Risk Factors for Transmission of Middle East Respiratory Syndrome Coronavirus Infection During the 2015 Outbreak in South Korea
Identifieur interne : 000B78 ( Pmc/Curation ); précédent : 000B77; suivant : 000B79Risk Factors for Transmission of Middle East Respiratory Syndrome Coronavirus Infection During the 2015 Outbreak in South Korea
Auteurs : Seung Woo Kim ; Jung Wan Park ; Hee-Dong Jung ; Jeong-Sun Yang ; Yong-Shik Park ; Changhwan Lee ; Kyung Min Kim ; Keon-Joo Lee ; Donghyok Kwon ; Young Joo Hur ; Boyoul Choi ; Moran Ki [Corée du Sud]Source :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America [ 1058-4838 ] ; 2017.
Abstract
We evaluated the epidemiological risk factors for MERS-CoV transmission during the recent South Korean outbreak. MERS-CoV transmission was determined by host infectivity and the number of contacts, whereas super-spreading events were determined by the number of contacts and hospital visits.
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DOI: 10.1093/cid/ciw768
PubMed: 27940937
PubMed Central: 7108049
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Disease,</institution></nlm:aff></affiliation></author><author><name sortKey="Yang, Jeong Sun" sort="Yang, Jeong Sun" uniqKey="Yang J" first="Jeong-Sun" last="Yang">Jeong-Sun Yang</name><affiliation><nlm:aff id="AF0002"><institution>Division of Respiratory Viruses, Center of Infectious Disease,</institution></nlm:aff></affiliation></author><author><name sortKey="Park, Yong Shik" sort="Park, Yong Shik" uniqKey="Park Y" first="Yong-Shik" last="Park">Yong-Shik Park</name><affiliation><nlm:aff id="AF0001"><institution>Division of Epidemic Intelligence Service,</institution></nlm:aff></affiliation></author><author><name sortKey="Lee, Changhwan" sort="Lee, Changhwan" uniqKey="Lee C" first="Changhwan" last="Lee">Changhwan Lee</name><affiliation><nlm:aff id="AF0001"><institution>Division of Epidemic Intelligence Service,</institution></nlm:aff></affiliation></author><author><name sortKey="Kim, Kyung Min" sort="Kim, Kyung Min" uniqKey="Kim K" first="Kyung Min" last="Kim">Kyung Min Kim</name><affiliation><nlm:aff id="AF0001"><institution>Division of Epidemic Intelligence Service,</institution></nlm:aff></affiliation></author><author><name sortKey="Lee, Keon Joo" sort="Lee, Keon Joo" uniqKey="Lee K" first="Keon-Joo" last="Lee">Keon-Joo Lee</name><affiliation><nlm:aff id="AF0001"><institution>Division of Epidemic Intelligence Service,</institution></nlm:aff></affiliation></author><author><name sortKey="Kwon, Donghyok" sort="Kwon, Donghyok" uniqKey="Kwon D" first="Donghyok" last="Kwon">Donghyok Kwon</name><affiliation><nlm:aff id="AF0001"><institution>Division of Epidemic Intelligence Service,</institution></nlm:aff></affiliation></author><author><name sortKey="Hur, Young Joo" sort="Hur, Young Joo" uniqKey="Hur Y" first="Young Joo" last="Hur">Young Joo Hur</name><affiliation><nlm:aff id="AF0003"><institution>Center for Infectious Disease Control, Korea Centers for Disease Control and Prevention</institution>,<addr-line>Cheongju</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Choi, Boyoul" sort="Choi, Boyoul" uniqKey="Choi B" first="Boyoul" last="Choi">Boyoul Choi</name><affiliation><nlm:aff wicri:cut=", and" id="AF0004"><institution>Department of Preventive Medicine, Hanyang University Medical College</institution>,<addr-line>Seoul</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ki, Moran" sort="Ki, Moran" uniqKey="Ki M" first="Moran" last="Ki">Moran Ki</name><affiliation wicri:level="1"><nlm:aff id="AF0005"><institution>Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center</institution>,<addr-line>Goyang</addr-line>,<country>Republic of Korea</country></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27940937</idno><idno type="pmc">7108049</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108049</idno><idno type="RBID">PMC:7108049</idno><idno type="doi">10.1093/cid/ciw768</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000B78</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B78</idno><idno type="wicri:Area/Pmc/Curation">000B78</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000B78</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Risk Factors for Transmission of Middle East Respiratory Syndrome Coronavirus Infection During the 2015 Outbreak in South