Risk Factors for Transmission of Middle East Respiratory Syndrome Coronavirus Infection During the 2015 Outbreak in South Korea
Identifieur interne : 000B78 ( Pmc/Curation ); précédent : 000B77; suivant : 000B79Risk Factors for Transmission of Middle East Respiratory Syndrome Coronavirus Infection During the 2015 Outbreak in South Korea
Auteurs : Seung Woo Kim ; Jung Wan Park ; Hee-Dong Jung ; Jeong-Sun Yang ; Yong-Shik Park ; Changhwan Lee ; Kyung Min Kim ; Keon-Joo Lee ; Donghyok Kwon ; Young Joo Hur ; Boyoul Choi ; Moran Ki [Corée du Sud]Source :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America [ 1058-4838 ] ; 2017.
Abstract
We evaluated the epidemiological risk factors for MERS-CoV transmission during the recent South Korean outbreak. MERS-CoV transmission was determined by host infectivity and the number of contacts, whereas super-spreading events were determined by the number of contacts and hospital visits.
Url:
DOI: 10.1093/cid/ciw768
PubMed: 27940937
PubMed Central: 7108049
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<author><name sortKey="Kim, Seung Woo" sort="Kim, Seung Woo" uniqKey="Kim S" first="Seung Woo" last="Kim">Seung Woo Kim</name>
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<author><name sortKey="Jung, Hee Dong" sort="Jung, Hee Dong" uniqKey="Jung H" first="Hee-Dong" last="Jung">Hee-Dong Jung</name>
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<author><name sortKey="Yang, Jeong Sun" sort="Yang, Jeong Sun" uniqKey="Yang J" first="Jeong-Sun" last="Yang">Jeong-Sun Yang</name>
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<author><name sortKey="Park, Yong Shik" sort="Park, Yong Shik" uniqKey="Park Y" first="Yong-Shik" last="Park">Yong-Shik Park</name>
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<author><name sortKey="Kim, Kyung Min" sort="Kim, Kyung Min" uniqKey="Kim K" first="Kyung Min" last="Kim">Kyung Min Kim</name>
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<author><name sortKey="Choi, Boyoul" sort="Choi, Boyoul" uniqKey="Choi B" first="Boyoul" last="Choi">Boyoul Choi</name>
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<author><name sortKey="Ki, Moran" sort="Ki, Moran" uniqKey="Ki M" first="Moran" last="Ki">Moran Ki</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Risk Factors for Transmission of Middle East Respiratory Syndrome Coronavirus Infection During the 2015 Outbreak in South Korea</title>
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<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p>We evaluated the epidemiological risk factors for MERS-CoV transmission during the recent South Korean outbreak. MERS-CoV transmission was determined by host infectivity and the number of contacts, whereas super-spreading events were determined by the number of contacts and hospital visits.</p>
</div>
</front>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Infect Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">Clin. Infect. Dis</journal-id>
<journal-id journal-id-type="publisher-id">cid</journal-id>
<journal-title-group><journal-title>Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</journal-title>
</journal-title-group>
<issn pub-type="ppub">1058-4838</issn>
<issn pub-type="epub">1537-6591</issn>
<publisher><publisher-name>Oxford University Press</publisher-name>
<publisher-loc>US</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27940937</article-id>
<article-id pub-id-type="pmc">7108049</article-id>
<article-id pub-id-type="doi">10.1093/cid/ciw768</article-id>
<article-id pub-id-type="publisher-id">ciw768</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Major Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Risk Factors for Transmission of Middle East Respiratory Syndrome Coronavirus Infection During the 2015 Outbreak in South Korea</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Kim</surname>
<given-names>Seung Woo</given-names>
</name>
<xref ref-type="aff" rid="AF0001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Park</surname>
<given-names>Jung Wan</given-names>
</name>
<xref ref-type="aff" rid="AF0001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jung</surname>
<given-names>Hee-Dong</given-names>
</name>
<xref ref-type="aff" rid="AF0002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yang</surname>
<given-names>Jeong-Sun</given-names>
</name>
<xref ref-type="aff" rid="AF0002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Park</surname>
<given-names>Yong-Shik</given-names>
</name>
<xref ref-type="aff" rid="AF0001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lee</surname>
<given-names>Changhwan</given-names>
</name>
<xref ref-type="aff" rid="AF0001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kim</surname>
<given-names>Kyung Min</given-names>
</name>
<xref ref-type="aff" rid="AF0001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lee</surname>
<given-names>Keon-Joo</given-names>
</name>
<xref ref-type="aff" rid="AF0001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kwon</surname>
