A Novel Coronavirus from Patients with Pneumonia in China, 2019
Identifieur interne : 000F33 ( Pmc/Curation ); précédent : 000F32; suivant : 000F34A Novel Coronavirus from Patients with Pneumonia in China, 2019
Auteurs : Na Zhu ; Dingyu Zhang ; Wenling Wang ; Xingwang Li ; Bo Yang ; Jingdong Song ; Xiang Zhao ; Baoying Huang ; Weifeng Shi ; Roujian Lu ; Peihua Niu ; Faxian Zhan ; Xuejun Ma ; Dayan Wang ; Wenbo Xu ; Guizhen Wu ; George F. Gao ; Wenjie TanSource :
- The New England Journal of Medicine [ 0028-4793 ] ; 2020.
Abstract
In December 2019, a cluster of patients with pneumonia of unknown cause was linked to a seafood wholesale market in Wuhan, China. A previously unknown betacoronavirus was discovered through the use of unbiased sequencing in samples from patients with pneumonia. Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily. Different from both MERS-CoV and SARS-CoV, 2019-nCoV is the seventh member of the family of coronaviruses that infect humans. Enhanced surveillance and further investigation are ongoing. (Funded by the National Key Research and Development Program of China and the National Major Project for Control and Prevention of Infectious Disease in China.)
Url:
DOI: 10.1056/NEJMoa2001017
PubMed: 31978945
PubMed Central: 7092803
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Novel Coronavirus from Patients with Pneumonia in China, 2019</title><author><name sortKey="Zhu, Na" sort="Zhu, Na" uniqKey="Zhu N" first="Na" last="Zhu">Na Zhu</name></author><author><name sortKey="Zhang, Dingyu" sort="Zhang, Dingyu" uniqKey="Zhang D" first="Dingyu" last="Zhang">Dingyu Zhang</name></author><author><name sortKey="Wang, Wenling" sort="Wang, Wenling" uniqKey="Wang W" first="Wenling" last="Wang">Wenling Wang</name></author><author><name sortKey="Li, Xingwang" sort="Li, Xingwang" uniqKey="Li X" first="Xingwang" last="Li">Xingwang Li</name></author><author><name sortKey="Yang, Bo" sort="Yang, Bo" uniqKey="Yang B" first="Bo" last="Yang">Bo Yang</name></author><author><name sortKey="Song, Jingdong" sort="Song, Jingdong" uniqKey="Song J" first="Jingdong" last="Song">Jingdong Song</name></author><author><name sortKey="Zhao, Xiang" sort="Zhao, Xiang" uniqKey="Zhao X" first="Xiang" last="Zhao">Xiang Zhao</name></author><author><name sortKey="Huang, Baoying" sort="Huang, Baoying" uniqKey="Huang B" first="Baoying" last="Huang">Baoying Huang</name></author><author><name sortKey="Shi, Weifeng" sort="Shi, Weifeng" uniqKey="Shi W" first="Weifeng" last="Shi">Weifeng Shi</name></author><author><name sortKey="Lu, Roujian" sort="Lu, Roujian" uniqKey="Lu R" first="Roujian" last="Lu">Roujian Lu</name></author><author><name sortKey="Niu, Peihua" sort="Niu, Peihua" uniqKey="Niu P" first="Peihua" last="Niu">Peihua Niu</name></author><author><name sortKey="Zhan, Faxian" sort="Zhan, Faxian" uniqKey="Zhan F" first="Faxian" last="Zhan">Faxian Zhan</name></author><author><name sortKey="Ma, Xuejun" sort="Ma, Xuejun" uniqKey="Ma X" first="Xuejun" last="Ma">Xuejun Ma</name></author><author><name sortKey="Wang, Dayan" sort="Wang, Dayan" uniqKey="Wang D" first="Dayan" last="Wang">Dayan Wang</name></author><author><name sortKey="Xu, Wenbo" sort="Xu, Wenbo" uniqKey="Xu W" first="Wenbo" last="Xu">Wenbo Xu</name></author><author><name sortKey="Wu, Guizhen" sort="Wu, Guizhen" uniqKey="Wu G" first="Guizhen" last="Wu">Guizhen Wu</name></author><author><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name></author><author><name sortKey="Tan, Wenjie" sort="Tan, Wenjie" uniqKey="Tan W" first="Wenjie" last="Tan">Wenjie Tan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31978945</idno><idno type="pmc">7092803</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092803</idno><idno type="RBID">PMC:7092803</idno><idno type="doi">10.1056/NEJMoa2001017</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000F33</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000F33</idno><idno type="wicri:Area/Pmc/Curation">000F33</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000F33</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Novel Coronavirus from Patients with Pneumonia in China, 2019</title><author><name sortKey="Zhu, Na" sort="Zhu, Na" uniqKey="Zhu