Serveur d'exploration MERS

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Replicative virus shedding in the respiratory tract of patients with Middle East respiratory syndrome coronavirus infection.

Identifieur interne : 000785 ( PubMed/Checkpoint ); précédent : 000784; suivant : 000786

Replicative virus shedding in the respiratory tract of patients with Middle East respiratory syndrome coronavirus infection.

Auteurs : Wan Beom Park [Corée du Sud] ; Leo L M. Poon [République populaire de Chine] ; Su-Jin Choi [Corée du Sud] ; Pyoeng Gyun Choe [Corée du Sud] ; Kyoung-Ho Song [Corée du Sud] ; Ji Hwan Bang [Corée du Sud] ; Eu Suk Kim [Corée du Sud] ; Hong Bin Kim [Corée du Sud] ; Sang Won Park [Corée du Sud] ; Nam Joong Kim [Corée du Sud] ; Malik Peiris [République populaire de Chine] ; Myoung-Don Oh [Corée du Sud]

Source :

RBID : pubmed:29753119

Descripteurs français

English descriptors

Abstract

Information on the duration of replicative Middle East respiratory syndrome coronavirus (MERS-CoV) shedding is important for infection control. The detection of MERS-CoV sub-genomic mRNAs indicates that the virus is replicative. This study examined the duration for detecting MERS-CoV sub-genomic mRNA compared with genomic RNA in diverse respiratory specimens.

DOI: 10.1016/j.ijid.2018.05.003
PubMed: 29753119


Affiliations:


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pubmed:29753119

Le document en format XML

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<term>Coronavirus Infections (physiopathology)</term>
<term>Coronavirus Infections (virology)</term>
<term>Humans</term>
<term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>Respiratory System (physiopathology)</term>
<term>Respiratory System (virology)</term>
<term>Reverse Transcription</term>
<term>Sputum (virology)</term>
<term>Virus Replication</term>
<term>Virus Shedding</term>
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<term>Appareil respiratoire (physiopathologie)</term>
<term>Appareil respiratoire (virologie)</term>
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<term>Excrétion virale</term>
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<term>Infections à coronavirus (physiopathologie)</term>
<term>Infections à coronavirus (virologie)</term>
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<term>Réplication virale</term>
<term>Transcription inverse</term>
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<term>Middle East Respiratory Syndrome Coronavirus</term>
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<term>Coronavirus Infections</term>
<term>Respiratory System</term>
<term>Sputum</term>
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<term>Humans</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>Reverse Transcription</term>
<term>Virus Replication</term>
<term>Virus Shedding</term>
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<keywords scheme="MESH" xml:lang="fr">
<term>Excrétion virale</term>
<term>Humains</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
<term>Réplication virale</term>
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<div type="abstract" xml:lang="en">Information on the duration of replicative Middle East respiratory syndrome coronavirus (MERS-CoV) shedding is important for infection control. The detection of MERS-CoV sub-genomic mRNAs indicates that the virus is replicative. This study examined the duration for detecting MERS-CoV sub-genomic mRNA compared with genomic RNA in diverse respiratory specimens.</div>
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<PMID Version="1">29753119</PMID>
<DateCompleted>
<Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised>
<Year>2020</Year>
<Month>04</Month>
<Day>07</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">1878-3511</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>72</Volume>
<PubDate>
<Year>2018</Year>
<Month>Jul</Month>
</PubDate>
</JournalIssue>
<Title>International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases</Title>
<ISOAbbreviation>Int. J. Infect. Dis.</ISOAbbreviation>
</Journal>
<ArticleTitle>Replicative virus shedding in the respiratory tract of patients with Middle East respiratory syndrome coronavirus infection.</ArticleTitle>
<Pagination>
<MedlinePgn>8-10</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S1201-9712(18)34411-4</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ijid.2018.05.003</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Information on the duration of replicative Middle East respiratory syndrome coronavirus (MERS-CoV) shedding is important for infection control. The detection of MERS-CoV sub-genomic mRNAs indicates that the virus is replicative. This study examined the duration for detecting MERS-CoV sub-genomic mRNA compared with genomic RNA in diverse respiratory specimens.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Upper and lower respiratory samples were obtained from 17 MERS-CoV-infected patients. MERS-CoV sub-genomic mRNA was detected by reverse transcription PCR (RT-PCR) and MERS-CoV genomic RNA by real-time RT-PCR.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">In sputum and transtracheal aspirate, sub-genomic mRNA was detected for up to 4 weeks after symptoms developed, which correlated with the detection of genomic RNA. In oropharyngeal and nasopharyngeal swab specimens, the detection of sub-genomic mRNA and genomic RNA did not correlate.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These findings suggest that MERS-CoV does not replicate well in the upper respiratory tract.</AbstractText>
<CopyrightInformation>Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.</CopyrightInformation>
</Abstract>
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<LastName>Park</LastName>
<ForeName>Wan Beom</ForeName>
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<Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea; Laboratory of Infection and Immunity, Seoul National University Hospital Biomedical Research Institute, Seoul, South Korea.</Affiliation>
</AffiliationInfo>
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<LastName>Poon</LastName>
<ForeName>Leo L M</ForeName>
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<ForeName>Su-Jin</ForeName>
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<Reference>
<Citation>Sci Rep. 2016 May 05;6:25359</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">27146253</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList>
<Reference>
<Citation>Clin Infect Dis. 2016 Feb 15;62(4):477-483</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">26565003</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList>
<Reference>
<Citation>Int J Infect Dis. 2014 Dec;29:307-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">25448335</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList>
<Reference>
<Citation>N Engl J Med. 2016 Sep 29;375(13):1303-5</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">27682053</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList>
<Reference>
<Citation>J Virol. 2007 Jan;81(1):20-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16928755</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList>
<Reference>
<Citation>Int J Mol Sci. 2016 May 07;17(5):</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">27164099</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList>
<Reference>
<Citation>Emerg Infect Dis. 2015 Dec;21(12):2186-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">26583829</ArticleId>
</ArticleIdList>
</Reference>
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<li>Corée du Sud</li>
<li>République populaire de Chine</li>
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<li>Séoul</li>
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<name sortKey="Choi, Su Jin" sort="Choi, Su Jin" uniqKey="Choi S" first="Su-Jin" last="Choi">Su-Jin Choi</name>
<name sortKey="Kim, Eu Suk" sort="Kim, Eu Suk" uniqKey="Kim E" first="Eu Suk" last="Kim">Eu Suk Kim</name>
<name sortKey="Kim, Hong Bin" sort="Kim, Hong Bin" uniqKey="Kim H" first="Hong Bin" last="Kim">Hong Bin Kim</name>
<name sortKey="Kim, Nam Joong" sort="Kim, Nam Joong" uniqKey="Kim N" first="Nam Joong" last="Kim">Nam Joong Kim</name>
<name sortKey="Oh, Myoung Don" sort="Oh, Myoung Don" uniqKey="Oh M" first="Myoung-Don" last="Oh">Myoung-Don Oh</name>
<name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang Won" last="Park">Sang Won Park</name>
<name sortKey="Song, Kyoung Ho" sort="Song, Kyoung Ho" uniqKey="Song K" first="Kyoung-Ho" last="Song">Kyoung-Ho Song</name>
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