A Case Study Evaluating the Risk of Infection from Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV) in a Hospital Setting Through Bioaerosols.
Identifieur interne : 000712 ( PubMed/Checkpoint ); précédent : 000711; suivant : 000713A Case Study Evaluating the Risk of Infection from Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV) in a Hospital Setting Through Bioaerosols.
Auteurs : Umesh Adhikari [États-Unis] ; Alexandre Chabrelie [États-Unis] ; Mark Weir [États-Unis] ; Kevin Boehnke [États-Unis] ; Erica Mckenzie [États-Unis] ; Luisa Ikner [États-Unis] ; Meng Wang [États-Unis] ; Qing Wang [États-Unis] ; Kyana Young [États-Unis] ; Charles N. Haas [États-Unis] ; Joan Rose [États-Unis] ; Jade Mitchell [États-Unis]Source :
- Risk analysis : an official publication of the Society for Risk Analysis [ 1539-6924 ] ; 2019.
Abstract
Middle Eastern respiratory syndrome, an emerging viral infection with a global case fatality rate of 35.5%, caused major outbreaks first in 2012 and 2015, though new cases are continuously reported around the world. Transmission is believed to mainly occur in healthcare settings through aerosolized particles. This study uses Quantitative Microbial Risk Assessment to develop a generalizable model that can assist with interpreting reported outbreak data or predict risk of infection with or without the recommended strategies. The exposure scenario includes a single index patient emitting virus-containing aerosols into the air by coughing, leading to short- and long-range airborne exposures for other patients in the same room, nurses, healthcare workers, and family visitors. Aerosol transport modeling was coupled with Monte Carlo simulation to evaluate the risk of MERS illness for the exposed population. Results from a typical scenario show the daily mean risk of infection to be the highest for the nurses and healthcare workers (8.49 × 10-4 and 7.91 × 10-4 , respectively), and the lowest for family visitors and patients staying in the same room (3.12 × 10-4 and 1.29 × 10-4 , respectively). Sensitivity analysis indicates that more than 90% of the uncertainty in the risk characterization is due to the viral concentration in saliva. Assessment of risk interventions showed that respiratory masks were found to have a greater effect in reducing the risks for all the groups evaluated (>90% risk reduction), while increasing the air exchange was effective for the other patients in the same room only (up to 58% risk reduction).
DOI: 10.1111/risa.13389
PubMed: 31524301
Affiliations:
- États-Unis
- Arizona, Delaware, Floride, Michigan, Ohio, Pennsylvanie
- East Lansing, Tampa
- Université d'État du Michigan, Université de Floride du Sud
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xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biosystems and Agricultural Engineering, Michigan State University, East Lansing, MI</wicri:regionArea><placeName><region type="state">Michigan</region><settlement type="city">East Lansing</settlement></placeName><orgName type="university">Université d'État du Michigan</orgName></affiliation></author><author><name sortKey="Chabrelie, Alexandre" sort="Chabrelie, Alexandre" uniqKey="Chabrelie A" first="Alexandre" last="Chabrelie">Alexandre Chabrelie</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biosystems and Agricultural Engineering, Michigan State University, East Lansing, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biosystems and Agricultural Engineering, Michigan State University, East Lansing, MI</wicri:regionArea><placeName><region type="state">Michigan</region><settlement type="city">East Lansing</settlement></placeName><orgName type="university">Université d'État du Michigan</orgName></affiliation></author><author><name sortKey="Weir, Mark" sort="Weir, Mark" uniqKey="Weir M" first="Mark" last="Weir">Mark Weir</name><affiliation wicri:level="2"><nlm:affiliation>Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Boehnke, Kevin" sort="Boehnke, Kevin" uniqKey="Boehnke K" first="Kevin" last="Boehnke">Kevin Boehnke</name><affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology & the Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Anesthesiology & the Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Mckenzie, Erica" sort="Mckenzie, Erica" uniqKey="Mckenzie E" first="Erica" last="Mckenzie">Erica Mckenzie</name><affiliation wicri:level="2"><nlm:affiliation>Department of Civil and Environmental Engineering, Temple University, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Civil and Environmental Engineering, Temple University, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Ikner, Luisa" sort="Ikner, Luisa" uniqKey="Ikner