Complement Receptor C5aR1 Inhibition Reduces Pyroptosis in hDPP4-Transgenic Mice Infected with MERS-CoV.
Identifieur interne : 000629 ( PubMed/Checkpoint ); précédent : 000628; suivant : 000630Complement Receptor C5aR1 Inhibition Reduces Pyroptosis in hDPP4-Transgenic Mice Infected with MERS-CoV.
Auteurs : Yuting Jiang [République populaire de Chine] ; Junfeng Li [République populaire de Chine] ; Yue Teng [République populaire de Chine] ; Hong Sun [République populaire de Chine] ; Guang Tian [République populaire de Chine] ; Lei He [République populaire de Chine] ; Pei Li [République populaire de Chine] ; Yuehong Chen [République populaire de Chine] ; Yan Guo [République populaire de Chine] ; Jiangfan Li [République populaire de Chine] ; Guangyu Zhao [République populaire de Chine] ; Yusen Zhou [République populaire de Chine] ; Shihui Sun [République populaire de Chine]Source :
- Viruses [ 1999-4915 ] ; 2019.
Descripteurs français
- KwdFr :
- Activation du complément, Animaux, Caspase-1 (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient, Dipeptidyl peptidase 4 (génétique), Femelle, Humains, Infections à coronavirus (anatomopathologie), Infections à coronavirus (immunologie), Interleukine-1 bêta (sang), Macrophages (immunologie), Macrophages (virologie), Modèles animaux de maladie humaine, Pyroptose, Rate (immunologie), Récepteur à l'anaphylatoxine C5a (antagonistes et inhibiteurs), Récepteur à l'anaphylatoxine C5a (immunologie), Souris, Souris transgéniques.
- MESH :
- anatomopathologie : Infections à coronavirus.
- antagonistes et inhibiteurs : Récepteur à l'anaphylatoxine C5a.
- génétique : Caspase-1, Dipeptidyl peptidase 4.
- immunologie : Infections à coronavirus, Macrophages, Rate, Récepteur à l'anaphylatoxine C5a.
- sang : Interleukine-1 bêta.
- virologie : Macrophages.
- Activation du complément, Animaux, Coronavirus du syndrome respiratoire du Moyen-Orient, Femelle, Humains, Modèles animaux de maladie humaine, Pyroptose, Souris, Souris transgéniques.
English descriptors
- KwdEn :
- Animals, Caspase 1 (genetics), Complement Activation, Coronavirus Infections (immunology), Coronavirus Infections (pathology), Dipeptidyl Peptidase 4 (genetics), Disease Models, Animal, Female, Humans, Interleukin-1beta (blood), Macrophages (immunology), Macrophages (virology), Mice, Mice, Transgenic, Middle East Respiratory Syndrome Coronavirus, Pyroptosis, Receptor, Anaphylatoxin C5a (antagonists & inhibitors), Receptor, Anaphylatoxin C5a (immunology), Spleen (immunology), THP-1 Cells.
- MESH :
- chemical , antagonists & inhibitors : Receptor, Anaphylatoxin C5a.
- chemical , blood : Interleukin-1beta.
- chemical , genetics : Caspase 1, Dipeptidyl Peptidase 4.
- immunology : Coronavirus Infections, Macrophages, Receptor, Anaphylatoxin C5a, Spleen.
- pathology : Coronavirus Infections.
- virology : Macrophages.
- Animals, Complement Activation, Disease Models, Animal, Female, Humans, Mice, Mice, Transgenic, Middle East Respiratory Syndrome Coronavirus, Pyroptosis, THP-1 Cells.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic virus with a crude mortality rate of ~35%. Previously, we established a human DPP4 transgenic (hDPP4-Tg) mouse model in which we studied complement overactivation-induced immunopathogenesis. Here, to better understand the pathogenesis of MERS-CoV, we studied the role of pyroptosis in THP-1 cells and hDPP4 Tg mice with MERS-CoV infection. We found that MERS-CoV infection induced pyroptosis and over-activation of complement in human macrophages. The hDPP4-Tg mice infected with MERS-CoV overexpressed caspase-1 in the spleen and showed high IL-1β levels in serum, suggesting that pyroptosis occurred after infection. However, when the C5a-C5aR1 axis was blocked by an anti-C5aR1 antibody (Ab), expression of caspase-1 and IL-1β fell. These data indicate that MERS-CoV infection induces overactivation of complement, which may contribute to pyroptosis and inflammation. Pyroptosis and inflammation were suppressed by inhibiting C5aR1. These results will further our understanding of the pathogenesis of MERS-CoV infection.
