Topological dynamics of the 2015 South Korea MERS-CoV spread-on-contact networks
Identifieur interne : 000465 ( Pmc/Curation ); précédent : 000464; suivant : 000466Topological dynamics of the 2015 South Korea MERS-CoV spread-on-contact networks
Auteurs : Chang Hoon Yang ; Hyejin JungSource :
- Scientific Reports [ 2045-2322 ] ; 2020.
Abstract
Network analysis to examine infectious contact relations provides an important means to uncover the topologies of individual infectious contact networks. This study aims to investigate the spread of diseases among individuals over contact networks by exploring the 2015 Middle East Respiratory Syndrome (MERS) outbreak in Korea. We present several distinct features of MERS transmission by employing a comprehensive approach in network research to examine both the traced relationship matrix of infected individuals and their bipartite transmission routes among healthcare facilities visited for treatment. The results indicate that a few super-spreaders were more likely to hold certain structural advantages by linking to an exceptional number of other individuals, causing several ongoing transmission events in neighbourhoods without the aid of any intermediary. Thus, the infectious contact network exhibited small-world dynamics characterised by locally clustered contacts exposed to transmission paths via short path lengths. In addition, nosocomial infection analysis shows the pattern of a common-source outbreak followed by secondary person-to-person transmission of the disease. Based on the results, we suggest policy implications related to the redesign of prevention and control strategies against the spread of epidemics.
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DOI: 10.1038/s41598-020-61133-9
PubMed: 32152361
PubMed Central: 7062829
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Chang Hoon Yang<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0470 5702</institution-id><institution-id institution-id-type="GRID">grid.411199.5</institution-id><institution>Catholic Kwandong University 24,</institution></institution-wrap>Beomil-ro 579beon-gil, Gangneung-si, Gangwon-do 25601 Korea</nlm:aff><wicri:noCountry code="subfield">Gangwon-do 25601 Korea</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0719 8572</institution-id><institution-id institution-id-type="GRID">grid.262229.f</institution-id><institution>Pusan National University 2,</institution></institution-wrap>Busandaehak-ro 63beon-gil, Geumjeong-gu, Busan 46241 Korea</nlm:aff><wicri:noCountry code="subfield">Busan 46241 Korea</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Topological dynamics of the 2015 South Korea MERS-CoV spread-on-contact networks</title><author><name sortKey="Yang, Chang Hoon" sort="Yang, Chang Hoon" uniqKey="Yang C" first="Chang Hoon" last="Yang">Chang Hoon Yang</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0470 5702</institution-id><institution-id institution-id-type="GRID">grid.411199.5</institution-id><institution>Catholic Kwandong University 24,</institution></institution-wrap>Beomil-ro 579beon-gil, Gangneung-si, Gangwon-do 25601 Korea</nlm:aff><wicri:noCountry code="subfield">Gangwon-do 25601 Korea</wicri:noCountry></affiliation></author><author><name sortKey="Jung, Hyejin" sort="Jung, Hyejin" uniqKey="Jung H" first="Hyejin" last="Jung">Hyejin Jung</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0719 8572</institution-id><institution-id institution-id-type="GRID">grid.262229.f</institution-id><institution>Pusan National University 2,</institution></institution-wrap>Busandaehak-ro 63beon-gil, Geumjeong-gu, Busan 46241 Korea</nlm:aff><wicri:noCountry code="subfield">Busan 46241 Korea</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32152361</idno><idno type="pmc">7062829</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062829</idno><idno type="RBID">PMC:7062829</idno><idno type="doi">10.1038/s41598-020-61133-9</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000465</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000465</idno><idno type="wicri:Area/Pmc/Curation">000465</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000465</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Topological dynamics of the 2015 South Korea MERS-CoV spread-on-contact networks</title><author><name sortKey="Yang, Chang Hoon" sort="Yang, Chang Hoon" uniqKey="Yang C" first="Chang Hoon" last="Yang">Chang Hoon Yang</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0470 5702</institution-id><institution-id institution-id-type="GRID">grid.411199.5</institution-id><institution>Catholic Kwandong University 24,</institution></institution-wrap>Beomil-ro 579beon-gil, Gangneung-si, Gangwon-do 25601 Korea</nlm:aff><wicri:noCountry code="subfield">Gangwon-do 25601 Korea</wicri:noCountry></affiliation></author><author><name sortKey="Jung, Hyejin" sort="Jung, Hyejin" uniqKey="Jung H" first="Hyejin" last="Jung">Hyejin Jung</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0719 8572</institution-id><institution-id institution-id-type="GRID">grid.262229.f</institution-id><institution>Pusan National University 2,</institution></institution-wrap>Busandaehak-ro 63beon-gil, Geumjeong-gu, Busan 46241 Korea</nlm:aff><wicri:noCountry code="subfield">Busan 46241 Korea</wicri:noCountry></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Network analysis to examine infectious contact relations provides an important means to uncover the topologies of individual infectious contact networks. This study aims to investigate the spread of diseases among individuals over