Coronavirus MHV-A59 infects the lung and causes severe pneumonia in C57BL/6 mice
Identifieur interne : 000486 ( Pmc/Curation ); précédent : 000485; suivant : 000487Coronavirus MHV-A59 infects the lung and causes severe pneumonia in C57BL/6 mice
Auteurs : Zhangsheng Yang [République populaire de Chine] ; Jun Du [République populaire de Chine] ; Gang Chen [République populaire de Chine] ; Jie Zhao [République populaire de Chine] ; Xuanming Yang [République populaire de Chine] ; Lishan Su [États-Unis] ; Genhong Cheng [États-Unis] ; Hong Tang [République populaire de Chine]Source :
- Virologica Sinica [ 1674-0769 ] ; 2014.
Abstract
It remains challenging to develop animal models of lung infection and severe pneumonia by severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome cornavirus (MERS-CoV) without high level of containment. This inevitably hinders understanding of virushost interaction and development of appropriate countermeasures. Here we report that intranasal inoculation of sublethal doses of murine coronavirus mouse hepatitis virus A-59 (MHV-A59), a hepatic and neuronal tropic coronavirus, can induce acute pneumonia and severe lung injuries in C57BL/6 mice. Inflammatory leukocyte infiltrations, hemorrhages and fibrosis of alveolar walls can be observed 2–11 days after MHV-A59 infection. This pathological manifestation is associated with dramatical elevation of tissue IP-10 and IFN-γ and moderate increase of TNF-α and IL-1β, but inability of anti-viral type I interferon response. These results suggest that intranasal infection of MHV-A59 would serve as a surrogate mouse model of acute respiratory distress syndrome by SARS-CoV and MERS-CoV infections.
Url:
DOI: 10.1007/s12250-014-3530-y
PubMed: 25547683
PubMed Central: 7090691
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when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>It remains challenging to develop animal models of lung infection and severe pneumonia by severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome cornavirus (MERS-CoV) without high level of containment. This inevitably hinders understanding of virushost interaction and development of appropriate countermeasures. Here we report that intranasal inoculation of sublethal doses of murine coronavirus mouse hepatitis virus A-59 (MHV-A59), a hepatic and neuronal tropic coronavirus, can induce acute pneumonia and severe lung injuries in C57BL/6 mice. Inflammatory leukocyte infiltrations, hemorrhages and fibrosis of alveolar walls can be observed 2–11 days after MHV-A59 infection. This pathological manifestation is associated with dramatical elevation of tissue IP-10 and IFN-γ and moderate increase of TNF-α and IL-1β, but inability of anti-viral type I interferon response. These results suggest that intranasal infection of MHV-A59 would serve as a surrogate mouse model of acute respiratory distress syndrome by SARS-CoV and MERS-CoV infections.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Aparicio, J L" uniqKey="Aparicio J">J L Aparicio</name></author><author><name sortKey="Pena, C" uniqKey="Pena C">C Pena</name></author><author><name sortKey="Retegui, L A" uniqKey="Retegui L">L A Retegui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barthold, S W" uniqKey="Barthold S">S W Barthold</name></author><author><name sortKey="Smith, A L" uniqKey="Smith A">A L Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biddison, W E" uniqKey="Biddison W">W E Biddison</name></author><author><name sortKey="Cruikshank, W W" uniqKey="Cruikshank W">W W Cruikshank</name></author><author><name sortKey="Center, D M" uniqKey="Center D">D M Center</name></author><author><name sortKey="Pelfrey, C M" uniqKey="Pelfrey C">C M Pelfrey</name></author><author><name sortKey="Taub, D D" uniqKey="Taub D">D D Taub</name></author><author><name sortKey="Turner, R V" uniqKey="Turner R">R V Turner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, J F" uniqKey="Chan J">J F Chan</name></author><author><name sortKey="Li, K S" uniqKey="Li K">K S Li</name></author><author><name sortKey="To, K K" uniqKey="To K">K K To</name></author><author><name sortKey="Cheng, V C" uniqKey="Cheng V">V C Cheng</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K Y Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chesler, D A" uniqKey="Chesler D">D A Chesler</name></author><author><name sortKey="Reiss, C S" uniqKey="Reiss C">C S Reiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chu, H" uniqKey="Chu H">H Chu</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author><author><name sortKey="Wong, B H" uniqKey="Wong B">B H Wong</name></author><author><name sortKey="Li, C" uniqKey="Li C">C Li</name></author><author><name sortKey="Cheng, Z S" uniqKey="Cheng Z">Z S Cheng</name></author><author><name sortKey="Lin, X" uniqKey="Lin X">X Lin</name></author><author><name sortKey="Poon, V K" uniqKey="Poon V">V K Poon</name></author><author><name sortKey="Sun, T" uniqKey="Sun T">T Sun</name></author><author><name sortKey="Lau, C C" uniqKey="Lau C">C C Lau</name></author><author><name sortKey="Chan, J F" uniqKey="Chan J">J F Chan</name></author><author><name sortKey="To, K K" uniqKey="To K">K K To</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K H Chan</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author><author><name sortKey="Zheng, B J" uniqKey="Zheng B">B J Zheng</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K Y Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coleman, C M" uniqKey="Coleman C">C M Coleman</name></author><author><name sortKey="Matthews, K L" uniqKey="Matthews K">K L Matthews</name></author><author><name sortKey="Goicochea, L" uniqKey="Goicochea L">L Goicochea</name></author><author><name sortKey="Frieman, M B" uniqKey="Frieman M">M B Frieman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coutelier, J