Middle East respiratory syndrome
Identifieur interne : 001383 ( Pmc/Curation ); précédent : 001382; suivant : 001384Middle East respiratory syndrome
Auteurs : Ziad A. Memish [Arabie saoudite, États-Unis] ; Stanley Perlman [États-Unis] ; Maria D. Van Kerkhove [Suisse] ; Alimuddin Zumla [Royaume-Uni]Source :
- Lancet (London, England) [ 0140-6736 ] ; 2020.
Abstract
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a lethal zoonotic pathogen that was first identified in humans in Saudi Arabia and Jordan in 2012. Intermittent sporadic cases, community clusters, and nosocomial outbreaks of MERS-CoV continue to occur. Between April 2012 and December 2019, 2499 laboratory-confirmed cases of MERS-CoV infection, including 858 deaths (34·3% mortality) were reported from 27 countries to WHO, the majority of which were reported by Saudi Arabia (2106 cases, 780 deaths). Large outbreaks of human-to-human transmission have occurred, the largest in Riyadh and Jeddah in 2014 and in South Korea in 2015. MERS-CoV remains a high-threat pathogen identified by WHO as a priority pathogen because it causes severe disease that has a high mortality rate, epidemic potential, and no medical countermeasures. This Seminar provides an update on the current knowledge and perspectives on MERS epidemiology, virology, mode of transmission, pathogenesis, diagnosis, clinical features, management, infection control, development of new therapeutics and vaccines, and highlights unanswered questions and priorities for research, improved management, and prevention.
Url:
DOI: 10.1016/S0140-6736(19)33221-0
PubMed: 32145185
PubMed Central: 7155742
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Memish</name><affiliation wicri:level="1"><nlm:aff id="aff1">College of Medicine, Alfaisal University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, Alfaisal University, Riyadh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Research Center, King Saud Medical City Ministry of Health, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Research Center, King Saud Medical City Ministry of Health, Riyadh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA</wicri:regionArea></affiliation></author><author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Microbiology and Immunology, and Department of Pediatrics, University of Iowa, Iowa City, IA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, and Department of Pediatrics, University of Iowa, Iowa City, IA</wicri:regionArea></affiliation></author><author><name sortKey="Van Kerkhove, Maria D" sort="Van Kerkhove, Maria D" uniqKey="Van Kerkhove M" first="Maria D" last="Van Kerkhove">Maria D. 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Memish</name><affiliation wicri:level="1"><nlm:aff id="aff1">College of Medicine, Alfaisal University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, Alfaisal University, Riyadh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Research Center, King Saud Medical City Ministry of Health, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Research Center, King Saud Medical City Ministry of Health, Riyadh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA</wicri:regionArea></affiliation></author><author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Microbiology and Immunology, and Department of Pediatrics, University of Iowa, Iowa City, IA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, and Department of Pediatrics, University of Iowa, Iowa City, IA</wicri:regionArea></affiliation></author><author><name sortKey="Van Kerkhove, Maria D" sort="Van Kerkhove, Maria D" uniqKey="Van Kerkhove M" first="Maria D" last="Van Kerkhove">Maria D. Van Kerkhove</name><affiliation wicri:level="1"><nlm:aff id="aff5">Infectious Hazards Management, Health Emergencies Programme, World Health Organization, Geneva, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Infectious Hazards Management, Health Emergencies Programme, World Health Organization, Geneva</wicri:regionArea></affiliation></author><author><name sortKey="Zumla, Alimuddin" sort="Zumla, Alimuddin" uniqKey="Zumla A" first="Alimuddin" last="Zumla">Alimuddin Zumla</name><affiliation wicri:level="1"><nlm:aff id="aff6">Department of Infection, Division of Infection and Immunity, Centre for Clinical Microbiology, University College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infection, Division of Infection and Immunity, Centre for Clinical Microbiology, University College London, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7">National Institute for Health Research Biomedical Research Centre, University College London Hospitals, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research Biomedical Research Centre, University College London Hospitals, London</wicri:regionArea></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="ISSN">0140-6736</idno><idno type="eISSN">1474-547X</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>The Middle East respiratory syndrome coronavirus (MERS-CoV) is a lethal zoonotic pathogen that was first identified in humans in Saudi Arabia and Jordan in 2012. Intermittent sporadic cases, community clusters, and nosocomial outbreaks of MERS-CoV continue to occur. Between April 2012 and December 2019, 2499 laboratory-confirmed cases of MERS-CoV infection, including 858 deaths (34·3% mortality) were reported from 27 countries to WHO, the majority of which were reported by Saudi Arabia (2106 cases, 780 deaths). Large outbreaks of human-to-human transmission have occurred, the largest in Riyadh and Jeddah in 2014 and in South Korea in 2015. MERS-CoV remains a high-threat pathogen identified by WHO as a priority pathogen because it causes severe disease that has a high mortality rate, epidemic potential, and no medical countermeasures. This Seminar provides an update on the current knowledge and perspectives on MERS epidemiology, virology, mode of transmission, pathogenesis, diagnosis, clinical features, management, infection control, development of new therapeutics and vaccines, and highlights unanswered questions and priorities for research, improved management, and prevention.