L" first="Luisa" last="Ikner">Luisa Ikner</name><affiliation wicri:level="2"><nlm:affiliation>Department of Soil, Water and Environmental Science, University of Arizona, Tucson, AZ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Soil, Water and Environmental Science, University of Arizona, Tucson, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Wang, Meng" sort="Wang, Meng" uniqKey="Wang M" first="Meng" last="Wang">Meng Wang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Civil & Environmental Engineering, University of South Florida, Tampa, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Civil & Environmental Engineering, University of South Florida, Tampa, FL</wicri:regionArea><placeName><region type="state">Floride</region><settlement type="city">Tampa</settlement></placeName><orgName type="university">Université de Floride du Sud</orgName></affiliation></author><author><name sortKey="Wang, Qing" sort="Wang, Qing" uniqKey="Wang Q" first="Qing" last="Wang">Qing Wang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Animal and Food Sciences, University of Delaware, Newark, DE, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Animal and Food Sciences, University of Delaware, Newark, DE</wicri:regionArea><placeName><region type="state">Delaware</region></placeName></affiliation></author><author><name sortKey="Young, Kyana" sort="Young, Kyana" uniqKey="Young K" first="Kyana" last="Young">Kyana Young</name><affiliation wicri:level="4"><nlm:affiliation>Department of Fisheries and Wildlife, Michigan State University, East Lansing, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Fisheries and Wildlife, Michigan State University, East Lansing, MI</wicri:regionArea><placeName><region type="state">Michigan</region><settlement type="city">East Lansing</settlement></placeName><orgName type="university">Université d'État du Michigan</orgName></affiliation></author><author><name sortKey="Haas, Charles N" sort="Haas, Charles N" uniqKey="Haas C" first="Charles N" last="Haas">Charles N. Haas</name><affiliation wicri:level="2"><nlm:affiliation>Department of Civil, Architectural and Environmental Engineering, Drexel University, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Civil, Architectural and Environmental Engineering, Drexel University, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Rose, Joan" sort="Rose, Joan" uniqKey="Rose J" first="Joan" last="Rose">Joan Rose</name><affiliation wicri:level="4"><nlm:affiliation>Department of Fisheries and Wildlife, Michigan State University, East Lansing, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Fisheries and Wildlife, Michigan State University, East Lansing, MI</wicri:regionArea><placeName><region type="state">Michigan</region><settlement type="city">East Lansing</settlement></placeName><orgName type="university">Université d'État du Michigan</orgName></affiliation></author><author><name sortKey="Mitchell, Jade" sort="Mitchell, Jade" uniqKey="Mitchell J" first="Jade" last="Mitchell">Jade Mitchell</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biosystems and Agricultural Engineering, Michigan State University, East Lansing, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biosystems and Agricultural Engineering, Michigan State University, East Lansing, MI</wicri:regionArea><placeName><region type="state">Michigan</region><settlement type="city">East Lansing</settlement></placeName><orgName type="university">Université d'État du Michigan</orgName></affiliation></author></analytic><series><title level="j">Risk analysis : an official publication of the Society for Risk Analysis</title><idno type="eISSN">1539-6924</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle Eastern respiratory syndrome, an emerging viral infection with a global case fatality rate of 35.5%, caused major outbreaks first in 2012 and 2015, though new cases are continuously reported around the world. Transmission is believed to mainly occur in healthcare settings through aerosolized particles. This study uses Quantitative Microbial Risk Assessment to develop a generalizable model that can assist with interpreting reported outbreak data or predict risk of infection with or without the recommended strategies. The exposure scenario includes a single index patient emitting virus-containing aerosols into the air by coughing, leading to short- and long-range airborne exposures for other patients in the same room, nurses, healthcare workers, and family visitors. Aerosol transport modeling was coupled with Monte Carlo simulation to evaluate the risk of MERS