Replication and Shedding of MERS-CoV in Upper Respiratory Tract of Inoculated Dromedary Camels
Identifieur interne : 000C14 ( Pmc/Curation ); précédent : 000C13; suivant : 000C15Replication and Shedding of MERS-CoV in Upper Respiratory Tract of Inoculated Dromedary Camels
Auteurs : Danielle R. Adney ; Neeltje Van Doremalen ; Vienna R. Brown ; Trenton Bushmaker ; Dana Scott ; Emmie De Wit ; Richard A. Bowen ; Vincent J. MunsterSource :
- Emerging Infectious Diseases [ 1080-6040 ] ; 2014.
Abstract
Camels infected with MERS-CoV show few symptoms and likely transmit the virus to humans and other camels through respiratory secretions.
Url:
DOI: 10.3201/eid2012.141280
PubMed: 25418529
PubMed Central: 4257817
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Replication and Shedding of MERS-CoV in Upper Respiratory Tract of Inoculated Dromedary Camels</title><author><name sortKey="Adney, Danielle R" sort="Adney, Danielle R" uniqKey="Adney D" first="Danielle R." last="Adney">Danielle R. Adney</name></author><author><name sortKey="Van Doremalen, Neeltje" sort="Van Doremalen, Neeltje" uniqKey="Van Doremalen N" first="Neeltje" last="Van Doremalen">Neeltje Van Doremalen</name></author><author><name sortKey="Brown, Vienna R" sort="Brown, Vienna R" uniqKey="Brown V" first="Vienna R." last="Brown">Vienna R. Brown</name></author><author><name sortKey="Bushmaker, Trenton" sort="Bushmaker, Trenton" uniqKey="Bushmaker T" first="Trenton" last="Bushmaker">Trenton Bushmaker</name></author><author><name sortKey="Scott, Dana" sort="Scott, Dana" uniqKey="Scott D" first="Dana" last="Scott">Dana Scott</name></author><author><name sortKey="De Wit, Emmie" sort="De Wit, Emmie" uniqKey="De Wit E" first="Emmie" last="De Wit">Emmie De Wit</name></author><author><name sortKey="Bowen, Richard A" sort="Bowen, Richard A" uniqKey="Bowen R" first="Richard A." last="Bowen">Richard A. Bowen</name></author><author><name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J." last="Munster">Vincent J. Munster</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25418529</idno><idno type="pmc">4257817</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257817</idno><idno type="RBID">PMC:4257817</idno><idno type="doi">10.3201/eid2012.141280</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000C14</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C14</idno><idno type="wicri:Area/Pmc/Curation">000C14</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C14</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Replication and Shedding of MERS-CoV in Upper Respiratory Tract of Inoculated Dromedary Camels</title><author><name sortKey="Adney, Danielle R" sort="Adney, Danielle R" uniqKey="Adney D" first="Danielle R." last="Adney">Danielle R. Adney</name></author><author><name sortKey="Van Doremalen, Neeltje" sort="Van Doremalen, Neeltje" uniqKey="Van Doremalen N" first="Neeltje" last="Van Doremalen">Neeltje Van Doremalen</name></author><author><name sortKey="Brown, Vienna R" sort="Brown, Vienna R" uniqKey="Brown V" first="Vienna R." last="Brown">Vienna R. Brown</name></author><author><name sortKey="Bushmaker, Trenton" sort="Bushmaker, Trenton" uniqKey="Bushmaker T" first="Trenton" last="Bushmaker">Trenton Bushmaker</name></author><author><name sortKey="Scott, Dana" sort="Scott, Dana" uniqKey="Scott D" first="Dana" last="Scott">Dana Scott</name></author><author><name sortKey="De Wit, Emmie" sort="De Wit, Emmie" uniqKey="De Wit E" first="Emmie" last="De Wit">Emmie De Wit</name></author><author><name sortKey="Bowen, Richard A" sort="Bowen, Richard A" uniqKey="Bowen R" first="Richard A." last="Bowen">Richard A. Bowen</name></author><author><name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J." last="Munster">Vincent J. Munster</name></author></analytic><series><title level="j">Emerging Infectious Diseases</title><idno type="ISSN">1080-6040</idno><idno type="eISSN">1080-6059</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Camels infected with MERS-CoV show few symptoms and likely transmit the virus to humans and other camels through respiratory secretions.