Serveur d'exploration MERS

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Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in South Korea, 2015: epidemiology, characteristics and public health implications

Identifieur interne : 000E11 ( Pmc/Curation ); précédent : 000E10; suivant : 000E12

Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in South Korea, 2015: epidemiology, characteristics and public health implications

Auteurs : K. H. Kim [Corée du Sud] ; T. E. Tandi [Corée du Sud, Cameroun] ; J. W. Choi [Corée du Sud] ; J. M. Moon [Corée du Sud] ; M. S. Kim [Corée du Sud]

Source :

RBID : PMC:7114867

Abstract

SummaryBackground

Since the first case of Middle East respiratory syndrome coronavirus (MERS-CoV) in South Korea was reported on 20th May 2015, there have been 186 confirmed cases, 38 deaths and 16,752 suspected cases. Previously published research on South Korea's MERS outbreak was limited to the early stages, when few data were available. Now that the outbreak has ended, albeit unofficially, a more comprehensive review is appropriate.

Methods

Data were obtained through the MERS portal by the Ministry for Health and Welfare (MOHW) and Korea Centres for Disease Control and Prevention, press releases by MOHW, and reports by the MERS Policy Committee of the Korean Medical Association. Cases were analysed for general characteristics, exposure source, timeline and infection generation. Sex, age and underlying diseases were analysed for the 38 deaths.

Findings

Beginning with the index case that infected 28 others, an in-depth analysis was conducted. The average age was 55 years, which was a little higher than the global average of 50 years. As in most other countries, more men than women were affected. The case fatality rate was 19.9%, which was lower than the global rate of 38.7% and the rate in Saudi Arabia (36.5%). In total, 184 patients were infected nosocomially and there were no community-acquired infections. The main underlying diseases were respiratory diseases, cancer and hypertension. The main contributors to the outbreak were late diagnosis, quarantine failure of ‘super spreaders’, familial care-giving and visiting, non-disclosure by patients, poor communication by the South Korean Government, inadequate hospital infection management, and ‘doctor shopping’. The outbreak was entirely nosocomial, and was largely attributable to infection management and policy failures, rather than biomedical factors.


