coronavirus (sang), Infections à coronavirus (virologie), Interférons (métabolisme), Interférons (sang), Jeune adulte, Lymphocytes auxiliaires Th1 (métabolisme), Mâle, Structure secondaire des protéines.
- MESH :
- immunologie : Infections à coronavirus.
- métabolisme : Cellules Th17, Cytokines, Interférons, Lymphocytes auxiliaires Th1.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- sang : Cytokines, Infections à coronavirus, Interférons.
- virologie : Infections à coronavirus.
- Adulte, Adulte d'âge moyen, Cytokines, Humains, Jeune adulte, Mâle, Structure secondaire des protéines.
English descriptors
- KwdEn :
- Adult, Coronavirus Infections (blood), Coronavirus Infections (immunology), Coronavirus Infections (virology), Cytokines (blood), Cytokines (chemistry), Cytokines (metabolism), Humans, Interferons (blood), Interferons (metabolism), Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (physiology), Protein Structure, Secondary, Th1 Cells (metabolism), Th17 Cells (metabolism), Young Adult.
- MESH :
- chemical , blood : Cytokines, Interferons.
- blood : Coronavirus Infections.
- chemical , chemistry : Cytokines.
- immunology : Coronavirus Infections.
- chemical , metabolism : Cytokines, Interferons, Th1 Cells, Th17 Cells.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections.
- Adult, Humans, Male, Middle Aged, Protein Structure, Secondary, Young Adult.
Abstract
The Middle East respiratory syndrome coronavirus (MERS-CoV) has been recognized as a highly pathogenic virus to humans that infects the respiratory tract and is associated with high morbidity and mortality. Studies in animal models suggest that MERS-CoV infection induces a strong inflammatory response, which may be related to the severity of disease. Data showing the cytokine profiles in humans during the acute phase of MERS-CoV infection are limited. In this study, we have analyzed the profile of cytokine responses in plasma samples from patients with confirmed MERS-CoV infections (n = 7) compared to healthy controls (n = 13). The cytokine profiles, including T helper (Th) 1, Th2 and Th17 responses, were analyzed using cytometric bead array (CBA). A prominent pro-inflammatory Th1 and Th17 response was clearly seen in patients with MERS-CoV infection, with markedly increased concentrations of IFN-γ, TNF-α, IL-15 and IL-17 compared to controls. IL-12 expression levels showed no difference between patients with MERS-CoV infection and the healthy controls despite the significantly increased levels of IFN-α2 and IFN-γ (P < .01). No changes were observed in the levels of IL-2, IL-4, IL-5, IL-13, and TGF-α (P > .05). Our results demonstrate a marked pro-inflammatory cytokine response during the acute phase of MERS-CoV infection in humans.
DOI: 10.1016/j.cyto.2018.01.025
PubMed: 29414327
Affiliations:
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pubmed:29414327Le document en format XML
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<front><div type="abstract" xml:lang="en">The Middle East respiratory syndrome coronavirus (MERS-CoV) has been recognized as a highly pathogenic virus to humans that infects the respiratory tract and is associated with high morbidity and mortality. Studies in animal models suggest that MERS-CoV infection induces a strong inflammatory response, which may be related to the severity of disease. Data showing the cytokine profiles in humans during the acute phase of MERS-CoV infection are limited. In this study, we have analyzed the profile of cytokine responses in plasma samples from patients with confirmed MERS-CoV infections (n = 7) compared to healthy controls (n = 13). The cytokine profiles, including T helper (Th) 1, Th2 and Th17 responses, were analyzed using cytometric bead array (CBA). A prominent pro-inflammatory Th1 and Th17 response was clearly seen in patients with MERS-CoV infection, with markedly increased concentrations of IFN-γ, TNF-α, IL-15 and IL-17 compared to controls. IL-12 expression levels showed no difference between patients with MERS-CoV infection and the healthy controls despite the significantly increased levels of IFN-α2 and IFN-γ (P < .01). No changes were observed in the levels of IL-2, IL-4, IL-5, IL-13, and TGF-α (P > .05). Our results demonstrate a marked pro-inflammatory cytokine response during the acute phase of MERS-CoV infection in humans.</div>
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<Abstract><AbstractText>The Middle East respiratory syndrome coronavirus (MERS-CoV) has been recognized as a highly pathogenic virus to humans that infects the respiratory tract and is associated with high morbidity and mortality. Studies in animal models suggest that MERS-CoV infection induces a strong inflammatory response, which may be related to the severity of disease. Data showing the cytokine profiles in humans during the acute phase of MERS-CoV infection are limited. In this study, we have analyzed the profile of cytokine responses in plasma samples from patients with confirmed MERS-CoV infections (n = 7) compared to healthy controls (n = 13). The cytokine profiles, including T helper (Th) 1, Th2 and Th17 responses, were analyzed using cytometric bead array (CBA). A prominent pro-inflammatory Th1 and Th17 response was clearly seen in patients with MERS-CoV infection, with markedly increased concentrations of IFN-γ, TNF-α, IL-15 and IL-17 compared to controls. IL-12 expression levels showed no difference between patients with MERS-CoV infection and the healthy controls despite the significantly increased levels of IFN-α2 and IFN-γ (P < .01). No changes were observed in the levels of IL-2, IL-4, IL-5, IL-13, and TGF-α (P > .05). Our results demonstrate a marked pro-inflammatory cytokine response during the acute phase of MERS-CoV infection in humans.</AbstractText>
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</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Epidemiol Glob Health. 2017 Mar;7(1):29-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27302882</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>JAKSTAT. 2012 Jul 1;1(3):159-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24058765</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>BMC Genomics. 2014 Dec 22;15:1161</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25534508</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Trends Microbiol. 2007 Apr;15(4):143-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17336072</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2002 Feb;76(3):1071-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11773383</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Emerg Microbes Infect. 2013 Sep;2(9):e60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26038490</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PeerJ. 2015 Dec 17;3:e1505</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26713252</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Clin Immunol. 2004 Mar;110(3):252-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15047203</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Paediatr Respir Rev. 2015 Jun;16(3):197-202</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26002405</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virus Res. 2014 Dec 19;194:124-37</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25093995</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virol J. 2015 Dec 22;12:222</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26695637</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):9081-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27457935</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Eur Cytokine Netw. 2002 Jan-Mar;13(1):5-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11956016</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Br J Hosp Med (Lond). 