Korea</title><author><name sortKey="Kim, Seung Woo" sort="Kim, Seung Woo" uniqKey="Kim S" first="Seung Woo" last="Kim">Seung Woo Kim</name><affiliation><nlm:aff id="AF0001"><institution>Division of Epidemic Intelligence Service,</institution></nlm:aff></affiliation></author><author><name sortKey="Park, Jung Wan" sort="Park, Jung Wan" uniqKey="Park J" first="Jung Wan" last="Park">Jung Wan Park</name><affiliation><nlm:aff id="AF0001"><institution>Division of Epidemic Intelligence Service,</institution></nlm:aff></affiliation></author><author><name sortKey="Jung, Hee Dong" sort="Jung, Hee Dong" uniqKey="Jung H" first="Hee-Dong" last="Jung">Hee-Dong Jung</name><affiliation><nlm:aff id="AF0002"><institution>Division of Respiratory Viruses, Center of Infectious Disease,</institution></nlm:aff></affiliation></author><author><name sortKey="Yang, Jeong Sun" sort="Yang, Jeong Sun" uniqKey="Yang J" first="Jeong-Sun" last="Yang">Jeong-Sun Yang</name><affiliation><nlm:aff id="AF0002"><institution>Division of Respiratory Viruses, Center of Infectious Disease,</institution></nlm:aff></affiliation></author><author><name sortKey="Park, Yong Shik" sort="Park, Yong Shik" uniqKey="Park Y" first="Yong-Shik" last="Park">Yong-Shik Park</name><affiliation><nlm:aff id="AF0001"><institution>Division of Epidemic Intelligence Service,</institution></nlm:aff></affiliation></author><author><name sortKey="Lee, Changhwan" sort="Lee, Changhwan" uniqKey="Lee C" first="Changhwan" last="Lee">Changhwan Lee</name><affiliation><nlm:aff id="AF0001"><institution>Division of Epidemic Intelligence Service,</institution></nlm:aff></affiliation></author><author><name sortKey="Kim, Kyung Min" sort="Kim, Kyung Min" uniqKey="Kim K" first="Kyung Min" last="Kim">Kyung Min Kim</name><affiliation><nlm:aff id="AF0001"><institution>Division of Epidemic Intelligence Service,</institution></nlm:aff></affiliation></author><author><name sortKey="Lee, Keon Joo" sort="Lee, Keon Joo" uniqKey="Lee K" first="Keon-Joo" last="Lee">Keon-Joo Lee</name><affiliation><nlm:aff id="AF0001"><institution>Division of Epidemic Intelligence Service,</institution></nlm:aff></affiliation></author><author><name sortKey="Kwon, Donghyok" sort="Kwon, Donghyok" uniqKey="Kwon D" first="Donghyok" last="Kwon">Donghyok Kwon</name><affiliation><nlm:aff id="AF0001"><institution>Division of Epidemic Intelligence Service,</institution></nlm:aff></affiliation></author><author><name sortKey="Hur, Young Joo" sort="Hur, Young Joo" uniqKey="Hur Y" first="Young Joo" last="Hur">Young Joo Hur</name><affiliation><nlm:aff id="AF0003"><institution>Center for Infectious Disease Control, Korea Centers for Disease Control and Prevention</institution>,<addr-line>Cheongju</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Choi, Boyoul" sort="Choi, Boyoul" uniqKey="Choi B" first="Boyoul" last="Choi">Boyoul Choi</name><affiliation><nlm:aff wicri:cut=", and" id="AF0004"><institution>Department of Preventive Medicine, Hanyang University Medical College</institution>,<addr-line>Seoul</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ki, Moran" sort="Ki, Moran" uniqKey="Ki M" first="Moran" last="Ki">Moran Ki</name><affiliation wicri:level="1"><nlm:aff id="AF0005"><institution>Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center</institution>,<addr-line>Goyang</addr-line>,<country>Republic of Korea</country></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>We evaluated the epidemiological risk factors for MERS-CoV transmission during the recent South Korean outbreak. MERS-CoV transmission was determined by host infectivity and the number of contacts, whereas super-spreading events were determined by the number of contacts and hospital visits.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author><author><name sortKey="Mcgeer, A" uniqKey="Mcgeer A">A McGeer</name></author><author><name sortKey="Perl, Tm" uniqKey="Perl T">TM Perl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lloyd Smith, Jo" uniqKey="Lloyd Smith J">JO Lloyd-Smith</name></author><author><name sortKey="Schreiber, Sj" uniqKey="Schreiber S">SJ Schreiber</name></author><author><name sortKey="Kopp, Pe" uniqKey="Kopp P">PE Kopp</name></author><author><name sortKey="Getz, Wm" uniqKey="Getz W">WM Getz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, It" uniqKey="Yu I">IT Yu</name></author><author><name