Long-term Respiratory Complication in Patients with Middle East Respiratory Syndrome: 1-year Follow-up After the 2015 Outbreak in South Korea
Identifieur interne : 000638 ( Pmc/Curation ); précédent : 000637; suivant : 000639Long-term Respiratory Complication in Patients with Middle East Respiratory Syndrome: 1-year Follow-up After the 2015 Outbreak in South Korea
Auteurs : Kang Il Jun ; Wan Beom Park ; Gayeon Kim ; Jae-Phil Choi ; Ji-Young Rhee ; Shinhye Cheon ; Jun-Sun Park ; Yeonjae Kim ; Joonsung Joh ; Bum Sik Chin ; Pyeong Gyun Choe ; Ji Whan Bang ; Sang-Won Park ; Nam Joong Kim ; Dong-Gyun Lim ; Yeon-Sook Kim ; Myoung-Don Oh ; Hyoung-Shik ShinSource :
- Open Forum Infectious Diseases [ 2328-8957 ] ; 2017.
Abstract
There are few data about long-term respiratory complications following Middle East Respiratory Syndrome coronavirus (MERS-CoV) infection. This study aimed to evaluate respiratory functions and radiologic sequelae according to the severity of infection one year after the patients experienced MERS-CoV infection.
A total of 73 patients undergoing MERS-CoV infection during the 2015 MERS outbreak in South Korea were enrolled in this prospective multicenter study. Pulmonary function tests and 6-minute walking tests were performed 1 year after infection. Radiologic sequelae was defined as fibrosis or atelectasis on chest computer tomography and severe pneumonia was defined as that requiring oxygen therapy. Multivariate linear regression tests were used to evaluate the effect of infection severity on respiratory function.
At the time of MERS-CoV infection, 18 patients had no pneumonia, 35 experienced mild pneumonia, and 20 did severe pneumonia. The median age was not different between groups (P = 0.942). Forced vital capacity (FVC) was 102.6%, 94.9%, and 88.7% in the no, mild, and severe pneumonia group, respectively (P = 0.010) and forced expiratory volume in 1 second was 105.3%, 95.7%, and 91.7% (P = 0.057). Diffusing capacity (DLCO) was significantly lower in the severe pneumonia group than in the no or mild pneumonia group (78.3% vs. 89.4% or 88.6%, P = 0.035). In multivariate analyses, FVC and DLCO were significantly correlated with infection severity after adjustment with age, sex, underlying lung disease, and smoking. There was no difference in the walking distance of 6 minute tests between groups. Radiologic sequelae were shown in 18.8%, 65.6%, and 100% in the no, mild, and severe pneumonia group, respectively (P < 0.001).
The patients with more severe pneumonia by MERS-CoV had more impaired respiratory function in one year follow-up, which was compatible with radiologic sequelae.
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DOI: 10.1093/ofid/ofx163.1508
PubMed: NONE
PubMed Central: 7107210
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Long-term Respiratory Complication in Patients with Middle East Respiratory Syndrome: 1-year Follow-up After the 2015 Outbreak in South Korea</title><author><name sortKey="Il Jun, Kang" sort="Il Jun, Kang" uniqKey="Il Jun K" first="Kang" last="Il Jun">Kang Il Jun</name><affiliation wicri:level="1"><nlm:aff id="AF0001"><institution>Department of Internal Medicine, Seoul National University Hospital</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Park, Wan Beom" sort="Park, Wan Beom" uniqKey="Park W" first="Wan Beom" last="Park">Wan Beom Park</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Department of Internal Medicine, Seoul National University College of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Gayeon" sort="Kim, Gayeon" uniqKey="Kim G" first="Gayeon" last="Kim">Gayeon Kim</name><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Department of Internal Medicine, National Medical Center</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Choi, Jae Phil" sort="Choi, Jae Phil" uniqKey="Choi J" first="Jae-Phil" last="Choi">Jae-Phil Choi</name><affiliation wicri:level="1"><nlm:aff id="AF0004"><institution>Division of Infectious Diseases, Seoul Medical Center</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name 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country</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Nam Joong" sort="Kim, Nam Joong" uniqKey="Kim N" first="Nam Joong" last="Kim">Nam Joong Kim</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Department of Internal Medicine, Seoul National University College of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Lim, Dong Gyun" sort="Lim, Dong Gyun" uniqKey="Lim D" first="Dong-Gyun" last="Lim">Dong-Gyun Lim</name><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Department of Internal Medicine, National Medical Center</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Yeon Sook" sort="Kim, Yeon Sook" uniqKey="Kim Y" first="Yeon-Sook" last="Kim">Yeon-Sook Kim</name><affiliation wicri:level="1"><nlm:aff id="AF0006"><institution>Department of Internal Medicine, Chungnam National University Hospital</institution>,<addr-line>Daejeon</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Oh, Myoung Don" sort="Oh, Myoung Don" uniqKey="Oh M" first="Myoung-Don" last="Oh">Myoung-Don Oh</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Department of Internal Medicine, Seoul National University College of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Shin, Hyoung Shik" sort="Shin, Hyoung Shik" uniqKey="Shin H" first="Hyoung-Shik" last="Shin">Hyoung-Shik Shin</name><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Department