DOI: 10.3390/v11010039
PubMed: 30634407
Affiliations:
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<term>Macrophages</term>
<term>Receptor, Anaphylatoxin C5a</term>
<term>Spleen</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Interleukine-1 bêta</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Macrophages</term>
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<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Macrophages</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Complement Activation</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Transgenic</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
<term>Pyroptosis</term>
<term>THP-1 Cells</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Activation du complément</term>
<term>Animaux</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Femelle</term>
<term>Humains</term>
<term>Modèles animaux de maladie humaine</term>
<term>Pyroptose</term>
<term>Souris</term>
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<front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic virus with a crude mortality rate of ~35%. Previously, we established a human DPP4 transgenic (hDPP4-Tg) mouse model in which we studied complement overactivation-induced immunopathogenesis. Here, to better understand the pathogenesis of MERS-CoV, we studied the role of pyroptosis in THP-1 cells and hDPP4 Tg mice with MERS-CoV infection. We found that MERS-CoV infection induced pyroptosis and over-activation of complement in human macrophages. The hDPP4-Tg mice infected with MERS-CoV overexpressed caspase-1 in the spleen and showed high IL-1β levels in serum, suggesting that pyroptosis occurred after infection. However, when the C5a-C5aR1 axis was blocked by an anti-C5aR1 antibody (Ab), expression of caspase-1 and IL-1β fell. These data indicate that MERS-CoV infection induces overactivation of complement, which may contribute to pyroptosis and inflammation. Pyroptosis and inflammation were suppressed by inhibiting C5aR1. These results will further our understanding of the pathogenesis of MERS-CoV infection.</div>
</front>
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<DateCompleted><Year>2019</Year>
<Month>05</Month>
<Day>16</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>09</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1999-4915</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>11</Volume>
<Issue>1</Issue>
<PubDate><Year>2019</Year>
<Month>01</Month>
<Day>09</Day>
</PubDate>
</JournalIssue>
<Title>Viruses</Title>
<ISOAbbreviation>Viruses</ISOAbbreviation>
</Journal>
<ArticleTitle>Complement Receptor C5aR1 Inhibition Reduces Pyroptosis in hDPP4-Transgenic Mice Infected with MERS-CoV.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">E39</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.3390/v11010039</ELocationID>
<Abstract><AbstractText>Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic virus with a crude mortality rate of ~35%. Previously, we established a human DPP4 transgenic (hDPP4-Tg) mouse model in which we studied complement overactivation-induced immunopathogenesis. Here, to better understand the pathogenesis of MERS-CoV, we studied the role of pyroptosis in THP-1 cells and hDPP4 Tg mice with MERS-CoV infection. We found that MERS-CoV infection induced pyroptosis and over-activation of complement in human macrophages. The hDPP4-Tg mice infected with MERS-CoV overexpressed caspase-1 in the spleen and showed high IL-1β levels in serum, suggesting that pyroptosis occurred after infection. However, when the C5a-C5aR1 axis was blocked by an anti-C5aR1 antibody (Ab), expression of caspase-1 and IL-1β fell. These data indicate that MERS-CoV infection induces overactivation of complement, which may contribute to pyroptosis and inflammation. Pyroptosis and inflammation were suppressed by inhibiting C5aR1. These results will further our understanding of the pathogenesis of MERS-CoV infection.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jiang</LastName>
<ForeName>Yuting</ForeName>
<Initials>Y</Initials>
<Identifier Source="ORCID">0000-0001-7404-5250</Identifier>
<AffiliationInfo><Affiliation>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China. captain99@126.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Junfeng</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China. lijunfeng2113@126.com.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Teng</LastName>
<ForeName>Yue</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China. yueteng@me.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sun</LastName>
<ForeName>Hong</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063210, China. xun1@hotmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tian</LastName>
<ForeName>Guang</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China. tglnx05@tom.com.</Affiliation>
</AffiliationInfo>
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<ForeName>Lei</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China. helei_happy@126.com.</Affiliation>
</AffiliationInfo>
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<Initials>P</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China. lwhisperer@163.com.</Affiliation>
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<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Yuehong</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China. chenyuehong.happy@163.com.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Guo</LastName>
<ForeName>Yan</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China. muhan0425@126.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Jiangfan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China. anatee@163.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhao</LastName>
<ForeName>Guangyu</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China. guangyu0525@163.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Yusen</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China. yszhou@bmi.ac.cn.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450052, China. yszhou@bmi.ac.cn.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sun</LastName>
<ForeName>Shihui</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China. sunsh01@163.com.</Affiliation>
</AffiliationInfo>
</Author>
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<Language>eng</Language>
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<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<Month>01</Month>
<Day>09</Day>
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<ArticleIdList><ArticleId IdType="pubmed">30634407</ArticleId>
<ArticleId IdType="pii">v11010039</ArticleId>
<ArticleId IdType="doi">10.3390/v11010039</ArticleId>