N" first="Na" last="Zhu">Na Zhu</name></author><author><name sortKey="Zhang, Dingyu" sort="Zhang, Dingyu" uniqKey="Zhang D" first="Dingyu" last="Zhang">Dingyu Zhang</name></author><author><name sortKey="Wang, Wenling" sort="Wang, Wenling" uniqKey="Wang W" first="Wenling" last="Wang">Wenling Wang</name></author><author><name sortKey="Li, Xingwang" sort="Li, Xingwang" uniqKey="Li X" first="Xingwang" last="Li">Xingwang Li</name></author><author><name sortKey="Yang, Bo" sort="Yang, Bo" uniqKey="Yang B" first="Bo" last="Yang">Bo Yang</name></author><author><name sortKey="Song, Jingdong" sort="Song, Jingdong" uniqKey="Song J" first="Jingdong" last="Song">Jingdong Song</name></author><author><name sortKey="Zhao, Xiang" sort="Zhao, Xiang" uniqKey="Zhao X" first="Xiang" last="Zhao">Xiang Zhao</name></author><author><name sortKey="Huang, Baoying" sort="Huang, Baoying" uniqKey="Huang B" first="Baoying" last="Huang">Baoying Huang</name></author><author><name sortKey="Shi, Weifeng" sort="Shi, Weifeng" uniqKey="Shi W" first="Weifeng" last="Shi">Weifeng Shi</name></author><author><name sortKey="Lu, Roujian" sort="Lu, Roujian" uniqKey="Lu R" first="Roujian" last="Lu">Roujian Lu</name></author><author><name sortKey="Niu, Peihua" sort="Niu, Peihua" uniqKey="Niu P" first="Peihua" last="Niu">Peihua Niu</name></author><author><name sortKey="Zhan, Faxian" sort="Zhan, Faxian" uniqKey="Zhan F" first="Faxian" last="Zhan">Faxian Zhan</name></author><author><name sortKey="Ma, Xuejun" sort="Ma, Xuejun" uniqKey="Ma X" first="Xuejun" last="Ma">Xuejun Ma</name></author><author><name sortKey="Wang, Dayan" sort="Wang, Dayan" uniqKey="Wang D" first="Dayan" last="Wang">Dayan Wang</name></author><author><name sortKey="Xu, Wenbo" sort="Xu, Wenbo" uniqKey="Xu W" first="Wenbo" last="Xu">Wenbo Xu</name></author><author><name sortKey="Wu, Guizhen" sort="Wu, Guizhen" uniqKey="Wu G" first="Guizhen" last="Wu">Guizhen Wu</name></author><author><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name></author><author><name sortKey="Tan, Wenjie" sort="Tan, Wenjie" uniqKey="Tan W" first="Wenjie" last="Tan">Wenjie Tan</name></author></analytic><series><title level="j">The New England Journal of Medicine</title><idno type="ISSN">0028-4793</idno><idno type="eISSN">1533-4406</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>In December 2019, a cluster of patients with pneumonia of unknown cause was linked to a seafood wholesale market in Wuhan, China. A previously unknown betacoronavirus was discovered through the use of unbiased sequencing in samples from patients with pneumonia. Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily. Different from both MERS-CoV and SARS-CoV, 2019-nCoV is the seventh member of the family of coronaviruses that infect humans. Enhanced surveillance and further investigation are ongoing. (Funded by the National Key Research and Development Program of China and the National Major Project for Control and Prevention of Infectious Disease in China.)</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">N Engl J Med</journal-id><journal-id journal-id-type="iso-abbrev">N. Engl. J. Med</journal-id><journal-id journal-id-type="publisher-id">nejm</journal-id><journal-title-group><journal-title>The New England Journal of Medicine</journal-title></journal-title-group><issn pub-type="ppub">0028-4793</issn><issn pub-type="epub">1533-4406</issn><publisher><publisher-name>Massachusetts Medical Society</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31978945</article-id><article-id pub-id-type="pmc">7092803</article-id><article-id pub-id-type="doi">10.1056/NEJMoa2001017</article-id><article-id pub-id-type="publisher-id">NJ202002203820808</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group><series-title>Brief Report</series-title></article-categories><title-group><article-title>A Novel Coronavirus from Patients with Pneumonia in China, 2019</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zhu</surname><given-names>Na</given-names></name><degrees>Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Dingyu</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Wenling</given-names></name><degrees>Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Xingwang</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Bo</given-names></name><degrees>M.S.