Serological Evidence of MERS-CoV Antibodies in Dromedary Camels (Camelus dromedaries) in Laikipia County, Kenya
Identifieur interne : 001013 ( Pmc/Curation ); précédent : 001012; suivant : 001014Serological Evidence of MERS-CoV Antibodies in Dromedary Camels (Camelus dromedaries) in Laikipia County, Kenya
Auteurs : Sharon L. Deem [États-Unis] ; Eric M. Fèvre [Royaume-Uni, Kenya] ; Margaret Kinnaird [Kenya, États-Unis] ; A. Springer Browne [Nouvelle-Zélande] ; Dishon Muloi [Kenya] ; Gert-Jan Godeke [Pays-Bas] ; Marion Koopmans [Pays-Bas] ; Chantal B. Reusken [Pays-Bas]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) is a recently identified virus causing severe viral respiratory illness in people. Little is known about the reservoir in the Horn of Africa. In Kenya, where no human MERS cases have been reported, our survey of 335 dromedary camels, representing nine herds in Laikipia County, showed a high seroprevalence (46.9%) to MERS-CoV antibodies. Between herd differences were present (14.3%– 82.9%), but was not related to management type or herd isolation. Further research should focus on identifying similarity between MERS-CoV viral isolates in Kenya and clinical isolates from the Middle East and elsewhere.
Url:
DOI: 10.1371/journal.pone.0140125
PubMed: 26473733
PubMed Central: 4608777
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<front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome coronavirus (MERS-CoV) is a recently identified virus causing severe viral respiratory illness in people. Little is known about the reservoir in the Horn of Africa. In Kenya, where no human MERS cases have been reported, our survey of 335 dromedary camels, representing nine herds in Laikipia County, showed a high seroprevalence (46.9%) to MERS-CoV antibodies. Between herd differences were present (14.3%– 82.9%), but was not related to management type or herd isolation. Further research should focus on identifying similarity between MERS-CoV viral isolates in Kenya and clinical isolates from the Middle East and elsewhere.</p>
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<title-group><article-title>Serological Evidence of MERS-CoV Antibodies in Dromedary Camels (<italic>Camelus dromedaries</italic>
) in Laikipia County, Kenya</article-title>
<alt-title alt-title-type="running-head">Serological Evidence of MERS-CoV in Dromedary Camels in Kenya</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Deem</surname>
<given-names>Sharon L.</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref rid="cor001" ref-type="corresp">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fèvre</surname>
<given-names>Eric M.</given-names>
</name>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff003"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kinnaird</surname>
<given-names>Margaret</given-names>
</name>
<xref ref-type="aff" rid="aff004"><sup>4</sup>
</xref>
<xref ref-type="aff" rid="aff005"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Browne</surname>
<given-names>A. Springer</given-names>
</name>
<xref ref-type="aff" rid="aff006"><sup>6</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Muloi</surname>
<given-names>Dishon</given-names>
</name>
<xref ref-type="aff" rid="aff003"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Godeke</surname>
<given-names>Gert-Jan</given-names>
</name>
<xref ref-type="aff" rid="aff007"><sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Koopmans</surname>
<given-names>Marion</given-names>
</name>
<xref ref-type="aff" rid="aff007"><sup>7</sup>
</xref>
<xref ref-type="aff" rid="aff008"><sup>8</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Reusken</surname>
<given-names>Chantal B.</given-names>
</name>
<xref ref-type="aff" rid="aff007"><sup>7</sup>
</xref>
</contrib>
</contrib-group>
<aff id="aff001"><label>1</label>
<addr-line>Saint Louis Zoo Institute for Conservation Medicine, Saint Louis, Missouri, United States of America</addr-line>
</aff>
<aff id="aff002"><label>2</label>
<addr-line>Institute of Infection and Global Health, University of Liverpool, Leahurst Campus, Neston, United Kingdom</addr-line>
</aff>
<aff id="aff003"><label>3</label>
<addr-line>International Livestock Research Institute, Nairobi, Kenya</addr-line>
</aff>
<aff id="aff004"><label>4</label>
<addr-line>Mpala Research Centre, Nanyuki, Kenya</addr-line>
</aff>
<aff id="aff005"><label>5</label>