sortKey="Xie, Zh" uniqKey="Xie Z">ZH Xie</name></author><author><name sortKey="Tsoi, Kk" uniqKey="Tsoi K">KK Tsoi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shen, Z" uniqKey="Shen Z">Z Shen</name></author><author><name sortKey="Ning, F" uniqKey="Ning F">F Ning</name></author><author><name sortKey="Zhou, W" uniqKey="Zhou W">W Zhou</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Chowell, G" uniqKey="Chowell G">G Chowell</name></author><author><name sortKey="Abdirizak, F" uniqKey="Abdirizak F">F Abdirizak</name></author><author><name sortKey="Lee, S" uniqKey="Lee S">S Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stein, Ra" uniqKey="Stein R">RA Stein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ki, M" uniqKey="Ki M">M Ki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Km" uniqKey="Kim K">KM Kim</name></author><author><name sortKey="Ki, M" uniqKey="Ki M">M Ki</name></author><author><name sortKey="Cho, Si" uniqKey="Cho S">SI Cho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, Jh" uniqKey="Choi J">JH Choi</name></author><author><name sortKey="Yoo, B" uniqKey="Yoo B">B Yoo</name></author><author><name sortKey="Lee, Sy" uniqKey="Lee S">SY Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Ys" uniqKey="Park Y">YS Park</name></author><author><name sortKey="Lee, C" uniqKey="Lee C">C Lee</name></author><author><name sortKey="Kim, Km" uniqKey="Kim K">KM Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chang, K" uniqKey="Chang K">K Chang</name></author><author><name sortKey="Ki, M" uniqKey="Ki M">M Ki</name></author><author><name sortKey="Lee, Eg" uniqKey="Lee E">EG Lee</name></author><author><name sortKey="Lee, Sy" uniqKey="Lee S">SY Lee</name></author><author><name sortKey="Yoo, B" uniqKey="Yoo B">B Yoo</name></author><author><name sortKey="Choi, Jh" uniqKey="Choi J">JH Choi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cho, Sy" uniqKey="Cho S">SY Cho</name></author><author><name sortKey="Kang, Jm" uniqKey="Kang J">JM Kang</name></author><author><name sortKey="Ha, Ye" uniqKey="Ha Y">YE Ha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farrington, P" uniqKey="Farrington P">P. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Clin. Infect. Dis</journal-id><journal-id journal-id-type="publisher-id">cid</journal-id><journal-title-group><journal-title>Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</journal-title></journal-title-group><issn pub-type="ppub">1058-4838</issn><issn pub-type="epub">1537-6591</issn><publisher><publisher-name>Oxford University Press</publisher-name><publisher-loc>US</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27940937</article-id><article-id pub-id-type="pmc">7108049</article-id><article-id pub-id-type="doi">10.1093/cid/ciw768</article-id><article-id pub-id-type="publisher-id">ciw768</article-id><article-categories><subj-group subj-group-type="heading"><subject>Major Article</subject></subj-group></article-categories><title-group><article-title>Risk Factors for Transmission of Middle East Respiratory Syndrome Coronavirus Infection During the 2015 Outbreak in South Korea</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Seung Woo</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>Jung Wan</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jung</surname><given-names>Hee-Dong</given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Jeong-Sun</given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>Yong-Shik</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Changhwan</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Kyung Min</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Keon-Joo</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kwon</surname><given-names>Donghyok</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hur</surname><given-names>Young Joo</given-names></name><xref ref-type="aff" rid="AF0003"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Choi</surname><given-names>BoYoul</given-names></name><xref ref-type="aff" rid="AF0004"><sup>4</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Ki</surname><given-names>Moran</given-names></name><xref ref-type="aff" rid="AF0005"><sup>5</sup></xref><pmc-comment>moranki@ncc.re.kr </pmc-comment>
