Impact of Comorbidity on Fatality Rate of Patients with Middle East Respiratory Syndrome
Identifieur interne : 000446 ( Pmc/Curation ); précédent : 000445; suivant : 000447Impact of Comorbidity on Fatality Rate of Patients with Middle East Respiratory Syndrome
Auteurs : Ya-Min Yang [Taïwan] ; Chen-Yang Hsu [Taïwan] ; Chao-Chih Lai [Taïwan] ; Ming-Fang Yen [Taïwan] ; Paul S. Wikramaratna [Royaume-Uni] ; Hsiu-Hsi Chen [Taïwan] ; Tsung-Hsi Wang [Taïwan]Source :
- Scientific Reports [ 2045-2322 ] ; 2017.
Abstract
To date, 1841 cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection have been reported worldwide, with 652 deaths. We used a publically available case line list to explore the effect of relevant factors, notably underlying comorbidities, on fatal outcome of Middle East respiratory syndrome (MERS) cases up to the end of October 2016. A Bayesian Weibull proportional hazards regression model was used to assess the effect of comorbidity, age, epidemic period and sex on the fatality rate of MERS cases and its variation across countries. The crude fatality rate of MERS cases was 32.1% (95% credibility interval (CI): 29.9%, 34.3%). Notably, the incremental change of daily death rate was most prominent during the first week since disease onset with an average increase of 13%, but then stabilized in the remaining two weeks when it only increased 3% on average. Neither sex, nor country of infection were found to have a significant impact on fatality rates after taking into account the age and comorbidity status of patients. After adjusting for age, epidemic period, MERS patients with comorbidity had around 4 times the risk for fatal infection than those without (adjusted hazard ratio of 3.74 (95% CI: 2.57, 5.67)).
Url:
DOI: 10.1038/s41598-017-10402-1
PubMed: 28900101
PubMed Central: 5596001
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000446
Links to Exploration step
PMC:5596001Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impact of Comorbidity on Fatality Rate of Patients with Middle East Respiratory Syndrome</title><author><name sortKey="Yang, Ya Min" sort="Yang, Ya Min" uniqKey="Yang Y" first="Ya-Min" last="Yang">Ya-Min Yang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0546 0241</institution-id><institution-id institution-id-type="GRID">grid.19188.39</institution-id><institution>Division of Biostatistics,</institution><institution>College of Public Health, National Taiwan University,</institution></institution-wrap>Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Hsu, Chen Yang" sort="Hsu, Chen Yang" uniqKey="Hsu C" first="Chen-Yang" last="Hsu">Chen-Yang Hsu</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0546 0241</institution-id><institution-id institution-id-type="GRID">grid.19188.39</institution-id><institution>Division of Biostatistics,</institution><institution>College of Public Health, National Taiwan University,</institution></institution-wrap>Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Lai, Chao Chih" sort="Lai, Chao Chih" uniqKey="Lai C" first="Chao-Chih" last="Lai">Chao-Chih Lai</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Emergency Department, Taipei City Hospital, Ren-Ai Branch, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Emergency Department, Taipei City Hospital, Ren-Ai Branch, Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Yen, Ming Fang" sort="Yen, Ming Fang" uniqKey="Yen M" first="Ming-Fang" last="Yen">Ming-Fang Yen</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9337 0481</institution-id><institution-id institution-id-type="GRID">grid.412896.0</institution-id><institution>School of Oral Hygiene,</institution><institution>College of Oral Medicine, Taipei Medical University,</institution></institution-wrap>Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Wikramaratna, Paul S" sort="Wikramaratna, Paul S" uniqKey="Wikramaratna P" first="Paul S." last="Wikramaratna">Paul S. Wikramaratna</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id><institution-id institution-id-type="GRID">grid.4305.2</institution-id><institution>Institute of Evolutionary Biology,</institution><institution>University of Edinburgh,</institution></institution-wrap>Edinburgh, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Hsiu Hsi" sort="Chen, Hsiu Hsi" uniqKey="Chen H" first="Hsiu-Hsi" last="Chen">Hsiu-Hsi Chen</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0546 0241</institution-id><institution-id institution-id-type="GRID">grid.19188.39</institution-id><institution>Division of Biostatistics,</institution><institution>College of Public Health, National Taiwan University,</institution></institution-wrap>Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Tsung Hsi" sort="Wang, Tsung Hsi" uniqKey="Wang T" first="Tsung-Hsi" last="Wang">Tsung-Hsi Wang</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.454740.6</institution-id><institution>Ministry of Health and Welfare,</institution></institution-wrap>Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0425 