Unexpected Diversity of Cellular Immune Responses against Nef and Vif in HIV-1-Infected Patients Who Spontaneously Control Viral Replication
Identifieur interne : 001059 ( Pmc/Curation ); précédent : 001058; suivant : 001060Unexpected Diversity of Cellular Immune Responses against Nef and Vif in HIV-1-Infected Patients Who Spontaneously Control Viral Replication
Auteurs : Leandro F. Tarosso [Brésil] ; Mariana M. Sauer [Brésil] ; Sabri Sanabani [Brésil] ; Maria Teresa Giret [Brésil] ; Helena I. Tomiyama [Brésil] ; John Sidney [États-Unis] ; Shari M. Piaskowski [États-Unis] ; Ricardo S. Diaz [Brésil] ; Ester C. Sabino [Brésil] ; Alessandro Sette [États-Unis] ; Jorge Kalil-Filho [Brésil] ; David I. Watkins [États-Unis] ; Esper G. Kallas [Brésil]Source :
- PLoS ONE [ 1932-6203 ] ; 2010.
Abstract
HIV-1-infected individuals who spontaneously control viral replication represent an example of successful containment of the AIDS virus. Understanding the anti-viral immune responses in these individuals may help in vaccine design. However, immune responses against HIV-1 are normally analyzed using HIV-1 consensus B 15-mers that overlap by 11 amino acids. Unfortunately, this method may underestimate the real breadth of the cellular immune responses against the autologous sequence of the infecting virus.
Here we compared cellular immune responses against
This suggests that the cellular immune responses against HIV-1 in controller patients may be broader than we had previously anticipated.
Url:
DOI: 10.1371/journal.pone.0011436
PubMed: 20625436
PubMed Central: 2896403
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Tarosso</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Clinical Immunology and Allergy Division, University of Sao Paulo, Sao Paulo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Clinical Immunology and Allergy Division, University of Sao Paulo, Sao Paulo</wicri:regionArea></affiliation></author><author><name sortKey="Sauer, Mariana M" sort="Sauer, Mariana M" uniqKey="Sauer M" first="Mariana M." last="Sauer">Mariana M. Sauer</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Division of Infectious Diseases, Federal University of Sao Paulo, Sao Paulo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Division of Infectious Diseases, Federal University of Sao Paulo, Sao Paulo</wicri:regionArea></affiliation></author><author><name sortKey="Sanabani, Sabri" sort="Sanabani, Sabri" uniqKey="Sanabani S" first="Sabri" last="Sanabani">Sabri Sanabani</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Sao Paulo Blood Bank, Sao Paulo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Sao Paulo Blood Bank, Sao Paulo</wicri:regionArea></affiliation></author><author><name sortKey="Giret, Maria Teresa" sort="Giret, Maria Teresa" uniqKey="Giret M" first="Maria Teresa" last="Giret">Maria Teresa Giret</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Division of Infectious Diseases, Federal University of Sao Paulo, Sao Paulo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Division of Infectious Diseases, Federal University of Sao Paulo, Sao Paulo</wicri:regionArea></affiliation></author><author><name sortKey="Tomiyama, Helena I" sort="Tomiyama, Helena I" uniqKey="Tomiyama H" first="Helena I." last="Tomiyama">Helena I. Tomiyama</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Division of Infectious Diseases, Federal University of Sao Paulo, Sao Paulo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Division of Infectious Diseases, Federal University of Sao Paulo, Sao Paulo</wicri:regionArea></affiliation></author><author><name sortKey="Sidney, John" sort="Sidney, John" uniqKey="Sidney J" first="John" last="Sidney">John Sidney</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>La Jolla Institute for Allergy and Immunology, La Jolla, California</wicri:regionArea></affiliation></author><author><name sortKey="Piaskowski, Shari M" sort="Piaskowski, Shari M" uniqKey="Piaskowski S" first="Shari M." last="Piaskowski">Shari M. Piaskowski</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Department of Pathology, Medical School, University of Wisconsin-Madison, Madison, Wisconsin, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Medical School, University of Wisconsin-Madison, Madison, Wisconsin</wicri:regionArea></affiliation></author><author><name sortKey="Diaz, Ricardo S" sort="Diaz, Ricardo S" uniqKey="Diaz R" first="Ricardo S." last="Diaz">Ricardo S. Diaz</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Division of Infectious Diseases, Federal University of Sao Paulo, Sao Paulo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Division of Infectious Diseases, Federal University of Sao Paulo, Sao Paulo</wicri:regionArea></affiliation></author><author><name sortKey="Sabino, Ester C" sort="Sabino, Ester C" uniqKey="Sabino E" first="Ester C." last="Sabino">Ester C. Sabino</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Sao Paulo Blood Bank, Sao Paulo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Sao Paulo Blood Bank, Sao Paulo</wicri:regionArea></affiliation></author><author><name sortKey="Sette, Alessandro" sort="Sette, Alessandro" uniqKey="Sette A" first="Alessandro" last="Sette">Alessandro Sette</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>La Jolla Institute for Allergy and Immunology, La Jolla, California</wicri:regionArea></affiliation></author><author><name sortKey="Kalil Filho, Jorge" sort="Kalil Filho, Jorge" uniqKey="Kalil Filho J" first="Jorge" last="Kalil-Filho">Jorge Kalil-Filho</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Clinical Immunology and Allergy Division, University of Sao Paulo, Sao Paulo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Clinical Immunology and Allergy Division, University of Sao Paulo, Sao Paulo</wicri:regionArea></affiliation></author><author><name sortKey="Watkins, David I" sort="Watkins, David I" uniqKey="Watkins D" first="David I." last="Watkins">David I. Watkins</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Department of Pathology, Medical School, University of Wisconsin-Madison, Madison, Wisconsin, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Medical School, University of Wisconsin-Madison, Madison, Wisconsin</wicri:regionArea></affiliation></author><author><name sortKey="Kallas, Esper G" sort="Kallas, Esper G" uniqKey="Kallas E" first="Esper G." last="Kallas">Esper G. Kallas</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Clinical Immunology and Allergy Division, University of Sao Paulo, Sao Paulo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Clinical Immunology and Allergy Division, University of Sao Paulo, Sao Paulo</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Division of Infectious Diseases, Federal University of Sao Paulo, Sao Paulo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Division of Infectious Diseases, Federal University of Sao Paulo, Sao Paulo</wicri:regionArea></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>HIV-1-infected individuals who spontaneously control viral replication represent an example of successful containment of the AIDS virus. Understanding the anti-viral immune responses in these individuals may help in vaccine design. However, immune responses against HIV-1 are normally analyzed using HIV-1 consensus B 15-mers that overlap by 11 amino acids. Unfortunately, this method may underestimate the real breadth of the cellular immune responses against the autologous sequence of the infecting virus.</p></sec><sec><title>Methodology and Principal Findings</title><p>Here we compared cellular immune responses against <italic>nef</italic> and <italic>vif</italic>-encoded consensus B 15-mer peptides to responses against HLA class I-predicted minimal optimal epitopes from consensus B and autologous sequences in six patients who have controlled HIV-1 replication. Interestingly, our analysis revealed that three of our patients had broader cellular immune responses against HLA class I-predicted minimal optimal epitopes from either autologous viruses or from the HIV-1 consensus B sequence, when compared to responses against the 15-mer HIV-1 type B consensus peptides.</p></sec><sec><title>Conclusion and Significance</title><p>This suggests that the cellular immune responses against HIV-1 in controller patients may be broader than we had previously anticipated.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Emu, B" uniqKey="Emu B">B Emu</name></author><author><name sortKey="Sinclair, E" uniqKey="Sinclair E">E Sinclair</name></author><author><name sortKey="Hatano, H" uniqKey="Hatano H">H Hatano</name></author><author><name sortKey="Ferre, A" uniqKey="Ferre A">A Ferre</name></author><author><name sortKey="Shacklett, B" uniqKey="Shacklett B">B 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Brenchley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Altfeld, M" uniqKey="Altfeld M">M Altfeld</name></author><author><name sortKey="Addo, Mm" uniqKey="Addo M">MM Addo</name></author><author><name sortKey="Shankarappa, R" uniqKey="Shankarappa R">R Shankarappa</name></author><author><name sortKey="Lee, Pk" uniqKey="Lee P">PK Lee</name></author><author><name sortKey="Allen, Tm" uniqKey="Allen T">TM Allen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20625436</article-id><article-id pub-id-type="pmc">2896403</article-id><article-id pub-id-type="publisher-id">09-PONE-RA-15027R1</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0011436</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline"><subject>Immunology/Immunity to Infections</subject><subject>Virology/Immunodeficiency Viruses</subject><subject>Infectious Diseases/HIV Infection and AIDS</subject></subj-group></article-categories><title-group><article-title>Unexpected Diversity of Cellular Immune Responses against Nef and Vif in HIV-1-Infected Patients Who Spontaneously Control Viral Replication</article-title><alt-title alt-title-type="running-head">Immunity in HIV Controllers</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Tarosso</surname><given-names>Leandro F.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sauer</surname><given-names>Mariana M.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sanabani</surname><given-names>Sabri</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Giret</surname><given-names>Maria Teresa</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tomiyama</surname><given-names>Helena I.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sidney</surname><given-names>John</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Piaskowski</surname><given-names>Shari M.</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Diaz</surname><given-names>Ricardo S.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sabino</surname><given-names>Ester C.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sette</surname><given-names>Alessandro</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kalil-Filho</surname><given-names>Jorge</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Watkins</surname><given-names>David I.</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kallas</surname><given-names>Esper G.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Clinical Immunology and Allergy Division, University of Sao Paulo, Sao Paulo, Brazil</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Division of Infectious Diseases, Federal University of Sao Paulo, Sao Paulo, Brazil</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Sao Paulo Blood Bank, Sao Paulo, Brazil</addr-line></aff><aff id="aff4"><label>4</label><addr-line>La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America</addr-line></aff><aff id="aff5"><label>5</label><addr-line>Department of Pathology, Medical School, University of Wisconsin-Madison, Madison, Wisconsin, United States of America</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Ostrowski</surname><given-names>Mario A.</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1">University of Toronto, Canada</aff><author-notes><corresp id="cor1">* E-mail: <email>esper.kallas@gmail.com</email></corresp><fn fn-type="con"><p>Conceived and designed the experiments: LFT SS MTMG HT JS DIW EGK. Performed the experiments: LFT SS MTMG HT JS SMP. Analyzed the data: LFT SS JS DIW EGK. Contributed reagents/materials/analysis tools: SS JS SMP RSD ECS AS JKF DIW EGK. Wrote the paper: LFT. Saw the patients: MMS. Collected clinical data: MMS. Reviewed and approved the manuscript: RSD ECS AS JKF DIW EGK.</p></fn></author-notes><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>2</day><month>7</month><year>2010</year></pub-date><volume>5</volume><issue>7</issue><elocation-id>e11436</elocation-id><history><date date-type="received"><day>18</day><month>12</month><year>2009</year></date><date date-type="accepted"><day>25</day><month>5</month><year>2010</year></date></history><permissions><copyright-statement>Tarosso et al.</copyright-statement><copyright-year>2010</copyright-year><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.</license-p></license></permissions><abstract><sec><title>Background</title><p>HIV-1-infected individuals who spontaneously control viral replication represent an example of successful containment of the AIDS virus. Understanding the anti-viral immune responses in these individuals may help in vaccine design. However, immune responses against HIV-1 are normally analyzed using HIV-1 consensus B 15-mers that overlap by 11 amino acids. Unfortunately, this method may underestimate the real breadth of the cellular immune responses against the autologous sequence of the infecting virus.</p></sec><sec><title>Methodology and Principal Findings</title><p>Here we compared cellular immune responses against <italic>nef</italic> and <italic>vif</italic>-encoded consensus B 15-mer peptides to responses against HLA class I-predicted minimal optimal epitopes from consensus B and autologous sequences in six patients who have controlled HIV-1 replication. Interestingly, our analysis revealed that three of our patients had broader cellular immune responses against HLA class I-predicted minimal optimal epitopes from either autologous viruses or from the HIV-1 consensus B sequence, when compared to responses against the 15-mer HIV-1 type B consensus peptides.</p></sec><sec><title>Conclusion and Significance</title><p>This suggests that the cellular immune responses against HIV-1 in controller patients may be broader than we had previously anticipated.</p></sec></abstract><counts><page-count count="9"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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