Animal models of Middle East respiratory syndrome coronavirus infection
Identifieur interne : 001287 ( Pmc/Curation ); précédent : 001286; suivant : 001288Animal models of Middle East respiratory syndrome coronavirus infection
Auteurs : Neeltje Van Doremalen ; Vincent J. MunsterSource :
- Antiviral Research [ 0166-3542 ] ; 2015.
Abstract
MERS-CoV has infected >1100 patients to date, with an associated case fatality rate of approximately 40%. Animals ranging from mice to rabbits to nonhuman primates have been inoculated with MERS-CoV, with varying outcomes. Mice expressing human DPP4 are susceptible to infection and develop severe disease. Rhesus macaques and marmosets are also susceptible, but marmosets develop more severe disease. Further development of appropriate animal models to conduct medical countermeasure research is a public health priority.
Url:
DOI: 10.1016/j.antiviral.2015.07.005
PubMed: 26192750
PubMed Central: 4561025
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Animal models of Middle East respiratory syndrome coronavirus infection</title><author><name sortKey="Van Doremalen, Neeltje" sort="Van Doremalen, Neeltje" uniqKey="Van Doremalen N" first="Neeltje" last="Van Doremalen">Neeltje Van Doremalen</name></author><author><name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J." last="Munster">Vincent J. Munster</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26192750</idno><idno type="pmc">4561025</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561025</idno><idno type="RBID">PMC:4561025</idno><idno type="doi">10.1016/j.antiviral.2015.07.005</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001287</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001287</idno><idno type="wicri:Area/Pmc/Curation">001287</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001287</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Animal models of Middle East respiratory syndrome coronavirus infection</title><author><name sortKey="Van Doremalen, Neeltje" sort="Van Doremalen, Neeltje" uniqKey="Van Doremalen N" first="Neeltje" last="Van Doremalen">Neeltje Van Doremalen</name></author><author><name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J." last="Munster">Vincent J. Munster</name></author></analytic><series><title level="j">Antiviral Research</title><idno type="ISSN">0166-3542</idno><idno type="eISSN">1872-9096</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label><p id="p0005">MERS-CoV has infected >1100 patients to date, with an associated case fatality rate of approximately 40%.</p></list-item><list-item id="o0010"><label>•</label><p id="p0010">Animals ranging from mice to rabbits to nonhuman primates have been inoculated with MERS-CoV, with varying outcomes.</p></list-item><list-item id="o0015"><label>•</label><p id="p0015">Mice expressing human DPP4 are susceptible to infection and develop severe disease.</p></list-item><list-item id="o0020"><label>•</label><p id="p0020">Rhesus macaques and marmosets are also susceptible, but marmosets develop more severe disease.</p></list-item><list-item id="o0025"><label>•</label><p id="p0025">Further development of appropriate animal models to conduct medical countermeasure research is a public health priority.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Adney, D R" uniqKey="Adney D">D.R. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Antiviral Res</journal-id><journal-id journal-id-type="iso-abbrev">Antiviral Res</journal-id><journal-title-group><journal-title>Antiviral Research</journal-title></journal-title-group><issn pub-type="ppub">0166-3542</issn><issn pub-type="epub">1872-9096</issn><publisher><publisher-name>Elsevier</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26192750</article-id><article-id pub-id-type="pmc">4561025</article-id><article-id pub-id-type="publisher-id">S0166-3542(15)00168-0</article-id><article-id pub-id-type="doi">10.1016/j.antiviral.2015.07.005</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Animal models of Middle East respiratory syndrome coronavirus infection</article-title></title-group><contrib-group><contrib contrib-type="author" id="au005"><name><surname>van Doremalen</surname><given-names>Neeltje</given-names></name></contrib><contrib contrib-type="author" id="au010"><name><surname>Munster</surname><given-names>Vincent J.</given-names></name><email>Vincent.munster@nih.gov</email><xref rid="cor1" ref-type="corresp">⁎</xref></contrib></contrib-group><aff id="af005">Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA</aff><author-notes><corresp id="cor1"><label>⁎</label>Corresponding author at: Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, MT, USA. <email>Vincent.munster@nih.gov</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>17</day><month>7</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>10</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>17</day><month>7</month><year>2015</year></pub-date><volume>122</volume><fpage>28</fpage><lpage>38</lpage><history><date date-type="received"><day>29</day><month>5</month><year>2015</year></date><date date-type="rev-recd"><day>12</day><month>7</month><year>2015</year></date><date date-type="accepted"><day>16</day><month>7</month><year>2015</year></date></history><permissions><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract abstract-type="author-highlights" id="ab005"><title>Highlights</title><p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label><p id="p0005">MERS-CoV has infected >1100 patients to date, with an associated case fatality rate of approximately 40%.</p></list-item><list-item id="o0010"><label>•</label><p id="p0010">Animals ranging from mice to rabbits to nonhuman primates have been inoculated with MERS-CoV, with varying outcomes.</p></list-item><list-item id="o0015"><label>•</label><p id="p0015">Mice expressing human DPP4 are susceptible to infection and develop severe disease.</p></list-item><list-item id="o0020"><label>•</label><p id="p0020">Rhesus macaques and marmosets are also susceptible, but marmosets develop more severe disease.</p></list-item><list-item id="o0025"><label>•</label><p id="p0025">Further development of appropriate animal models to conduct medical countermeasure research is a public health priority.</p></list-item></list></p></abstract><abstract id="ab010"><p>The emergence of the Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second time that a new, highly pathogenic coronavirus has emerged in the human population in the 21st century. In this review, we discuss the current state of knowledge of animal models of MERS-CoV infection. Commonly used laboratory animal species such as Syrian hamsters, mice and ferrets are not susceptible to MERS-CoV, due to differences in the MERS-CoV receptor dipeptidyl peptidase 4 (DPP4). The initially developed animal models comprise two nonhuman primate species, the rhesus macaque and the common marmoset. Rhesus macaques develop a mild to moderate respiratory disease upon inoculation, reminiscent of milder MERS cases, whereas marmosets develop a moderate to severe respiratory disease, recapitulating the severe disease observed in some patients. Dromedary camels, considered to be the reservoir for MERS-CoV, develop a mild upper respiratory tract infection with abundant viral shedding. Although normal mice are not susceptible to MERS-CoV, expression of the human DPP4 (hDPP4) overcomes the lack of susceptibility. Transgenic hDPP4 mice develop severe and lethal respiratory disease upon inoculation with MERS-CoV. These hDPP4 transgenic mice are potentially the ideal first line animal model for efficacy testing of therapeutic and prophylactic countermeasures. Further characterization of identified countermeasures would ideally be performed in the common marmoset model, due to the more severe disease outcome. This article forms part of a symposium in <italic>Antiviral Research</italic> on “From SARS to MERS: research on highly pathogenic human coronaviruses.”</p></abstract><kwd-group id="kg005"><title>Keywords</title><kwd>MERS-CoV</kwd><kwd>Animal models</kwd><kwd>Coronavirus</kwd><kwd>Middle East respiratory syndrome coronavirus</kwd><kwd>Emerging viruses</kwd><kwd>Public health</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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