</contrib></contrib-group><aff id="AF0001"><label>1</label><institution>Division of Epidemic Intelligence Service,</institution></aff><aff id="AF0002"><label>2</label><institution>Division of Respiratory Viruses, Center of Infectious Disease,</institution></aff><aff id="AF0003"><label>3</label><institution>Center for Infectious Disease Control, Korea Centers for Disease Control and Prevention</institution>,<addr-line>Cheongju</addr-line>,</aff><aff id="AF0004"><label>4</label><institution>Department of Preventive Medicine, Hanyang University Medical College</institution>,<addr-line>Seoul</addr-line>, and</aff><aff id="AF0005"><label>5</label><institution>Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center</institution>,<addr-line>Goyang</addr-line>,<country>Republic of Korea</country></aff><author-notes><fn id="fn-0002"><p>Correspondence: M. Ki, Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 10408, Republic of Korea (<email>moranki@ncc.re.kr</email>).</p></fn></author-notes><pub-date pub-type="ppub"><day>01</day><month>3</month><year>2017</year></pub-date><pub-date pub-type="epub" iso-8601-date="2017-02-09"><day>09</day><month>2</month><year>2017</year></pub-date><volume>64</volume><issue>5</issue><fpage>551</fpage><lpage>557</lpage><history><date date-type="received"><day>29</day><month>8</month><year>2016</year></date><date date-type="rev-recd"><day>27</day><month>10</month><year>2016</year></date><date date-type="accepted"><day>30</day><month>11</month><year>2016</year></date></history><permissions><copyright-statement>© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</copyright-statement><copyright-year>2017</copyright-year><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p></license></permissions><self-uri xlink:href="ciw768.pdf"></self-uri><abstract abstract-type="teaser"><title>Summary</title><p>We evaluated the epidemiological risk factors for MERS-CoV transmission during the recent South Korean outbreak. MERS-CoV transmission was determined by host infectivity and the number of contacts, whereas super-spreading events were determined by the number of contacts and hospital visits.</p></abstract><abstract><title>Abstract</title><sec><title>Background.</title><p>Transmission heterogeneity was observed during the 2015 Korean outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection. Only 22 of 186 cases transmitted the infection, and 5 super-spreading events caused 150 transmissions. We investigated the risk factors for MERS-CoV transmission.</p></sec><sec><title>Methods.</title><p>Epidemiological reports were used to classify patients as nonspreaders, spreaders, or those associated with a super-spreading event (5 or more transmissions). Logistic regression analyses were used to evaluate the factors for MERS-CoV transmission.</p></sec><sec><title>Results.</title><p>Compared to nonspreaders, spreaders exhibited a longer interval from symptom onset to isolation (7 days vs 3 days) and more frequent pre-isolation pneumonia diagnoses (68.2% vs 17.1%). Spreaders also exhibited higher values for pre-isolation contacts (149 vs 17.5), pre-isolation hospitalization (68.2% vs 16.5%), and emergency room (ER) visits (50% vs 7.3%). Spreaders exhibited lower cycle thresholds for the <italic>upE</italic> and <italic>ORF1a</italic> genes (22.7 vs 27.2 and 23.7 vs 27.9, respectively). In multivariate analysis, transmission was independently associated with the cycle threshold (odds ratio [OR], 0.84; 95% confidence interval [CI], 0.75–0.96) and pre-isolation hospitalization or ER visits (OR, 6.82; 95% CI, 2.06–22.84). The super-spreading events exhibited higher values for pre-isolation contacts (777 vs 78), pre-isolation ER visits (100% vs 35.3%), and doctor shopping (100% vs 47.1%) compared to non-super-spreading events.</p></sec><sec><title>Conclusions.</title><p>These findings indicate that transmission is determined by host infectivity and the number of contacts, whereas super-spreading events were determined by the number of contacts and hospital visits. These relationships highlight the importance of rapidly enforcing infection control measures to prevent outbreaks.</p></sec></abstract><kwd-group><kwd>epidemiology</kwd><kwd>South Korea</kwd><kwd>Middle East respiratory syndrome coronavirus</kwd><kwd>super-spreading event</kwd><kwd>transmission.</kwd></kwd-group><counts><page-count count="7"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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