Serveur d'exploration MERS

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Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) – possible lessons from a systematic review of SARS-CoV therapy

Identifieur interne : 000D49 ( Pmc/Curation ); précédent : 000D48; suivant : 000D50

Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) – possible lessons from a systematic review of SARS-CoV therapy

Auteurs : Hisham Momattin [Arabie saoudite] ; Khurram Mohammed [Arabie saoudite] ; Alimuddin Zumla [Royaume-Uni] ; Ziad A. Memish [Arabie saoudite] ; Jaffar A. Al-Tawfiq [États-Unis]

Source :

RBID : PMC:7110699

Abstract

The Middle East Respiratory Syndrome coronavirus (MERS-CoV) has been detected in a number of countries in the Middle East and Europe with an apparently high mortality rate. It is phylogenetically related to the SARS coronavirus and has also been associated with severe respiratory illness as well as nosocomial transmission in healthcare settings. Current international recommendations do not support any specific therapies; however, there are a number of agents, which were used during the SARS epidemic of 2003. It is possible that these might be active against the related MERS coronavirus. We have reviewed the literature on the safety and efficacy of therapies used in patients with SARS with a view to their potential use in patients with MERS-CoV infections.


Url:
DOI: 10.1016/j.ijid.2013.07.002
PubMed: 23993766
PubMed Central: 7110699

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PMC:7110699

Le document en format XML

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<pmc article-type="research-article">
<pmc-dir>properties open_access</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">Int J Infect Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">Int. J. Infect. Dis</journal-id>
<journal-title-group>
<journal-title>International Journal of Infectious Diseases</journal-title>
</journal-title-group>
<issn pub-type="ppub">1201-9712</issn>
<issn pub-type="epub">1878-3511</issn>
<publisher>
<publisher-name>International Society for Infectious Diseases. Published by Elsevier Ltd.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">23993766</article-id>
<article-id pub-id-type="pmc">7110699</article-id>
<article-id pub-id-type="publisher-id">S1201-9712(13)00229-4</article-id>
<article-id pub-id-type="doi">10.1016/j.ijid.2013.07.002</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) – possible lessons from a systematic review of SARS-CoV therapy</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" id="aut0005">
<name>
<surname>Momattin</surname>
<given-names>Hisham</given-names>
</name>
<xref rid="aff0005" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author" id="aut0010">
<name>
<surname>Mohammed</surname>
<given-names>Khurram</given-names>
</name>
<xref rid="aff0005" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author" id="aut0015">
<name>
<surname>Zumla</surname>
<given-names>Alimuddin</given-names>
</name>
<xref rid="aff0010" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author" id="aut0020">
<name>
<surname>Memish</surname>
<given-names>Ziad A.</given-names>
</name>
<xref rid="aff0015" ref-type="aff">c</xref>
</contrib>
<contrib contrib-type="author" id="aut0025">
<name>
<surname>Al-Tawfiq</surname>
<given-names>Jaffar A.</given-names>
</name>
<email>jaffar.tawfiq@aramco.com</email>
<email>jaltawfi@yahoo.com</email>
<xref rid="aff0020" ref-type="aff">d</xref>
<xref rid="cor0005" ref-type="corresp"></xref>
</contrib>
</contrib-group>
<aff id="aff0005">
<label>a</label>
Pharmacy Services Division, Saudi Aramco Medical Services Organization, Dhahran, Saudi Arabia</aff>
<aff id="aff0010">
<label>b</label>
Division of Infection and Immunity, University College London, London, and University College London Hospitals NHS Foundation Trust</aff>
<aff id="aff0015">
<label>c</label>
Deputy Minister for Public Health, and Director WHO Collaborating Center for Mass Gathering Medicine Ministry of Health, and Professor, Al-Faisal University, Riyadh, Saudi Arabia</aff>
<aff id="aff0020">
<label>d</label>
Specialty Internal Medicine, Saudi Aramco Medical Services Organization, Dhahran, Saudi Arabia, and Indiana University School of Medicine, Indiana, USA</aff>
<author-notes>
<corresp id="cor0005">
<label></label>
Corresponding author. P.O. Box 76, Room A-428-2, Building 61, Dhahran Health Center, Saudi Aramco, Dhahran 31311, Saudi Arabia. Tel.: +966 3 877 3524; fax: +966 3 877 3790.
<email>jaffar.tawfiq@aramco.com</email>
<email>jaltawfi@yahoo.com</email>
</corresp>
</author-notes>
<pub-date pub-type="pmc-release">
<day>29</day>
<month>8</month>
<year>2013</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub">
<month>10</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub">
<day>29</day>
<month>8</month>
<year>2013</year>
</pub-date>
<volume>17</volume>
<issue>10</issue>
<fpage>e792</fpage>
<lpage>e798</lpage>
<permissions>
<copyright-statement>Copyright © 2013 International Society for Infectious Diseases. Published by Elsevier Ltd.</copyright-statement>
<copyright-year>2013</copyright-year>
<copyright-holder>International Society for Infectious Diseases</copyright-holder>
<license>
<license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract id="abs0005">
<p>The Middle East Respiratory Syndrome coronavirus (MERS-CoV) has been detected in a number of countries in the Middle East and Europe with an apparently high mortality rate. It is phylogenetically related to the SARS coronavirus and has also been associated with severe respiratory illness as well as nosocomial transmission in healthcare settings. Current international recommendations do not support any specific therapies; however, there are a number of agents, which were used during the SARS epidemic of 2003. It is possible that these might be active against the related MERS coronavirus. We have reviewed the literature on the safety and efficacy of therapies used in patients with SARS with a view to their potential use in patients with MERS-CoV infections.</p>
</abstract>
<kwd-group id="kwd0005">
<title>Keywords</title>
<kwd>MERS-CoV</kwd>
<kwd>Interferon</kwd>
<kwd>Ribavarin</kwd>
<kwd>SARS</kwd>
</kwd-group>
</article-meta>
<notes>
<p id="misc0005">
<bold>Corresponding Editor:</bold>
Eskild Petersen, MD, DMSc, MBA, Editor-in-Chief, International Journal of Infectious Diseases</p>
</notes>
</front>
</pmc>
</record>

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