4-(4-Chlorophenyl)piperidin-4-ol
Identifieur interne : 000A06 ( Pmc/Curation ); précédent : 000A05; suivant : 000A074-(4-Chlorophenyl)piperidin-4-ol
Auteurs : Grzegorz Dutkiewicz [Pologne] ; B. P. Siddaraju [Inde] ; H. S. Yathirajan [Inde] ; M. S. Siddegowda [Inde] ; Maciej Kubicki [Pologne]Source :
- Acta Crystallographica Section E: Structure Reports Online [ 1600-5368 ] ; 2010.
Abstract
In the title compound, C11H14ClNO, the piperidine ring adopts a chair conformation: the hydroxyl substituent and the N-bound H atom occupy the axial positions, while the benzene ring occupies the equatorial position. In the crystal, the molecules are linked into a centrosymmetric tetramer through strong O—H⋯N and weak N—H⋯O hydrogen bonds; the N and O atoms act as both donor and acceptor for these interactions. The tetramers are further joined by hydrogen bonds into a layer parallel to (100).
Url:
DOI: 10.1107/S1600536810004216
PubMed: 21580330
PubMed Central: 2983646
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000A06
Links to Exploration step
PMC:2983646Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">4-(4-Chlorophenyl)piperidin-4-ol</title>
<author><name sortKey="Dutkiewicz, Grzegorz" sort="Dutkiewicz, Grzegorz" uniqKey="Dutkiewicz G" first="Grzegorz" last="Dutkiewicz">Grzegorz Dutkiewicz</name>
<affiliation wicri:level="1"><nlm:aff id="a">Department of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznań,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Siddaraju, B P" sort="Siddaraju, B P" uniqKey="Siddaraju B" first="B. P." last="Siddaraju">B. P. Siddaraju</name>
<affiliation wicri:level="1"><nlm:aff id="b">Department of Chemistry, V. V. Puram College of Science, Bangalore 560 004,<country>India</country>
</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yathirajan, H S" sort="Yathirajan, H S" uniqKey="Yathirajan H" first="H. S." last="Yathirajan">H. S. Yathirajan</name>
<affiliation wicri:level="1"><nlm:aff id="c">Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006,<country>India</country>
</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Siddegowda, M S" sort="Siddegowda, M S" uniqKey="Siddegowda M" first="M. S." last="Siddegowda">M. S. Siddegowda</name>
<affiliation wicri:level="1"><nlm:aff id="c">Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006,<country>India</country>
</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kubicki, Maciej" sort="Kubicki, Maciej" uniqKey="Kubicki M" first="Maciej" last="Kubicki">Maciej Kubicki</name>
<affiliation wicri:level="1"><nlm:aff id="a">Department of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznań,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21580330</idno>
<idno type="pmc">2983646</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983646</idno>
<idno type="RBID">PMC:2983646</idno>
<idno type="doi">10.1107/S1600536810004216</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">000A06</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A06</idno>
<idno type="wicri:Area/Pmc/Curation">000A06</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A06</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">4-(4-Chlorophenyl)piperidin-4-ol</title>
<author><name sortKey="Dutkiewicz, Grzegorz" sort="Dutkiewicz, Grzegorz" uniqKey="Dutkiewicz G" first="Grzegorz" last="Dutkiewicz">Grzegorz Dutkiewicz</name>
<affiliation wicri:level="1"><nlm:aff id="a">Department of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznań,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Siddaraju, B P" sort="Siddaraju, B P" uniqKey="Siddaraju B" first="B. P." last="Siddaraju">B. P. Siddaraju</name>
<affiliation wicri:level="1"><nlm:aff id="b">Department of Chemistry, V. V. Puram College of Science, Bangalore 560 004,<country>India</country>
</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yathirajan, H S" sort="Yathirajan, H S" uniqKey="Yathirajan H" first="H. S." last="Yathirajan">H. S. Yathirajan</name>
<affiliation wicri:level="1"><nlm:aff id="c">Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006,<country>India</country>
</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Siddegowda, M S" sort="Siddegowda, M S" uniqKey="Siddegowda M" first="M. S." last="Siddegowda">M. S. Siddegowda</name>
<affiliation wicri:level="1"><nlm:aff id="c">Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006,<country>India</country>
</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kubicki, Maciej" sort="Kubicki, Maciej" uniqKey="Kubicki M" first="Maciej" last="Kubicki">Maciej Kubicki</name>
<affiliation wicri:level="1"><nlm:aff id="a">Department of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznań,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Acta Crystallographica Section E: Structure Reports Online</title>
<idno type="eISSN">1600-5368</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>In the title compound, C<sub>11</sub>
H<sub>14</sub>
ClNO, the piperidine ring adopts a chair conformation: the hydroxyl substituent and the N-bound H atom occupy the axial positions, while the benzene ring occupies the equatorial position. In the crystal, the molecules are linked into a centrosymmetric tetramer through strong O—H⋯N and weak N—H⋯O hydrogen bonds; the N and O atoms act as both donor and acceptor for these interactions. The tetramers are further joined by hydrogen bonds into a layer parallel to (100).</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Acta Crystallogr Sect E Struct Rep Online</journal-id>
<journal-id journal-id-type="publisher-id">Acta Cryst. E</journal-id>
<journal-title-group><journal-title>Acta Crystallographica Section E: Structure Reports Online</journal-title>
</journal-title-group>
<issn pub-type="epub">1600-5368</issn>
<publisher><publisher-name>International Union of Crystallography</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21580330</article-id>
<article-id pub-id-type="pmc">2983646</article-id>
<article-id pub-id-type="publisher-id">is2520</article-id>
<article-id pub-id-type="doi">10.1107/S1600536810004216</article-id>
<article-id pub-id-type="coden">ACSEBH</article-id>
<article-id pub-id-type="pii">S1600536810004216</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Organic Papers</subject>
</subj-group>
</article-categories>
<title-group><article-title>4-(4-Chlorophenyl)piperidin-4-ol</article-title>
<alt-title><italic>C<sub>11</sub>
H<sub>14</sub>
ClNO</italic>
</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Dutkiewicz</surname>
<given-names>Grzegorz</given-names>
</name>
<xref ref-type="aff" rid="a">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Siddaraju</surname>
<given-names>B. P.</given-names>
</name>
<xref ref-type="aff" rid="b">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yathirajan</surname>
<given-names>H. S.</given-names>
</name>
<xref ref-type="aff" rid="c">c</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Siddegowda</surname>
<given-names>M. S.</given-names>
</name>
<xref ref-type="aff" rid="c">c</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kubicki</surname>
<given-names>Maciej</given-names>
</name>
<xref ref-type="aff" rid="a">a</xref>
<xref ref-type="corresp" rid="cor">*</xref>
</contrib>
<aff id="a"><label>a</label>
Department of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznań,<country>Poland</country>
</aff>
<aff id="b"><label>b</label>
Department of Chemistry, V. V. Puram College of Science, Bangalore 560 004,<country>India</country>
</aff>
<aff id="c"><label>c</label>
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006,<country>India</country>
</aff>
</contrib-group>
<author-notes><corresp id="cor">Correspondence e-mail: <email>mkubicki@amu.edu.pl</email>
</corresp>
</author-notes>
<pub-date pub-type="collection"><day>01</day>
<month>3</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="epub"><day>06</day>
<month>2</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>06</day>
<month>2</month>
<year>2010</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
. </pmc-comment>
<volume>66</volume>
<issue>Pt 3</issue>
<issue-id pub-id-type="publisher-id">e100300</issue-id>
<fpage>o562</fpage>
<lpage>o562</lpage>
<history><date date-type="received"><day>28</day>
<month>1</month>
<year>2010</year>
</date>
<date date-type="accepted"><day>02</day>
<month>2</month>
<year>2010</year>
</date>
</history>
<permissions><copyright-statement>© Dutkiewicz et al. 2010</copyright-statement>
<copyright-year>2010</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/uk/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.</license-p>
</license>
</permissions>
<self-uri xlink:type="simple" xlink:href="http://dx.doi.org/10.1107/S1600536810004216">A full version of this article is available from Crystallography Journals Online.</self-uri>
<abstract><p>In the title compound, C<sub>11</sub>
H<sub>14</sub>
ClNO, the piperidine ring adopts a chair conformation: the hydroxyl substituent and the N-bound H atom occupy the axial positions, while the benzene ring occupies the equatorial position. In the crystal, the molecules are linked into a centrosymmetric tetramer through strong O—H⋯N and weak N—H⋯O hydrogen bonds; the N and O atoms act as both donor and acceptor for these interactions. The tetramers are further joined by hydrogen bonds into a layer parallel to (100).</p>
</abstract>
</article-meta>
</front>
<floats-group><table-wrap id="table1" position="float"><label>Table 1</label>
<caption><title>Hydrogen-bond geometry (Å, °)</title>
</caption>
<table frame="hsides" rules="groups"><thead valign="bottom"><tr><th style="border-bottom:1px solid black;" rowspan="1" colspan="1" align="left" valign="bottom"><italic>D</italic>
—H⋯<italic>A</italic>
</th>
<th style="border-bottom:1px solid black;" rowspan="1" colspan="1" align="left" valign="bottom"><italic>D</italic>
—H</th>
<th style="border-bottom:1px solid black;" rowspan="1" colspan="1" align="left" valign="bottom">H⋯<italic>A</italic>
</th>
<th style="border-bottom:1px solid black;" rowspan="1" colspan="1" align="left" valign="bottom"><italic>D</italic>
⋯<italic>A</italic>
</th>
<th style="border-bottom:1px solid black;" rowspan="1" colspan="1" align="left" valign="bottom"><italic>D</italic>
—H⋯<italic>A</italic>
</th>
</tr>
</thead>
<tbody valign="top"><tr><td style="" rowspan="1" colspan="1" align="left" valign="top">N1—H1⋯O4<sup>i</sup>
</td>
<td style="" rowspan="1" colspan="1" align="left" valign="top">0.89 (2)</td>
<td style="" rowspan="1" colspan="1" align="left" valign="top">2.41 (2)</td>
<td style="" rowspan="1" colspan="1" align="left" valign="top">3.2036 (16)</td>
<td style="" rowspan="1" colspan="1" align="left" valign="top">147.2 (17)</td>
</tr>
<tr><td style="" rowspan="1" colspan="1" align="left" valign="top">O4—H4<italic>A</italic>
⋯N1<sup>ii</sup>
</td>
<td style="" rowspan="1" colspan="1" align="left" valign="top">0.84 (2)</td>
<td style="" rowspan="1" colspan="1" align="left" valign="top">1.97 (2)</td>
<td style="" rowspan="1" colspan="1" align="left" valign="top">2.8089 (17)</td>
<td style="" rowspan="1" colspan="1" align="left" valign="top">174 (2)</td>
</tr>
</tbody>
</table>
<table-wrap-foot><p>Symmetry codes: (i) <inline-formula><inline-graphic xlink:href="e-66-0o562-efi6.jpg" mimetype="image" mime-subtype="gif"></inline-graphic>
</inline-formula>
; (ii) <inline-formula><inline-graphic xlink:href="e-66-0o562-efi7.jpg" mimetype="image" mime-subtype="gif"></inline-graphic>
</inline-formula>
.</p>
</table-wrap-foot>
</table-wrap>
</floats-group>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A06 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000A06 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:2983646 |texte= 4-(4-Chlorophenyl)piperidin-4-ol }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:21580330" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a MersV1
This area was generated with Dilib version V0.6.33. |