P" uniqKey="Coutelier J">J P Coutelier</name></author><author><name sortKey="Van Der Logt, J T" uniqKey="Van Der Logt J">J T van der Logt</name></author><author><name sortKey="Heessen, F W" uniqKey="Heessen F">F W Heessen</name></author><author><name sortKey="Warnier, G" uniqKey="Warnier G">G Warnier</name></author><author><name sortKey="Van Snick, J" uniqKey="Van Snick J">J Van Snick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Day, C W" uniqKey="Day C">C W Day</name></author><author><name sortKey="Baric, R" uniqKey="Baric R">R Baric</name></author><author><name sortKey="Cai, S X" uniqKey="Cai S">S X Cai</name></author><author><name sortKey="Frieman, M" uniqKey="Frieman M">M Frieman</name></author><author><name sortKey="Kumaki, Y" uniqKey="Kumaki Y">Y Kumaki</name></author><author><name sortKey="Morrey, J D" uniqKey="Morrey J">J D Morrey</name></author><author><name sortKey="Smee, D F" uniqKey="Smee D">D F Smee</name></author><author><name sortKey="Barnard, D L" uniqKey="Barnard D">D L Barnard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Albuquerque, N" uniqKey="De Albuquerque N">N De Albuquerque</name></author><author><name sortKey="Baig, E" uniqKey="Baig E">E Baig</name></author><author><name sortKey="Ma, X" uniqKey="Ma X">X Ma</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="He, W" uniqKey="He W">W He</name></author><author><name sortKey="Rowe, A" uniqKey="Rowe A">A Rowe</name></author><author><name sortKey="Habal, M" uniqKey="Habal M">M Habal</name></author><author><name sortKey="Liu, M" uniqKey="Liu M">M Liu</name></author><author><name sortKey="Shalev, I" uniqKey="Shalev I">I Shalev</name></author><author><name sortKey="Downey, G P" uniqKey="Downey G">G P Downey</name></author><author><name sortKey="Gorczynski, R" uniqKey="Gorczynski R">R Gorczynski</name></author><author><name sortKey="Butany, J" uniqKey="Butany J">J Butany</name></author><author><name sortKey="Leibowitz, J" uniqKey="Leibowitz J">J Leibowitz</name></author><author><name sortKey="Weiss, S R" uniqKey="Weiss S">S R Weiss</name></author><author><name sortKey="Mcgilvray, I D" uniqKey="Mcgilvray I">I D McGilvray</name></author><author><name sortKey="Phillips, M J" uniqKey="Phillips M">M J Phillips</name></author><author><name sortKey="Fish, E N" uniqKey="Fish E">E N Fish</name></author><author><name sortKey="Levy, G A" uniqKey="Levy G">G A Levy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Prescott, J" uniqKey="Prescott J">J Prescott</name></author><author><name sortKey="Baseler, L" uniqKey="Baseler L">L Baseler</name></author><author><name sortKey="Bushmaker, T" uniqKey="Bushmaker T">T Bushmaker</name></author><author><name sortKey="Thomas, T" uniqKey="Thomas T">T Thomas</name></author><author><name sortKey="Lackemeyer, M G" uniqKey="Lackemeyer M">M G Lackemeyer</name></author><author><name sortKey="Martellaro, C" uniqKey="Martellaro C">C Martellaro</name></author><author><name sortKey="Milne Price, S" uniqKey="Milne Price S">S Milne-Price</name></author><author><name sortKey="Haddock, E" uniqKey="Haddock E">E Haddock</name></author><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B L Haagmans</name></author><author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H Feldmann</name></author><author><name sortKey="Munster, V J" uniqKey="Munster V">V J Munster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dealbuquerque, N" uniqKey="Dealbuquerque N">N DeAlbuquerque</name></author><author><name sortKey="Baig, E" uniqKey="Baig E">E Baig</name></author><author><name sortKey="Xuezhong, M" uniqKey="Xuezhong M">M Xuezhong</name></author><author><name sortKey="Shalev, I" uniqKey="Shalev I">I Shalev</name></author><author><name sortKey="Phillips, M J" uniqKey="Phillips M">M J Phillips</name></author><author><name sortKey="Habal, M" uniqKey="Habal M">M Habal</name></author><author><name sortKey="Leibowitz, J" uniqKey="Leibowitz J">J Leibowitz</name></author><author><name sortKey="Mcgilvray, I" uniqKey="Mcgilvray I">I McGilvray</name></author><author><name sortKey="Butany, J" uniqKey="Butany J">J Butany</name></author><author><name sortKey="Fish, E" uniqKey="Fish E">E Fish</name></author><author><name sortKey="Levy, G" uniqKey="Levy G">G Levy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Devitt, E" uniqKey="Devitt E">E Devitt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Doyle, S" uniqKey="Doyle S">S Doyle</name></author><author><name sortKey="Vaidya, S" uniqKey="Vaidya S">S Vaidya</name></author><author><name sortKey="O Onnell, R" uniqKey="O Onnell R">R O’Connell</name></author><author><name sortKey="Dadgostar, H" uniqKey="Dadgostar H">H Dadgostar</name></author><author><name sortKey="Dempsey, P" uniqKey="Dempsey P">P Dempsey</name></author><author><name sortKey="Wu, T" uniqKey="Wu T">T Wu</name></author><author><name sortKey="Rao, G" uniqKey="Rao G">G Rao</name></author><author><name sortKey="Sun, R" uniqKey="Sun R">R Sun</name></author><author><name sortKey="Haberland, M" uniqKey="Haberland M">M Haberland</name></author><author><name sortKey="Modlin, R" uniqKey="Modlin R">R Modlin</name></author><author><name sortKey="Cheng, G" uniqKey="Cheng G">G Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S Gunther</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W Preiser</name></author><author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S van der Werf</name></author><author><name sortKey="Brodt, H R" uniqKey="Brodt H">H R Brodt</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S Becker</name></author><author><name sortKey="Rabenau, H" uniqKey="Rabenau H">H Rabenau</name></author><author><name sortKey="Panning, M" uniqKey="Panning M">M Panning</name></author><author><name sortKey="Kolesnikova, L" uniqKey="Kolesnikova L">L Kolesnikova</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R A Fouchier</name></author><author><name