A Case Report of a Middle East Respiratory Syndrome Survivor with Kidney Biopsy Results
Identifieur interne : 000069 ( Pmc/Curation ); précédent : 000068; suivant : 000070A Case Report of a Middle East Respiratory Syndrome Survivor with Kidney Biopsy Results
Auteurs : Ran-Hui Cha [Corée du Sud] ; Seung Hee Yang [Corée du Sud] ; Kyung Chul Moon [Corée du Sud] ; Joon-Sung Joh [Corée du Sud] ; Ji Yeon Lee [Corée du Sud] ; Hyoung-Shik Shin [Corée du Sud] ; Dong Ki Kim [Corée du Sud] ; Yon Su Kim [Corée du Sud]Source :
- Journal of Korean Medical Science [ 1011-8934 ] ; 2016.
Abstract
A 68-year old man diagnosed with Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) presented with multiple pneumonic infiltrations on his chest X-ray, and the patient was placed on a mechanical ventilator because of progressive respiratory failure. Urinary protein excretion steadily increased for a microalbumin to creatinine ratio of 538.4 mg/g Cr and a protein to creatinine ratio of 3,025.8 mg/g Cr. The isotope dilution mass spectrometry traceable serum creatinine level increased to 3.0 mg/dL. We performed a kidney biopsy 8 weeks after the onset of symptoms. Acute tubular necrosis was the main finding, and proteinaceous cast formation and acute tubulointerstitial nephritis were found. There were no electron dense deposits observed with electron microscopy. We could not verify the virus itself by in situ hybridization and confocal microscopy (MERS-CoV co-stained with dipeptidyl peptidase 4). The viremic status, urinary virus excretion, and timely kidney biopsy results should be investigated with thorough precautions to reveal the direct effects of MERS-CoV with respect to renal complications.
Url:
DOI: 10.3346/jkms.2016.31.4.635
PubMed: 27051251
PubMed Central: 4810350
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sortKey="Cha, Ran Hui" sort="Cha, Ran Hui" uniqKey="Cha R" first="Ran-Hui" last="Cha">Ran-Hui Cha</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Internal Medicine, National Medical Center, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Seung Hee" sort="Yang, Seung Hee" uniqKey="Yang S" first="Seung Hee" last="Yang">Seung Hee Yang</name><affiliation wicri:level="1"><nlm:aff id="aff2">Kidney Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Moon, Kyung Chul" sort="Moon, Kyung Chul" uniqKey="Moon K" first="Kyung Chul" last="Moon">Kyung Chul Moon</name><affiliation wicri:level="1"><nlm:aff id="aff2">Kidney Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Pathology, Seoul National University College of Medicine, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Joh, Joon Sung" sort="Joh, Joon Sung" uniqKey="Joh J" first="Joon-Sung" last="Joh">Joon-Sung Joh</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Internal Medicine, National Medical Center, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Ji Yeon" sort="Lee, Ji Yeon" uniqKey="Lee J" first="Ji Yeon" last="Lee">Ji Yeon Lee</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Internal Medicine, National Medical Center, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shin, Hyoung Shik" sort="Shin, Hyoung Shik" uniqKey="Shin H" first="Hyoung-Shik" last="Shin">Hyoung-Shik Shin</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Internal Medicine, National Medical Center, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Dong Ki" sort="Kim, Dong Ki" uniqKey="Kim D" first="Dong Ki" last="Kim">Dong Ki Kim</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Internal Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Yon Su" sort="Kim, Yon Su" uniqKey="Kim Y" first="Yon Su" last="Kim">Yon Su Kim</name><affiliation wicri:level="1"><nlm:aff id="aff2">Kidney Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Internal Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Korean Medical Science</title><idno type="ISSN">1011-8934</idno><idno type="eISSN">1598-6357</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A 68-year old man diagnosed with Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) presented with multiple pneumonic infiltrations on his chest X-ray, and the patient was placed on a mechanical ventilator because of progressive respiratory failure. Urinary protein excretion steadily increased for a microalbumin to creatinine ratio of 538.4 mg/g Cr and a protein to creatinine ratio of 3,025.8 mg/g Cr. The isotope dilution mass spectrometry traceable serum creatinine level increased to 3.0 mg/dL. We performed a kidney biopsy 8 weeks after the onset of symptoms. Acute tubular necrosis was the main finding, and proteinaceous cast formation and acute tubulointerstitial nephritis were found. There were no electron dense deposits observed with electron microscopy. We could not verify the virus itself by in situ hybridization and confocal microscopy (MERS-CoV co-stained with dipeptidyl peptidase 4). The viremic status, urinary virus excretion, and timely kidney biopsy results should be investigated with thorough precautions to reveal the direct effects of MERS-CoV with respect to renal complications.