MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape
Identifieur interne : 001126 ( Pmc/Curation ); précédent : 001125; suivant : 001127MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape
Auteurs : Vineet D. Menachery ; Alexandra Sch Fer ; Kristin E. Burnum-Johnson ; Hugh D. Mitchell ; Amie J. Eisfeld ; Kevin B. Walters ; Carrie D. Nicora ; Samuel O. Purvine ; Cameron P. Casey ; Matthew E. Monroe ; Karl K. Weitz ; Kelly G. Stratton ; Bobbie-Jo M. Webb-Robertson ; Lisa E. Gralinski ; Thomas O. Metz ; Richard D. Smith ; Katrina M. Waters ; Amy C. Sims ; Yoshihiro Kawaoka [Japon] ; Ralph S. BaricSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2018.
Abstract
Both highly pathogenic avian influenza virus and Middle East respiratory syndrome coronavirus (MERS-CoV) infections are characterized by severe disease and high mortality. The continued threat of their emergence from zoonotic populations underscores an important need to understand the dynamics of their infection. By comparing the host responses across other related respiratory virus infections, these studies have identified a common avenue used by MERS-CoV and A/influenza/Vietnam/1203/2004 (H5N1-VN1203) influenza to antagonize antigen presentation through epigenetic modulation. Overall, the use of cross-comparisons provides an additional approach to leverage systems biology data to identify key pathways and strategies used by viruses to subvert host immune responses and may be critical in developing both vaccines and therapeutic treatment.
Url:
DOI: 10.1073/pnas.1706928115
PubMed: 29339515
PubMed Central: 5798318
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Menachery</name><affiliation><nlm:aff id="aff1">Department of Microbiology and Immunology,<institution>University of Texas Medical Branch</institution>, Galveston,<addr-line>TX</addr-line> 77555;</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Epidemiology,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill,<addr-line>NC</addr-line> 27599;</nlm:aff></affiliation></author><author><name sortKey="Sch Fer, Alexandra" sort="Sch Fer, Alexandra" uniqKey="Sch Fer A" first="Alexandra" last="Sch Fer">Alexandra Sch Fer</name><affiliation><nlm:aff id="aff2">Department of Epidemiology,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill,<addr-line>NC</addr-line> 27599;</nlm:aff></affiliation></author><author><name sortKey="Burnum Johnson, Kristin E" sort="Burnum Johnson, Kristin E" uniqKey="Burnum Johnson K" first="Kristin E." last="Burnum-Johnson">Kristin E. 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Webb-Robertson</name><affiliation><nlm:aff id="aff3"><institution>Biological Sciences Division, Pacific Northwest National Laboratory</institution>, Richland,<addr-line>WA</addr-line> 99354;</nlm:aff></affiliation></author><author><name sortKey="Gralinski, Lisa E" sort="Gralinski, Lisa E" uniqKey="Gralinski L" first="Lisa E." last="Gralinski">Lisa E. Gralinski</name><affiliation><nlm:aff id="aff2">Department of Epidemiology,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill,<addr-line>NC</addr-line> 27599;</nlm:aff></affiliation></author><author><name sortKey="Metz, Thomas O" sort="Metz, Thomas O" uniqKey="Metz T" first="Thomas O." last="Metz">Thomas O. 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Sims</name><affiliation><nlm:aff id="aff2">Department of Epidemiology,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill,<addr-line>NC</addr-line> 27599;</nlm:aff></affiliation></author><author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><affiliation><nlm:aff id="aff4">Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine,<institution>University of Wisconsin–Madison</institution>, Madison,<addr-line>WI</addr-line> 53706;</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science,<institution>University of Tokyo</institution>, Tokyo 113-8654,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">International Research Center for Infectious Diseases, Institute of Medical Science,<institution>University of Tokyo</institution>, Tokyo 113-8654,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name><affiliation><nlm:aff id="aff2">Department of Epidemiology,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill,<addr-line>NC</addr-line> 27599;</nlm:aff></affiliation><affiliation><nlm:aff id="aff7">Microbiology and Immunology,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill,<addr-line>NC</addr-line> 27599</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">29339515</idno><idno type="pmc">5798318</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798318</idno><idno type="RBID">PMC:5798318</idno><idno type="doi">10.1073/pnas.1706928115</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">001126</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001126</idno><idno