</degrees></contrib><contrib contrib-type="author"><name><surname>Song</surname><given-names>Jingdong</given-names></name><degrees>Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Xiang</given-names></name><degrees>Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Baoying</given-names></name><degrees>Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Shi</surname><given-names>Weifeng</given-names></name><degrees>Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Lu</surname><given-names>Roujian</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Niu</surname><given-names>Peihua</given-names></name><degrees>Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Zhan</surname><given-names>Faxian</given-names></name><degrees>Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Ma</surname><given-names>Xuejun</given-names></name><degrees>Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Dayan</given-names></name><degrees>Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Wenbo</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Guizhen</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Gao</surname><given-names>George F.</given-names></name><degrees>D.Phil.</degrees></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Tan</surname><given-names>Wenjie</given-names></name><degrees>M.D., Ph.D.</degrees></contrib><on-behalf-of>the China Novel Coronavirus Investigating and Research Team</on-behalf-of><aff>From the NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (N.Z., W.W., J.S., X.Z., B.H., R.L., P.N., X.M., D.W., W.X., G.W., G.F.G., W.T.), and the Department of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University (X.L.) — both in Beijing; Wuhan Jinyintan Hospital (D.Z.), the Division for Viral Disease Detection, Hubei Provincial Center for Disease Control and Prevention (B.Y., F.Z.), and the Center for Biosafety Mega-Science, Chinese Academy of Sciences (W.T.) — all in Wuhan; and the Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China (W.S.).</aff></contrib-group><author-notes><corresp>Address reprint requests to Dr. Tan at the NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, China CDC, 155 Changbai Road, Changping District, Beijing 102206, China; or at <email xlink:href="tanwj@ivdc.chinacdc.cn">tanwj@ivdc.chinacdc.cn</email>, Dr. Gao at the National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China, or at <email xlink:href="gaof@im.ac.cn">gaof@im.ac.cn</email>, or Dr. Wu at the NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China, or at <email xlink:href="wugz@ivdc.chinacdc.cn">wugz@ivdc.chinacdc.cn</email>.</corresp><fn fn-type="equal" id="fn1"><p>Drs. Zhu, Zhang, W. Wang, Li, and Yang contributed equally to this article.</p></fn></author-notes><pub-date pub-type="ppub"><day>20</day><month>2</month><year>2020</year></pub-date><volume>382</volume><issue>8</issue><fpage>727</fpage><lpage>733</lpage><permissions><copyright-statement>Copyright © 2020 Massachusetts Medical Society. All rights reserved.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder>Massachusetts Medical Society</copyright-holder><license specific-use="PMC_Covid-19"><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use, except commercial resale, and analyses in any form or by any means with acknowledgment of the original source. These permissions are granted for the duration of the Covid-19 pandemic or until revoked in writing. Upon expiration of these permissions, PMC is granted a license to make this article available via PMC and Europe PMC, subject to existing copyright protections.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="NEJMoa2001017.pdf"></self-uri><related-article related-article-type="commentary" id="d37e316" ext-link-type="doi" xlink:href="10.1056/NEJMe2001126"></related-article><abstract abstract-type="summary"><title>Summary</title><p>In December 2019, a cluster of patients with pneumonia of unknown cause was linked to a seafood wholesale market in Wuhan, China. A previously unknown betacoronavirus was discovered through the use of unbiased sequencing in samples from patients with pneumonia. Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily. Different from both MERS-CoV and SARS-CoV, 2019-nCoV is the seventh member of the family of coronaviruses that infect humans. Enhanced surveillance and further investigation are ongoing. (Funded by the National Key Research and Development Program of China and the National Major Project for Control and Prevention of Infectious Disease in China.)</p></abstract><kwd-group kwd-group-type="nejm-topics"><nested-kwd><compound-kwd><compound-kwd-part content-type="code">10</compound-kwd-part><compound-kwd-part content-type="keyword">Emergency Medicine</compound-kwd-part></compound-kwd><nested-kwd><compound-kwd><compound-kwd-part content-type="code">10_1</compound-kwd-part><compound-kwd-part content-type="keyword">Emergency Medicine General</compound-kwd-part></compound-kwd></nested-kwd></nested-kwd><nested-kwd><compound-kwd><compound-kwd-part content-type="code">12</compound-kwd-part><compound-kwd-part content-type="keyword">Pulmonary/Critical Care</compound-kwd-part></compound-kwd><nested-kwd><compound-kwd><compound-kwd-part content-type="code">12_1</compound-kwd-part><compound-kwd-part content-type="keyword">Pulmonary/Critical Care General</compound-kwd-part></compound-kwd></nested-kwd></nested-kwd><nested-kwd><compound-kwd><compound-kwd-part content-type="code">18</compound-kwd-part><compound-kwd-part content-type="keyword">Infectious Disease</compound-kwd-part></compound-kwd><nested-kwd><compound-kwd><compound-kwd-part content-type="code">18_1</compound-kwd-part><compound-kwd-part content-type="keyword">Infectious Disease General</compound-kwd-part></compound-kwd><compound-kwd><compound-kwd-part content-type="code">18_6</compound-kwd-part><compound-kwd-part content-type="keyword">Viral Infections</compound-kwd-part></compound-kwd><compound-kwd><compound-kwd-part content-type="code">18_9</compound-kwd-part><compound-kwd-part content-type="keyword">Global Health</compound-kwd-part></compound-kwd><compound-kwd><compound-kwd-part content-type="code">18_10</compound-kwd-part><compound-kwd-part content-type="keyword">Diagnostics</compound-kwd-part></compound-kwd></nested-kwd></nested-kwd></kwd-group></article-meta></front><floats-group><fig id="f1" orientation="portrait" position="float"><label>Figure 1</label><caption><title>Chest Radiographs.</title><p>Shown are chest radiographs from Patient 2 on days 8 and 11 after the onset of illness. The trachea was intubated and mechanical ventilation instituted in the period between the acquisition of the two images. Bilateral fluffy opacities are present in both images but are increased in density, profusion, and confluence in the second image; these changes are most marked in the lower lung fields. Changes consistent with the accumulation of pleural liquid are also visible in the second image.</p></caption><graphic xlink:href="NEJMoa2001017_f1"></graphic></fig><fig id="f2" orientation="portrait" position="float"><label>Figure 2</label><caption><title>Cytopathic Effects in Human Airway Epithelial Cell Cultures after Inoculation with 2019-nCoV.</title></caption><graphic xlink:href="NEJMoa2001017_f2"></graphic></fig><fig id="f3" orientation="portrait" position="float"><label>Figure 3</label><caption><title>Visualization of 2019-nCoV with Transmission Electron Microscopy.</title><p>Negative-stained 2019-nCoV particles are shown in Panel A, and 2019-nCoV particles in the human airway epithelial cell ultrathin sections are shown in Panel B. Arrowheads indicate extracellular virus particles, arrows indicate inclusion bodies formed by virus components, and triangles indicate cilia.</p></caption><graphic xlink:href="NEJMoa2001017_f3"></graphic></fig><fig id="f4" orientation="portrait" position="float"><label>Figure 4</label><caption><title>Schematic of 2019-nCoV and Phylogenetic Analysis of 2019-nCoV and Other Betacoronavirus Genomes.</title><p>Shown are a schematic of 2019-nCoV (Panel A) and full-length phylogenetic analysis of 2019-nCoV and other betacoronavirus genomes in the Orthocoronavirinae subfamily (Panel B).</p></caption><graphic xlink:href="NEJMoa2001017_f4"></graphic></fig></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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