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Stohr, K" uniqKey="Stohr K">K Stöhr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Lancet</journal-id><journal-id journal-id-type="iso-abbrev">Lancet</journal-id><journal-title-group><journal-title>Lancet (London, England)</journal-title></journal-title-group><issn pub-type="ppub">0140-6736</issn><issn pub-type="epub">1474-547X</issn><publisher><publisher-name>Elsevier Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32145185</article-id><article-id pub-id-type="pmc">7155742</article-id><article-id pub-id-type="publisher-id">S0140-6736(19)33221-0</article-id><article-id pub-id-type="doi">10.1016/S0140-6736(19)33221-0</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Middle East respiratory syndrome</article-title></title-group><contrib-group><contrib contrib-type="author" id="au10"><name><surname>Memish</surname><given-names>Ziad A</given-names></name><degrees>Prof</degrees><degrees>FRCP</degrees><xref rid="aff1" ref-type="aff">a</xref><xref rid="aff2" ref-type="aff">b</xref><xref rid="aff3" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au20"><name><surname>Perlman</surname><given-names>Stanley</given-names></name><degrees>Prof</degrees><degrees>PhD</degrees><xref rid="aff4" ref-type="aff">d</xref></contrib><contrib contrib-type="author" id="au30"><name><surname>Van Kerkhove</surname><given-names>Maria D</given-names></name><degrees>PhD</degrees><xref rid="aff5" ref-type="aff">e</xref></contrib><contrib contrib-type="author" id="au40"><name><surname>Zumla</surname><given-names>Alimuddin</given-names></name><degrees>Prof</degrees><degrees>FRCP</degrees><email>a.zumla@ucl.ac.uk</email><xref rid="aff6" ref-type="aff">f</xref><xref rid="aff7" ref-type="aff">g</xref><xref rid="cor1" ref-type="corresp">*</xref></contrib></contrib-group><aff id="aff1"><label>a</label>College of Medicine, Alfaisal University, Riyadh, Saudi Arabia</aff><aff id="aff2"><label>b</label>Research Center, King Saud Medical City Ministry of Health, Riyadh, Saudi Arabia</aff><aff id="aff3"><label>c</label>Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA</aff><aff id="aff4"><label>d</label>Department of Microbiology and Immunology, and Department of Pediatrics, University of Iowa, Iowa City, IA, USA</aff><aff id="aff5"><label>e</label>Infectious Hazards Management, Health Emergencies Programme, World Health Organization, Geneva, Switzerland</aff><aff id="aff6"><label>f</label>Department of Infection, Division of Infection and Immunity, Centre for Clinical Microbiology, University College London, London, UK</aff><aff id="aff7"><label>g</label>National Institute for Health Research Biomedical Research Centre, University College London Hospitals, London, UK</aff><author-notes><corresp id="cor1"><label>*</label>Correspondence to: Prof Sir Alimuddin Zumla, Department of Infection, Division of Infection and Immunity, Centre for Clinical Microbiology, University College London, London, NW3 OPE, UK <email>a.zumla@ucl.ac.uk</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>4</day><month>3</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub" iso-8601-date="2020-04-03"><season>28 March-3 April</season><year>2020</year></pub-date><pub-date pub-type="epub"><day>4</day><month>3</month><year>2020</year></pub-date><volume>395</volume><issue>10229</issue><fpage>1063</fpage><lpage>1077</lpage><permissions><copyright-statement>© 2020 Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder>Elsevier Ltd</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="ceab10"><title>Summary</title><p>The Middle East respiratory syndrome coronavirus (MERS-CoV) is a lethal zoonotic pathogen that was first identified in humans in Saudi Arabia and Jordan in 2012. Intermittent sporadic cases, community clusters, and nosocomial outbreaks of MERS-CoV continue to occur. Between April 2012 and December 2019, 2499 laboratory-confirmed cases of MERS-CoV infection, including 858 deaths (34·3% mortality) were reported from 27 countries to WHO, the majority of which were reported by Saudi Arabia (2106 cases, 780 deaths). Large outbreaks of human-to-human transmission have occurred, the largest in Riyadh and Jeddah in 2014 and in South Korea in 2015. MERS-CoV remains a high-threat pathogen identified by WHO as a priority pathogen because it causes severe disease that has a high mortality rate, epidemic potential, and no medical countermeasures. This Seminar provides an update on the current knowledge and perspectives on MERS epidemiology, virology, mode of transmission, pathogenesis, diagnosis, clinical features, management, infection control, development of new therapeutics and vaccines, and highlights unanswered questions and priorities for research, improved management, and prevention.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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