type="wicri:Area/Pmc/Curation">001126</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001126</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape</title><author><name sortKey="Menachery, Vineet D" sort="Menachery, Vineet D" uniqKey="Menachery V" first="Vineet D." last="Menachery">Vineet D. Menachery</name><affiliation><nlm:aff id="aff1">Department of Microbiology and Immunology,<institution>University of Texas Medical Branch</institution>, Galveston,<addr-line>TX</addr-line> 77555;</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Epidemiology,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill,<addr-line>NC</addr-line> 27599;</nlm:aff></affiliation></author><author><name sortKey="Sch Fer, Alexandra" sort="Sch Fer, Alexandra" uniqKey="Sch Fer A" first="Alexandra" last="Sch Fer">Alexandra Sch Fer</name><affiliation><nlm:aff id="aff2">Department of Epidemiology,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill,<addr-line>NC</addr-line> 27599;</nlm:aff></affiliation></author><author><name sortKey="Burnum Johnson, Kristin E" sort="Burnum Johnson, Kristin E" uniqKey="Burnum Johnson K" first="Kristin E." last="Burnum-Johnson">Kristin E. Burnum-Johnson</name><affiliation><nlm:aff id="aff3"><institution>Biological Sciences Division, Pacific Northwest National Laboratory</institution>, Richland,<addr-line>WA</addr-line> 99354;</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Hugh D" sort="Mitchell, Hugh D" uniqKey="Mitchell H" first="Hugh D." last="Mitchell">Hugh D. Mitchell</name><affiliation><nlm:aff id="aff3"><institution>Biological Sciences Division, Pacific Northwest National Laboratory</institution>, Richland,<addr-line>WA</addr-line> 99354;</nlm:aff></affiliation></author><author><name sortKey="Eisfeld, Amie J" sort="Eisfeld, Amie J" uniqKey="Eisfeld A" first="Amie J." last="Eisfeld">Amie J. Eisfeld</name><affiliation><nlm:aff id="aff4">Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine,<institution>University of Wisconsin–Madison</institution>, Madison,<addr-line>WI</addr-line> 53706;</nlm:aff></affiliation></author><author><name sortKey="Walters, Kevin B" sort="Walters, Kevin B" uniqKey="Walters K" first="Kevin B." last="Walters">Kevin B. Walters</name><affiliation><nlm:aff id="aff4">Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine,<institution>University of Wisconsin–Madison</institution>, Madison,<addr-line>WI</addr-line> 53706;</nlm:aff></affiliation></author><author><name sortKey="Nicora, Carrie D" sort="Nicora, Carrie D" uniqKey="Nicora C" first="Carrie D." last="Nicora">Carrie D. Nicora</name><affiliation><nlm:aff id="aff3"><institution>Biological Sciences Division, Pacific Northwest National Laboratory</institution>, Richland,<addr-line>WA</addr-line> 99354;</nlm:aff></affiliation></author><author><name sortKey="Purvine, Samuel O" sort="Purvine, Samuel O" uniqKey="Purvine S" first="Samuel O." last="Purvine">Samuel O. Purvine</name><affiliation><nlm:aff id="aff3"><institution>Biological Sciences Division, Pacific Northwest National Laboratory</institution>, Richland,<addr-line>WA</addr-line> 99354;</nlm:aff></affiliation></author><author><name sortKey="Casey, Cameron P" sort="Casey, Cameron P" uniqKey="Casey C" first="Cameron P." last="Casey">Cameron P. Casey</name><affiliation><nlm:aff id="aff3"><institution>Biological Sciences Division, Pacific Northwest National Laboratory</institution>, Richland,<addr-line>WA</addr-line> 99354;</nlm:aff></affiliation></author><author><name sortKey="Monroe, Matthew E" sort="Monroe, Matthew E" uniqKey="Monroe M" first="Matthew E." last="Monroe">Matthew E. Monroe</name><affiliation><nlm:aff id="aff3"><institution>Biological Sciences Division, Pacific Northwest National Laboratory</institution>, Richland,<addr-line>WA</addr-line> 99354;</nlm:aff></affiliation></author><author><name sortKey="Weitz, Karl K" sort="Weitz, Karl K" uniqKey="Weitz K" first="Karl K." last="Weitz">Karl K. Weitz</name><affiliation><nlm:aff id="aff3"><institution>Biological Sciences Division, Pacific Northwest National Laboratory</institution>, Richland,<addr-line>WA</addr-line> 99354;</nlm:aff></affiliation></author><author><name sortKey="Stratton, Kelly G" sort="Stratton, Kelly G" uniqKey="Stratton K" first="Kelly G." last="Stratton">Kelly G. Stratton</name><affiliation><nlm:aff id="aff3"><institution>Biological Sciences Division, Pacific Northwest National Laboratory</institution>, Richland,<addr-line>WA</addr-line> 99354;</nlm:aff></affiliation></author><author><name sortKey="Webb Robertson, Bobbie Jo M" sort="Webb Robertson, Bobbie Jo M" uniqKey="Webb Robertson B" first="Bobbie-Jo M." last="Webb-Robertson">Bobbie-Jo M. Webb-Robertson</name><affiliation><nlm:aff id="aff3"><institution>Biological Sciences Division, Pacific Northwest National