Url:
DOI: 10.1016/j.jhin.2016.10.008
PubMed: 28153558
PubMed Central: 7114867

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PMC:7114867

Le document en format XML

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<title>Background</title>
<p>Since the first case of Middle East respiratory syndrome coronavirus (MERS-CoV) in South Korea was reported on 20
<sup>th</sup>
May 2015, there have been 186 confirmed cases, 38 deaths and 16,752 suspected cases. Previously published research on South Korea's MERS outbreak was limited to the early stages, when few data were available. Now that the outbreak has ended, albeit unofficially, a more comprehensive review is appropriate.</p>
</sec>
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<title>Methods</title>
<p>Data were obtained through the MERS portal by the Ministry for Health and Welfare (MOHW) and Korea Centres for Disease Control and Prevention, press releases by MOHW, and reports by the MERS Policy Committee of the Korean Medical Association. Cases were analysed for general characteristics, exposure source, timeline and infection generation. Sex, age and underlying diseases were analysed for the 38 deaths.</p>
</sec>
<sec>
<title>Findings</title>
<p>Beginning with the index case that infected 28 others, an in-depth analysis was conducted. The average age was 55 years, which was a little higher than the global average of 50 years. As in most other countries, more men than women were affected. The case fatality rate was 19.9%, which was lower than the global rate of 38.7% and the rate in Saudi Arabia (36.5%). In total, 184 patients were infected nosocomially and there were no community-acquired infections. The main underlying diseases were respiratory diseases, cancer and hypertension. The main contributors to the outbreak were late diagnosis, quarantine failure of ‘super spreaders’, familial care-giving and visiting, non-disclosure by patients, poor communication by the South Korean Government, inadequate hospital infection management, and ‘doctor shopping’. The outbreak was entirely nosocomial, and was largely attributable to infection management and policy failures, rather than biomedical factors.</p>
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<name sortKey="Choi, J W" uniqKey="Choi J">J.W. Choi</name>
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<name sortKey="Kim, K H" uniqKey="Kim K">K.H. Kim</name>
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<author>
<name sortKey="Moon, J M" uniqKey="Moon J">J.M. Moon</name>
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<name sortKey="Kim, M S" uniqKey="Kim M">M.S. Kim</name>
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<name sortKey="Choi, J W" uniqKey="Choi J">J.W. Choi</name>
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<name sortKey="Choi, J W" uniqKey="Choi J">J.W. Choi</name>
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<name sortKey="Lee, J S" uniqKey="Lee J">J.S. Lee</name>
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<author>
<name sortKey="Kim, K H" uniqKey="Kim K">K.H. Kim</name>
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<pmc article-type="research-article">
<pmc-dir>properties open_access</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">J Hosp Infect</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Hosp. Infect</journal-id>
<journal-title-group>
<journal-title>The Journal of Hospital Infection</journal-title>
</journal-title-group>
<issn pub-type="ppub">0195-6701</issn>
<issn pub-type="epub">1532-2939</issn>
<publisher>
<publisher-name>The Healthcare Infection Society. Published by Elsevier Ltd.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">28153558</article-id>
<article-id pub-id-type="pmc">7114867</article-id>
<article-id pub-id-type="publisher-id">S0195-6701(16)30443-1</article-id>
<article-id pub-id-type="doi">10.1016/j.jhin.2016.10.008</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in South Korea, 2015: epidemiology, characteristics and public health implications</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" id="au1">
<name>
<surname>Kim</surname>
<given-names>K.H.</given-names>
</name>
<xref rid="aff1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author" id="au2">
<name>
<surname>Tandi</surname>
<given-names>T.E.</given-names>
</name>
<xref rid="aff1" ref-type="aff">a</xref>
<xref rid="aff2" ref-type="aff">b</xref>
<xref rid="aff3" ref-type="aff">c</xref>
<xref rid="aff4" ref-type="aff">d</xref>
</contrib>
<contrib contrib-type="author" id="au3">
<name>
<surname>Choi</surname>
<given-names>J.W.</given-names>
</name>
<email>shine@korea.ac.kr</email>
<xref rid="aff1" ref-type="aff">a</xref>
<xref rid="aff2" ref-type="aff">b</xref>
<xref rid="aff3" ref-type="aff">c</xref>
<xref rid="aff5" ref-type="aff">e</xref>
<xref rid="cor1" ref-type="corresp"></xref>
</contrib>
<contrib contrib-type="author" id="au4">
<name>
<surname>Moon</surname>
<given-names>J.M.</given-names>
</name>
<xref rid="aff1" ref-type="aff">a</xref>
<xref rid="aff2" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author" id="au5">
<name>
<surname>Kim</surname>
<given-names>M.S.</given-names>
</name>
<xref rid="aff1" ref-type="aff">a</xref>
<xref rid="aff2" ref-type="aff">b</xref>
</contrib>
</contrib-group>
<aff id="aff1">
<label>a</label>
Institute for Occupational and Environmental Health, Korea University, Seoul, Korea</aff>
<aff id="aff2">
<label>b</label>
Graduate School of Public Health, Korea University, Seoul, Korea</aff>
<aff id="aff3">
<label>c</label>
Department of Preventive Medicine, Korea University College of Medicine, Seoul, Korea</aff>
<aff id="aff4">
<label>d</label>
Ministry of Public Health Yaounde, Yaounde, Cameroon</aff>
<aff id="aff5">
<label>e</label>
MERS Policy Committee of the Korean Medical Association, Seoul, Korea</aff>
<author-notes>
<corresp id="cor1">
<label></label>
Corresponding author. Address: Department of Preventive Medicine, College of Medicine, Korea University, 73, Inchon-ro, Seongbuk-gu, Seoul 02841, Korea. Tel.: +82 2 926 4704; fax: +82 2 927 7220.
<email>shine@korea.ac.kr</email>
</corresp>
</author-notes>
<pub-date pub-type="pmc-release">
<day>14</day>
<month>10</month>
<year>2016</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub">
<month>2</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>14</day>
<month>10</month>
<year>2016</year>
</pub-date>
<volume>95</volume>
<issue>2</issue>
<fpage>207</fpage>
<lpage>213</lpage>
<history>
<date date-type="received">
<day>24</day>
<month>8</month>
<year>2016</year>
</date>
<date date-type="accepted">
<day>7</day>
<month>10</month>
<year>2016</year>
</date>
</history>
<permissions>
<copyright-statement>© 2016 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.</copyright-statement>
<copyright-year>2016</copyright-year>
<copyright-holder>The Healthcare Infection Society</copyright-holder>
<license>
<license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract id="abs0010">
<title>Summary</title>
<sec>
<title>Background</title>
<p>Since the first case of Middle East respiratory syndrome coronavirus (MERS-CoV) in South Korea was reported on 20
<sup>th</sup>
May 2015, there have been 186 confirmed cases, 38 deaths and 16,752 suspected cases. Previously published research on South Korea's MERS outbreak was limited to the early stages, when few data were available. Now that the outbreak has ended, albeit unofficially, a more comprehensive review is appropriate.</p>
</sec>
<sec>
<title>Methods</title>
<p>Data were obtained through the MERS portal by the Ministry for Health and Welfare (MOHW) and Korea Centres for Disease Control and Prevention, press releases by MOHW, and reports by the MERS Policy Committee of the Korean Medical Association. Cases were analysed for general characteristics, exposure source, timeline and infection generation. Sex, age and underlying diseases were analysed for the 38 deaths.</p>
</sec>
<sec>
<title>Findings</title>
<p>Beginning with the index case that infected 28 others, an in-depth analysis was conducted. The average age was 55 years, which was a little higher than the global average of 50 years. As in most other countries, more men than women were affected. The case fatality rate was 19.9%, which was lower than the global rate of 38.7% and the rate in Saudi Arabia (36.5%). In total, 184 patients were infected nosocomially and there were no community-acquired infections. The main underlying diseases were respiratory diseases, cancer and hypertension. The main contributors to the outbreak were late diagnosis, quarantine failure of ‘super spreaders’, familial care-giving and visiting, non-disclosure by patients, poor communication by the South Korean Government, inadequate hospital infection management, and ‘doctor shopping’. The outbreak was entirely nosocomial, and was largely attributable to infection management and policy failures, rather than biomedical factors.</p>
</sec>
</abstract>
<kwd-group id="kwrds0010">
<title>Keywords</title>
<kwd>MERS-CoV outbreak</kwd>
<kwd>Epidemiology</kwd>
<kwd>Public health</kwd>
<kwd>South Korea</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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