Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein.
Identifieur interne : 000822 ( PubMed/Checkpoint ); précédent : 000821; suivant : 000823Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein.
Auteurs : Jian Lei [Allemagne] ; Yuri Kusov [Allemagne] ; Rolf Hilgenfeld [Allemagne]Source :
- Antiviral research [ 1872-9096 ] ; 2018.
Descripteurs français
- KwdFr :
- Conformation des protéines, Coronaviridae (génétique), Coronaviridae (métabolisme), Domaines protéiques, Glutamine (), Humains, Liaison aux protéines, Modèles moléculaires, Motifs et domaines d'intéraction protéique, Papaïne (), Papaïne (métabolisme), Protéines virales non structurales (), Protéines virales non structurales (métabolisme), Relation structure-activité, Séquence d'acides aminés, Ubiquitine (), Ubiquitine (métabolisme).
- MESH :
- génétique : Coronaviridae.
- métabolisme : Coronaviridae, Papaïne, Protéines virales non structurales, Ubiquitine.
- Conformation des protéines, Domaines protéiques, Glutamine, Humains, Liaison aux protéines, Modèles moléculaires, Motifs et domaines d'intéraction protéique, Papaïne, Protéines virales non structurales, Relation structure-activité, Séquence d'acides aminés, Ubiquitine.
English descriptors
- KwdEn :
- Amino Acid Sequence, Coronaviridae (genetics), Coronaviridae (metabolism), Glutamine (chemistry), Humans, Models, Molecular, Papain (chemistry), Papain (metabolism), Protein Binding, Protein Conformation, Protein Domains, Protein Interaction Domains and Motifs, Structure-Activity Relationship, Ubiquitin (chemistry), Ubiquitin (metabolism), Viral Nonstructural Proteins (chemistry), Viral Nonstructural Proteins (metabolism).
- MESH :
- chemical , chemistry : Glutamine, Papain, Ubiquitin, Viral Nonstructural Proteins.
- genetics : Coronaviridae.
- metabolism : Coronaviridae, Papain, Ubiquitin, Viral Nonstructural Proteins.
- Amino Acid Sequence, Humans, Models, Molecular, Protein Binding, Protein Conformation, Protein Domains, Protein Interaction Domains and Motifs, Structure-Activity Relationship.
Abstract
The multi-domain non-structural protein 3 (Nsp3) is the largest protein encoded by the coronavirus (CoV) genome, with an average molecular mass of about 200 kD. Nsp3 is an essential component of the replication/transcription complex. It comprises various domains, the organization of which differs between CoV genera, due to duplication or absence of some domains. However, eight domains of Nsp3 exist in all known CoVs: the ubiquitin-like domain 1 (Ubl1), the Glu-rich acidic domain (also called "hypervariable region"), a macrodomain (also named "X domain"), the ubiquitin-like domain 2 (Ubl2), the papain-like protease 2 (PL2pro), the Nsp3 ectodomain (3Ecto, also called "zinc-finger domain"), as well as the domains Y1 and CoV-Y of unknown functions. In addition, the two transmembrane regions, TM1 and TM2, exist in all CoVs. The three-dimensional structures of domains in the N-terminal two thirds of Nsp3 have been investigated by X-ray crystallography and/or nuclear magnetic resonance (NMR) spectroscopy since the outbreaks of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) in 2003 as well as Middle-East Respiratory Syndrome coronavirus (MERS-CoV) in 2012. In this review, the structures and functions of these domains of Nsp3 are discussed in depth.
