MERS-CoV recombination: implications about the reservoir and potential for adaptation
Identifieur interne : 001187 ( Pmc/Curation ); précédent : 001186; suivant : 001188MERS-CoV recombination: implications about the reservoir and potential for adaptation
Auteurs : Gytis Dudas [Royaume-Uni] ; Andrew Rambaut [Royaume-Uni, États-Unis]Source :
- Virus Evolution [ 2057-1577 ] ; 2016.
Abstract
Recombination is a process that unlinks neighboring loci allowing for independent evolutionary trajectories within genomes of many organisms. If not properly accounted for, recombination can compromise many evolutionary analyses. In addition, when dealing with organisms that are not obligately sexually reproducing, recombination gives insight into the rate at which distinct genetic lineages come into contact. Since June 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) has caused 1,106 laboratory-confirmed infections, with 421 MERS-CoV-associated deaths as of 16 April 2015. Although bats are considered as the likely ultimate source of zoonotic betacoronaviruses, dromedary camels have been consistently implicated as the source of current human infections in the Middle East. In this article, we use phylogenetic methods and simulations to show that MERS-CoV genome has likely undergone numerous recombinations recently. Recombination in MERS-CoV implies frequent co-infection with distinct lineages of MERS-CoV, probably in camels given the current understanding of MERS-CoV epidemiology.
Url:
DOI: 10.1093/ve/vev023
PubMed: 27774293
PubMed Central: 4989901
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">MERS-CoV recombination: implications about the reservoir and potential for adaptation</title><author><name sortKey="Dudas, Gytis" sort="Dudas, Gytis" uniqKey="Dudas G" first="Gytis" last="Dudas">Gytis Dudas</name><affiliation wicri:level="1"><nlm:aff id="vev023-AFF1">Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Evolutionary Biology, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Rambaut, Andrew" sort="Rambaut, Andrew" uniqKey="Rambaut A" first="Andrew" last="Rambaut">Andrew Rambaut</name><affiliation wicri:level="1"><nlm:aff id="vev023-AFF1">Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Evolutionary Biology, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="vev023-AFF2">Centre for Immunology, Infection and Evolution at the University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Immunology, Infection and Evolution at the University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="vev023-AFF3">Fogarty International Center, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fogarty International Center, National Institutes of Health, Bethesda, MD</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27774293</idno><idno type="pmc">4989901</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989901</idno><idno type="RBID">PMC:4989901</idno><idno type="doi">10.1093/ve/vev023</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001187</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001187</idno><idno type="wicri:Area/Pmc/Curation">001187</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001187</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">MERS-CoV recombination: implications about the reservoir and potential for adaptation</title><author><name sortKey="Dudas, Gytis" sort="Dudas, Gytis" uniqKey="Dudas G" first="Gytis" last="Dudas">Gytis Dudas</name><affiliation wicri:level="1"><nlm:aff id="vev023-AFF1">Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Evolutionary Biology, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Rambaut, Andrew" sort="Rambaut, Andrew" uniqKey="Rambaut A" first="Andrew" last="Rambaut">Andrew Rambaut</name><affiliation wicri:level="1"><nlm:aff id="vev023-AFF1">Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Evolutionary Biology, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="vev023-AFF2">Centre for Immunology, Infection and Evolution at the University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Immunology, Infection and Evolution at the University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="vev023-AFF3">Fogarty International Center, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fogarty International Center, National Institutes of Health, Bethesda, MD</wicri:regionArea></affiliation></author></analytic><series><title level="j">Virus Evolution</title><idno type="eISSN">2057-1577</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Recombination is a process that unlinks neighboring loci allowing for independent evolutionary trajectories within genomes of many organisms. If not properly accounted for, recombination can