5914</institution-id><institution-id institution-id-type="GRID">grid.260770.4</institution-id><institution>School of Medicine, National Yangming University,</institution></institution-wrap>Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28900101</idno><idno type="pmc">5596001</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596001</idno><idno type="RBID">PMC:5596001</idno><idno type="doi">10.1038/s41598-017-10402-1</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000446</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000446</idno><idno type="wicri:Area/Pmc/Curation">000446</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000446</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Impact of Comorbidity on Fatality Rate of Patients with Middle East Respiratory Syndrome</title><author><name sortKey="Yang, Ya Min" sort="Yang, Ya Min" uniqKey="Yang Y" first="Ya-Min" last="Yang">Ya-Min Yang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0546 0241</institution-id><institution-id institution-id-type="GRID">grid.19188.39</institution-id><institution>Division of Biostatistics,</institution><institution>College of Public Health, National Taiwan University,</institution></institution-wrap>Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Hsu, Chen Yang" sort="Hsu, Chen Yang" uniqKey="Hsu C" first="Chen-Yang" last="Hsu">Chen-Yang Hsu</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0546 0241</institution-id><institution-id institution-id-type="GRID">grid.19188.39</institution-id><institution>Division of Biostatistics,</institution><institution>College of Public Health, National Taiwan University,</institution></institution-wrap>Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Lai, Chao Chih" sort="Lai, Chao Chih" uniqKey="Lai C" first="Chao-Chih" last="Lai">Chao-Chih Lai</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Emergency Department, Taipei City Hospital, Ren-Ai Branch, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Emergency Department, Taipei City Hospital, Ren-Ai Branch, Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Yen, Ming Fang" sort="Yen, Ming Fang" uniqKey="Yen M" first="Ming-Fang" last="Yen">Ming-Fang Yen</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9337 0481</institution-id><institution-id institution-id-type="GRID">grid.412896.0</institution-id><institution>School of Oral Hygiene,</institution><institution>College of Oral Medicine, Taipei Medical University,</institution></institution-wrap>Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Wikramaratna, Paul S" sort="Wikramaratna, Paul S" uniqKey="Wikramaratna P" first="Paul S." last="Wikramaratna">Paul S. Wikramaratna</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id><institution-id institution-id-type="GRID">grid.4305.2</institution-id><institution>Institute of Evolutionary Biology,</institution><institution>University of Edinburgh,</institution></institution-wrap>Edinburgh, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Hsiu Hsi" sort="Chen, Hsiu Hsi" uniqKey="Chen H" first="Hsiu-Hsi" last="Chen">Hsiu-Hsi Chen</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0546 0241</institution-id><institution-id institution-id-type="GRID">grid.19188.39</institution-id><institution>Division of Biostatistics,</institution><institution>College of Public Health, National Taiwan University,</institution></institution-wrap>Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Tsung Hsi" sort="Wang, Tsung Hsi" uniqKey="Wang T" first="Tsung-Hsi" last="Wang">Tsung-Hsi Wang</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.454740.6</institution-id><institution>Ministry of Health and Welfare,</institution></institution-wrap>Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0425 5914</institution-id><institution-id institution-id-type="GRID">grid.260770.4</institution-id><institution>School of Medicine, National Yangming University,</institution></institution-wrap>Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">To date, 1841 cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection have been reported worldwide, with 652 deaths. We used a publically available case line list to explore the effect of relevant factors, notably underlying comorbidities, on fatal outcome of Middle East respiratory syndrome (MERS) cases up to the end of October 2016. A Bayesian Weibull proportional hazards regression model was used to assess the effect of comorbidity, age, epidemic period and sex on the fatality rate of MERS cases and its variation across countries. The crude fatality rate of MERS cases was 32.1% (95% credibility interval (CI): 29.9%, 34.3%). Notably, the incremental change of daily death rate was most prominent during the first week since disease onset with an average increase of 13%, but then stabilized in the remaining two weeks when it only increased 3% on average. Neither sex, nor country of infection were found to have a significant impact on fatality rates after taking into account the age and comorbidity status of patients. After adjusting for age, epidemic period, MERS patients with comorbidity had around 4 times the risk for fatal infection than those without (adjusted hazard ratio of 3.74 (95% CI: 2.57, 5.67)).