Middle East respiratory syndrome vaccines
Identifieur interne : 000D59 ( Pmc/Curation ); précédent : 000D58; suivant : 000D60Middle East respiratory syndrome vaccines
Auteurs : Stanley Perlman ; Rahul VijaySource :
- International Journal of Infectious Diseases [ 1201-9712 ] ; 2016.
Abstract
Middle East respiratory syndrome (MERS), caused by a novel coronavirus, is a highly lethal respiratory disease. No vaccines or antiviral therapies are available. Camels are widely infected and may be good targets for vaccination. MERS monoclonal antibodies and human convalescent sera may be useful for prophylaxis and treatment. Active immunization strategies, based on the severe acute respiratory syndrome (SARS) experience, are under development.
Url:
DOI: 10.1016/j.ijid.2016.04.008
PubMed: 27062985
PubMed Central: 4969153
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Middle East respiratory syndrome vaccines</title><author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name></author><author><name sortKey="Vijay, Rahul" sort="Vijay, Rahul" uniqKey="Vijay R" first="Rahul" last="Vijay">Rahul Vijay</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27062985</idno><idno type="pmc">4969153</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969153</idno><idno type="RBID">PMC:4969153</idno><idno type="doi">10.1016/j.ijid.2016.04.008</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000D59</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D59</idno><idno type="wicri:Area/Pmc/Curation">000D59</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D59</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Middle East respiratory syndrome vaccines</title><author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name></author><author><name sortKey="Vijay, Rahul" sort="Vijay, Rahul" uniqKey="Vijay R" first="Rahul" last="Vijay">Rahul Vijay</name></author></analytic><series><title level="j">International Journal of Infectious Diseases</title><idno type="ISSN">1201-9712</idno><idno type="eISSN">1878-3511</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Middle East respiratory syndrome (MERS), caused by a novel coronavirus, is a highly lethal respiratory disease.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">No vaccines or antiviral therapies are available.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Camels are widely infected and may be good targets for vaccination.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">MERS monoclonal antibodies and human convalescent sera may be useful for prophylaxis and treatment.</p></list-item><list-item id="lsti0025"><label>•</label><p id="par0025">Active immunization strategies, based on the severe acute respiratory syndrome (SARS) experience, are under development.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Int. J. Infect. Dis</journal-id><journal-title-group><journal-title>International Journal of Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">1201-9712</issn><issn pub-type="epub">1878-3511</issn><publisher><publisher-name>The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27062985</article-id><article-id pub-id-type="pmc">4969153</article-id><article-id pub-id-type="publisher-id">S1201-9712(16)31021-9</article-id><article-id pub-id-type="doi">10.1016/j.ijid.2016.04.008</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Middle East respiratory syndrome vaccines</article-title></title-group><contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Perlman</surname><given-names>Stanley</given-names></name><email>Stanley-perlman@uiowa.edu</email><xref rid="cor0005" ref-type="corresp">⁎</xref></contrib><contrib contrib-type="author" id="aut0010"><name><surname>Vijay</surname><given-names>Rahul</given-names></name></contrib></contrib-group><aff id="aff0005">Department of Microbiology, BSB 3-712, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA</aff><author-notes><corresp id="cor0005"><label>⁎</label>Corresponding author. Tel.: +1 319 335 8549; fax: +1 319 335 9006. <email>Stanley-perlman@uiowa.edu</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>7</day><month>4</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>6</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>7</day><month>4</month><year>2016</year></pub-date><volume>47</volume><fpage>23</fpage><lpage>28</lpage><history><date date-type="received"><day>1</day><month>1</month><year>2016</year></date><date date-type="rev-recd"><day>31</day><month>3</month><year>2016</year></date><date date-type="accepted"><day>3</day><month>4</month><year>2016</year></date></history><permissions><copyright-statement>© 2016 The Authors</copyright-statement><copyright-year>2016</copyright-year><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract abstract-type="author-highlights" id="abs0005"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Middle East respiratory syndrome (MERS), caused by a novel coronavirus, is a highly lethal respiratory disease.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">No vaccines or antiviral therapies are available.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Camels are widely infected and may be good targets for vaccination.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">MERS monoclonal antibodies and human convalescent sera may be useful for prophylaxis and treatment.</p></list-item><list-item id="lsti0025"><label>•</label><p id="par0025">Active immunization strategies, based on the severe acute respiratory syndrome (SARS) experience, are under development.</p></list-item></list></p></abstract><abstract id="abs0010"><title>Summary</title><p>The Middle East respiratory syndrome coronavirus (MERS-CoV) has infected over 1600 individuals with nearly 600 deaths since it was first identified in human populations in 2012. No antiviral therapies or vaccines are available for its treatment or prophylaxis. Approaches to the development of MERS vaccines are discussed herein, including a summary of previous efforts to develop vaccines useful against human and non-human coronaviruses. A striking feature of MERS is the important role that camels have in transmission. Camel vaccination may be a novel approach to preventing human infection.</p></abstract><kwd-group id="kwd0005"><title>Keywords</title><kwd>Middle East respiratory syndrome</kwd><kwd>Vaccines</kwd><kwd>Coronavirus</kwd><kwd>Severe acute respiratory syndrome</kwd><kwd>Human respiratory disease</kwd></kwd-group></article-meta><notes><p id="misc0005"><bold>Corresponding Editor:</bold> Eskild Petersen, Aarhus, Denmark.</p></notes></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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