<given-names>Donghyok</given-names>
</name>
<xref ref-type="aff" rid="AF0001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hur</surname>
<given-names>Young Joo</given-names>
</name>
<xref ref-type="aff" rid="AF0003"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Choi</surname>
<given-names>BoYoul</given-names>
</name>
<xref ref-type="aff" rid="AF0004"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Ki</surname>
<given-names>Moran</given-names>
</name>
<xref ref-type="aff" rid="AF0005"><sup>5</sup>
</xref>
<pmc-comment>moranki@ncc.re.kr </pmc-comment>
</contrib>
</contrib-group>
<aff id="AF0001"><label>1</label>
<institution>Division of Epidemic Intelligence Service,</institution>
</aff>
<aff id="AF0002"><label>2</label>
<institution>Division of Respiratory Viruses, Center of Infectious Disease,</institution>
</aff>
<aff id="AF0003"><label>3</label>
<institution>Center for Infectious Disease Control, Korea Centers for Disease Control and Prevention</institution>
,<addr-line>Cheongju</addr-line>
,</aff>
<aff id="AF0004"><label>4</label>
<institution>Department of Preventive Medicine, Hanyang University Medical College</institution>
,<addr-line>Seoul</addr-line>
, and</aff>
<aff id="AF0005"><label>5</label>
<institution>Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center</institution>
,<addr-line>Goyang</addr-line>
,<country>Republic of Korea</country>
</aff>
<author-notes><fn id="fn-0002"><p>Correspondence: M. Ki, Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 10408, Republic of Korea (<email>moranki@ncc.re.kr</email>
).</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><day>01</day>
<month>3</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub" iso-8601-date="2017-02-09"><day>09</day>
<month>2</month>
<year>2017</year>
</pub-date>
<volume>64</volume>
<issue>5</issue>
<fpage>551</fpage>
<lpage>557</lpage>
<history><date date-type="received"><day>29</day>
<month>8</month>
<year>2016</year>
</date>
<date date-type="rev-recd"><day>27</day>
<month>10</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>30</day>
<month>11</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</copyright-statement>
<copyright-year>2017</copyright-year>
<license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p>
</license>
</permissions>
<self-uri xlink:href="ciw768.pdf"></self-uri>
<abstract abstract-type="teaser"><title>Summary</title>
<p>We evaluated the epidemiological risk factors for MERS-CoV transmission during the recent South Korean outbreak. MERS-CoV transmission was determined by host infectivity and the number of contacts, whereas super-spreading events were determined by the number of contacts and hospital visits.</p>
</abstract>
<abstract><title>Abstract</title>
<sec><title>Background.</title>
<p>Transmission heterogeneity was observed during the 2015 Korean outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection. Only 22 of 186 cases transmitted the infection, and 5 super-spreading events caused 150 transmissions. We investigated the risk factors for MERS-CoV transmission.</p>
</sec>
<sec><title>Methods.</title>
<p>Epidemiological reports were used to classify patients as nonspreaders, spreaders, or those associated with a super-spreading event (5 or more transmissions). Logistic regression analyses were used to evaluate the factors for MERS-CoV transmission.</p>
</sec>
<sec><title>Results.</title>
<p>Compared to nonspreaders, spreaders exhibited a longer interval from symptom onset to isolation (7 days vs 3 days) and more frequent pre-isolation pneumonia diagnoses (68.2% vs 17.1%). Spreaders also exhibited higher values for pre-isolation contacts (149 vs 17.5), pre-isolation hospitalization (68.2% vs 16.5%), and emergency room (ER) visits (50% vs 7.3%). Spreaders exhibited lower cycle thresholds for the <italic>upE</italic>
and <italic>ORF1a</italic>
genes (22.7 vs 27.2 and 23.7 vs 27.9, respectively). In multivariate analysis, transmission was independently associated with the cycle threshold (odds ratio [OR], 0.84; 95% confidence interval [CI], 0.75–0.96) and pre-isolation hospitalization or ER visits (OR, 6.82; 95% CI, 2.06–22.84). The super-spreading events exhibited higher values for pre-isolation contacts (777 vs 78), pre-isolation ER visits (100% vs 35.3%), and doctor shopping (100% vs 47.1%) compared to non-super-spreading events.</p>
</sec>
<sec><title>Conclusions.</title>
<p>These findings indicate that transmission is determined by host infectivity and the number of contacts, whereas super-spreading events were determined by the number of contacts and hospital visits. These relationships highlight the importance of rapidly enforcing infection control measures to prevent outbreaks.</p>
</sec>
</abstract>
<kwd-group><kwd>epidemiology</kwd>
<kwd>South Korea</kwd>
<kwd>Middle East respiratory syndrome coronavirus</kwd>
<kwd>super-spreading event</kwd>
<kwd>transmission.</kwd>
</kwd-group>
<counts><page-count count="7"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>
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