</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author><author><name sortKey="Zumla, Ai" uniqKey="Zumla A">AI Zumla</name></author><author><name sortKey="Al Hakeem, Rf" uniqKey="Al Hakeem R">RF Al-Hakeem</name></author><author><name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al-Rabeeah</name></author><author><name sortKey="Stephens, Gm" uniqKey="Stephens G">GM Stephens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Omrani, As" uniqKey="Omrani A">AS Omrani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guery, B" uniqKey="Guery B">B Guery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Breban, R" uniqKey="Breban R">R Breban</name></author><author><name sortKey="Riou, J" uniqKey="Riou J">J Riou</name></author><author><name sortKey="Fontanet, A" uniqKey="Fontanet A">A Fontanet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author><author><name sortKey="Zumla, A" uniqKey="Zumla A">A Zumla</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Cauchemez, S" uniqKey="Cauchemez S">S Cauchemez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cotten, M" uniqKey="Cotten M">M Cotten</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Zumla, A" uniqKey="Zumla A">A Zumla</name></author><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Hy" uniqKey="Park H">HY Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Twu, Sj" uniqKey="Twu S">SJ Twu</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Rivers, Cm" uniqKey="Rivers C">CM Rivers</name></author><author><name sortKey="Majumder, Ms" uniqKey="Majumder M">MS Majumder</name></author><author><name sortKey="Lofgren, Et" uniqKey="Lofgren E">ET Lofgren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lessler, J" uniqKey="Lessler J">J Lessler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghani, Ac" uniqKey="Ghani A">AC Ghani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, J" uniqKey="Chan J">J Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mizumoto, K" uniqKey="Mizumoto K">K Mizumoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cowling, Bj" uniqKey="Cowling B">BJ Cowling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lefebvre, A" uniqKey="Lefebvre A">A Lefebvre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohd, Ha" uniqKey="Mohd H">HA Mohd</name></author><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author><author><name sortKey="Chughtai, Aa" uniqKey="Chughtai A">AA Chughtai</name></author><author><name sortKey="Dyda, A" uniqKey="Dyda A">A Dyda</name></author><author><name sortKey="Macintyre, Cr" uniqKey="Macintyre C">CR MacIntyre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fiore, Ae" uniqKey="Fiore A">AE Fiore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moni, Ma" uniqKey="Moni M">MA Moni</name></author><author><name sortKey="Lio, P" uniqKey="Lio P">P Lio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bermejo Martin, Jf" uniqKey="Bermejo Martin J">JF Bermejo-Martin</name></author><author><name sortKey="Almansa, R" uniqKey="Almansa R">R Almansa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marais, Bj" uniqKey="Marais B">BJ Marais</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, J" uniqKey="Park J">J Park</name></author><author><name sortKey="Lee, Ds" uniqKey="Lee D">DS Lee</name></author><author><name sortKey="Christakis, Na" uniqKey="Christakis N">NA Christakis</name></author><author><name sortKey="Barabasi, Al" uniqKey="Barabasi A">AL Barabasi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Royston, P" uniqKey="Royston P">P Royston</name></author><author><name sortKey="Parmar, Mk" uniqKey="Parmar M">MK Parmar</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Reuss, A" uniqKey="Reuss A">A Reuss</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Gulland, A" uniqKey="Gulland A">A Gulland</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Vaida, F" uniqKey="Vaida F">F Vaida</name></author><author><name sortKey="Xu, R" uniqKey="Xu R">R Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lunn, Dj" uniqKey="Lunn D">DJ Lunn</name></author><author><name sortKey="Thomas, A" uniqKey="Thomas A">A Thomas</name></author><author><name sortKey="Best, N" uniqKey="Best N">N Best</name></author><author><name sortKey="Spiegelhalter, D" uniqKey="Spiegelhalter D">D Spiegelhalter</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Sci Rep</journal-id><journal-id journal-id-type="iso-abbrev">Sci Rep</journal-id><journal-title-group><journal-title>Scientific Reports</journal-title></journal-title-group><issn pub-type="epub">2045-2322</issn><publisher><publisher-name>Nature Publishing Group UK</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28900101</article-id><article-id pub-id-type="pmc">5596001</article-id><article-id pub-id-type="publisher-id">10402</article-id><article-id pub-id-type="doi">10.1038/s41598-017-10402-1</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Impact of Comorbidity on Fatality Rate of Patients with Middle East Respiratory Syndrome</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Ya-Min</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hsu</surname><given-names>Chen-Yang</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Lai</surname><given-names>Chao-Chih</given-names></name><address><email>Chaochin@ms1.hinet.net</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Yen</surname><given-names>Ming-Fang</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Wikramaratna</surname><given-names>Paul S.