<addr-line>Wildlife Conservation Society, Global Conservation Programs, Bronx, New York, United States of America</addr-line>
</aff>
<aff id="aff006"><label>6</label>
<addr-line>Molecular Epidemiology and Public Health Laboratory, Hopkirk Research Institute, Massey University, Palmerston North, New Zealand</addr-line>
</aff>
<aff id="aff007"><label>7</label>
<addr-line>Netherlands Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands</addr-line>
</aff>
<aff id="aff008"><label>8</label>
<addr-line>Department of Viroscience, Erasmus Medical Centre, Rotterdam, the Netherlands</addr-line>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Chan</surname>
<given-names>Renee W.Y.</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1"><addr-line>The Chinese University of Hong Kong, HONG KONG</addr-line>
</aff>
<author-notes><fn fn-type="COI-statement" id="coi001"><p><bold>Competing Interests: </bold>
The authors have declared that no competing interests exist.</p>
</fn>
<fn fn-type="con" id="contrib001"><p>Conceived and designed the experiments: SLD EMF MK. Performed the experiments: SLD EM MK ASB DM GJG MK CBR. Analyzed the data: SLD EM MK CBR. Contributed reagents/materials/analysis tools: SLD EMF GJG MK CBR. Wrote the paper: SLD EMF MK ASB CBR.</p>
</fn>
<corresp id="cor001">* E-mail: <email>deem@stlzoo.org</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>16</day>
<month>10</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="collection"><year>2015</year>
</pub-date>
<volume>10</volume>
<issue>10</issue>
<elocation-id>e0140125</elocation-id>
<history><date date-type="received"><day>29</day>
<month>4</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>22</day>
<month>9</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>© 2015 Deem et al</copyright-statement>
<copyright-year>2015</copyright-year>
<copyright-holder>Deem et al</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="pone.0140125.pdf"></self-uri>
<abstract><p>Middle East respiratory syndrome coronavirus (MERS-CoV) is a recently identified virus causing severe viral respiratory illness in people. Little is known about the reservoir in the Horn of Africa. In Kenya, where no human MERS cases have been reported, our survey of 335 dromedary camels, representing nine herds in Laikipia County, showed a high seroprevalence (46.9%) to MERS-CoV antibodies. Between herd differences were present (14.3%– 82.9%), but was not related to management type or herd isolation. Further research should focus on identifying similarity between MERS-CoV viral isolates in Kenya and clinical isolates from the Middle East and elsewhere.</p>
</abstract>
<funding-group><funding-statement>This work was funded by the Saint Louis Zoo Field Research for Conservation Grant (FRC 13-09), the Wellcome Trust (to EMF; 085308), and the CGIAR Research Program for Agriculture for Nutrition and Health. The authors thank the the Mpala Research Centre and Wildlife Foundation for logistical support. The authors thank Tim O’Brien for statistical advice, Berend-Jan Bosch for provision of CoV S1 antigen, and Christine Annie Wang and Peter Larson for field assistance.</funding-statement>
</funding-group>
<counts><fig-count count="0"></fig-count>
<table-count count="0"></table-count>
<page-count count="5"></page-count>
</counts>
<custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name>
<meta-value>All relevant data are within the paper and its Supporting Information files. The authors used the centroid for Laikipia District, but do not provide exact herd coordinates at the request of herd owners. Owners agreed to allow camel sampling if exact coordinates were not provided in a published report. Between the figure map and the Laikipia District coordinates (in methods), the location of the study is available for the reader.</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
<notes><title>Data Availability</title>
<p>All relevant data are within the paper and its Supporting Information files. The authors used the centroid for Laikipia District, but do not provide exact herd coordinates at the request of herd owners. Owners agreed to allow camel sampling if exact coordinates were not provided in a published report. Between the figure map and the Laikipia District coordinates (in methods), the location of the study is available for the reader.</p>
</notes>
</front>
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