illness for the exposed population. Results from a typical scenario show the daily mean risk of infection to be the highest for the nurses and healthcare workers (8.49 × 10<sup>-4</sup> and 7.91 × 10<sup>-4</sup> , respectively), and the lowest for family visitors and patients staying in the same room (3.12 × 10<sup>-4</sup> and 1.29 × 10<sup>-4</sup> , respectively). Sensitivity analysis indicates that more than 90% of the uncertainty in the risk characterization is due to the viral concentration in saliva. Assessment of risk interventions showed that respiratory masks were found to have a greater effect in reducing the risks for all the groups evaluated (>90% risk reduction), while increasing the air exchange was effective for the other patients in the same room only (up to 58% risk reduction).</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">31524301</PMID><DateRevised><Year>2020</Year><Month>03</Month><Day>12</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1539-6924</ISSN><JournalIssue CitedMedium="Internet"><Volume>39</Volume><Issue>12</Issue><PubDate><Year>2019</Year><Month>12</Month></PubDate></JournalIssue><Title>Risk analysis : an official publication of the Society for Risk Analysis</Title><ISOAbbreviation>Risk Anal.</ISOAbbreviation></Journal><ArticleTitle>A Case Study Evaluating the Risk of Infection from Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV) in a Hospital Setting Through Bioaerosols.</ArticleTitle><Pagination><MedlinePgn>2608-2624</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/risa.13389</ELocationID><Abstract><AbstractText>Middle Eastern respiratory syndrome, an emerging viral infection with a global case fatality rate of 35.5%, caused major outbreaks first in 2012 and 2015, though new cases are continuously reported around the world. Transmission is believed to mainly occur in healthcare settings through aerosolized particles. This study uses Quantitative Microbial Risk Assessment to develop a generalizable model that can assist with interpreting reported outbreak data or predict risk of infection with or without the recommended strategies. The exposure scenario includes a single index patient emitting virus-containing aerosols into the air by coughing, leading to short- and long-range airborne exposures for other patients in the same room, nurses, healthcare workers, and family visitors. Aerosol transport modeling was coupled with Monte Carlo simulation to evaluate the risk of MERS illness for the exposed population. Results from a typical scenario show the daily mean risk of infection to be the highest for the nurses and healthcare workers (8.49 × 10<sup>-4</sup> and 7.91 × 10<sup>-4</sup> , respectively), and the lowest for family visitors and patients staying in the same room (3.12 × 10<sup>-4</sup> and 1.29 × 10<sup>-4</sup> , respectively). Sensitivity analysis indicates that more than 90% of the uncertainty in the risk characterization is due to the viral concentration in saliva. Assessment of risk interventions showed that respiratory masks were found to have a greater effect in reducing the risks for all the groups evaluated (>90% risk reduction), while increasing the air exchange was effective for the other patients in the same room only (up to 58% risk reduction).</AbstractText><CopyrightInformation>© 2019 Society for Risk Analysis.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Adhikari</LastName><ForeName>Umesh</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Department of Biosystems and Agricultural Engineering, Michigan State University, East Lansing, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chabrelie</LastName><ForeName>Alexandre</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0002-0975-2044</Identifier><AffiliationInfo><Affiliation>Department of Biosystems and Agricultural Engineering, Michigan State University, East Lansing, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weir</LastName><ForeName>Mark</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-6995-1037</Identifier><AffiliationInfo><Affiliation>Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boehnke</LastName><ForeName>Kevin</ForeName><Initials>K</Initials><Identifier Source="ORCID">0000-0003-3696-3979</Identifier><AffiliationInfo><Affiliation>Department of Anesthesiology & the Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McKenzie</LastName><ForeName>Erica</ForeName><Initials>E</Initials><Identifier Source="ORCID">0000-0003-1982-2533</Identifier><AffiliationInfo><Affiliation>Department of Civil and Environmental Engineering, Temple University, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ikner</LastName><ForeName>Luisa</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Soil, Water and Environmental Science, University of Arizona, Tucson, AZ, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Meng</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Civil & Environmental Engineering, University of South Florida, Tampa, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Qing</ForeName><Initials>Q</Initials><Identifier Source="ORCID">0000-0002-3560-5195</Identifier><AffiliationInfo><Affiliation>Department of Animal and Food Sciences, University of Delaware, Newark, DE, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Young</LastName><ForeName>Kyana</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Fisheries and Wildlife, Michigan State University, East Lansing, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haas</LastName><ForeName>Charles N</ForeName><Initials>CN</Initials><Identifier Source="ORCID">0000-0002-9255-9930</Identifier><AffiliationInfo><Affiliation>Department of Civil, Architectural and Environmental Engineering, Drexel University, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rose</LastName><ForeName>Joan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Fisheries and Wildlife, Michigan State University, East Lansing, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mitchell</LastName><ForeName>Jade</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0003-2199-4190</Identifier><AffiliationInfo><Affiliation>Department of Biosystems and Agricultural Engineering, Michigan State University, East Lansing, MI, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R25GM108593</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>09</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Risk Anal</MedlineTA><NlmUniqueID>8109978</NlmUniqueID><ISSNLinking>0272-4332</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Hospital</Keyword><Keyword MajorTopicYN="Y">MERS-CoV</Keyword><Keyword MajorTopicYN="Y">QMRA</Keyword><Keyword MajorTopicYN="Y">mitigation</Keyword><Keyword MajorTopicYN="Y">risk characterization</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>07</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>05</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>06</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>9</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>9</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>9</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31524301</ArticleId><ArticleId IdType="doi">10.1111/risa.13389</ArticleId></ArticleIdList><ReferenceList><Title>REFERENCES</Title><Reference><Citation>Al-Abdallar, M. (2014). Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: A serologic, epidemiologic, and clinical description. Clinical Infectious Diseases, 59(9), 1-9. http://doi.org/10.1093/cid/ciu359.Hospital-Associated</Citation></Reference><Reference><Citation>Al-Tawfiq, J. A. (2013). Middle East respiratory syndrome-coronavirus infection: An overview. Journal of Infection and Public Health, 6(5), 319-322. http://doi.org/10.1016/j.jiph.2013.06.001</Citation></Reference><Reference><Citation>Al-Tawfiq, J. A., & Perl, T. M. (2015). Middle East respiratory syndrome coronavirus in healthcare settings. Current Opinion in Infectious Diseases, 28(4), 392-396. http://doi.org/10.1097/QCO.0000000000000178</Citation></Reference><Reference><Citation>Bałazy, A., Toivola, M., Adhikari, A., Sivasubramani, S. K., Reponen, T., & Grinshpun, S. A. (2006). Do N95 respirators provide 95% protection level against airborne viruses, and how adequate are surgical masks? American Journal of Infection Control, 34(2), 51-57. http://doi.org/10.1016/j.ajic.2005.08.018</Citation></Reference><Reference><Citation>Bałazy, A., Toivola, M., Reponen, T., Podgórski, A., Zimmer, A., & Grinshpun, S. A. (2006). Manikin-based performance evaluation of N95 filtering-facepiece respirators challenged with nanoparticles. Annals of Occupational Hygiene, 50(3), 259-269. http://doi.org/10.1093/annhyg/mei058</Citation></Reference><Reference><Citation>Banik, G. R., Khandaker, G., & Rashid, H. (2015). Middle East respiratory syndrome coronavirus “MERS-CoV”: Current knowledge gaps. Paediatric Respiratory Reviews, 16(3), 197-202. http://doi.org/10.1016/j.prrv.2015.04.002</Citation></Reference><Reference><Citation>Borkow, G., Zhou, S. S., Page, T., & Gabbay, J. (2010). A novel anti-influenza copper oxide containing respiratory face mask. PLoS One, 5(6), 1-8. http://doi.org/10.1371/journal.pone.0011295</Citation></Reference><Reference><Citation>Breban, R., Riou, J., & Fontanet, A. (2013). Interhuman