compromise many evolutionary analyses. In addition, when dealing with organisms that are not obligately sexually reproducing, recombination gives insight into the rate at which distinct genetic lineages come into contact. Since June 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) has caused 1,106 laboratory-confirmed infections, with 421 MERS-CoV-associated deaths as of 16 April 2015. Although bats are considered as the likely ultimate source of zoonotic betacoronaviruses, dromedary camels have been consistently implicated as the source of current human infections in the Middle East. In this article, we use phylogenetic methods and simulations to show that MERS-CoV genome has likely undergone numerous recombinations recently. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Virus Evol</journal-id><journal-id journal-id-type="iso-abbrev">Virus Evol</journal-id><journal-id journal-id-type="publisher-id">vevolu</journal-id><journal-id journal-id-type="hwp">vevolu</journal-id><journal-title-group><journal-title>Virus Evolution</journal-title></journal-title-group><issn pub-type="epub">2057-1577</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27774293</article-id><article-id pub-id-type="pmc">4989901</article-id><article-id pub-id-type="doi">10.1093/ve/vev023</article-id><article-id pub-id-type="publisher-id">vev023</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>MERS-CoV recombination: implications about the reservoir and potential for adaptation</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Dudas</surname><given-names>Gytis</given-names></name><xref ref-type="aff" rid="vev023-AFF1"><sup>1</sup></xref><xref ref-type="corresp" rid="vev023-COR1">*</xref></contrib><contrib contrib-type="author"><name><surname>Rambaut</surname><given-names>Andrew</given-names></name><xref ref-type="aff" rid="vev023-AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="vev023-AFF2"><sup>2</sup></xref><xref ref-type="aff" rid="vev023-AFF3"><sup>3</sup></xref><xref ref-type="corresp" rid="vev023-COR2"><sup>†</sup></xref></contrib><aff id="vev023-AFF1"><sup>1</sup>Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK,</aff><aff id="vev023-AFF2"><sup>2</sup>Centre for Immunology, Infection and Evolution at the University of Edinburgh, Edinburgh, UK and</aff><aff id="vev023-AFF3"><sup>3</sup>Fogarty International Center, National Institutes of Health, Bethesda, MD, USA</aff></contrib-group><author-notes><corresp id="vev023-COR1">*Corresponding author: E-mail: <email>g.dudas@sms.ed.ac.uk</email></corresp><corresp id="vev023-COR2"><sup>†</sup><ext-link ext-link-type="uri" xlink:href="http://orcid.org/0000-0003-4337-3707">http://orcid.org/0000-0003-4337-3707</ext-link></corresp></author-notes><pub-date pub-type="collection"><month>1</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>20</day><month>1</month><year>2016</year></pub-date><volume>2</volume><issue>1</issue><elocation-id>vev023</elocation-id><permissions><copyright-statement>© The Author 2016. Published by Oxford University Press.</copyright-statement><copyright-year>2016</copyright-year><license xlink:href="http://creativecommons.org/licenses/by-nc/4.0/" license-type="creative-commons"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com</license-p></license></permissions><abstract><p>Recombination is a process that unlinks neighboring loci allowing for independent evolutionary trajectories within genomes of many organisms. If not properly accounted for, recombination can compromise many evolutionary analyses. In addition, when dealing with organisms that are not obligately sexually reproducing, recombination gives insight into the rate at which distinct genetic lineages come into contact. Since June 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) has caused 1,106 laboratory-confirmed infections, with 421 MERS-CoV-associated deaths as of 16 April 2015. Although bats are considered as the likely ultimate source of zoonotic betacoronaviruses, dromedary camels have been consistently implicated as the source of current human infections in the Middle East. In this article, we use phylogenetic methods and simulations to show that MERS-CoV genome has likely undergone numerous recombinations recently. Recombination in MERS-CoV implies frequent co-infection with distinct lineages of MERS-CoV, probably in camels given the current understanding of MERS-CoV epidemiology.</p></abstract><kwd-group><kwd>MERS-CoV</kwd><kwd>recombination</kwd><kwd>co-infection</kwd><kwd>homoplasy</kwd><kwd>coronavirus</kwd><kwd>MERS</kwd></kwd-group><counts><page-count count="11"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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