DOI: 10.1016/j.antiviral.2017.11.001
PubMed: 29128390
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:29128390Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein.</title>
<author><name sortKey="Lei, Jian" sort="Lei, Jian" uniqKey="Lei J" first="Jian" last="Lei">Jian Lei</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck</wicri:regionArea>
<wicri:noRegion>23562 Lübeck</wicri:noRegion>
<wicri:noRegion>23562 Lübeck</wicri:noRegion>
<wicri:noRegion>23562 Lübeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kusov, Yuri" sort="Kusov, Yuri" uniqKey="Kusov Y" first="Yuri" last="Kusov">Yuri Kusov</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck</wicri:regionArea>
<wicri:noRegion>23562 Lübeck</wicri:noRegion>
<wicri:noRegion>23562 Lübeck</wicri:noRegion>
<wicri:noRegion>23562 Lübeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hilgenfeld, Rolf" sort="Hilgenfeld, Rolf" uniqKey="Hilgenfeld R" first="Rolf" last="Hilgenfeld">Rolf Hilgenfeld</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany; German Center for Infection Research (DZIF), Hamburg - Lübeck - Borstel - Riems Site, University of Lübeck, Germany. Electronic address: hilgenfeld@biochem.uni-luebeck.de.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany; German Center for Infection Research (DZIF), Hamburg - Lübeck - Borstel - Riems Site, University of Lübeck</wicri:regionArea>
<wicri:noRegion>University of Lübeck</wicri:noRegion>
<wicri:noRegion>University of Lübeck</wicri:noRegion>
<wicri:noRegion>University of Lübeck</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2018">2018</date>
<idno type="RBID">pubmed:29128390</idno>
<idno type="pmid">29128390</idno>
<idno type="doi">10.1016/j.antiviral.2017.11.001</idno>
<idno type="wicri:Area/PubMed/Corpus">000A91</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A91</idno>
<idno type="wicri:Area/PubMed/Curation">000A91</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A91</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000822</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000822</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein.</title>
<author><name sortKey="Lei, Jian" sort="Lei, Jian" uniqKey="Lei J" first="Jian" last="Lei">Jian Lei</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck</wicri:regionArea>
<wicri:noRegion>23562 Lübeck</wicri:noRegion>
<wicri:noRegion>23562 Lübeck</wicri:noRegion>
<wicri:noRegion>23562 Lübeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kusov, Yuri" sort="Kusov, Yuri" uniqKey="Kusov Y" first="Yuri" last="Kusov">Yuri Kusov</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck</wicri:regionArea>
<wicri:noRegion>23562 Lübeck</wicri:noRegion>
<wicri:noRegion>23562 Lübeck</wicri:noRegion>
<wicri:noRegion>23562 Lübeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hilgenfeld, Rolf" sort="Hilgenfeld, Rolf" uniqKey="Hilgenfeld R" first="Rolf" last="Hilgenfeld">Rolf Hilgenfeld</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany; German Center for Infection Research (DZIF), Hamburg - Lübeck - Borstel - Riems Site, University of Lübeck, Germany. Electronic address: hilgenfeld@biochem.uni-luebeck.de.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany; German Center for Infection Research (DZIF), Hamburg - Lübeck - Borstel - Riems Site, University of Lübeck</wicri:regionArea>
<wicri:noRegion>University of Lübeck</wicri:noRegion>
<wicri:noRegion>University of Lübeck</wicri:noRegion>
<wicri:noRegion>University of Lübeck</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Antiviral research</title>
<idno type="eISSN">1872-9096</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Coronaviridae (genetics)</term>
<term>Coronaviridae (metabolism)</term>
<term>Glutamine (chemistry)</term>
<term>Humans</term>
<term>Models, Molecular</term>
<term>Papain (chemistry)</term>
<term>Papain (metabolism)</term>
<term>Protein Binding</term>
<term>Protein Conformation</term>
<term>Protein Domains</term>
<term>Protein Interaction Domains and Motifs</term>
<term>Structure-Activity Relationship</term>
<term>Ubiquitin (chemistry)</term>
<term>Ubiquitin (metabolism)</term>
<term>Viral Nonstructural Proteins (chemistry)</term>
<term>Viral Nonstructural Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Conformation des protéines</term>
<term>Coronaviridae (génétique)</term>
<term>Coronaviridae (métabolisme)</term>
<term>Domaines protéiques</term>
<term>Glutamine ()</term>
<term>Humains</term>
<term>Liaison aux protéines</term>
<term>Modèles moléculaires</term>
<term>Motifs et domaines d'intéraction protéique</term>
<term>Papaïne ()</term>
<term>Papaïne (métabolisme)</term>
<term>Protéines virales non structurales ()</term>
<term>Protéines virales non structurales (métabolisme)</term>
<term>Relation structure-activité</term>
<term>Séquence d'acides aminés</term>
<term>Ubiquitine ()</term>
<term>Ubiquitine (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Glutamine</term>
<term>Papain</term>
<term>Ubiquitin</term>
<term>Viral Nonstructural Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronaviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronaviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Coronaviridae</term>
<term>Papain</term>
<term>Ubiquitin</term>
<term>Viral Nonstructural Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Coronaviridae</term>
<term>Papaïne</term>
<term>Protéines virales non structurales</term>
<term>Ubiquitine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Humans</term>
<term>Models, Molecular</term>
<term>Protein Binding</term>
<term>Protein Conformation</term>
<term>Protein Domains</term>
<term>Protein Interaction Domains and Motifs</term>
<term>Structure-Activity Relationship</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Conformation des protéines</term>
<term>Domaines protéiques</term>
<term>Glutamine</term>
<term>Humains</term>
<term>Liaison aux protéines</term>
<term>Modèles moléculaires</term>
<term>Motifs et domaines d'intéraction protéique</term>
<term>Papaïne</term>
<term>Protéines virales non structurales</term>
<term>Relation structure-activité</term>
<term>Séquence d'acides aminés</term>
<term>Ubiquitine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The multi-domain non-structural protein 3 (Nsp3) is the largest protein encoded by the coronavirus (CoV) genome, with an average molecular mass of about 200 kD. Nsp3 is an essential component of the replication/transcription complex. It comprises various domains, the organization of which differs between CoV genera, due to duplication or absence of some domains. However, eight domains of Nsp3 exist in all known CoVs: the ubiquitin-like domain 1 (Ubl1), the Glu-rich acidic domain (also called "hypervariable region"), a macrodomain (also named "X domain"), the ubiquitin-like domain 2 (Ubl2), the papain-like protease 2 (PL2<sup>pro</sup>
), the Nsp3 ectodomain (3Ecto, also called "zinc-finger domain"), as well as the domains Y1 and CoV-Y of unknown functions. In addition, the two transmembrane regions, TM1 and TM2, exist in all CoVs. The three-dimensional structures of domains in the N-terminal two thirds of Nsp3 have been investigated by X-ray crystallography and/or nuclear magnetic resonance (NMR) spectroscopy since the outbreaks of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) in 2003 as well as Middle-East Respiratory Syndrome coronavirus (MERS-CoV) in 2012. In this review, the structures and functions of these domains of Nsp3 are discussed in depth.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29128390</PMID>