<ArticleId IdType="pmc">PMC6356766</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Trends Immunol. 2010 Apr;31(4):154-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20153254</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Emerg Microbes Infect. 2018 Apr 24;7(1):77</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29691378</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS One. 2015 Dec 23;10(12):e0145561</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26701103</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Commun. 2018 Jan 9;9(1):106</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29317641</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Cell. 2010 Mar 19;140(6):821-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20303873</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Immunol. 2014 Mar 15;192(6):2837-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24554772</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>FASEB J. 2005 Jun;19(8):1003-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15784721</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virulence. 2010 Jul-Aug;1(4):276-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21178453</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet Infect Dis. 2013 Sep;13(9):752-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23891402</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Immunity. 2013 Dec 12;39(6):1143-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24315997</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 2005 Dec 2;280(48):39677-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16204243</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Curr Biol. 2016 Jul 11;26(13):R568-R572</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27404251</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Cell. 2001 Mar 9;104(5):709-18</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11257225</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Semin Immunol. 2018 Aug;38:54-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29631809</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 1991 Feb 14;349(6310):614-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1847994</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Immunol. 1998 Mar 15;160(6):2983-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9510203</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Infect Dis. 2014 May 1;209(9):1331-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24065148</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS Pathog. 2017 Jan 6;13(1):e1006123</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28060938</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Inflamm Allergy Drug Targets. 2009 Jul;8(3):236-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19601884</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Int Immunopharmacol. 2007 Dec 20;7(14):1909-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18039528</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS Pathog. 2013;9(5):e1003392</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23737748</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Immunity. 2009 Apr 17;30(4):556-65</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19362020</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Exp Med. 2005 Aug 1;202(3):415-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16043521</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Arthritis Rheumatol. 2014 Sep;66(9):2423-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24910235</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 2006 Mar 9;440(7081):228-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16407890</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2013 Jun 29;381(9885):2265-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23727167</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Rev Immunol. 2005 Aug;5(8):606-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16056254</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Ann Intern Med. 2014 Mar 18;160(6):389-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24474051</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 2014 Jan 23;505(7484):509-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24356306</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Science. 2016 Jun 17;352(6292):aad1210</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27313051</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Blood. 2013 Nov 14;122(20):3473-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23878142</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Mol Neurosci. 2017 Mar;61(3):385-395</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27933491</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Sci Rep. 2017 Aug 8;7(1):7625</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28790324</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Clin Exp Immunol. 1997 Jan;107(1):1-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9010248</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 2006 Dec 1;281(48):36560-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17008311</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 2016 Jul 7;535(7610):111-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27281216</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Proteome Res. 2017 Jan 6;16(1):170-178</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27684284</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Clin Infect Dis. 2014 Nov 1;59(9):1225-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24829216</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Science. 2008 May 2;320(5876):674-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18403674</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Annu Rev Immunol. 2009;27:519-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19302047</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 2017 Jan 20;292(3):826-836</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27913620</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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</settlement>
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<name sortKey="Sun, Hong" sort="Sun, Hong" uniqKey="Sun H" first="Hong" last="Sun">Hong Sun</name>
<name sortKey="Sun, Shihui" sort="Sun, Shihui" uniqKey="Sun S" first="Shihui" last="Sun">Shihui Sun</name>
<name sortKey="Teng, Yue" sort="Teng, Yue" uniqKey="Teng Y" first="Yue" last="Teng">Yue Teng</name>
<name sortKey="Tian, Guang" sort="Tian, Guang" uniqKey="Tian G" first="Guang" last="Tian">Guang Tian</name>
<name sortKey="Zhao, Guangyu" sort="Zhao, Guangyu" uniqKey="Zhao G" first="Guangyu" last="Zhao">Guangyu Zhao</name>
<name sortKey="Zhou, Yusen" sort="Zhou, Yusen" uniqKey="Zhou Y" first="Yusen" last="Zhou">Yusen Zhou</name>
</country>
</tree>
</affiliations>
</record>
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