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Emerg Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Emerging Infect. Dis</journal-id><journal-id journal-id-type="publisher-id">EID</journal-id><journal-title-group><journal-title>Emerging Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">1080-6040</issn><issn pub-type="epub">1080-6059</issn><publisher><publisher-name>Centers for Disease Control and Prevention</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25418529</article-id><article-id pub-id-type="pmc">4257817</article-id><article-id pub-id-type="publisher-id">14-1280</article-id><article-id pub-id-type="doi">10.3201/eid2012.141280</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research</subject></subj-group><subj-group subj-group-type="TOC-title"><subject>Replication and Shedding of MERS-CoV in Upper Respiratory Tract of Inoculated Dromedary Camels</subject></subj-group></article-categories><title-group><article-title>Replication and Shedding of MERS-CoV in Upper Respiratory Tract of Inoculated Dromedary Camels</article-title><alt-title alt-title-type="running-head">MERS-CoV in Inoculated Camels</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Adney</surname><given-names>Danielle R.</given-names></name></contrib><contrib contrib-type="author"><name><surname>van Doremalen</surname><given-names>Neeltje</given-names></name></contrib><contrib contrib-type="author"><name><surname>Brown</surname><given-names>Vienna R.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bushmaker</surname><given-names>Trenton</given-names></name></contrib><contrib contrib-type="author"><name><surname>Scott</surname><given-names>Dana</given-names></name></contrib><contrib contrib-type="author"><name><surname>de Wit</surname><given-names>Emmie</given-names></name></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Bowen</surname><given-names>Richard A.</given-names></name><xref ref-type="fn" rid="FN1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Munster</surname><given-names>Vincent J.</given-names></name><xref ref-type="fn" rid="FN1"><sup>1</sup></xref></contrib><aff id="aff1">Colorado State University, Fort Collins, Colorado, USA; (D.R. Adney, V.R. Brown, R.A. Bowen);</aff><aff id="aff2">National Institutes of Health, Hamilton, Montana, USA (N. van Doremalen, T. Bushmaker, D. Scott, E. de Wit, V.J. Munster)</aff></contrib-group><author-notes><corresp id="cor1">Address for correspondence: Richard A. Bowen, Department of Biomedical Sciences, Colorado State University, W113 ARBL Bldg, Foothills Campus, Fort Collins, CO, 80523-1601, USA; email: <email xlink:href="Richard.Bowen@colostate.edu">Richard.Bowen@colostate.edu</email></corresp></author-notes><pub-date pub-type="ppub"><month>12</month><year>2014</year></pub-date><volume>20</volume><issue>12</issue><fpage>1999</fpage><lpage>2005</lpage><abstract abstract-type="toc"><p>Camels infected with MERS-CoV show few symptoms and likely transmit the virus to humans and other camels through respiratory secretions.</p></abstract><abstract><p>In 2012, a novel coronavirus associated with severe respiratory disease in humans emerged in the Middle East. Epidemiologic investigations identified dromedary camels as the likely source of zoonotic transmission of Middle East respiratory syndrome coronavirus (MERS-CoV). Here we provide experimental support for camels as a reservoir for MERS-CoV. We inoculated 3 adult camels with a human isolate of MERS-CoV and a transient, primarily upper respiratory tract infection developed in each of the 3 animals. Clinical signs of the MERS-CoV infection were benign, but each of the camels shed large quantities of virus from the upper respiratory tract. We detected infectious virus in nasal secretions through 7 days postinoculation, and viral RNA up to 35 days postinoculation. The pattern of shedding and propensity for the upper respiratory tract infection in dromedary camels may help explain the lack of systemic illness among naturally infected camels and the means of efficient camel-to-camel and camel-to-human transmission.</p></abstract><kwd-group kwd-group-type="author"><title>Keywords: </title><kwd>MERS-CoV</kwd><kwd>coronavirus</kwd><kwd>Middle East Respiratory Syndrome</kwd><kwd>dromedary</kwd><kwd>camels</kwd><kwd>inoculation</kwd><kwd>infection</kwd><kwd>upper respiratory tract</kwd><kwd>transmission</kwd><kwd>experimental</kwd><kwd>zoonoses</kwd><kwd>viruses</kwd><kwd>zoonosis</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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