Laboratory</institution>, Richland,<addr-line>WA</addr-line> 99354;</nlm:aff></affiliation></author><author><name sortKey="Gralinski, Lisa E" sort="Gralinski, Lisa E" uniqKey="Gralinski L" first="Lisa E." last="Gralinski">Lisa E. Gralinski</name><affiliation><nlm:aff id="aff2">Department of Epidemiology,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill,<addr-line>NC</addr-line> 27599;</nlm:aff></affiliation></author><author><name sortKey="Metz, Thomas O" sort="Metz, Thomas O" uniqKey="Metz T" first="Thomas O." last="Metz">Thomas O. Metz</name><affiliation><nlm:aff id="aff3"><institution>Biological Sciences Division, Pacific Northwest National Laboratory</institution>, Richland,<addr-line>WA</addr-line> 99354;</nlm:aff></affiliation></author><author><name sortKey="Smith, Richard D" sort="Smith, Richard D" uniqKey="Smith R" first="Richard D." last="Smith">Richard D. Smith</name><affiliation><nlm:aff id="aff3"><institution>Biological Sciences Division, Pacific Northwest National Laboratory</institution>, Richland,<addr-line>WA</addr-line> 99354;</nlm:aff></affiliation></author><author><name sortKey="Waters, Katrina M" sort="Waters, Katrina M" uniqKey="Waters K" first="Katrina M." last="Waters">Katrina M. Waters</name><affiliation><nlm:aff id="aff3"><institution>Biological Sciences Division, Pacific Northwest National Laboratory</institution>, Richland,<addr-line>WA</addr-line> 99354;</nlm:aff></affiliation></author><author><name sortKey="Sims, Amy C" sort="Sims, Amy C" uniqKey="Sims A" first="Amy C." last="Sims">Amy C. Sims</name><affiliation><nlm:aff id="aff2">Department of Epidemiology,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill,<addr-line>NC</addr-line> 27599;</nlm:aff></affiliation></author><author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><affiliation><nlm:aff id="aff4">Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine,<institution>University of Wisconsin–Madison</institution>, Madison,<addr-line>WI</addr-line> 53706;</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science,<institution>University of Tokyo</institution>, Tokyo 113-8654,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">International Research Center for Infectious Diseases, Institute of Medical Science,<institution>University of Tokyo</institution>, Tokyo 113-8654,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name><affiliation><nlm:aff id="aff2">Department of Epidemiology,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill,<addr-line>NC</addr-line> 27599;</nlm:aff></affiliation><affiliation><nlm:aff id="aff7">Microbiology and Immunology,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill,<addr-line>NC</addr-line> 27599</nlm:aff></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Significance</title><p>Both highly pathogenic avian influenza virus and Middle East respiratory syndrome coronavirus (MERS-CoV) infections are characterized by severe disease and high mortality. The continued threat of their emergence from zoonotic populations underscores an important need to understand the dynamics of their infection. By comparing the host responses across other related respiratory virus infections, these studies have identified a common avenue used by MERS-CoV and A/influenza/Vietnam/1203/2004 (H5N1-VN1203) influenza to antagonize antigen presentation through epigenetic modulation. Overall, the use of cross-comparisons provides an additional approach to leverage systems biology data to identify key pathways and strategies used by viruses to subvert host immune responses and may be critical in developing both vaccines and therapeutic treatment.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mandl, Jn" uniqKey="Mandl J">JN Mandl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kreuder Johnson, C" uniqKey="Kreuder Johnson C">C Kreuder Johnson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morse, Ss" uniqKey="Morse S">SS Morse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sawyer, Sl" uniqKey="Sawyer S">SL Sawyer</name></author><author><name sortKey="Elde, Nc" uniqKey="Elde N">NC Elde</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Menachery, Vd" uniqKey="Menachery 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Proc Natl Acad Sci U S A</journal-id><journal-id journal-id-type="iso-abbrev">Proc. Natl. Acad. Sci. U.S.A</journal-id><journal-id journal-id-type="hwp">pnas</journal-id><journal-id journal-id-type="pmc">pnas</journal-id><journal-id journal-id-type="publisher-id">PNAS</journal-id><journal-title-group><journal-title>Proceedings of the National Academy of Sciences of the United States of America</journal-title></journal-title-group><issn pub-type="ppub">0027-8424</issn><issn pub-type="epub">1091-6490</issn><publisher><publisher-name>National Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">29339515</article-id><article-id