transmissibility of Middle East respiratory syndrome coronavirus: Estimation of pandemic risk. The Lancet, 382(9893), 694-699. http://doi.org/10.1016/S0140-6736(13)61492-0</Citation></Reference><Reference><Citation>CDC. (2017a). Implementing home care and isolation or quarantine of people not requiring hospitalization for MERS-CoV. Retrieved from https://www.cdc.gov/coronavirus/mers/hcp/home-care.html</Citation></Reference><Reference><Citation>CDC. (2017b). Preventing MERS-CoV from spreading to others in homes and communities. Retrieved from https://www.cdc.gov/coronavirus/mers/hcp/home-care-patient.html</Citation></Reference><Reference><Citation>Chabrelie, A., Mitchell, J., Rose, J., Charbonneau, D., & Ishida, Y. (2018). Evaluation of the influenza risk reduction from antimicrobial spray application on porous surfaces. Risk Analysis, 38(7), 1502-1517. http://doi.org/10.1111/risa.12952</Citation></Reference><Reference><Citation>Chan, J. F. W., Lau, S. K. P., To, K. K. W., Cheng, V. C. C., Woo, P. C. Y., & Yue, K. Y. (2015). Middle East respiratory syndrome coronavirus: Another zoonotic betacoronavirus causing SARS-like disease. Clinical Microbiology Reviews, 28(2), 465-522. http://doi.org/10.1128/CMR.00102-14</Citation></Reference><Reference><Citation>Cho, S. Y., Kang, J. M., Ha, Y. E., Park, G. E., Lee, J. Y., Ko, J. H., … Kim, Y. J. (2016). MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: An epidemiological outbreak study. The Lancet, 388(10048), 994-1001. http://doi.org/10.1016/S0140-6736(16)30623-7</Citation></Reference><Reference><Citation>Cohen, B., Hyman, S., Rosenberg, L., & Larson, E. (2012). Frequency of patient contact with health care personnel and visitors: Implications for infection prevention. Journal of Investigative Dermatology, 38(12), 560-565. http://doi.org/10.1038/jid.2014.371</Citation></Reference><Reference><Citation>Corman, V. M., Albarrak, A. M., Omrani, A. S., Albarrak, M. M., Farah, M. E., Almasri, M., … Memish, Z. A. (2015). Viral shedding and antibody response in 37 patients with Middle East respiratory syndrome coronavirus infection. Clinical Infectious Diseases, 62(4), 477-483. http://doi.org/10.1093/cid/civ951</Citation></Reference><Reference><Citation>Cowling, B. J., Park, M., Fang, V. J., Wu, P., Leung, G. M., & Wu, J. T. (2015). Preliminary epidemiologic assessment of MERS-CoV outbreak in South Korea, May-June 2015. Euro Surveillance, 20(25), 7-13. http://doi.org/10.1002/nbm.3369.Three</Citation></Reference><Reference><Citation>De Albuquerque, N., Baig, E., Ma, X., Zhang, J., He, W., Rowe, A., … Levy, G. A. (2006). Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice. Journal of Virology, 80(21), 10382-10394. http://doi.org/10.1128/JVI.00747-06</Citation></Reference><Reference><Citation>DeDiego, M. L., Pewe, L., Alvarez, E., Rejas, M. T., Perlman, S., & Enjuanes, L. (2008). Pathogenicity of severe acute respiratory coronavirus deletion mutants in hACE-2 transgenic mice. Virology, 376(2), 379-389. http://doi.org/10.1016/j.virol.2008.03.005</Citation></Reference><Reference><Citation>de Groot, R. J., Baker, S. C., Baric, R. S., Brown, C. S., Drosten, C., Enjuanes, L., … Ziebuhr, J. (2013). Middle East respiratory syndrome coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group. Journal of Virology, 87(14), 7790-7792. http://doi.org/10.1128/JVI.01244-13</Citation></Reference><Reference><Citation>Drosten, C., Muth, D., Corman, V. M., Hussain, R., Al Masri, M., HajOmar, W., … Memish, Z. A. (2015). An observational, laboratory-based study of outbreaks of Middle East respiratory syndrome coronavirus in Jeddah and Riyadh, Kingdom of Saudi Arabia, 2014. Clinical Infectious Diseases, 60(3), 369-377. http://doi.org/10.1093/cid/ciu812</Citation></Reference><Reference><Citation>Duguid, J. P. (1946). The size and the duration of air-carriage of respiratory droplets and droplet-nuclei. The Journal of Hygiene, 44(6), 471-479. http://doi.org/10.1017/S0022172400019288</Citation></Reference><Reference><Citation>EPA, US. (2011). Exposure factors handbook 2011 edition (final). Washington, DC. Retrieved from https://cfpub.epa.gov/ncea/risk/recordisplay.cfm?deid=236252</Citation></Reference><Reference><Citation>Gupta, S. (2011). Surgical masks vs. N95 respirator masks for protecting health care professionals. Indian Journal of Pediatrics, 78(2), 242-243. http://doi.org/10.1007/s12098-010-0264-1</Citation></Reference><Reference><Citation>Haas, C., Rose, J., & Gerba, C. (2014). Quantitative microbial risk assessment. In C. Haas, J. Rose, & C. Gerba (Eds.), Quantitative microbial risk assessment (2nd ed., pp. 323-373). Hoboken, NJ: John Wiley & Sons, Inc. Retrieved from https://onlinelibrary.wiley.com/doi/book/10.1002/9781118910030</Citation></Reference><Reference><Citation>Han, H.