Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential.
Identifieur interne : 000292 ( PubMed/Checkpoint ); précédent : 000291; suivant : 000293Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential.
Auteurs : Jimin Xu ; Pei-Yong Shi ; Hongmin Li [États-Unis] ; Jia ZhouSource :
- ACS infectious diseases [ 2373-8227 ] ; 2020.
Abstract
The recent outbreak of coronavirus disease 2019 (COVID-19) highlights an urgent need for therapeutics. Through a series of drug repurposing screening campaigns, niclosamide, an FDA-approved anthelminthic drug, was found to be effective against various viral infections with nanomolar to micromolar potency such as SARS-CoV, MERS-CoV, ZIKV, HCV, and human adenovirus, indicating its potential as an antiviral agent. In this brief review, we summarize the broad antiviral activity of niclosamide and highlight its potential clinical use in the treatment of COVID-19.
DOI: 10.1021/acsinfecdis.0c00052
PubMed: 32125140
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Through a series of drug repurposing screening campaigns, niclosamide, an FDA-approved anthelminthic drug, was found to be effective against various viral infections with nanomolar to micromolar potency such as SARS-CoV, MERS-CoV, ZIKV, HCV, and human adenovirus, indicating its potential as an antiviral agent. 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