of Internal Medicine, National Medical Center</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7107210</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7107210</idno><idno type="RBID">PMC:7107210</idno><idno type="doi">10.1093/ofid/ofx163.1508</idno><idno type="pmid">NONE</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000638</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000638</idno><idno type="wicri:Area/Pmc/Curation">000638</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000638</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Long-term Respiratory Complication in Patients with Middle East Respiratory Syndrome: 1-year Follow-up After the 2015 Outbreak in South Korea</title><author><name sortKey="Il Jun, Kang" sort="Il Jun, Kang" uniqKey="Il Jun K" first="Kang" last="Il Jun">Kang Il Jun</name><affiliation wicri:level="1"><nlm:aff id="AF0001"><institution>Department of Internal Medicine, Seoul National University Hospital</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Park, Wan Beom" sort="Park, Wan Beom" uniqKey="Park W" first="Wan Beom" last="Park">Wan Beom Park</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Department of Internal Medicine, Seoul National University College of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Gayeon" sort="Kim, Gayeon" uniqKey="Kim G" first="Gayeon" last="Kim">Gayeon Kim</name><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Department of Internal Medicine, National Medical Center</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Choi, Jae Phil" sort="Choi, Jae Phil" uniqKey="Choi J" first="Jae-Phil" last="Choi">Jae-Phil Choi</name><affiliation wicri:level="1"><nlm:aff id="AF0004"><institution>Division of Infectious Diseases, Seoul Medical Center</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Rhee, Ji Young" sort="Rhee, Ji Young" uniqKey="Rhee J" first="Ji-Young" last="Rhee">Ji-Young Rhee</name><affiliation wicri:level="1"><nlm:aff id="AF0005"><institution>Department of Medicine, Dankook University</institution>,<addr-line>Cheonan</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Cheon, Shinhye" sort="Cheon, Shinhye" uniqKey="Cheon S" first="Shinhye" last="Cheon">Shinhye Cheon</name><affiliation wicri:level="1"><nlm:aff id="AF0006"><institution>Department of Internal Medicine, Chungnam National University Hospital</institution>,<addr-line>Daejeon</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Park, Jun Sun" sort="Park, Jun Sun" uniqKey="Park J" first="Jun-Sun" last="Park">Jun-Sun Park</name><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Department of Internal Medicine, National Medical Center</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Yeonjae" sort="Kim, Yeonjae" uniqKey="Kim Y" first="Yeonjae" last="Kim">Yeonjae Kim</name><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Department of Internal Medicine, National Medical Center</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Joh, Joonsung" sort="Joh, Joonsung" uniqKey="Joh J" first="Joonsung" last="Joh">Joonsung Joh</name><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Department of Internal Medicine, National Medical Center</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Chin, Bum Sik" sort="Chin, Bum Sik" uniqKey="Chin B" first="Bum Sik" last="Chin">Bum Sik Chin</name><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Department of Internal Medicine, National Medical Center</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Choe, Pyeong Gyun" sort="Choe, Pyeong Gyun" uniqKey="Choe P" first="Pyeong Gyun" last="Choe">Pyeong Gyun Choe</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Department of Internal Medicine, Seoul National University College of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Bang, Ji Whan" sort="Bang, Ji Whan" uniqKey="Bang J" first="Ji Whan" last="Bang">Ji Whan Bang</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Department of Internal Medicine, Seoul National University College of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang-Won" last="Park">Sang-Won Park</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Department of Internal Medicine, Seoul National University College of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Nam Joong" sort="Kim, Nam Joong" uniqKey="Kim N" first="Nam Joong" last="Kim">Nam Joong Kim</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Department of Internal Medicine, Seoul National University College of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Lim, Dong Gyun" sort="Lim, Dong Gyun" uniqKey="Lim D" first="Dong-Gyun" last="Lim">Dong-Gyun Lim</name><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Department of Internal Medicine, National Medical Center</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Yeon Sook" sort="Kim, Yeon Sook" uniqKey="Kim Y" first="Yeon-Sook" last="Kim">Yeon-Sook Kim</name><affiliation wicri:level="1"><nlm:aff id="AF0006"><institution>Department of Internal Medicine, Chungnam National University Hospital</institution>,<addr-line>Daejeon</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Oh, Myoung Don" sort="Oh, Myoung Don" uniqKey="Oh M" first="Myoung-Don" last="Oh">Myoung-Don Oh</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Department of Internal Medicine, Seoul National University College of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Shin, Hyoung Shik" sort="Shin, Hyoung Shik" uniqKey="Shin H" first="Hyoung-Shik" last="Shin">Hyoung-Shik Shin</name><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Department of Internal Medicine, National Medical Center</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></nlm:aff><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author></analytic><series><title level="j">Open Forum Infectious Diseases</title><idno type="eISSN">2328-8957</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><sec id="s1"><title>Background</title><p>There are few data about long-term respiratory complications following Middle East Respiratory Syndrome coronavirus (MERS-CoV) infection. This study aimed to evaluate respiratory functions and radiologic sequelae according to the severity of infection one year after the patients experienced MERS-CoV infection.