contact networks by exploring the 2015 Middle East Respiratory Syndrome (MERS) outbreak in Korea. We present several distinct features of MERS transmission by employing a comprehensive approach in network research to examine both the traced relationship matrix of infected individuals and their bipartite transmission routes among healthcare facilities visited for treatment. The results indicate that a few super-spreaders were more likely to hold certain structural advantages by linking to an exceptional number of other individuals, causing several ongoing transmission events in neighbourhoods without the aid of any intermediary. Thus, the infectious contact network exhibited small-world dynamics characterised by locally clustered contacts exposed to transmission paths via short path lengths. In addition, nosocomial infection analysis shows the pattern of a common-source outbreak followed by secondary person-to-person transmission of the disease. Based on the results, we suggest policy implications related to the redesign of prevention and control strategies against the spread of epidemics.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bansal, S" uniqKey="Bansal S">S Bansal</name></author><author><name sortKey="Read, J" uniqKey="Read J">J Read</name></author><author><name sortKey="Pourbohloul, B" uniqKey="Pourbohloul B">B Pourbohloul</name></author><author><name sortKey="Meyers, La" uniqKey="Meyers L">LA Meyers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rolls, Da" uniqKey="Rolls D">DA Rolls</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Hertzberg, Vs" uniqKey="Hertzberg V">VS Hertzberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Watts, Dj" uniqKey="Watts D">DJ Watts</name></author><author><name sortKey="Strogatz, Sh" 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Sci Rep</journal-id><journal-id journal-id-type="iso-abbrev">Sci Rep</journal-id><journal-title-group><journal-title>Scientific Reports</journal-title></journal-title-group><issn pub-type="epub">2045-2322</issn><publisher><publisher-name>Nature Publishing Group UK</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32152361</article-id><article-id pub-id-type="pmc">7062829</article-id><article-id pub-id-type="publisher-id">61133</article-id><article-id pub-id-type="doi">10.1038/s41598-020-61133-9</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Topological dynamics of the 2015 South Korea MERS-CoV spread-on-contact networks</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Chang Hoon</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Jung</surname><given-names>Hyejin</given-names></name><address><email>hjung@pusan.ac.kr</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0470 5702</institution-id><institution-id institution-id-type="GRID">grid.411199.5</institution-id><institution>Catholic Kwandong University 24,</institution></institution-wrap>Beomil-ro 579beon-gil, Gangneung-si, Gangwon-do 25601 Korea</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0719 8572</institution-id><institution-id institution-id-type="GRID">grid.262229.f</institution-id><institution>Pusan National University 2,</institution></institution-wrap>Busandaehak-ro 63beon-gil, Geumjeong-gu, Busan 46241 Korea</aff></contrib-group><pub-date pub-type="epub"><day>9</day><month>3</month><year>2020</year></pub-date><pub-date pub-type="pmc-release"><day>9</day><month>3</month><year>2020</year></pub-date><pub-date pub-type="collection"><year>2020</year></pub-date><volume>10</volume><elocation-id>4327</elocation-id><history><date date-type="received"><day>21</day><month>11</month><year>2019</year></date><date date-type="accepted"><day>22</day><month>2</month><year>2020</year></date></history><permissions><copyright-statement>© The Author(s) 2020</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold> This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>.</license-p></license></permissions><abstract id="Abs1"><p id="Par1">Network analysis to examine infectious contact relations provides an important means to uncover the topologies of individual infectious contact networks. This study aims to investigate the spread of diseases among individuals over contact networks by exploring the 2015 Middle East Respiratory Syndrome (MERS) outbreak in Korea. We present several distinct features of MERS transmission by employing a comprehensive approach in network research to examine both the traced relationship matrix of infected individuals and their bipartite transmission routes among healthcare facilities visited for treatment. The results indicate that a few super-spreaders were more likely to hold certain structural advantages by linking to an exceptional number of other individuals, causing several ongoing transmission events in neighbourhoods without the aid of any intermediary. Thus, the infectious contact network exhibited small-world dynamics characterised by locally clustered contacts exposed to transmission paths via short path lengths. In addition, nosocomial infection analysis shows the pattern of a common-source outbreak followed by secondary person-to-person transmission of the disease. Based on the results, we suggest policy implications related to the redesign of prevention and control strategies against the spread of epidemics.</p></abstract><kwd-group kwd-group-type="npg-subject"><title>Subject terms</title><kwd>Infectious diseases</kwd><kwd>Health care</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2020</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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