2017 Jan 2;78(1):23-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28067571</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Inflamm Allergy Drug Targets. 2009 Mar;8(1):40-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19275692</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 2013 Aug 8;500(7461):227-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23831647</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Respir Care. 2016 Mar;61(3):340-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26701365</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Rev Med Virol. 2015 Sep;25(5):320-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26258805</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Infect Dis. 2014 May 1;209(9):1331-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24065148</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Clin Ter. 2006 Sep-Oct;157(5):457-68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17147054</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 2002 May 10;277(19):16592-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11877397</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2012 Nov 8;367(19):1814-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23075143</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Pharmaceuticals (Basel). 2010 Apr 20;3(4):1162-1186</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27713294</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet Respir Med. 2014 Oct;2(10):779-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25174550</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Immunol Cell Biol. 2014 Mar;92(3):256-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24366517</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2014 May 31;383(9932):1869-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24857701</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Korean Med Sci. 2007 Dec;22(6):987-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18162711</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>FEBS Lett. 2004 Nov 5;577(1-2):187-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15527783</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS One. 2014 Feb 14;9(2):e88716</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24551142</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>mBio. 2013 Apr 30;4(3):e00165-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23631916</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet Respir Med. 2014 Jan;2(1):23-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24461892</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virology. 2014 Dec;471-473:49-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25461530</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Travel Med Infect Dis. 2016 Sep - Oct;14(5):464-470</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27671972</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>mBio. 2014 Apr 29;5(3):e01146-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24781747</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet Infect Dis. 2014 Nov;14(11):1113-1122</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25189350</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virus Genes. 2015 Jun;50(3):509-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25653016</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Immunity. 2008 Oct 17;29(4):628-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18848474</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Int J Infect Dis. 2016 Aug;49:129-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27352628</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Science. 1994 Jun 3;264(5164):1415-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8197455</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Infect Chemother. 2016 Mar;48(1):61-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27104019</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Euro Surveill. 2012 Oct 04;17(40):20290</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23078800</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Antiviral Res. 2017 Jan;137:82-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27840203</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Interferon Cytokine Res. 1999 Jun;19(6):563-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10433356</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Soc Exp Biol Med. 2000 Mar;223(3):241-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10719836</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS One. 2010 Nov 10;5(11):e13927</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21085662</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Pathog Glob Health. 2015;109(8):354-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26924345</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Infection. 2015 Aug;43(4):495-501</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25600929</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2002 Mar;76(6):2721-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11861839</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2013 Aug 1;369(5):407-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23782161</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Korean Med Sci. 2015 Dec;30(12):1807-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26713056</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virology. 2014 Apr;454-455:197-205</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24725946</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Transbound Emerg Dis. 2017 Apr;64(2):344-353</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26256102</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet Infect Dis. 2014 Jan;14(1):6-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24239325</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS Pathog. 2015 Dec 28;11(12):e1005338</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26709698</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Euro Surveill. 2014 May 08;19(18):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24832116</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Ann Acad Med Singapore. 2015 May;44(5):155-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26198320</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Infect. 2016 Nov;73(5):468-475</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27519621</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Public Health Rep. 2016 Jul-Aug;131(4):552-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27453599</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Euro Surveill. 2013 Jun 13;18(24):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23787161</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2015 Nov;89(22):11534-48</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26355085</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Expert Rev Respir Med. 2014 Feb;8(1):25-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24325586</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Front Immunol. 2015 Jul 20;6:355</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26257729</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>FEBS Lett. 2013 May 21;587(10):1571-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23587486</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2011 Apr;85(7):3664-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21270150</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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