Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches
Identifieur interne : 001309 ( Pmc/Curation ); précédent : 001308; suivant : 001310Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches
Auteurs : Nisreen Ma Okba ; V Stalin Raj ; Bart L. HaagmansSource :
- Current Opinion in Virology [ 1879-6257 ] ; 2017.
Abstract
MERS-CoV vaccine target groups and the desired vaccine induced immunological response for each group. I: camels; II: camel contacts; III-A: healthcare workers and patients; III-B: house-hold contacts and MERS cases.
Url:
DOI: 10.1016/j.coviro.2017.03.007
PubMed: 28412285
PubMed Central: 7102752
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches</title><author><name sortKey="Okba, Nisreen Ma" sort="Okba, Nisreen Ma" uniqKey="Okba N" first="Nisreen Ma" last="Okba">Nisreen Ma Okba</name></author><author><name sortKey="Raj, V Stalin" sort="Raj, V Stalin" uniqKey="Raj V" first="V Stalin" last="Raj">V Stalin Raj</name></author><author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28412285</idno><idno type="pmc">7102752</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102752</idno><idno type="RBID">PMC:7102752</idno><idno type="doi">10.1016/j.coviro.2017.03.007</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">001309</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001309</idno><idno type="wicri:Area/Pmc/Curation">001309</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001309</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches</title><author><name sortKey="Okba, Nisreen Ma" sort="Okba, Nisreen Ma" uniqKey="Okba N" first="Nisreen Ma" last="Okba">Nisreen Ma Okba</name></author><author><name sortKey="Raj, V Stalin" sort="Raj, V Stalin" uniqKey="Raj V" first="V Stalin" last="Raj">V Stalin Raj</name></author><author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name></author></analytic><series><title level="j">Current Opinion in Virology</title><idno type="ISSN">1879-6257</idno><idno type="eISSN">1879-6265</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Graphical abstract</title><p>MERS-CoV vaccine target groups and the desired vaccine induced immunological response for each group. I: camels; II: camel contacts; III-A: healthcare workers and patients; III-B: house-hold contacts and MERS cases.</p><p><fig id="fig0010" position="anchor"><graphic xlink:href="fx1_lrg"></graphic></fig></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Curr Opin Virol</journal-id><journal-id journal-id-type="iso-abbrev">Curr Opin Virol</journal-id><journal-title-group><journal-title>Current Opinion in Virology</journal-title></journal-title-group><issn pub-type="ppub">1879-6257</issn><issn pub-type="epub">1879-6265</issn><publisher><publisher-name>The Authors. Published by Elsevier B.V.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28412285</article-id><article-id pub-id-type="pmc">7102752</article-id><article-id pub-id-type="publisher-id">S1879-6257(16)30148-1</article-id><article-id pub-id-type="doi">10.1016/j.coviro.2017.03.007</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches</article-title></title-group><contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Okba</surname><given-names>Nisreen MA</given-names></name></contrib><contrib contrib-type="author" id="aut0010"><name><surname>Raj</surname><given-names>V Stalin</given-names></name></contrib><contrib contrib-type="author" id="aut0015"><name><surname>Haagmans</surname><given-names>Bart L</given-names></name><email>b.haagmans@erasmusmc.nl</email></contrib></contrib-group><aff id="aff0005">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</aff><pub-date pub-type="pmc-release"><day>13</day><month>4</month><year>2017</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>4</month><year>2017</year></pub-date><pub-date pub-type="epub"><day>13</day><month>4</month><year>2017</year></pub-date><volume>23</volume><fpage>49</fpage><lpage>58</lpage><permissions><copyright-statement>© 2017 The Authors</copyright-statement><copyright-year>2017</copyright-year><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract abstract-type="graphical" id="abs0005"><title>Graphical abstract</title><p>MERS-CoV vaccine target groups and the desired vaccine induced immunological response for each group. I: camels; II: camel contacts; III-A: healthcare workers and patients; III-B: house-hold contacts and MERS cases.</p><p><fig id="fig0010" position="anchor"><graphic xlink:href="fx1_lrg"></graphic></fig></p></abstract><abstract abstract-type="author-highlights" id="abs0010"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">MERS-CoV vaccines for dromedary camels and their human contacts can potentially stop virus transmission in the community.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Both neutralizing antibody and T-cell responses are required for protection</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">MERS-CoV vaccines should aim at inducing (long term) mucosal immunity in the different target populations.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">The spike protein induces both neutralizing antibodies and T-cell responses and is the main target of the current vaccine candidates.</p></list-item><list-item id="lsti0025"><label>•</label><p id="par0025">Epitope-based vaccines, focusing at (cross)-protective epitopes, could induce higher and/or broader responses.</p></list-item></list></p></abstract><abstract id="abs0015"><p>Middle East respiratory syndrome coronavirus (MERS-CoV) is a cause of severe respiratory infection in humans, specifically the elderly and people with comorbidities. The re-emergence of lethal coronaviruses calls for international collaboration to produce coronavirus vaccines, which are still lacking to date. Ongoing efforts to develop MERS-CoV vaccines should consider the different target populations (dromedary camels and humans) and the correlates of protection. Extending on our current knowledge of MERS, vaccination of dromedary camels to induce mucosal immunity could be a promising approach to diminish MERS-CoV transmission to humans. In addition, it is equally important to develop vaccines for humans that induce broader reactivity against various coronaviruses to be prepared for a potential next CoV outbreak.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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