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author><author><name sortKey="Zumla, Ai" uniqKey="Zumla A">AI Zumla</name></author><author><name sortKey="Al Hakeem, Rf" uniqKey="Al Hakeem R">RF Al-Hakeem</name></author><author><name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al-Rabeeah</name></author><author><name sortKey="Stephens, Gm" uniqKey="Stephens G">GM Stephens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guery, B" uniqKey="Guery B">B Guery</name></author><author><name sortKey="Poissy, J" uniqKey="Poissy J">J Poissy</name></author><author><name sortKey="El Mansouf, L" uniqKey="El Mansouf L">L el 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article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Korean Med Sci</journal-id><journal-id journal-id-type="iso-abbrev">J. Korean Med. Sci</journal-id><journal-id journal-id-type="publisher-id">JKMS</journal-id><journal-title-group><journal-title>Journal of Korean Medical Science</journal-title></journal-title-group><issn pub-type="ppub">1011-8934</issn><issn pub-type="epub">1598-6357</issn><publisher><publisher-name>The Korean Academy of Medical Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27051251</article-id><article-id pub-id-type="pmc">4810350</article-id><article-id pub-id-type="doi">10.3346/jkms.2016.31.4.635</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject><subj-group subj-group-type="subheading"><subject>Infectious Diseases, Microbiology & Parasitology</subject></subj-group></subj-group></article-categories><title-group><article-title>A Case Report of a Middle East Respiratory Syndrome Survivor with Kidney Biopsy Results</article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0003-2783-2600</contrib-id><name><surname>Cha</surname><given-names>Ran-hui</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0002-8575-6610</contrib-id><name><surname>Yang</surname><given-names>Seung Hee</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0002-1969-8360</contrib-id><name><surname>Moon</surname><given-names>Kyung Chul</given-names></name><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0002-5044-2742</contrib-id><name><surname>Joh</surname><given-names>Joon-Sung</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0002-7026-8235</contrib-id><name><surname>Lee</surname><given-names>Ji Yeon</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0001-6504-3413</contrib-id><name><surname>Shin</surname><given-names>Hyoung-Shik</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0002-5195-7852</contrib-id><name><surname>Kim</surname><given-names>Dong Ki</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0003-3091-2388</contrib-id><name><surname>Kim</surname><given-names>Yon Su</given-names></name><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff4">4</xref></contrib></contrib-group><aff id="aff1"><label>1</label>Department of Internal Medicine, National Medical Center, Seoul,<country>Korea</country>.</aff><aff id="aff2"><label>2</label>Kidney Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul,<country>Korea</country>.</aff><aff id="aff3"><label>3</label>Department of Pathology, Seoul National University College of Medicine, Seoul,<country>Korea</country>.</aff><aff id="aff4"><label>4</label>Department of Internal Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>.</aff><author-notes><corresp>Address for Correspondence: Yon Su Kim, MD. Department of Internal Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Korea. <email>yonsukim@snu.ac.kr</email></corresp></author-notes><pub-date pub-type="ppub"><month>4</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>10</day><month>3</month><year>2016</year></pub-date><volume>31</volume><issue>4</issue><fpage>635</fpage><lpage>640</lpage><history><date date-type="received"><day>05</day><month>12</month><year>2015</year></date><date date-type="accepted"><day>17</day><month>2</month><year>2016</year></date></history><permissions><copyright-statement>© 2016 The Korean Academy of Medical Sciences.</copyright-statement><copyright-year>2016</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>A 68-year old man diagnosed with Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) presented with multiple pneumonic infiltrations on his chest X-ray, and the patient was placed on a mechanical ventilator because of progressive respiratory failure. Urinary protein excretion steadily increased for a microalbumin to creatinine ratio of 538.4 mg/g Cr and a protein to creatinine ratio of 3,025.8 mg/g Cr. The isotope dilution mass spectrometry traceable serum creatinine level increased to 3.0 mg/dL. We performed a kidney biopsy 8 weeks after the onset of symptoms. Acute tubular necrosis was the main finding, and proteinaceous cast formation and acute tubulointerstitial nephritis were found. There were no electron dense deposits observed with electron microscopy. We could not verify the virus itself by in situ hybridization and confocal microscopy (MERS-CoV co-stained with dipeptidyl peptidase 4). The viremic status, urinary virus excretion, and timely kidney biopsy results should be investigated with thorough precautions to reveal the direct effects of MERS-CoV with respect to renal complications.</p></abstract><kwd-group kwd-group-type="author"><kwd>Acute Tubulointerstitial Nephritis</kwd><kwd>Kidney Tubular Necrosis, Acute</kwd><kwd>Middle East Respiratory Syndrome-Coronavirus</kwd><kwd>Renal Pathology</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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