-J., Wen, H.-I., Zhou, C.-M., Chen, F.-F., Luo, L.-M., Liu, J., & Yu, X.-J. (2015). Bats as reservoirs of severe emerging infectious diseases. Virus Research, 205, 1-6. http://doi.org/10.1016/j.virusres.2015.05.006</Citation></Reference><Reference><Citation>Hilgenfeld, R., & Peiris, M. (2013). From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses. Antiviral Research, 100(1), 286-295. http://doi.org/10.1016/j.antiviral.2013.08.015</Citation></Reference><Reference><Citation>Houng, H. S. H., Norwood, D., Ludwig, G. V., Sun, W., Lin, M., & Vaughn, D. W. (2004). Development and evaluation of an efficient 3′-noncoding region based SARS coronavirus (SARS-CoV) RT-PCR assay for detection of SARS-CoV infections. Journal of Virological Methods, 120(1), 33-40. http://doi.org/10.1016/j.jviromet.2004.04.008</Citation></Reference><Reference><Citation>Huang, Y. (2013). SARS: Dose response models. Retrieved from http://qmrawiki.canr.msu.edu/index.php/SARS:_Dose_Response_Models#_9f6e9f18777d09a3e4569b0d5784d92f</Citation></Reference><Reference><Citation>Ijaz, M. K., Brunner, A. H., Sattar, S. A., Nair, R. C., & Johnson-Lussenburg, C. M. (1985). Survival characteristics of airborne human coronavirus 229E. Journal of General Virology, 66(12), 2743-2748. http://doi.org/10.1099/0022-1317-66-12-2743</Citation></Reference><Reference><Citation>Ki, M. (2015). 2015 MERS outbreak in Korea: Hospital-to-hospital transmission. Epidemiology and Health, 37, 1-4. http://doi.org/10.4178/epih/e2015033</Citation></Reference><Reference><Citation>Kim, K. M., Ki, M., Cho, S.-I., Sung, M., Hong, J. K., Cheong, H.-K., … Choi, B. Y. (2015). Epidemiologic features of the first MERS outbreak in Korea: Focus on Pyeongtaek St. Mary's Hospital. Epidemiology and Health, 37(October), e2015041. http://doi.org/10.4178/epih/e2015041</Citation></Reference><Reference><Citation>Loudon, R., & Brown, L. (1967). Droplet expulsion from the respiratory tract. The American Review of Respiratory Disease, 95(3), 435-442. https://www.atsjournals.org/doi/pdf/10.1164/arrd.1967.95.3.435</Citation></Reference><Reference><Citation>Lu, G., Wang, Q., & Gao, G. F. (2015). Bat-to-human: Spike features determining “host jump” of coronaviruses SARS-CoV, MERS-CoV, and beyond. Trends in Microbiology, 23(8), 468-478. http://doi.org/10.1016/j.tim.2015.06.003</Citation></Reference><Reference><Citation>Memish, Z. A., Assiri, A. M., & Al-Tawfiq, J. A. (2014). Middle East respiratory syndrome coronavirus (MERS-CoV) viral shedding in the respiratory tract: An observational analysis with infection control implications. International Journal of Infectious Diseases, 29, 307-308. http://doi.org/10.1016/j.ijid.2014.10.002</Citation></Reference><Reference><Citation>Min, C. K., Cheon, S., Ha, N. Y., Sohn, K. M., Kim, Y., Aigerim, A., … Kim, Y. S. (2016). Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity. Scientific Reports, 6(April), 1-12. http://doi.org/10.1038/srep25359</Citation></Reference><Reference><Citation>Mitchell, J., & Weir, M. (n.d.). SARS. Retrieved from http://www.qmrawiki.org/pathogens/sars</Citation></Reference><Reference><Citation>Muth, D., Corman, V. M., Meyer, B., Assiri, A., Al-Masri, M., Farah, M., … Memishc, Z. A. (2015). Infectious Middle East respiratory syndrome coronavirus excretion and serotype variability based on live virus isolates from patients in Saudi Arabia. Journal of Clinical Microbiology, 53(9), 2951-2955. http://doi.org/10.1128/JCM.01368-15</Citation></Reference><Reference><Citation>Nicas, M., & Jones, R. M. (2009). Relative contributions of four exposure pathways to influenza infection risk. Risk Analysis, 29(9), 1292-1303. http://doi.org/10.1111/j.1539-6924.2009.01253.x</Citation></Reference><Reference><Citation>Nicas, M., Nazaroff, W., & Hubbard, A. (2005). Toward understanding the risk of secondary airborne infection: Emission of respirable pathogens. Journal of Occupational and Environmental Hygiene, 2(3), 143-154. http://doi.org/10.1080/15459620590918466</Citation></Reference><Reference><Citation>Nichol, K., Bigelow, P., O'Brien-Pallas, L., McGeer, A., Manno, M., & Holness, D. L. (2008). The individual, environmental, and organizational factors that influence nurses’ use of facial protection to prevent occupational transmission of communicable respiratory illness in acute care hospitals. American Journal of Infection Control, 36(7), 481-487. http://doi.org/10.1016/j.ajic.2007.12.004</Citation></Reference><Reference><Citation>Nishiura, H., Miyamatsu, Y., Chowell, G., & Saitoh, M. (2015). Assessing