COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics.
Identifieur interne : 000283 ( PubMed/Checkpoint ); précédent : 000282; suivant : 000284COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics.
Auteurs : Kuldeep Dhama [Inde] ; Khan Sharun [Inde] ; Ruchi Tiwari [Inde] ; Maryam Dadar [Iran] ; Yashpal Singh Malik [Inde] ; Karam Pal Singh [Inde] ; Wanpen Chaicumpa [Thaïlande]Source :
- Human vaccines & immunotherapeutics [ 2164-554X ] ; 2020.
Abstract
The novel coronavirus infection (COVID-19 or Coronavirus disease 2019) that emerged from Wuhan, Hubei province of China has spread to many countries worldwide. Efforts have been made to develop vaccines against human coronavirus (CoV) infections such as MERS and SARS in the past decades. However, to date, no licensed antiviral treatment or vaccine exists for MERS and SARS. Most of the efforts for developing CoV vaccines and drugs target the spike glycoprotein or S protein, the major inducer of neutralizing antibodies. Although a few candidates have shown efficacy in in vitro studies, not many have progressed to randomized animal or human trials, hence may have limited use to counter COVID-19 infection. This article highlights ongoing advances in designing vaccines and therapeutics to counter COVID-19 while also focusing on such experiences and advances as made with earlier SARS- and MERS-CoVs, which together could enable efforts to halt this emerging virus infection.
DOI: 10.1080/21645515.2020.1735227
PubMed: 32186952
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Bareilly</wicri:regionArea><wicri:noRegion>Bareilly</wicri:noRegion></affiliation></author><author><name sortKey="Singh, Karam Pal" sort="Singh, Karam Pal" uniqKey="Singh K" first="Karam Pal" last="Singh">Karam Pal Singh</name><affiliation wicri:level="1"><nlm:affiliation>Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly</wicri:regionArea><wicri:noRegion>Bareilly</wicri:noRegion></affiliation></author><author><name sortKey="Chaicumpa, Wanpen" sort="Chaicumpa, Wanpen" uniqKey="Chaicumpa W" first="Wanpen" last="Chaicumpa">Wanpen Chaicumpa</name><affiliation wicri:level="1"><nlm:affiliation>Center of Research Excellence on Therapeutic Proteins and Antibody Engineering, Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Center of Research Excellence on Therapeutic Proteins and Antibody Engineering, Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author></analytic><series><title level="j">Human vaccines & immunotherapeutics</title><idno type="eISSN">2164-554X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The novel coronavirus infection (COVID-19 or Coronavirus disease 2019) that emerged from Wuhan, Hubei province of China has spread to many countries worldwide. Efforts have been made to develop vaccines against human coronavirus (CoV) infections such as MERS and SARS in the past decades. However, to date, no licensed antiviral treatment or vaccine exists for MERS and SARS. Most of the efforts for developing CoV vaccines and drugs target the spike glycoprotein or S protein, the major inducer of neutralizing antibodies. Although a few candidates have shown efficacy in <i>in vitro</i> studies, not many have progressed to randomized animal or human trials, hence may have limited use to counter COVID-19 infection. This article highlights ongoing advances in designing vaccines and therapeutics to counter COVID-19 while also focusing on such experiences and advances as made with earlier SARS- and MERS-CoVs, which together could enable efforts to halt this emerging virus infection.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32186952</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2164-554X</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Mar</Month><Day>18</Day></PubDate></JournalIssue><Title>Human vaccines & immunotherapeutics</Title><ISOAbbreviation>Hum Vaccin Immunother</ISOAbbreviation></Journal><ArticleTitle>COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics.</ArticleTitle><Pagination><MedlinePgn>1-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/21645515.2020.1735227</ELocationID><Abstract><AbstractText>The novel coronavirus infection (COVID-19 or Coronavirus disease 2019) that emerged from Wuhan, Hubei province of China has spread to many countries worldwide. Efforts have been made to develop vaccines against human coronavirus (CoV) infections such as MERS and SARS in the past decades. However, to date, no licensed antiviral treatment or vaccine exists for MERS and SARS. Most of the efforts for developing CoV vaccines and drugs target the spike glycoprotein or S protein, the major inducer of neutralizing antibodies. Although a few candidates have shown efficacy in <i>in vitro</i> studies, not many have progressed to randomized animal or human trials, hence may have limited use to counter COVID-19 infection. This article highlights ongoing advances in designing vaccines and therapeutics to counter COVID-19 while also focusing on such experiences and advances as made with earlier SARS- and MERS-CoVs, which together could enable efforts to halt this emerging virus infection.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dhama</LastName><ForeName>Kuldeep</ForeName><Initials>K</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-7469-4752</Identifier><AffiliationInfo><Affiliation>Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sharun</LastName><ForeName>Khan</ForeName><Initials>K</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-1040-3746</Identifier><AffiliationInfo><Affiliation>Division of Surgery, ICAR-Indian Veterinary Research Institute, Bareilly, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tiwari</LastName><ForeName>Ruchi</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Veterinary Microbiology and Immunology, College of Veterinary Sciences, Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishwavidyalay Evum Go-Anusandhan Sansthan (DUVASU), Mathura, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dadar</LastName><ForeName>Maryam</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Malik</LastName><ForeName>Yashpal Singh</ForeName><Initials>YS</Initials><AffiliationInfo><Affiliation>Division of Biological Standardization, ICAR-Indian Veterinary Research Institute, Bareilly, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Singh</LastName><ForeName>Karam Pal</ForeName><Initials>KP</Initials><AffiliationInfo><Affiliation>Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chaicumpa</LastName><ForeName>Wanpen</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Center of Research Excellence on Therapeutic Proteins and Antibody Engineering, Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Hum Vaccin 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