</given-names></name><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Hsiu-Hsi</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Wang</surname><given-names>Tsung-Hsi</given-names></name><address><email>joyce12wang@gmail.com</email></address><xref ref-type="aff" rid="Aff5">5</xref><xref ref-type="aff" rid="Aff6">6</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0546 0241</institution-id><institution-id institution-id-type="GRID">grid.19188.39</institution-id><institution>Division of Biostatistics,</institution><institution>College of Public Health, National Taiwan University,</institution></institution-wrap>Taipei, Taiwan</aff><aff id="Aff2"><label>2</label>Emergency Department, Taipei City Hospital, Ren-Ai Branch, Taipei, Taiwan</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9337 0481</institution-id><institution-id institution-id-type="GRID">grid.412896.0</institution-id><institution>School of Oral Hygiene,</institution><institution>College of Oral Medicine, Taipei Medical University,</institution></institution-wrap>Taipei, Taiwan</aff><aff id="Aff4"><label>4</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id><institution-id institution-id-type="GRID">grid.4305.2</institution-id><institution>Institute of Evolutionary Biology,</institution><institution>University of Edinburgh,</institution></institution-wrap>Edinburgh, United Kingdom</aff><aff id="Aff5"><label>5</label><institution-wrap><institution-id institution-id-type="GRID">grid.454740.6</institution-id><institution>Ministry of Health and Welfare,</institution></institution-wrap>Taipei, Taiwan</aff><aff id="Aff6"><label>6</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0425 5914</institution-id><institution-id institution-id-type="GRID">grid.260770.4</institution-id><institution>School of Medicine, National Yangming University,</institution></institution-wrap>Taipei, Taiwan</aff></contrib-group><pub-date pub-type="epub"><day>12</day><month>9</month><year>2017</year></pub-date><pub-date pub-type="pmc-release"><day>12</day><month>9</month><year>2017</year></pub-date><pub-date pub-type="collection"><year>2017</year></pub-date><volume>7</volume><elocation-id>11307</elocation-id><history><date date-type="received"><day>25</day><month>4</month><year>2017</year></date><date date-type="accepted"><day>7</day><month>8</month><year>2017</year></date></history><permissions><copyright-statement>© The Author(s) 2017</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold> This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>.</license-p></license></permissions><abstract id="Abs1"><p id="Par1">To date, 1841 cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection have been reported worldwide, with 652 deaths. We used a publically available case line list to explore the effect of relevant factors, notably underlying comorbidities, on fatal outcome of Middle East respiratory syndrome (MERS) cases up to the end of October 2016. A Bayesian Weibull proportional hazards regression model was used to assess the effect of comorbidity, age, epidemic period and sex on the fatality rate of MERS cases and its variation across countries. The crude fatality rate of MERS cases was 32.1% (95% credibility interval (CI): 29.9%, 34.3%). Notably, the incremental change of daily death rate was most prominent during the first week since disease onset with an average increase of 13%, but then stabilized in the remaining two weeks when it only increased 3% on average. Neither sex, nor country of infection were found to have a significant impact on fatality rates after taking into account the age and comorbidity status of patients. After adjusting for age, epidemic period, MERS patients with comorbidity had around 4 times the risk for fatal infection than those without (adjusted hazard ratio of 3.74 (95% CI: 2.57, 5.67)).</p></abstract><kwd-group kwd-group-type="npg-subject"><title>Subject terms</title><kwd>Viral infection</kwd><kwd>Risk factors</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2017</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000446 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000446 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:5596001
|texte= Impact of Comorbidity on Fatality Rate of Patients with Middle East Respiratory Syndrome
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:28900101" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |