Middle East respiratory syndrome coronavirus disease is rare in children: An update from Saudi Arabia
Identifieur interne : 001226 ( Pmc/Curation ); précédent : 001225; suivant : 001227Middle East respiratory syndrome coronavirus disease is rare in children: An update from Saudi Arabia
Auteurs : Jaffar A. Al-Tawfiq ; Rana F. Kattan ; Ziad A. MemishSource :
- World Journal of Clinical Pediatrics [ 2219-2808 ] ; 2016.
Abstract
To summarize the reported Middle East respiratory syndrome-coronavirus (MERS-CoV) cases, the associated clinical presentations and the outcomes.
We searched the Saudi Ministry of Health website, the World Health Organization website, and the Flutracker website. We also searched MEDLINE and PubMed for the keywords: Middle East respiratory syndrome-coronavirus, MERS-CoV in combination with pediatric, children, childhood, infancy and pregnancy from the initial discovery of the virus in 2012 to 2016. The retrieved articles were also read to further find other articles. Relevant data were placed into an excel sheet and analyzed accordingly. Descriptive analytic statistics were used in the final analysis as deemed necessary.
From June 2012 to April 19, 2016, there were a total of 31 pediatric MERS-CoV cases. Of these cases 13 (42%) were asymptomatic and the male to female ratio was 1.7:1. The mean age of patients was 9.8 ± 5.4 years. Twenty-five (80.6%) of the cases were reported from the Kingdom of Saudi Arabia. The most common source of infection was household contact (10 of 15 with reported source) and 5 patients acquired infection within a health care facility. Using real time reverse transcriptase polymerase chain reaction of pediatric patients revealed that 9 out of 552 (1.6%) was positive in the Kingdom of Saudi Arabia.
Utilizing serology for MERS-CoV infection in Jordan and Saudi Arabia did not reveal any positive patients. Thus, the number of the pediatric MERS-CoV is low; the exact reason for the low prevalence of the disease in children is not known.
Url:
DOI: 10.5409/wjcp.v5.i4.391
PubMed: 27872828
PubMed Central: 5099592
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Middle East respiratory syndrome coronavirus disease is rare in children: An update from Saudi Arabia</title><author><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A" last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name></author><author><name sortKey="Kattan, Rana F" sort="Kattan, Rana F" uniqKey="Kattan R" first="Rana F" last="Kattan">Rana F. Kattan</name></author><author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A" last="Memish">Ziad A. Memish</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27872828</idno><idno type="pmc">5099592</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099592</idno><idno type="RBID">PMC:5099592</idno><idno type="doi">10.5409/wjcp.v5.i4.391</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001226</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001226</idno><idno type="wicri:Area/Pmc/Curation">001226</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001226</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Middle East respiratory syndrome coronavirus disease is rare in children: An update from Saudi Arabia</title><author><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A" last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name></author><author><name sortKey="Kattan, Rana F" sort="Kattan, Rana F" uniqKey="Kattan R" first="Rana F" last="Kattan">Rana F. Kattan</name></author><author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A" last="Memish">Ziad A. Memish</name></author></analytic><series><title level="j">World Journal of Clinical Pediatrics</title><idno type="eISSN">2219-2808</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>AIM</title><p>To summarize the reported Middle East respiratory syndrome-coronavirus (MERS-CoV) cases, the associated clinical presentations and the outcomes.</p></sec><sec><title>METHODS</title><p>We searched the Saudi Ministry of Health website, the World Health Organization website, and the Flutracker website. We also searched MEDLINE and PubMed for the keywords: Middle East respiratory syndrome-coronavirus, MERS-CoV in combination with pediatric, children, childhood, infancy and pregnancy from the initial discovery of the virus in 2012 to 2016. The retrieved articles were also read to further find other articles. Relevant data were placed into an excel sheet and analyzed accordingly. Descriptive analytic statistics were used in the final analysis as deemed necessary.</p></sec><sec><title>RESULTS</title><p>From June 2012 to April 19, 2016, there were a total of 31 pediatric MERS-CoV cases. Of these cases 13 (42%) were asymptomatic and the male to female ratio was 1.7:1. The mean age of patients was 9.8 ± 5.4 years. Twenty-five (80.6%) of the cases were reported from the Kingdom of Saudi Arabia. The most common source of infection was household contact (10 of 15 with reported source) and 5 patients acquired infection within a health care facility. Using real time reverse transcriptase polymerase chain reaction of pediatric patients revealed that 9 out of 552 (1.6%) was positive in the Kingdom of Saudi Arabia.</p></sec><sec><title>CONCLUSION</title><p>Utilizing serology for MERS-CoV infection in Jordan and Saudi Arabia did not reveal any positive patients. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">World J Clin Pediatr</journal-id><journal-id journal-id-type="publisher-id">WJCP</journal-id><journal-title-group><journal-title>World Journal of Clinical Pediatrics</journal-title></journal-title-group><issn pub-type="epub">2219-2808</issn><publisher><publisher-name>Baishideng Publishing Group Inc</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27872828</article-id><article-id pub-id-type="pmc">5099592</article-id><article-id pub-id-type="other">jWJCP.v5.i4.pg391</article-id><article-id pub-id-type="doi">10.5409/wjcp.v5.i4.391</article-id><article-categories><subj-group subj-group-type="heading"><subject>Systematic Reviews</subject></subj-group></article-categories><title-group><article-title>Middle East respiratory syndrome coronavirus disease is rare in children: An update from Saudi Arabia</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Al-Tawfiq</surname><given-names>Jaffar A</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kattan</surname><given-names>Rana F</given-names></name></contrib><contrib contrib-type="author"><name><surname>Memish</surname><given-names>Ziad A</given-names></name></contrib><aff>Jaffar A Al-Tawfiq, Johns Hopkins Aramco Healthcare, Dhahran 31311, Kingdom of Saudi Arabia</aff><aff>Jaffar A Al-Tawfiq, Indiana University School of Medicine, Indianapolis, IN 46202, United States</aff><aff>Rana F Kattan, Department of Pediatric, King Saud bin Abdulaziz University for Health Sciences, King Abdullah Specialist Children’s Hospital, Riyadh 11514, Kingdom of Saudi Arabia</aff><aff>Ziad A Memish, Ministry of Health, Riyadh 1151, Kingdom of Saudi Arabia</aff><aff>Ziad A Memish, College of Medicine, Alfaisal University, Riyadh 11514, Kingdom of Saudi Arabia</aff></contrib-group><author-notes><fn><p>Author contributions: Al-Tawfiq JA developed the research protocol, performed the research and data analysis; Al-Tawfiq JA, Kattan RF and Memish ZA authored and approved the article.</p><p>Correspondence to: Ziad A Memish, Professor, College of Medicine, Alfaisal University, P.O. Box 54146, Riyadh 11514, Kingdom of Saudi Arabia. <email>zmemish@yahoo.com</email></p><p>Telephone: +966-50-5483515 Fax: +966-11-2616464</p></fn></author-notes><pub-date pub-type="collection"><day>8</day><month>11</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>8</day><month>11</month><year>2016</year></pub-date><volume>5</volume><issue>4</issue><fpage>391</fpage><lpage>396</lpage><history><date date-type="received"><day>27</day><month>5</month><year>2016</year></date><date date-type="rev-recd"><day>16</day><month>8</month><year>2016</year></date><date date-type="accepted"><day>27</day><month>8</month><year>2016</year></date></history><permissions><copyright-statement>©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.</copyright-statement><copyright-year>2016</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/"><license-p>This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.</license-p></license></permissions><abstract><sec><title>AIM</title><p>To summarize the reported Middle East respiratory syndrome-coronavirus (MERS-CoV) cases, the associated clinical presentations and the outcomes.</p></sec><sec><title>METHODS</title><p>We searched the Saudi Ministry of Health website, the World Health Organization website, and the Flutracker website. We also searched MEDLINE and PubMed for the keywords: Middle East respiratory syndrome-coronavirus, MERS-CoV in combination with pediatric, children, childhood, infancy and pregnancy from the initial discovery of the virus in 2012 to 2016. The retrieved articles were also read to further find other articles. Relevant data were placed into an excel sheet and analyzed accordingly. Descriptive analytic statistics were used in the final analysis as deemed necessary.</p></sec><sec><title>RESULTS</title><p>From June 2012 to April 19, 2016, there were a total of 31 pediatric MERS-CoV cases. Of these cases 13 (42%) were asymptomatic and the male to female ratio was 1.7:1. The mean age of patients was 9.8 ± 5.4 years. Twenty-five (80.6%) of the cases were reported from the Kingdom of Saudi Arabia. The most common source of infection was household contact (10 of 15 with reported source) and 5 patients acquired infection within a health care facility. Using real time reverse transcriptase polymerase chain reaction of pediatric patients revealed that 9 out of 552 (1.6%) was positive in the Kingdom of Saudi Arabia.</p></sec><sec><title>CONCLUSION</title><p>Utilizing serology for MERS-CoV infection in Jordan and Saudi Arabia did not reveal any positive patients. Thus, the number of the pediatric MERS-CoV is low; the exact reason for the low prevalence of the disease in children is not known.</p></sec></abstract><kwd-group><kwd>Pediatric</kwd><kwd>Middle East respiratory syndrome-coronavirus</kwd><kwd>Children</kwd><kwd>Respiratory tract infection</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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