MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015
Identifieur interne : 000C19 ( Pmc/Curation ); précédent : 000C18; suivant : 000C20MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015
Auteurs : Pyoeng Gyun Choe ; R. A. P. M. Perera ; Wan Beom Park ; Kyoung-Ho Song ; Ji Hwan Bang ; Eu Suk Kim ; Hong Bin Kim ; Long Wei Ronald Ko ; Sang Won Park ; Nam-Joong Kim ; Eric H. Y. Lau ; Leo L. M. Poon ; Malik Peiris ; Myoung-Don OhSource :
- Emerging Infectious Diseases [ 1080-6040 ] ; 2017.
Abstract
We investigated the kinetics of the Middle East respiratory syndrome coronavirus (MERS-CoV) neutralizing and spike protein antibody titers over the course of 1 year in 11 patients who were confirmed by reverse transcription PCR to have been infected during the outbreak in South Korea in 2015. Robust antibody responses were detected in all survivors who had severe disease; responses remained detectable, albeit with some waning, for
Url:
DOI: 10.3201/eid2307.170310
PubMed: 28585916
PubMed Central: 5512479
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015</title><author><name sortKey="Choe, Pyoeng Gyun" sort="Choe, Pyoeng Gyun" uniqKey="Choe P" first="Pyoeng Gyun" last="Choe">Pyoeng Gyun Choe</name></author><author><name sortKey="Perera, R A P M" sort="Perera, R A P M" uniqKey="Perera R" first="R. A. P. M." last="Perera">R. A. P. M. Perera</name></author><author><name sortKey="Park, Wan Beom" sort="Park, Wan Beom" uniqKey="Park W" first="Wan Beom" last="Park">Wan Beom Park</name></author><author><name sortKey="Song, Kyoung Ho" sort="Song, Kyoung Ho" uniqKey="Song K" first="Kyoung-Ho" last="Song">Kyoung-Ho Song</name></author><author><name sortKey="Bang, Ji Hwan" sort="Bang, Ji Hwan" uniqKey="Bang J" first="Ji Hwan" last="Bang">Ji Hwan Bang</name></author><author><name sortKey="Kim, Eu Suk" sort="Kim, Eu Suk" uniqKey="Kim E" first="Eu Suk" last="Kim">Eu Suk Kim</name></author><author><name sortKey="Kim, Hong Bin" sort="Kim, Hong Bin" uniqKey="Kim H" first="Hong Bin" last="Kim">Hong Bin Kim</name></author><author><name sortKey="Ko, Long Wei Ronald" sort="Ko, Long Wei Ronald" uniqKey="Ko L" first="Long Wei Ronald" last="Ko">Long Wei Ronald Ko</name></author><author><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang Won" last="Park">Sang Won Park</name></author><author><name sortKey="Kim, Nam Joong" sort="Kim, Nam Joong" uniqKey="Kim N" first="Nam-Joong" last="Kim">Nam-Joong Kim</name></author><author><name sortKey="Lau, Eric H Y" sort="Lau, Eric H Y" uniqKey="Lau E" first="Eric H. Y." last="Lau">Eric H. Y. Lau</name></author><author><name sortKey="Poon, Leo L M" sort="Poon, Leo L M" uniqKey="Poon L" first="Leo L. M." last="Poon">Leo L. M. Poon</name></author><author><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name></author><author><name sortKey="Oh, Myoung Don" sort="Oh, Myoung Don" uniqKey="Oh M" first="Myoung-Don" last="Oh">Myoung-Don Oh</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28585916</idno><idno type="pmc">5512479</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512479</idno><idno type="RBID">PMC:5512479</idno><idno type="doi">10.3201/eid2307.170310</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000C19</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C19</idno><idno type="wicri:Area/Pmc/Curation">000C19</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C19</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015</title><author><name sortKey="Choe, Pyoeng Gyun" sort="Choe, Pyoeng Gyun" uniqKey="Choe P" first="Pyoeng Gyun" last="Choe">Pyoeng Gyun Choe</name></author><author><name sortKey="Perera, R A P M" sort="Perera, R A P M" uniqKey="Perera R" first="R. A. P. M." last="Perera">R. A. P. M. Perera</name></author><author><name sortKey="Park, Wan Beom" sort="Park, Wan Beom" uniqKey="Park W" first="Wan Beom" last="Park">Wan Beom Park</name></author><author><name sortKey="Song, Kyoung Ho" sort="Song, Kyoung Ho" uniqKey="Song K" first="Kyoung-Ho" last="Song">Kyoung-Ho Song</name></author><author><name sortKey="Bang, Ji Hwan" sort="Bang, Ji Hwan" uniqKey="Bang J" first="Ji Hwan" last="Bang">Ji Hwan Bang</name></author><author><name sortKey="Kim, Eu Suk" sort="Kim, Eu Suk" uniqKey="Kim E" first="Eu Suk" last="Kim">Eu Suk Kim</name></author><author><name sortKey="Kim, Hong Bin" sort="Kim, Hong Bin" uniqKey="Kim H" first="Hong Bin" last="Kim">Hong Bin Kim</name></author><author><name sortKey="Ko, Long Wei Ronald" sort="Ko, Long Wei Ronald" uniqKey="Ko L" first="Long Wei Ronald" last="Ko">Long Wei Ronald Ko</name></author><author><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang Won" last="Park">Sang Won Park</name></author><author><name sortKey="Kim, Nam Joong" sort="Kim, Nam Joong" uniqKey="Kim N" first="Nam-Joong" last="Kim">Nam-Joong Kim</name></author><author><name sortKey="Lau, Eric H Y" sort="Lau, Eric H Y" uniqKey="Lau E" first="Eric H. Y." last="Lau">Eric H. Y. Lau</name></author><author><name sortKey="Poon, Leo L M" sort="Poon, Leo L M" uniqKey="Poon L" first="Leo L. M." last="Poon">Leo L. M. Poon</name></author><author><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name></author><author><name sortKey="Oh, Myoung Don" sort="Oh, Myoung Don" uniqKey="Oh M" first="Myoung-Don" last="Oh">Myoung-Don Oh</name></author></analytic><series><title level="j">Emerging Infectious Diseases</title><idno type="ISSN">1080-6040</idno><idno type="eISSN">1080-6059</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We investigated the kinetics of the Middle East respiratory syndrome coronavirus (MERS-CoV) neutralizing and spike protein antibody titers over the course of 1 year in 11 patients who were confirmed by reverse transcription PCR to have been infected during the outbreak in South Korea in 2015. Robust antibody responses were detected in all survivors who had severe disease; responses remained detectable, albeit with some waning, for <underline><</underline>1 year. The duration of viral RNA detection (but not viral load) in sputum significantly correlated with the antibody response magnitude. The MERS S1 ELISA antibody titers correlated well with the neutralizing antibody response. Antibody titers in 4 of 6 patients who had mild illness were undetectable even though most had evidence of pneumonia. This finding implies that MERS-CoV seroepidemiologic studies markedly underestimate the extent of mild and asymptomatic infection. Obtaining convalescent-phase plasma with high antibody titers to treat MERS will be challenging.