<DateCompleted><Year>2018</Year>
<Month>06</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>07</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-9096</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>149</Volume>
<PubDate><Year>2018</Year>
<Month>01</Month>
</PubDate>
</JournalIssue>
<Title>Antiviral research</Title>
<ISOAbbreviation>Antiviral Res.</ISOAbbreviation>
</Journal>
<ArticleTitle>Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein.</ArticleTitle>
<Pagination><MedlinePgn>58-74</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0166-3542(17)30397-2</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.antiviral.2017.11.001</ELocationID>
<Abstract><AbstractText>The multi-domain non-structural protein 3 (Nsp3) is the largest protein encoded by the coronavirus (CoV) genome, with an average molecular mass of about 200 kD. Nsp3 is an essential component of the replication/transcription complex. It comprises various domains, the organization of which differs between CoV genera, due to duplication or absence of some domains. However, eight domains of Nsp3 exist in all known CoVs: the ubiquitin-like domain 1 (Ubl1), the Glu-rich acidic domain (also called "hypervariable region"), a macrodomain (also named "X domain"), the ubiquitin-like domain 2 (Ubl2), the papain-like protease 2 (PL2<sup>pro</sup>
), the Nsp3 ectodomain (3Ecto, also called "zinc-finger domain"), as well as the domains Y1 and CoV-Y of unknown functions. In addition, the two transmembrane regions, TM1 and TM2, exist in all CoVs. The three-dimensional structures of domains in the N-terminal two thirds of Nsp3 have been investigated by X-ray crystallography and/or nuclear magnetic resonance (NMR) spectroscopy since the outbreaks of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) in 2003 as well as Middle-East Respiratory Syndrome coronavirus (MERS-CoV) in 2012. In this review, the structures and functions of these domains of Nsp3 are discussed in depth.</AbstractText>
<CopyrightInformation>Copyright © 2017 Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lei</LastName>
<ForeName>Jian</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kusov</LastName>
<ForeName>Yuri</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hilgenfeld</LastName>
<ForeName>Rolf</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany; German Center for Infection Research (DZIF), Hamburg - Lübeck - Borstel - Riems Site, University of Lübeck, Germany. Electronic address: hilgenfeld@biochem.uni-luebeck.de.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>11</Month>
<Day>08</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Antiviral Res</MedlineTA>
<NlmUniqueID>8109699</NlmUniqueID>
<ISSNLinking>0166-3542</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D025801">Ubiquitin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D017361">Viral Nonstructural Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0RH81L854J</RegistryNumber>
<NameOfSubstance UI="D005973">Glutamine</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.4.22.2</RegistryNumber>
<NameOfSubstance UI="D010206">Papain</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003332" MajorTopicYN="N">Coronaviridae</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005973" MajorTopicYN="N">Glutamine</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008958" MajorTopicYN="N">Models, Molecular</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010206" MajorTopicYN="N">Papain</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011485" MajorTopicYN="N">Protein Binding</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011487" MajorTopicYN="N">Protein Conformation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000072417" MajorTopicYN="N">Protein Domains</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054730" MajorTopicYN="N">Protein Interaction Domains and Motifs</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013329" MajorTopicYN="N">Structure-Activity Relationship</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D025801" MajorTopicYN="N">Ubiquitin</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017361" MajorTopicYN="N">Viral Nonstructural Proteins</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Innate immunity</Keyword>
<Keyword MajorTopicYN="Y">Macrodomain</Keyword>
<Keyword MajorTopicYN="Y">Nucleic-acid binding domain</Keyword>
<Keyword MajorTopicYN="Y">Papain-like protease</Keyword>
<Keyword MajorTopicYN="Y">Structural biology</Keyword>
<Keyword MajorTopicYN="Y">Ubiquitin-like domain</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year>
<Month>05</Month>
<Day>24</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2017</Year>
<Month>10</Month>
<Day>29</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>11</Month>
<Day>02</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>11</Month>
<Day>13</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2018</Year>
<Month>6</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>11</Month>
<Day>13</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">29128390</ArticleId>
<ArticleId IdType="pii">S0166-3542(17)30397-2</ArticleId>
<ArticleId IdType="doi">10.1016/j.antiviral.2017.11.001</ArticleId>
<ArticleId IdType="pmc">PMC7113668</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Nat Struct Mol Biol. 2009 Dec;16(12):1209-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19956206</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Sci Rep. 2017 Jan 12;7:40292</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28079137</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virol Sin. 2016 Aug;31(4):288-99</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27245450</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Rev Mol Cell Biol. 2005 Aug;6(8):599-609</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16064136</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2006 Sep;80(17):8493-502</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16912299</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5192-201</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27519799</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2003 Jul 26;362(9380):263-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12892955</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochim Biophys Acta. 2013 Nov;1833(11):2430-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23583305</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Cell. 2002 Dec 27;111(7):1041-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12507430</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 2007 Nov 2;282(44):32208-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17761676</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nucleic Acids Res. 2010 Jul;38(Web Server issue):W545-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20457744</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>FEBS J. 2014 Sep;281(18):4085-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25039866</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1953-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12690092</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virus Res. 2008 May;133(2):136-48</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18255185</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Rev Mol Cell Biol. 2012 Jun 20;13(7):411-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22713970</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Int J Mol Sci. 2016 May 05;17(5):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27164085</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Commun. 