the risk of observing multiple generations of Middle East respiratory syndrome (MERS) cases given an imported case. Eurosurveillance, 20(27), 6-11. http://doi.org/10.2807/1560-7917.ES2015.20.27.21181</Citation></Reference><Reference><Citation>Papineni, R. S., & Rosenthal, F. S. (1997). The size distribution of droplets in the exhaled breath of healthy human subjects. Journal of Aerosol Medicine, 10(2), 105-116. http://doi.org/10.1089/jam.1997.10.105</Citation></Reference><Reference><Citation>Park, B., Peck, A., Kuehnert, M., Newbern, C., Smelser, C., Comer, J. A., … McDonald, C. (2004). Lack of SARS transmission among healthcare workers, United States. Emerging Infectious Diseases, 10(2), 217-224. http://doi.org/10.3201/eid1002.030746</Citation></Reference><Reference><Citation>Park, H. Y., Lee, E. J., Ryu, Y. W., Kim, Y., Kim, H., Lee, H., & Yi, S. J. (2015). Epidemiological investigation of MERS-CoV spread in a single hospital in South Korea, May to June 2015. Eurosurveillance, 20(25), 1-5. http://doi.org/10.2807/1560-7917.ES2015.20.25.21169</Citation></Reference><Reference><Citation>Park, J. W., Lee, K. J., Lee, K. H., Lee, S. H., Cho, J. R., Mo, J. W., … Nam, H. S. (2017). Hospital outbreaks of Middle East respiratory syndrome, Daejeon, South Korea, 2015. Emerging Infectious Diseases, 23(6), 898-905. http://doi.org/10.3201/eid2306.160120</Citation></Reference><Reference><Citation>Park, S. H., Kim, Y. S., Jung, Y., Choi, S. young, Cho, N. H., Jeong, H. W., … Sohn, K. M. (2016). Outbreaks of Middle East respiratory syndrome in two hospitals initiated by a single patient in Daejeon, South Korea. Infection and Chemotherapy, 48(2), 99-107. http://doi.org/10.3947/ic.2016.48.2.99</Citation></Reference><Reference><Citation>Poletto, C., Pelat, C., Lévy-Bruhl, D., Boelle, P. Y., & Colizza, V. (2016). Assessment of the Middle East respiratory syndrome coronavirus (MERS-CoV) epidemic in the Middle East and risk of international spread using a novel maximum likelihood analysis approach. Eurosurveillance, 19(6), 1-10. https://www.eurosurveillance.org/content/10.2807/1560-7917.ES2014.19.23.20824</Citation></Reference><Reference><Citation>Rengasamy, A., Zhuang, Z., & Berryann, R. (2004). Respiratory protection against bioaerosols: Literature review and research needs. American Journal of Infection Control, 32(6), 345-354. http://doi.org/10.1016/j.ajic.2004.04.199</Citation></Reference><Reference><Citation>Sampath, R., Hofstadler, S. A., Blyn, L. B., Eshoo, M. W., Hall, T. A., Massire, C., … Ecker, D. J. (2005). Rapid identification of emerging pathogens: Coronavirus. Emerging Infectious Diseases, 11(3), 373-379. http://doi.org/10.3201/eid1103.040629</Citation></Reference><Reference><Citation>Seto, W. H. (2015). Airborne transmission and precautions: Facts and myths. Journal of Hospital Infection, 89(4), 225-228. http://doi.org/10.1016/j.jhin.2014.11.005</Citation></Reference><Reference><Citation>Seto, W., Tsang, D., Yung, R., Ching, T., Ng, T., Ho, M., … Peiris, J. (2003). Effectiveness of precautions against droplets and contact in prevention of nosocomial transmission of severe acute respiratory syndrome (SARS). The Lancet, 361(9368), 1519-1520. http://doi.org/10.1016/S0140-6736(03)13168-6</Citation></Reference><Reference><Citation>Stilianakis, N. I., & Drossinos, Y. (2010). Dynamics of infectious disease transmission by inhalable respiratory droplets. Journal of the Royal Society, 7(50), 1355-1366. http://doi.org/10.1098/rsif.2010.0026</Citation></Reference><Reference><Citation>Sutton, T. C., & Subbarao, K. (2015). Development of animal models against emerging coronaviruses: From SARS to MERS coronavirus. Virology, 479-480, 247-258. http://doi.org/10.1016/j.virol.2015.02.030</Citation></Reference><Reference><Citation>Thompson, K. A., Pappachan, J. V., Bennett, A. M., Mittal, H., Macken, S., Dove, B. K., … Thomson, G. (2013). Influenza Aerosols in UK Hospitals during the H1N1 (2009) Pandemic-The risk of aerosol generation during medical procedures. PLoS One, 8(2), 1-15. http://doi.org/10.1371/journal.pone.0056278</Citation></Reference><Reference><Citation>Tran, K., Cimon, K., Severn, M., Pessoa-Silva, C. L., & Conly, J. (2012). Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: A systematic review. PLoS One, 7(4), 1-8. http://doi.org/10.1371/journal.pone.0035797</Citation></Reference><Reference><Citation>Van Doremalen, N., & Munster, V. J. (2015). Animal models of Middle East respiratory syndrome coronavirus infection. Antiviral Research, 122, 28-38. http://doi.org/10.1016/j.antiviral.2015.07.005</Citation></Reference><Reference><Citation>Watanabe, T., Bartrand, T. A., Weir, M. H., Omura, T., & Haas, C. N. (2010). Development of a dose-response model for SARS coronavirus. Risk Analysis, 30(7), 1129-1138. http://doi.org/10.1111/j.1539-6924.2010.01427.x</Citation></Reference><Reference><Citation>Wen, Z., Yu, L., Yang, W., Hu, L., Li, N., Wang, J., … Zhang, K. (2013). Assessment the protection performance of different level personal respiratory protection masks against viral aerosol. Aerobiologia, 29(3), 365-372. http://doi.org/10.1007/s10453-012-9286-7</Citation></Reference><Reference><Citation>Widagdo, W., Okba, N. M. A., Stalin Raj, V., & Haagmans, B. L. (2017). MERS-coronavirus: From discovery to intervention. One Health, 3, 11-16. http://doi.org/10.1016/j.onehlt.2016.12.001</Citation></Reference><Reference><Citation>World Health Organization. (2015). Middle East respiratory syndrome coronavirus (MERS-CoV): Summary and risk assessment of current situation in the Republic of Korea and China-As of 19 June 2015. Retrieved from who.int/csr/disease/coronavirus_infections/risk-assessment-19june2015/en/</Citation></Reference><Reference><Citation>World Health Organization. (2018). WHO MERS global summary and assessment of risk. Retrieved from http://www.who.int/csr/disease/coronavirus_infections/risk-assessment-august-2018.pdf</Citation></Reference><Reference><Citation>Xia, S., Liu, Q., Wang, Q., Sun, Z., Su, S., Du, L., … Jiang, S. (2014). Middle East respiratory syndrome coronavirus (MERS-CoV) entry inhibitors targeting spike protein. Virus Research, 194, 200-210. http://doi.org/10.1016/j.virusres.2014.10.007</Citation></Reference><Reference><Citation>Xiao, S., Li, Y., Sung, M., Wei, J., & Yang, Z. (2018). A study of the probable transmission routes of MERS-CoV during the first hospital outbreak in the Republic of Korea. Indoor Air, 28(1), 51-63. http://doi.org/10.1111/ina.12430</Citation></Reference><Reference><Citation>Yin, Y., Gupta, J. K., Zhang, X., Liu, J., & Chen, Q. (2011). Distributions of respiratory contaminants from a patient with different postures and exhaling modes in a single-bed inpatient room. Building and Environment, 46(1), 75-81. http://doi.org/10.1016/j.buildenv.2010.07.003</Citation></Reference><Reference><Citation>Zhou, J., Chu, H., Chan, J. F.-W., & Yuen, K.-Y. (2015). Middle East respiratory syndrome coronavirus infection: Virus-host cell interactions and implications on pathogenesis. Virology Journal, 12(1), 218. http://doi.org/10.1186/s12985-015-0446-6</Citation></Reference><Reference><Citation>Zumla, A., & Hui, D. S. (2014). Infection control and MERS-CoV in health-care workers. The Lancet, 383(9932), 1869-1871. http://doi.org/10.1016/S0140-6736(14)60852-7</Citation></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Arizona</li><li>Delaware</li><li>Floride</li><li>Michigan</li><li>Ohio</li><li>Pennsylvanie</li></region><settlement><li>East Lansing</li><li>Tampa</li></settlement><orgName><li>Université d'État du Michigan</li><li>Université de Floride du Sud</li></orgName></list><tree><country name="États-Unis"><region name="Michigan"><name sortKey="Adhikari, Umesh" sort="Adhikari, Umesh" uniqKey="Adhikari U" first="Umesh" last="Adhikari">Umesh Adhikari</name></region><name sortKey="Boehnke, Kevin" sort="Boehnke, Kevin" uniqKey="Boehnke K" first="Kevin" last="Boehnke">Kevin Boehnke</name><name sortKey="Chabrelie, Alexandre" sort="Chabrelie, Alexandre" uniqKey="Chabrelie A" first="Alexandre" last="Chabrelie">Alexandre Chabrelie</name><name sortKey="Haas, Charles N" sort="Haas, Charles N" uniqKey="Haas C" first="Charles N" last="Haas">Charles N. Haas</name><name sortKey="Ikner, Luisa" sort="Ikner, Luisa" uniqKey="Ikner L" first="Luisa" last="Ikner">Luisa Ikner</name><name sortKey="Mckenzie, Erica" sort="Mckenzie, Erica" uniqKey="Mckenzie E" first="Erica" last="Mckenzie">Erica Mckenzie</name><name sortKey="Mitchell, Jade" sort="Mitchell, Jade" uniqKey="Mitchell J" first="Jade" last="Mitchell">Jade Mitchell</name><name sortKey="Rose, Joan" sort="Rose, Joan" uniqKey="Rose J" first="Joan" last="Rose">Joan Rose</name><name sortKey="Wang, Meng" sort="Wang, Meng" uniqKey="Wang M" first="Meng" last="Wang">Meng Wang</name><name sortKey="Wang, Qing" sort="Wang, Qing" uniqKey="Wang Q" first="Qing" last="Wang">Qing Wang</name><name sortKey="Weir, Mark" sort="Weir, Mark" uniqKey="Weir M" first="Mark" last="Weir">Mark Weir</name><name sortKey="Young, Kyana" sort="Young, Kyana" uniqKey="Young K" first="Kyana" last="Young">Kyana Young</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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