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Emerg Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Emerging Infect. Dis</journal-id><journal-id journal-id-type="publisher-id">EID</journal-id><journal-title-group><journal-title>Emerging Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">1080-6040</issn><issn pub-type="epub">1080-6059</issn><publisher><publisher-name>Centers for Disease Control and Prevention</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28585916</article-id><article-id pub-id-type="pmc">5512479</article-id><article-id pub-id-type="publisher-id">17-0310</article-id><article-id pub-id-type="doi">10.3201/eid2307.170310</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research</subject></subj-group><subj-group subj-group-type="TOC-title"><subject>MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015</subject></subj-group></article-categories><title-group><article-title>MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015</article-title><alt-title alt-title-type="running-head">MERS-CoV Antibody Responses, South Korea</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Choe</surname><given-names>Pyoeng Gyun</given-names></name><xref ref-type="fn" rid="FN1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Perera</surname><given-names>R.A.P.M.</given-names></name><xref ref-type="fn" rid="FN1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>Wan Beom</given-names></name></contrib><contrib contrib-type="author"><name><surname>Song</surname><given-names>Kyoung-Ho</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bang</surname><given-names>Ji Hwan</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Eu Suk</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Hong Bin</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ko</surname><given-names>Long Wei Ronald</given-names></name></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>Sang Won</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Nam-Joong</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lau</surname><given-names>Eric H.Y.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Poon</surname><given-names>Leo L.M.</given-names></name></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Peiris</surname><given-names>Malik</given-names></name></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Oh</surname><given-names>Myoung-don</given-names></name></contrib><aff id="aff1">Seoul National University College of Medicine, Seoul, South Korea (P.G. Choe, W.B. Park, K.-H. Song, J.H. Bang, E.S. Kim, H.B. Kim, S.W. Park, N.-J. Kim, M.-D. Oh);</aff><aff id="aff2">University of Hong Kong School of Public Health, Hong Kong, China (R.A.P.M. Perera, L.W.R. Ko, E.H.Y. Lau, L.L.M. Poon, M. Peiris)</aff></contrib-group><author-notes><corresp id="cor1">Address for correspondence: Malik Peiris, School of Public Health, 7 Sassoon Rd, Pokfulam, Hong Kong, China; email: <email xlink:href="malik@hku.hk">malik@hku.hk</email>; Myoung-don Oh, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 110-799, South Korea; email: <email xlink:href="mdohmd@snu.ac.kr">mdohmd@snu.ac.kr</email></corresp></author-notes><pub-date pub-type="ppub"><month>7</month><year>2017</year></pub-date><volume>23</volume><issue>7</issue><fpage seq="b">1079</fpage><lpage>1084</lpage><abstract><p>We investigated the kinetics of the Middle East respiratory syndrome coronavirus (MERS-CoV) neutralizing and spike protein antibody titers over the course of 1 year in 11 patients who were confirmed by reverse transcription PCR to have been infected during the outbreak in South Korea in 2015. Robust antibody responses were detected in all survivors who had severe disease; responses remained detectable, albeit with some waning, for <underline><</underline>1 year. The duration of viral RNA detection (but not viral load) in sputum significantly correlated with the antibody response magnitude. The MERS S1 ELISA antibody titers correlated well with the neutralizing antibody response. Antibody titers in 4 of 6 patients who had mild illness were undetectable even though most had evidence of pneumonia. This finding implies that MERS-CoV seroepidemiologic studies markedly underestimate the extent of mild and asymptomatic infection. Obtaining convalescent-phase plasma with high antibody titers to treat MERS will be challenging.</p></abstract><kwd-group kwd-group-type="author"><title>Keywords: </title><kwd>Middle East respiratory syndrome coronavirus</kwd><kwd>MERS</kwd><kwd>coronavirus</kwd><kwd>MERS-CoV</kwd><kwd>antibody</kwd><kwd>serology</kwd><kwd>kinetics</kwd><kwd>human</kwd><kwd>South Korea</kwd><kwd>viruses</kwd><kwd>zoonoses</kwd><kwd>neutralization</kwd><kwd>China</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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