2013;4:1683</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23575687</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Gen Virol. 2006 Mar;87(Pt 3):651-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16476987</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Protein Sci. 2017 Sep;26(9):1726-1737</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28580734</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Enzyme Inhib Med Chem. 2016;31(1):23-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25683083</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Mol Biol. 2010 Jul 23;400(4):724-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20493876</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS Pathog. 2014 May 22;10(5):e1004113</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24854014</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2000 Feb;74(4):1674-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10644337</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochemistry. 2004 Dec 28;43(51):16254-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15610019</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS One. 2008 Oct 01;3(10):e3299</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18827877</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2000 Sep;74(17):7911-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10933699</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2009 Jan;83(2):1083-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18987156</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):572-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24531491</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Mol Biol. 2003 Aug 29;331(5):991-1004</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12927536</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11089-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7972015</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Comput Chem. 2004 Oct;25(13):1605-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15264254</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Exp Med. 2016 Jan 11;213(1):1-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26712804</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2014 Feb;88(4):2116-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24335297</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Clin Microbiol Rev. 2009 Apr;22(2):240-73, Table of Contents</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19366914</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2010 Oct;84(19):10276-88</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20660183</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>FEBS J. 2013 Aug;280(15):3519-29</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23639026</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>EMBO J. 2005 Jun 1;24(11):1911-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15902274</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Crit Rev Biochem Mol Biol. 2006 Sep-Oct;41(5):269-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16911956</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Chem Biol. 2016 Dec;12(12):998-1000</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27723750</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2004 Dec;78(24):13600-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15564471</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2005 Oct;79(20):12721-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16188975</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Gen Virol. 2013 Feb;94(Pt 2):298-307</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23136361</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2015 May;89(9):4907-17</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25694594</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 2014 Dec 12;289(50):34667-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25320088</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Mol Biol. 1987 Apr 5;194(3):531-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3041007</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1666-1671</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28143925</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virology. 2007 May 10;361(2):391-401</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17222884</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Curr Comput Aided Drug Des. 2016 Feb 26;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26916649</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virology. 2014 Feb;450-451:64-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24503068</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS Pathog. 2015 Jun 05;11(6):e1004950</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26046769</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Antiviral Res. 2015 Mar;115:21-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25554382</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>FEBS Lett. 2017 Oct;591(20):3190-3210</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28850669</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Acta Crystallogr D Biol Crystallogr. 2009 Dec;65(Pt 12):1292-300</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19966415</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2012 Nov 8;367(19):1814-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23075143</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS Biol. 2008 Sep 16;6(9):e226</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18798692</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Antiviral Res. 2016 Nov;135:97-107</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27743916</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5717-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16581910</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2009 Dec;83(24):12998-3008</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19828617</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem Soc Trans. 2012 Jun 1;40(3):539-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22616864</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Mutat Res. 2011 May-Jun;727(3):86-103</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21421074</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2017 Nov 14;91(23):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28931677</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2011 May;85(9):4572-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21345958</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Curr Top Microbiol Immunol. 2005;287:1-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15609507</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2006 Dec;80(23):11610-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16971428</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Cell. 1989 May 19;57(4):537-47</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2720781</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1967-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12690091</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Bioinformatics. 