pub-id-type="pmc">5798318</article-id><article-id pub-id-type="publisher-id">201706928</article-id><article-id pub-id-type="doi">10.1073/pnas.1706928115</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>530</subject></subj-group><subj-group subj-group-type="heading"><subject>PNAS Plus</subject></subj-group><subj-group subj-group-type="heading"><subject>Biological Sciences</subject><subj-group><subject>Microbiology</subject></subj-group></subj-group><series-title>PNAS Plus</series-title></article-categories><title-group><article-title>MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape</article-title><alt-title alt-title-type="short">MERS and H5N1 antagonize MHC via epigenetics</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Menachery</surname><given-names>Vineet D.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="aff" rid="aff2"><sup>b</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Schäfer</surname><given-names>Alexandra</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-2722-4149</contrib-id><name><surname>Burnum-Johnson</surname><given-names>Kristin E.</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mitchell</surname><given-names>Hugh D.</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Eisfeld</surname><given-names>Amie J.</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Walters</surname><given-names>Kevin B.</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref><xref ref-type="author-notes" rid="fn2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nicora</surname><given-names>Carrie D.</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Purvine</surname><given-names>Samuel O.</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Casey</surname><given-names>Cameron P.</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Monroe</surname><given-names>Matthew E.</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Weitz</surname><given-names>Karl K.</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Stratton</surname><given-names>Kelly G.</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Webb-Robertson</surname><given-names>Bobbie-Jo M.</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gralinski</surname><given-names>Lisa E.</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Metz</surname><given-names>Thomas O.</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>Richard D.</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Waters</surname><given-names>Katrina M.</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sims</surname><given-names>Amy C.</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref><xref ref-type="author-notes" rid="fn3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kawaoka</surname><given-names>Yoshihiro</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref><xref ref-type="aff" rid="aff5"><sup>e</sup></xref><xref ref-type="aff" rid="aff6"><sup>f</sup></xref><xref ref-type="author-notes" rid="fn3"><sup>3</sup></xref><xref ref-type="corresp" rid="cor1"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Baric</surname><given-names>Ralph S.</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref><xref ref-type="aff" rid="aff7"><sup>g</sup></xref><xref ref-type="author-notes" rid="fn3"><sup>3</sup></xref><xref ref-type="corresp" rid="cor1"><sup>4</sup></xref></contrib><aff id="aff1"><sup>a</sup>Department of Microbiology and Immunology,<institution>University of Texas Medical Branch</institution>, Galveston,<addr-line>TX</addr-line> 77555;</aff><aff id="aff2"><sup>b</sup>Department of Epidemiology,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill,<addr-line>NC</addr-line> 27599;</aff><aff id="aff3"><sup>c</sup><institution>Biological Sciences Division, Pacific Northwest National Laboratory</institution>, Richland,<addr-line>WA</addr-line> 99354;</aff><aff id="aff4"><sup>d</sup>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine,<institution>University of Wisconsin–Madison</institution>, Madison,<addr-line>WI</addr-line> 53706;</aff><aff id="aff5"><sup>e</sup>Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science,<institution>University of Tokyo</institution>, Tokyo 113-8654,<country>Japan</country>;</aff><aff id="aff6"><sup>f</sup>International Research Center for Infectious Diseases, Institute of Medical Science,<institution>University of Tokyo</institution>, Tokyo 113-8654,<country>Japan</country>;</aff><aff id="aff7"><sup>g</sup>Microbiology and Immunology,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill,<addr-line>NC</addr-line> 27599</aff></contrib-group><author-notes><corresp id="cor1"><sup>4</sup>To whom correspondence may be addressed. Email: <email>yoshihiro.kawaoka@wisc.edu</email> or <email>rbaric@email.unc.edu</email>.