</p></sec><sec id="s2"><title>Methods</title><p>A total of 73 patients undergoing MERS-CoV infection during the 2015 MERS outbreak in South Korea were enrolled in this prospective multicenter study. Pulmonary function tests and 6-minute walking tests were performed 1 year after infection. Radiologic sequelae was defined as fibrosis or atelectasis on chest computer tomography and severe pneumonia was defined as that requiring oxygen therapy. Multivariate linear regression tests were used to evaluate the effect of infection severity on respiratory function.</p></sec><sec id="s3"><title>Results</title><p>At the time of MERS-CoV infection, 18 patients had no pneumonia, 35 experienced mild pneumonia, and 20 did severe pneumonia. The median age was not different between groups (P = 0.942). Forced vital capacity (FVC) was 102.6%, 94.9%, and 88.7% in the no, mild, and severe pneumonia group, respectively (P = 0.010) and forced expiratory volume in 1 second was 105.3%, 95.7%, and 91.7% (P = 0.057). Diffusing capacity (DLCO) was significantly lower in the severe pneumonia group than in the no or mild pneumonia group (78.3% vs. 89.4% or 88.6%, P = 0.035). In multivariate analyses, FVC and DLCO were significantly correlated with infection severity after adjustment with age, sex, underlying lung disease, and smoking. There was no difference in the walking distance of 6 minute tests between groups. Radiologic sequelae were shown in 18.8%, 65.6%, and 100% in the no, mild, and severe pneumonia group, respectively (P < 0.001).</p></sec><sec id="s4"><title>Conclusion</title><p>The patients with more severe pneumonia by MERS-CoV had more impaired respiratory function in one year follow-up, which was compatible with radiologic sequelae.</p></sec><sec id="s5"><title>Disclosures</title><p><bold>All authors:</bold> No reported disclosures.</p></sec></div></front></TEI><pmc article-type="abstract"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Open Forum Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Open Forum Infect Dis</journal-id><journal-id journal-id-type="publisher-id">ofid</journal-id><journal-title-group><journal-title>Open Forum Infectious Diseases</journal-title></journal-title-group><issn pub-type="epub">2328-8957</issn><publisher><publisher-name>Oxford University Press</publisher-name><publisher-loc>US</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7107210</article-id><article-id pub-id-type="doi">10.1093/ofid/ofx163.1508</article-id><article-id pub-id-type="publisher-id">ofx163.1508</article-id><article-categories><subj-group subj-group-type="heading"><subject>Abstracts</subject><subj-group subj-group-type="category-toc-heading"><subject>Poster Abstract</subject></subj-group></subj-group></article-categories><title-group><article-title>Long-term Respiratory Complication in Patients with Middle East Respiratory Syndrome: 1-year Follow-up After the 2015 Outbreak in South Korea</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Il Jun</surname><given-names>Kang</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="AF0001">1</xref></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>Wan Beom</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="AF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Gayeon</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="AF0003">3</xref></contrib><contrib contrib-type="author"><name><surname>Choi</surname><given-names>Jae-Phil</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="AF0004">4</xref></contrib><contrib contrib-type="author"><name><surname>Rhee</surname><given-names>Ji-Young</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="AF0005">5</xref></contrib><contrib contrib-type="author"><name><surname>Cheon</surname><given-names>Shinhye</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="AF0006">6</xref></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>Jun-Sun</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="AF0003">3</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Yeonjae</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="AF0003">3</xref></contrib><contrib contrib-type="author"><name><surname>Joh</surname><given-names>Joonsung</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="AF0003">3</xref></contrib><contrib contrib-type="author"><name><surname>Chin</surname><given-names>Bum Sik</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="AF0003">3</xref></contrib><contrib contrib-type="author"><name><surname>Choe</surname><given-names>Pyeong Gyun</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="AF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Bang</surname><given-names>Ji