sortKey="Berger, A" uniqKey="Berger A">A Berger</name></author><author><name sortKey="Burguiere, A M" uniqKey="Burguiere A">A M Burguiere</name></author><author><name sortKey="Cinatl, J" uniqKey="Cinatl J">J Cinatl</name></author><author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M Eickmann</name></author><author><name sortKey="Escriou, N" uniqKey="Escriou N">N Escriou</name></author><author><name sortKey="Grywna, K" uniqKey="Grywna K">K Grywna</name></author><author><name sortKey="Kramme, S" uniqKey="Kramme S">S Kramme</name></author><author><name sortKey="Manuguerra, J C" uniqKey="Manuguerra J">J C Manuguerra</name></author><author><name sortKey="Muller, S" uniqKey="Muller S">S Muller</name></author><author><name sortKey="Rickerts, V" uniqKey="Rickerts V">V Rickerts</name></author><author><name sortKey="Sturmer, M" uniqKey="Sturmer M">M Sturmer</name></author><author><name sortKey="Vieth, S" uniqKey="Vieth S">S Vieth</name></author><author><name sortKey="Klenk, H D" uniqKey="Klenk H">H D Klenk</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A D Osterhaus</name></author><author><name sortKey="Schmitz, H" uniqKey="Schmitz H">H Schmitz</name></author><author><name sortKey="Doerr, H W" uniqKey="Doerr H">H W Doerr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Feldmann, F" uniqKey="Feldmann F">F Feldmann</name></author><author><name sortKey="Rasmussen, A L" uniqKey="Rasmussen A">A L Rasmussen</name></author><author><name sortKey="Okumura, A" uniqKey="Okumura A">A Okumura</name></author><author><name sortKey="Peng, X" uniqKey="Peng X">X Peng</name></author><author><name sortKey="Thomas, M J" uniqKey="Thomas M">M J Thomas</name></author><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name></author><author><name sortKey="Haddock, E" uniqKey="Haddock E">E Haddock</name></author><author><name sortKey="Nagy, L" uniqKey="Nagy L">L Nagy</name></author><author><name sortKey="Lacasse, R" uniqKey="Lacasse R">R LaCasse</name></author><author><name sortKey="Liu, T" uniqKey="Liu T">T Liu</name></author><author><name sortKey="Zhu, J" uniqKey="Zhu J">J Zhu</name></author><author><name sortKey="Mclellan, J S" uniqKey="Mclellan J">J S McLellan</name></author><author><name sortKey="Scott, D P" uniqKey="Scott D">D P Scott</name></author><author><name sortKey="Katze, M G" uniqKey="Katze M">M G Katze</name></author><author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H Feldmann</name></author><author><name sortKey="Munster, V J" uniqKey="Munster V">V J Munster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farrar, M A" uniqKey="Farrar M">M A Farrar</name></author><author><name sortKey="Schreiber, R D" uniqKey="Schreiber R">R D Schreiber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frieman, M" uniqKey="Frieman M">M Frieman</name></author><author><name sortKey="Yount, B" uniqKey="Yount B">B Yount</name></author><author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S Agnihothram</name></author><author><name sortKey="Page, C" uniqKey="Page C">C Page</name></author><author><name sortKey="Donaldson, E" uniqKey="Donaldson E">E Donaldson</name></author><author><name sortKey="Roberts, A" uniqKey="Roberts A">A Roberts</name></author><author><name sortKey="Vogel, L" uniqKey="Vogel L">L Vogel</name></author><author><name sortKey="Woodruff, B" uniqKey="Woodruff B">B Woodruff</name></author><author><name sortKey="Scorpio, D" uniqKey="Scorpio D">D Scorpio</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R S Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ge, X Y" uniqKey="Ge X">X Y Ge</name></author><author><name sortKey="Li, J L" uniqKey="Li J">J L Li</name></author><author><name sortKey="Yang, X L" uniqKey="Yang X">X L Yang</name></author><author><name sortKey="Chmura, A A" uniqKey="Chmura A">A A Chmura</name></author><author><name sortKey="Zhu, G" uniqKey="Zhu G">G Zhu</name></author><author><name sortKey="Epstein, J H" uniqKey="Epstein J">J H Epstein</name></author><author><name sortKey="Mazet, J K" uniqKey="Mazet J">J K Mazet</name></author><author><name sortKey="Hu, B" uniqKey="Hu B">B Hu</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Peng, C" uniqKey="Peng C">C Peng</name></author><author><name sortKey="Zhang, Y J" uniqKey="Zhang Y">Y J Zhang</name></author><author><name sortKey="Luo, C M" uniqKey="Luo C">C M Luo</name></author><author><name sortKey="Tan, B" uniqKey="Tan B">B Tan</name></author><author><name sortKey="Wang, N" uniqKey="Wang N">N Wang</name></author><author><name sortKey="Zhu, Y" uniqKey="Zhu Y">Y Zhu</name></author><author><name sortKey="Crameri, G" uniqKey="Crameri G">G Crameri</name></author><author><name sortKey="Zhang, S Y" uniqKey="Zhang S">S Y Zhang</name></author><author><name sortKey="Wang, L F" uniqKey="Wang L">L F Wang</name></author><author><name sortKey="Daszak, P" uniqKey="Daszak P">P Daszak</name></author><author><name sortKey="Shi, Z L" uniqKey="Shi Z">Z L Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Godfraind, C" uniqKey="Godfraind C">C Godfraind</name></author><author><name sortKey="Holmes, K V" uniqKey="Holmes K">K V Holmes</name></author><author><name sortKey="Coutelier, J P" uniqKey="Coutelier J">J P Coutelier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gombold, J L" uniqKey="Gombold J">J L Gombold</name></author><author><name sortKey="Hingley, S T" uniqKey="Hingley S">S T Hingley</name></author><author><name sortKey="Weiss, S R" uniqKey="Weiss S">S R Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graham, R L" uniqKey="Graham R">R L Graham</name></author><author><name sortKey="Donaldson, E F" uniqKey="Donaldson E">E F Donaldson</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R S Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, L" uniqKey="He L">L He</name></author><author><name sortKey="Ding, Y" uniqKey="Ding Y">Y