</corresp><fn fn-type="edited-by"><p>Contributed by Yoshihiro Kawaoka, December 14, 2017 (sent for review May 15, 2017; reviewed by Cornelia Bergmann, Brenda G. Hogue, and Vincent J. Munster)</p></fn><fn fn-type="con"><p>Author contributions: V.D.M., A.S., A.J.E., Y.K., and R.S.B. designed research; V.D.M., A.S., A.J.E., K.B.W., L.E.G., and A.C.S. performed research; V.D.M., A.S., K.E.B.-J., H.D.M., C.D.N., S.O.P., C.P.C., M.E.M., K.K.W., K.G.S., B.-J.M.W.-R., T.O.M., R.D.S., and K.M.W. analyzed data; and V.D.M., A.S., and R.S.B. wrote the paper.</p></fn><fn fn-type="con"><p>Reviewers: C.B., Cleveland Clinic; B.G.H., Arizona State University; and V.J.M., NIH.</p></fn><fn fn-type="equal" id="fn1"><p><sup>1</sup>V.D.M. and A.S. contributed equally to this work.</p></fn><fn fn-type="present-address" id="fn2"><p><sup>2</sup>Present address: Drug Development Division, Southern Research, Frederick, MD 21701.</p></fn><fn fn-type="equal" id="fn3"><p><sup>3</sup>A.C.S., Y.K., and R.S.B. contributed equally to this work.</p></fn></author-notes><pub-date pub-type="ppub"><day>30</day><month>1</month><year>2018</year></pub-date><pub-date pub-type="epub"><day>16</day><month>1</month><year>2018</year></pub-date><pub-date pub-type="pmc-release"><day>16</day><month>1</month><year>2018</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>115</volume><issue>5</issue><fpage>E1012</fpage><lpage>E1021</lpage><permissions><copyright-statement>Copyright © 2018 the Author(s). Published by PNAS.</copyright-statement><copyright-year>2018</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by-nc-nd/4.0/"><ali:license_ref specific-use="vor">https://creativecommons.org/licenses/by-nc-nd/4.0/</ali:license_ref><license-p>This open access article is distributed under <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by-nc-nd/4.0/">Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND)</ext-link>.</license-p></license></permissions><self-uri xlink:title="pdf" xlink:href="pnas.201706928.pdf"></self-uri><abstract abstract-type="executive-summary"><title>Significance</title><p>Both highly pathogenic avian influenza virus and Middle East respiratory syndrome coronavirus (MERS-CoV) infections are characterized by severe disease and high mortality. The continued threat of their emergence from zoonotic populations underscores an important need to understand the dynamics of their infection. By comparing the host responses across other related respiratory virus infections, these studies have identified a common avenue used by MERS-CoV and A/influenza/Vietnam/1203/2004 (H5N1-VN1203) influenza to antagonize antigen presentation through epigenetic modulation. Overall, the use of cross-comparisons provides an additional approach to leverage systems biology data to identify key pathways and strategies used by viruses to subvert host immune responses and may be critical in developing both vaccines and therapeutic treatment.</p></abstract><abstract><p>Convergent evolution dictates that diverse groups of viruses will target both similar and distinct host pathways to manipulate the immune response and improve infection. In this study, we sought to leverage this uneven viral antagonism to identify critical host factors that govern disease outcome. Utilizing a systems-based approach, we examined differential regulation of IFN-γ–dependent genes following infection with robust respiratory viruses including influenza viruses [A/influenza/Vietnam/1203/2004 (H5N1-VN1203) and A/influenza/California/04/2009 (H1N1-CA04)] and coronaviruses [severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV)]. Categorizing by function, we observed down-regulation of gene expression associated with antigen presentation following both H5N1-VN1203 and MERS-CoV infection. Further examination revealed global down-regulation of antigen-presentation gene expression, which was confirmed by proteomics for both H5N1-VN1203 and MERS-CoV infection. Importantly, epigenetic analysis suggested that DNA methylation, rather than histone modification, plays a crucial role in MERS-CoV–mediated antagonism of antigen-presentation gene expression; in contrast, H5N1-VN1203 likely utilizes a combination of epigenetic mechanisms to target antigen presentation. Together, the results indicate a common mechanism utilized by H5N1-VN1203 and MERS-CoV to modulate antigen presentation and the host adaptive immune response.</p></abstract><kwd-group><kwd>antigen presentation</kwd><kwd>epigenetics</kwd><kwd>coronavirus</kwd><kwd>influenza</kwd><kwd>DNA methylation</kwd></kwd-group><counts><page-count count="10"></page-count></counts><custom-meta-group><custom-meta><meta-name>access-type</meta-name><meta-value>free</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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