Whan</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="AF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>Sang-Won</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="AF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Nam Joong</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="AF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Lim</surname><given-names>Dong-Gyun</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="AF0003">3</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Yeon-Sook</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="AF0006">6</xref></contrib><contrib contrib-type="author"><name><surname>Oh</surname><given-names>Myoung-Don</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="AF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Shin</surname><given-names>Hyoung-Shik</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="AF0003">3</xref></contrib></contrib-group><aff id="AF0001"><label>1</label><institution>Department of Internal Medicine, Seoul National University Hospital</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></aff><aff id="AF0002"><label>2</label><institution>Department of Internal Medicine, Seoul National University College of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></aff><aff id="AF0003"><label>3</label><institution>Department of Internal Medicine, National Medical Center</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></aff><aff id="AF0004"><label>4</label><institution>Division of Infectious Diseases, Seoul Medical Center</institution>,<addr-line>Seoul</addr-line>,<country>Korea, Republic of (South)</country></aff><aff id="AF0005"><label>5</label><institution>Department of Medicine, Dankook University</institution>,<addr-line>Cheonan</addr-line>,<country>Korea, Republic of (South)</country></aff><aff id="AF0006"><label>6</label><institution>Department of Internal Medicine, Chungnam National University Hospital</institution>,<addr-line>Daejeon</addr-line>,<country>Korea, Republic of (South)</country></aff><author-notes><fn id="fn-0001"><p><bold>Session:</bold> 233. Clinical: Respiratory Track</p><p><italic>Saturday, October 7, 2017: 12:30 PM</italic></p></fn></author-notes><pub-date pub-type="collection"><season>Fall</season><year>2017</year></pub-date><pub-date pub-type="epub" iso-8601-date="2017-10-04"><day>04</day><month>10</month><year>2017</year></pub-date><pub-date pub-type="pmc-release"><day>04</day><month>10</month><year>2017</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>4</volume><issue>Suppl 1</issue><issue-title>ID Week 2017 Abstracts</issue-title><fpage>S577</fpage><lpage>S577</lpage><permissions><copyright-statement>© The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America.</copyright-statement><copyright-year>2017</copyright-year><license license-type="cc-by-nc-nd" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/">http://creativecommons.org/licenses/by-nc-nd/4.0/</ext-link>), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com</license-p></license></permissions><self-uri xlink:href="ofx163.1508.pdf"></self-uri><abstract><title>Abstract</title><sec id="s1"><title>Background</title><p>There are few data about long-term respiratory complications following Middle East Respiratory Syndrome coronavirus (MERS-CoV) infection. This study aimed to evaluate respiratory functions and radiologic sequelae according to the severity of infection one year after the patients experienced MERS-CoV infection.</p></sec><sec id="s2"><title>Methods</title><p>A total of 73 patients undergoing MERS-CoV infection during the 2015 MERS outbreak in South Korea were enrolled in this prospective multicenter study. Pulmonary function tests and 6-minute walking tests were performed 1 year after infection. Radiologic sequelae was defined as fibrosis or atelectasis on chest computer tomography and severe pneumonia was defined as that requiring oxygen therapy. Multivariate linear regression tests were used to evaluate the effect of infection severity on respiratory function.</p></sec><sec id="s3"><title>Results</title><p>At the time of MERS-CoV infection, 18 patients had no pneumonia, 35 experienced mild pneumonia, and 20 did severe pneumonia. The median age was not different between groups (P = 0.942). Forced vital capacity (FVC) was 102.6%, 94.9%, and 88.7% in the no, mild, and severe pneumonia group, respectively (P = 0.010) and forced expiratory volume in 1 second was 105.3%, 95.7%, and 91.7% (P = 0.057). Diffusing capacity (DLCO) was significantly lower in the severe pneumonia group than in the no or mild pneumonia group (78.3% vs. 89.4% or 88.6%, P = 0.035). In multivariate analyses, FVC and DLCO were significantly correlated with infection severity after adjustment with age, sex, underlying lung disease, and smoking. There was no difference in the walking distance of 6 minute tests between groups. Radiologic sequelae were shown in 18.8%, 65.6%, and 100% in the no, mild, and severe pneumonia group, respectively (P < 0.001).</p></sec><sec id="s4"><title>Conclusion</title><p>The patients with more severe pneumonia by MERS-CoV had more impaired respiratory function in one year follow-up, which was compatible with radiologic sequelae.</p></sec><sec id="s5"><title>Disclosures</title><p><bold>All authors:</bold> No reported disclosures.</p></sec></abstract><counts><page-count count="1"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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