1999 Apr;15(4):305-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10320398</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2009 Feb;83(4):1823-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19052085</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Gen Virol. 2000 Apr;81(Pt 4):853-79</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10725411</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 2016 Mar 4;291(10):4894-902</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26740631</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Rev Mol Cell Biol. 2009 Aug;10(8):550-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19626045</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>ACS Chem Biol. 2015 Jun 19;10(6):1456-65</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25746232</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 2015 Mar 13;290(11):7160-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25609249</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem Biophys Res Commun. 2007 Dec 28;364(4):877-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17976532</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>EMBO Rep. 2008 Jun;9(6):536-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18516089</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Gen Virol. 2013 Aug;94(Pt 8):1749-1760</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23620378</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biol Pharm Bull. 2017;40(3):345-351</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28250277</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2016 Jan 20;90(7):3627-39</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26792741</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virology. 2015 Oct;484:313-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26149721</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>EMBO J. 2005 Nov 2;24(21):3747-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16211010</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2010 May;84(9):4619-29</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20181693</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2002 Apr;76(8):3697-708</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11907209</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2014 Nov;88(21):12511-27</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25142582</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>mBio. 2013 Aug 13;4(4):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23943763</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Antiviral Res. 2014 Mar;103:39-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24418573</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Protein Sci. 2009 Jan;18(1):6-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19177346</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Amino Acids. 2011 Jul;41(2):257-69</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20652610</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2004 Jun;78(11):5658-69</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15140963</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Mol Biosyst. 2015 Aug;11(8):2144-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26088262</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Protein Cell. 2014 May;5(5):369-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24622840</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 2015 Jan 30;290(5):3172-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25505178</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virus Res. 2006 Apr;117(1):17-37</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16503362</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>FEBS Lett. 1997 Jul 14;411(2-3):373-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9271239</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Structure. 2005 Nov;13(11):1665-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16271890</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 2001 Aug 31;276(35):33220-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11431476</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Mol Cell. 2016 May 19;62(4):572-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27203180</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Science. 1992 Sep 4;257(5075):1398-400</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1529340</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2008 Jun;82(11):5279-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18367524</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2008 Dec;82(24):12325-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18922871</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Rev Mol Cell Biol. 2009 Oct;10(10):659-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19773779</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2005 Dec;79(24):15189-98</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16306590</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Sci Rep. 2017 Feb 02;7:41746</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28150709</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8259-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1518855</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2007 Jun;81(11):6007-18</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17392370</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Arch Virol. 2012 Jul;157(7):1411-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22481600</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Curr Protein Pept Sci. 2015;16(6):491-501</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25938242</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Antiviral Res. 2013 Oct;100(1):286-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24012996</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 2015 Oct 16;290(42):25293-306</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26296883</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Mol Biol. 2017 Jun 2;429(11):1661-1683</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28438633</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Struct Mol Biol. 2017 Mar;24(3):270-278</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28165509</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2010 Oct;84(19):10063-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20668092</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Mol Biol. 2001 Jan 19;305(3):567-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11152613</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Med. 2004 Apr;10(4):368-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15034574</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2005 Jan;79(2):884-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15613317</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Curr Top Microbiol Immunol. 