Ding</name></author><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name></author><author><name sortKey="Che, X" uniqKey="Che X">X Che</name></author><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author><author><name sortKey="Shen, H" uniqKey="Shen H">H Shen</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name></author><author><name sortKey="Zhao, L" uniqKey="Zhao L">L Zhao</name></author><author><name sortKey="Geng, J" uniqKey="Geng J">J Geng</name></author><author><name sortKey="Deng, Y" uniqKey="Deng Y">Y Deng</name></author><author><name sortKey="Yang, L" uniqKey="Yang L">L Yang</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Cai, J" uniqKey="Cai J">J Cai</name></author><author><name sortKey="Qiu, L" uniqKey="Qiu L">L Qiu</name></author><author><name sortKey="Wen, K" uniqKey="Wen K">K Wen</name></author><author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hemmila, E" uniqKey="Hemmila E">E Hemmila</name></author><author><name sortKey="Turbide, C" uniqKey="Turbide C">C Turbide</name></author><author><name sortKey="Olson, M" uniqKey="Olson M">M Olson</name></author><author><name sortKey="Jothy, S" uniqKey="Jothy S">S Jothy</name></author><author><name sortKey="Holmes, K V" uniqKey="Holmes K">K V Holmes</name></author><author><name sortKey="Beauchemin, N" uniqKey="Beauchemin N">N Beauchemin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, K J" uniqKey="Huang K">K J Huang</name></author><author><name sortKey="Su, I J" uniqKey="Su I">I J Su</name></author><author><name sortKey="Theron, M" uniqKey="Theron M">M Theron</name></author><author><name sortKey="Wu, Y C" uniqKey="Wu Y">Y C Wu</name></author><author><name sortKey="Lai, S K" uniqKey="Lai S">S K Lai</name></author><author><name sortKey="Liu, C C" uniqKey="Liu C">C C Liu</name></author><author><name sortKey="Lei, H Y" uniqKey="Lei H">H Y Lei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y Jiang</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author><author><name sortKey="Zhou, C" uniqKey="Zhou C">C Zhou</name></author><author><name sortKey="Wu, Z" uniqKey="Wu Z">Z Wu</name></author><author><name sortKey="Zhong, S" uniqKey="Zhong S">S Zhong</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Luo, W" uniqKey="Luo W">W Luo</name></author><author><name sortKey="Chen, T" uniqKey="Chen T">T Chen</name></author><author><name sortKey="Qin, Q" uniqKey="Qin Q">Q Qin</name></author><author><name sortKey="Deng, P" uniqKey="Deng P">P Deng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, J C" uniqKey="Kim J">J C Kim</name></author><author><name sortKey="Spence, R A" uniqKey="Spence R">R A Spence</name></author><author><name sortKey="Currier, P F" uniqKey="Currier P">P F Currier</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name></author><author><name sortKey="Denison, M R" uniqKey="Denison M">M R Denison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, K D" uniqKey="Kim K">K D Kim</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Auh, S" uniqKey="Auh S">S Auh</name></author><author><name sortKey="Yang, X" uniqKey="Yang X">X Yang</name></author><author><name sortKey="Du, P" uniqKey="Du P">P Du</name></author><author><name sortKey="Tang, H" uniqKey="Tang H">H Tang</name></author><author><name sortKey="Fu, Y X" uniqKey="Fu Y">Y X Fu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ksiazek, T G" uniqKey="Ksiazek T">T G Ksiazek</name></author><author><name sortKey="Erdman, D" uniqKey="Erdman D">D Erdman</name></author><author><name sortKey="Goldsmith, C S" uniqKey="Goldsmith C">C S Goldsmith</name></author><author><name sortKey="Zaki, S R" uniqKey="Zaki S">S R Zaki</name></author><author><name sortKey="Peret, T" uniqKey="Peret T">T Peret</name></author><author><name sortKey="Emery, S" uniqKey="Emery S">S Emery</name></author><author><name sortKey="Tong, S" uniqKey="Tong S">S Tong</name></author><author><name sortKey="Urbani, C" uniqKey="Urbani C">C Urbani</name></author><author><name sortKey="Comer, J A" uniqKey="Comer J">J A Comer</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name></author><author><name sortKey="Rollin, P E" uniqKey="Rollin P">P E Rollin</name></author><author><name sortKey="Dowell, S F" uniqKey="Dowell S">S F Dowell</name></author><author><name sortKey="Ling, A E" uniqKey="Ling A">A E Ling</name></author><author><name sortKey="Humphrey, C D" uniqKey="Humphrey C">C D Humphrey</name></author><author><name sortKey="Shieh, W J" uniqKey="Shieh W">W J Shieh</name></author><author><name sortKey="Guarner, J" uniqKey="Guarner J">J Guarner</name></author><author><name sortKey="Paddock, C D" uniqKey="Paddock C">C D Paddock</name></author><author><name sortKey="Rota, P" uniqKey="Rota P">P Rota</name></author><author><name sortKey="Fields, B" uniqKey="Fields B">B Fields</name></author><author><name sortKey="Derisi, J" uniqKey="Derisi J">J DeRisi</name></author><author><name sortKey="Yang, J Y" uniqKey="Yang J">J Y Yang</name></author><author><name sortKey="Cox, N" uniqKey="Cox N">N Cox</name></author><author><name sortKey="Hughes, J M" uniqKey="Hughes J">J M Hughes</name></author><author><name sortKey="Leduc, J W" uniqKey="Leduc J">J W LeDuc</name></author><author><name sortKey="Bellini, W J" uniqKey="Bellini W">W J Bellini</name></author><author><name sortKey="Anderson, L J" uniqKey="Anderson L">L J Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, S K" uniqKey="Lau S">S K Lau</name></author><author><name sortKey="Lau, C C" uniqKey="Lau C">C C Lau</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K H Chan</name></author><author><name sortKey="Li, C P" uniqKey="Li C">C P Li</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Jin, D Y" uniqKey="Jin D">D Y Jin</name></author><author><name sortKey="Chan, J F" uniqKey="Chan J">J F Chan</name></author><author><name sortKey="Woo, P C" uniqKey="Woo P">P C Woo</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K Y Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, S K" uniqKey="Lau S">S K Lau</name></author><author><name sortKey="Woo, P C" uniqKey="Woo P">P C Woo</name></author><author><name sortKey="Li, K S" uniqKey="Li K">K S Li</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name></author><author><name sortKey="Tsoi, H W" uniqKey="Tsoi H">H W Tsoi</name></author><author><name sortKey="Wong, B H" uniqKey="Wong B">B H Wong</name></author><author><name sortKey="Wong, S S" uniqKey="Wong S">S S Wong</name></author><author><name sortKey="Leung, S Y" uniqKey="Leung S">S Y Leung</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K H Chan</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K Y Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lavi, E" uniqKey="Lavi E">E Lavi</name></author><author><name sortKey="Gilden, D H" uniqKey="Gilden D">D H Gilden</name></author><author><name sortKey="Highkin, M K" uniqKey="Highkin M">M K Highkin</name></author><author><name sortKey="Weiss, S R" uniqKey="Weiss S">S R Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lavi, E" uniqKey="Lavi E">E Lavi</name></author><author><name sortKey="Gilden, D H" uniqKey="Gilden D">D H Gilden</name></author><author><name sortKey="Wroblewska, Z" uniqKey="Wroblewska Z">Z Wroblewska</name></author><author><name sortKey="Rorke, L B" uniqKey="Rorke L">L B Rorke</name></author><author><name sortKey="Weiss, S R" uniqKey="Weiss S">S R Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leibowitz, J L" uniqKey="Leibowitz J">J L Leibowitz</name></author><author><name sortKey="Srinivasa, R" uniqKey="Srinivasa R">R Srinivasa</name></author><author><name sortKey="Williamson, S T" uniqKey="Williamson S">S T Williamson</name></author><author><name sortKey="Chua, M M" uniqKey="Chua M">M M Chua</name></author><author><name sortKey="Liu, M" uniqKey="Liu M">M Liu</name></author><author><name sortKey="Wu, S" uniqKey="Wu S">S Wu</name></author><author><name sortKey="Kang, H" uniqKey="Kang H">H Kang</name></author><author><name sortKey="Ma, X Z" uniqKey="Ma X">X Z Ma</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Shalev, I" uniqKey="Shalev I">I Shalev</name></author><author><name sortKey="Smith, R" uniqKey="Smith R">R Smith</name></author><author><name sortKey="Phillips, M J" uniqKey="Phillips M">M J Phillips</name></author><author><name sortKey="Levy, G A" uniqKey="Levy G">G A Levy</name></author><author><name sortKey="Weiss, S R" uniqKey="Weiss S">S R Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Shi, Z" uniqKey="Shi Z">Z Shi</name></author><author><name sortKey="Yu, M" uniqKey="Yu M">M Yu</name></author><author><name sortKey="Ren, W" uniqKey="Ren W">W Ren</name></author><author><name sortKey="Smith, C" uniqKey="Smith C">C Smith</name></author><author><name sortKey="Epstein, J H" uniqKey="Epstein J">J H Epstein</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Crameri, G" uniqKey="Crameri G">G Crameri</name></author><author><name sortKey="Hu, Z" uniqKey="Hu Z">Z Hu</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Mceachern, J" uniqKey="Mceachern J">J McEachern</name></author><author><name sortKey="Field, H" uniqKey="Field H">H Field</name></author><author><name sortKey="Daszak, P" uniqKey="Daszak P">P Daszak</name></author><author><name sortKey="Eaton, B T" uniqKey="Eaton B">B T Eaton</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Wang, L F" uniqKey="Wang L">L F Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loetscher, M" uniqKey="Loetscher M">M Loetscher</name></author><author><name sortKey="Gerber, B" uniqKey="Gerber B">B Gerber</name></author><author><name sortKey="Loetscher, P" uniqKey="Loetscher P">P Loetscher</name></author><author><name sortKey="Jones, S A" uniqKey="Jones S">S A Jones</name></author><author><name sortKey="Piali, L" uniqKey="Piali L">L Piali</name></author><author><name sortKey="Clark Lewis, I" uniqKey="Clark Lewis I">I Clark-Lewis</name></author><author><name sortKey="Baggiolini, M" uniqKey="Baggiolini M">M Baggiolini</name></author><author><name sortKey="Moser, B" uniqKey="Moser B">B Moser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ma, X Z" uniqKey="Ma X">X Z Ma</name></author><author><name sortKey="Bartczak, A" uniqKey="Bartczak A">A Bartczak</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Khattar, R" uniqKey="Khattar R">R Khattar</name></author><author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name></author><author><name sortKey="Liu, M F" uniqKey="Liu M">M F Liu</name></author><author><name sortKey="Edwards, A" uniqKey="Edwards A">A Edwards</name></author><author><name sortKey="Levy, G" uniqKey="Levy G">G Levy</name></author><author><name sortKey="Mcgilvray, I D" uniqKey="Mcgilvray I">I D McGilvray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marten, N W" uniqKey="Marten N">N W Marten</name></author><author><name sortKey="Stohlman, S A" uniqKey="Stohlman S">S A Stohlman</name></author><author><name sortKey="Bergmann, C C" uniqKey="Bergmann C">C C Bergmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccray, P B" uniqKey="Mccray P">P B McCray</name></author><author><name sortKey="Pewe, L" uniqKey="Pewe L">L Pewe</name></author><author><name sortKey="Wohlford Lenane, C" uniqKey="Wohlford Lenane C">C Wohlford-Lenane</name></author><author><name sortKey="Hickey, M" uniqKey="Hickey M">M Hickey</name></author><author><name sortKey="Manzel, L" uniqKey="Manzel L">L Manzel</name></author><author><name sortKey="Shi, L" uniqKey="Shi L">L Shi</name></author><author><name sortKey="Netland, J" uniqKey="Netland J">J Netland</name></author><author><name sortKey="Jia, H P" uniqKey="Jia H">H P Jia</name></author><author><name sortKey="Halabi, C" uniqKey="Halabi C">C Halabi</name></author><author><name sortKey="Sigmund, C D" uniqKey="Sigmund C">C D Sigmund</name></author><author><name sortKey="Meyerholz, D K" uniqKey="Meyerholz D">D K Meyerholz</name></author><author><name sortKey="Kirby, P" uniqKey="Kirby P">P Kirby</name></author><author><name sortKey="Look, D C" uniqKey="Look D">D C Look</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meduri, G U" uniqKey="Meduri G">G U Meduri</name></author><author><name sortKey="Kohler, G" uniqKey="Kohler G">G Kohler</name></author><author><name sortKey="Headley, S" uniqKey="Headley S">S Headley</name></author><author><name sortKey="Tolley, E" uniqKey="Tolley E">E Tolley</name></author><author><name sortKey="Stentz, F" uniqKey="Stentz F">F Stentz</name></author><author><name sortKey="Postlethwaite, A" uniqKey="Postlethwaite A">A Postlethwaite</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meduri, G U" uniqKey="Meduri G">G U Meduri</name></author><author><name sortKey="Headley, S" uniqKey="Headley S">S Headley</name></author><author><name sortKey="Kohler, G" uniqKey="Kohler G">G Kohler</name></author><author><name sortKey="Stentz, F" uniqKey="Stentz F">F Stentz</name></author><author><name sortKey="Tolley, E" uniqKey="Tolley E">E Tolley</name></author><author><name sortKey="Umberger, R" uniqKey="Umberger R">R Umberger</name></author><author><name sortKey="Leeper, K" uniqKey="Leeper K">K Leeper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Munster, V J" uniqKey="Munster V">V J Munster</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H Feldmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nicholls, J M" uniqKey="Nicholls J">J M Nicholls</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L L Poon</name></author><author><name sortKey="Lee, K C" uniqKey="Lee K">K C Lee</name></author><author><name sortKey="Ng, W F" uniqKey="Ng W">W F Ng</name></author><author><name sortKey="Lai, S T" uniqKey="Lai S">S T Lai</name></author><author><name sortKey="Leung, C Y" uniqKey="Leung C">C Y Leung</name></author><author><name sortKey="Chu, C M" uniqKey="Chu C">C M Chu</name></author><author><name sortKey="Hui, P K" uniqKey="Hui P">P K Hui</name></author><author><name sortKey="Mak, K L" uniqKey="Mak K">K L Mak</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name></author><author><name sortKey="Yan, K W" uniqKey="Yan K">K W Yan</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K H Chan</name></author><author><name sortKey="Tsang, N C" uniqKey="Tsang N">N C Tsang</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K Y Yuen</name></author><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J S Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A D Osterhaus</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R A Fouchier</name></author><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parra, B" uniqKey="Parra B">B Parra</name></author><author><name sortKey="Hinton, D R" uniqKey="Hinton D">D R Hinton</name></author><author><name sortKey="Marten, N W" uniqKey="Marten N">N W Marten</name></author><author><name sortKey="Bergmann, C C" uniqKey="Bergmann C">C C Bergmann</name></author><author><name sortKey="Lin, M T" uniqKey="Lin M">M T Lin</name></author><author><name sortKey="Yang, C S" uniqKey="Yang C">C S Yang</name></author><author><name sortKey="Stohlman, S A" uniqKey="Stohlman S">S A Stohlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J S Peiris</name></author><author><name sortKey="Lai, S T" uniqKey="Lai S">S T Lai</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L L Poon</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Yam, L Y" uniqKey="Yam L">L Y Yam</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name></author><author><name sortKey="Nicholls, J" uniqKey="Nicholls J">J Nicholls</name></author><author><name sortKey="Yee, W K" uniqKey="Yee W">W K Yee</name></author><author><name sortKey="Yan, W W" uniqKey="Yan W">W W Yan</name></author><author><name sortKey="Cheung, M T" uniqKey="Cheung M">M T Cheung</name></author><author><name sortKey="Cheng, V C" uniqKey="Cheng V">V C Cheng</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K H Chan</name></author><author><name sortKey="Tsang, D N" uniqKey="Tsang D">D N Tsang</name></author><author><name sortKey="Yung, R W" uniqKey="Yung R">R W Yung</name></author><author><name sortKey="Ng, T K" uniqKey="Ng T">T K Ng</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K Y Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reghunathan, R" uniqKey="Reghunathan R">R Reghunathan</name></author><author><name sortKey="Jayapal, M" uniqKey="Jayapal M">M Jayapal</name></author><author><name sortKey="Hsu, L Y" uniqKey="Hsu L">L Y Hsu</name></author><author><name sortKey="Chng, H H" uniqKey="Chng H">H H Chng</name></author><author><name sortKey="Tai, D" uniqKey="Tai D">D Tai</name></author><author><name sortKey="Leung, B P" uniqKey="Leung B">B P Leung</name></author><author><name sortKey="Melendez, A J" uniqKey="Melendez A">A J Melendez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts, A" uniqKey="Roberts A">A Roberts</name></author><author><name sortKey="Deming, D" uniqKey="Deming D">D Deming</name></author><author><name sortKey="Paddock, C D" uniqKey="Paddock C">C D Paddock</name></author><author><name sortKey="Cheng, A" uniqKey="Cheng A">A Cheng</name></author><author><name sortKey="Yount, B" uniqKey="Yount B">B Yount</name></author><author><name sortKey="Vogel, L" uniqKey="Vogel L">L Vogel</name></author><author><name sortKey="Herman, B D" uniqKey="Herman B">B D Herman</name></author><author><name sortKey="Sheahan, T" uniqKey="Sheahan T">T Sheahan</name></author><author><name sortKey="Heise, M" uniqKey="Heise M">M Heise</name></author><author><name sortKey="Genrich, G L" uniqKey="Genrich G">G L Genrich</name></author><author><name sortKey="Zaki, S R" uniqKey="Zaki S">S R Zaki</name></author><author><name sortKey="Baric, R" uniqKey="Baric R">R Baric</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruby, J" uniqKey="Ruby J">J Ruby</name></author><author><name sortKey="Ramshaw, I" uniqKey="Ramshaw I">I Ramshaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schaad, M C" uniqKey="Schaad M">M C Schaad</name></author><author><name sortKey="Stohlman, S A" uniqKey="Stohlman S">S A Stohlman</name></author><author><name sortKey="Egbert, J" uniqKey="Egbert J">J Egbert</name></author><author><name sortKey="Lum, K" uniqKey="Lum K">K Lum</name></author><author><name sortKey="Fu, K" uniqKey="Fu K">K Fu</name></author><author><name sortKey="Wei, T" uniqKey="Wei T">T Wei</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R S Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schijns, V E" uniqKey="Schijns V">V E Schijns</name></author><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B L Haagmans</name></author><author><name sortKey="Wierda, C M" uniqKey="Wierda C">C M Wierda</name></author><author><name sortKey="Kruithof, B" uniqKey="Kruithof B">B Kruithof</name></author><author><name sortKey="Heijnen, I A" uniqKey="Heijnen I">I A Heijnen</name></author><author><name sortKey="Alber, G" uniqKey="Alber G">G Alber</name></author><author><name sortKey="Horzinek, M C" uniqKey="Horzinek M">M C Horzinek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snijder, E J" uniqKey="Snijder E">E J Snijder</name></author><author><name sortKey="Bredenbeek, P J" uniqKey="Bredenbeek P">P J Bredenbeek</name></author><author><name sortKey="Dobbe, J C" uniqKey="Dobbe J">J C Dobbe</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name></author><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J Ziebuhr</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L L Poon</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Rozanov, M" uniqKey="Rozanov M">M Rozanov</name></author><author><name sortKey="Spaan, W J" uniqKey="Spaan W">W J Spaan</name></author><author><name sortKey="Gorbalenya, A E" uniqKey="Gorbalenya A">A E Gorbalenya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, G" uniqKey="Wang G">G Wang</name></author><author><name sortKey="Chen, G" uniqKey="Chen G">G Chen</name></author><author><name sortKey="Zheng, D" uniqKey="Zheng D">D Zheng</name></author><author><name sortKey="Cheng, G" uniqKey="Cheng G">G Cheng</name></author><author><name sortKey="Tang, H" uniqKey="Tang H">H Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ward, S E" uniqKey="Ward S">S E Ward</name></author><author><name sortKey="Loutfy, M R" uniqKey="Loutfy M">M R Loutfy</name></author><author><name sortKey="Blatt, L M" uniqKey="Blatt L">L M Blatt</name></author><author><name sortKey="Siminovitch, K A" uniqKey="Siminovitch K">K A Siminovitch</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Hinek, A" uniqKey="Hinek A">A Hinek</name></author><author><name sortKey="Wolff, B" uniqKey="Wolff B">B Wolff</name></author><author><name sortKey="Pham, D H" uniqKey="Pham D">D H Pham</name></author><author><name sortKey="Deif, H" uniqKey="Deif H">H Deif</name></author><author><name sortKey="Lamere, E A" uniqKey="Lamere E">E A LaMere</name></author><author><name sortKey="Kain, K C" uniqKey="Kain K">K C Kain</name></author><author><name sortKey="Farcas, G A" uniqKey="Farcas G">G A Farcas</name></author><author><name sortKey="Ferguson, P" uniqKey="Ferguson P">P Ferguson</name></author><author><name sortKey="Latchford, M" uniqKey="Latchford M">M Latchford</name></author><author><name sortKey="Levy, G" uniqKey="Levy G">G Levy</name></author><author><name sortKey="Fung, L" uniqKey="Fung L">L Fung</name></author><author><name sortKey="Dennis, J W" uniqKey="Dennis J">J W Dennis</name></author><author><name sortKey="Lai, E K" uniqKey="Lai E">E K Lai</name></author><author><name sortKey="Fish, E N" uniqKey="Fish E">E N Fish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weiss, S R" uniqKey="Weiss S">S R Weiss</name></author><author><name sortKey="Navas Martin, S" uniqKey="Navas Martin S">S Navas-Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A M Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, T M" uniqKey="Bestebroer T">T M Bestebroer</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A D Osterhaus</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R A Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Kim, K D" uniqKey="Kim K">K D Kim</name></author><author><name sortKey="Yang, X" uniqKey="Yang X">X Yang</name></author><author><name sortKey="Auh, S" uniqKey="Auh S">S Auh</name></author><author><name sortKey="Fu, Y X" uniqKey="Fu Y">Y X Fu</name></author><author><name sortKey="Tang, H" uniqKey="Tang H">H Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Li, K" uniqKey="Li K">K Li</name></author><author><name sortKey="Wohlford Lenane, C" uniqKey="Wohlford Lenane C">C Wohlford-Lenane</name></author><author><name sortKey="Agnihothram, S S" uniqKey="Agnihothram S">S S Agnihothram</name></author><author><name sortKey="Fett, C" uniqKey="Fett C">C Fett</name></author><author><name sortKey="Gale, M J" uniqKey="Gale M">M J Gale</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R S Baric</name></author><author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L Enjuanes</name></author><author><name sortKey="Gallagher, T" uniqKey="Gallagher T">T Gallagher</name></author><author><name sortKey="Mccray, P B" uniqKey="Mccray P">P B McCray</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, D" uniqKey="Zheng D">D Zheng</name></author><author><name sortKey="Chen, G" uniqKey="Chen G">G Chen</name></author><author><name sortKey="Guo, B" uniqKey="Guo B">B Guo</name></author><author><name sortKey="Cheng, G" uniqKey="Cheng G">G Cheng</name></author><author><name sortKey="Tang, H" uniqKey="Tang H">H Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author><author><name sortKey="Chu, H" uniqKey="Chu H">H Chu</name></author><author><name sortKey="Li, C" uniqKey="Li C">C Li</name></author><author><name sortKey="Wong, B H" uniqKey="Wong B">B H Wong</name></author><author><name sortKey="Cheng, Z S" uniqKey="Cheng Z">Z S Cheng</name></author><author><name sortKey="Poon, V K" uniqKey="Poon V">V K Poon</name></author><author><name sortKey="Sun, T" uniqKey="Sun T">T Sun</name></author><author><name sortKey="Lau, C C" uniqKey="Lau C">C C Lau</name></author><author><name sortKey="Wong, K K" uniqKey="Wong K">K K Wong</name></author><author><name sortKey="Chan, J Y" uniqKey="Chan J">J Y Chan</name></author><author><name sortKey="Chan, J F" uniqKey="Chan J">J F Chan</name></author><author><name sortKey="To, K K" uniqKey="To K">K K To</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K H Chan</name></author><author><name sortKey="Zheng, B J" uniqKey="Zheng B">B J Zheng</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K Y Yuen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Virol Sin</journal-id><journal-id journal-id-type="iso-abbrev">Virol Sin</journal-id><journal-title-group><journal-title>Virologica Sinica</journal-title></journal-title-group><issn pub-type="ppub">1674-0769</issn><issn pub-type="epub">1995-820X</issn><publisher><publisher-name>Wuhan Institute of Virology, CAS</publisher-name><publisher-loc>Heidelberg</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25547683</article-id><article-id pub-id-type="pmc">7090691</article-id><article-id pub-id-type="publisher-id">3530</article-id><article-id pub-id-type="doi">10.1007/s12250-014-3530-y</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Coronavirus MHV-A59 infects the lung and causes severe pneumonia in C57BL/6 mice</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Zhangsheng</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Du</surname><given-names>Jun</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Gang</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Jie</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Xuanming</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Su</surname><given-names>Lishan</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Cheng</surname><given-names>Genhong</given-names></name><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Tang</surname><given-names>Hong</given-names></name><address><phone>+86-27-87197727</phone><email>tanghong@moon.ibp.ac.cn</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.9227.e</institution-id><institution-id institution-id-type="ISNI">0000000119573309</institution-id><institution>Key Laboratory of Infection and Immunity (CASKLII), Institute of Biophysics,</institution><institution>Chinese Academy of Sciences,</institution></institution-wrap>15 Datun Road, Chaoyang District, Beijing, 100101 China</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.163032.5</institution-id><institution-id institution-id-type="ISNI">0000000417602008</institution-id><institution>Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology,</institution><institution>Shanxi University,</institution></institution-wrap>Taiyuan, 030006 China</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="GRID">grid.10698.36</institution-id><institution-id institution-id-type="ISNI">0000000122483208</institution-id><institution>Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center,</institution><institution>University of North Carolina at Chapel Hill School of Medicine,</institution></institution-wrap>Chapel Hill, NC 27599-7295 USA</aff><aff id="Aff4"><label>4</label><institution-wrap><institution-id institution-id-type="GRID">grid.19006.3e</institution-id><institution-id institution-id-type="ISNI">0000000096326718</institution-id><institution>Department of Microbiology, Immunology and Molecular Genetics,</institution><institution>University of California,</institution></institution-wrap>Los Angeles, CA 90095 USA</aff></contrib-group><pub-date pub-type="epub"><day>22</day><month>12</month><year>2014</year></pub-date><pub-date pub-type="collection"><month>12</month><year>2014</year></pub-date><volume>29</volume><issue>6</issue><fpage>393</fpage><lpage>402</lpage><history><date date-type="received"><day>2</day><month>11</month><year>2014</year></date><date date-type="accepted"><day>10</day><month>12</month><year>2014</year></date></history><permissions><copyright-statement>© Wuhan Institute of Virology, CAS and Springer-Verlag Berlin Heidelberg 2014</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><p>It remains challenging to develop animal models of lung infection and severe pneumonia by severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome cornavirus (MERS-CoV) without high level of containment. This inevitably hinders understanding of virushost interaction and development of appropriate countermeasures. Here we report that intranasal inoculation of sublethal doses of murine coronavirus mouse hepatitis virus A-59 (MHV-A59), a hepatic and neuronal tropic coronavirus, can induce acute pneumonia and severe lung injuries in C57BL/6 mice. Inflammatory leukocyte infiltrations, hemorrhages and fibrosis of alveolar walls can be observed 2–11 days after MHV-A59 infection. This pathological manifestation is associated with dramatical elevation of tissue IP-10 and IFN-γ and moderate increase of TNF-α and IL-1β, but inability of anti-viral type I interferon response. These results suggest that intranasal infection of MHV-A59 would serve as a surrogate mouse model of acute respiratory distress syndrome by SARS-CoV and MERS-CoV infections.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>coronavirus</kwd><kwd>MHV-A59</kwd><kwd>pneumonia</kwd><kwd>inflammation</kwd><kwd>cytokine</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Wuhan Institute of Virology, CAS and Springer-Verlag Berlin Heidelberg 2014</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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