2015;384:3-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25027823</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2009 Jul;83(13):6689-705</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19369340</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Cell. 2003 Mar 21;112(6):779-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12654245</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>EMBO J. 2001 Feb 1;20(3):362-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11157743</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virology. 2009 Sep 1;391(2):304-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19580983</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2006 Jun;80(12):5927-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16731931</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Soc Exp Biol Med. 1966 Jan;121(1):190-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4285768</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 2005 Jul 22;280(29):27356-65</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15917233</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>FEBS J. 2008 Aug;275(16):4152-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18631359</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Cells. 2015 Sep 25;4(4):569-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26426055</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virology. 2014 Jun;458-459:125-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24928045</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS Pathog. 2011 Oct;7(10):e1002331</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22046132</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Gen Virol. 2011 Aug;92(Pt 8):1899-1905</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21525212</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2007 Nov;81(21):12049-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17728234</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2015 Feb;89(3):1523-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25428866</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Rev Mol Cell Biol. 2004 May;5(5):355-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15122349</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Oncogene. 2006 Oct 30;25(51):6844-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17072332</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 1997 Feb;71(2):900-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8995606</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2000 Jun;74(11):5053-65</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10799579</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Mol Biol. 2013 Dec 13;425(24):4995-5008</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24095857</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS Pathog. 2008 May 02;4(5):e1000054</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18451981</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Mol Biol. 2009 Dec 4;394(3):544-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19782089</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2013 Aug;87(16):9159-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23760243</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Methods Mol Biol. 2015;1282:1-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25720466</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Antiviral Res. 2014 Sep;109:72-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24992731</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Gen Virol. 2014 Mar;95(Pt 3):614-626</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24362959</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 1997 May 15;387(6630):296-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9153395</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2008 Dec;82(24):12392-405</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18842706</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Viral Immunol. 2012 Aug;25(4):277-88</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22876772</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochemistry. 1991 Sep 17;30(37):8924-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1892809</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS One. 2007 May 23;2(5):e459</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17520018</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Arch Gesamte Virusforsch. 1973;40(3):285-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4573193</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>FEBS Lett. 1991 Aug 19;288(1-2):201-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1652473</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Struct Biol. 1998 Jun;5(6):422-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9628477</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS Pathog. 2009 May;5(5):e1000428</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19436709</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2003 Apr 19;361(9366):1319-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12711465</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2013 Mar;87(6):3502-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23302895</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 2009 Mar 26;458(7237):422-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19325621</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Cell Res. 2006 Feb;16(2):141-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16474426</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>mBio. 2016 Dec 13;7(6):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27965448</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem J. 2015 Jun 1;468(2):215-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25764917</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2007 Apr;81(8):3922-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17251282</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proteins. 2012 Jul;80(7):1715-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22411565</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Br Med J. 1965 Jun 5;1(5448):1467-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14288084</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virol J. 2005 Aug 17;2:66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16107218</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2005 Dec;79(24):15199-208</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16306591</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2016 Sep 12;90(19):8478-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27440879</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Allemagne</li>
</country>
</list>
<tree><country name="Allemagne"><noRegion><name sortKey="Lei, Jian" sort="Lei, Jian" uniqKey="Lei J" first="Jian" last="Lei">Jian Lei</name>
</noRegion>
<name sortKey="Hilgenfeld, Rolf" sort="Hilgenfeld, Rolf" uniqKey="Hilgenfeld R" first="Rolf" last="Hilgenfeld">Rolf Hilgenfeld</name>
<name sortKey="Kusov, Yuri" sort="Kusov, Yuri" uniqKey="Kusov Y" first="Yuri" last="Kusov">Yuri Kusov</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000822 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000822 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= PubMed |étape= Checkpoint |type= RBID |clé= pubmed:29128390 |texte= Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:29128390" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a MersV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |