Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus
Identifieur interne : 000041 ( Pmc/Curation ); précédent : 000040; suivant : 000042Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus
Auteurs : Xiaojuan Guo [République populaire de Chine] ; Yao Deng [République populaire de Chine] ; Hong Chen [République populaire de Chine] ; Jiaming Lan [République populaire de Chine] ; Wen Wang [République populaire de Chine] ; Xiaohui Zou [République populaire de Chine] ; Tao Hung [République populaire de Chine] ; Zhuozhuang Lu [République populaire de Chine] ; Wenjie Tan [République populaire de Chine]Source :
- Immunology [ 0019-2805 ] ; 2015.
Abstract
An ideal vaccine against mucosal pathogens such as Middle East respiratory syndrome coronavirus (MERS-CoV) should confer sustained, protective immunity at both systemic and mucosal levels. Here, we evaluated the
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DOI: 10.1111/imm.12462
PubMed: 25762305
PubMed Central: 4515128
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National Institute for Viral Disease Control and Prevention, China CDC</institution><addr-line>Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Lan, Jiaming" sort="Lan, Jiaming" uniqKey="Lan J" first="Jiaming" last="Lan">Jiaming Lan</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Key Laboratory of Medical Virology, Ministry of Health; National Institute for Viral Disease Control and Prevention, China CDC</institution><addr-line>Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pathogenic Biology, Hebei Medical University</institution><addr-line>Shijiazhuang, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shijiazhuang</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Wen" sort="Wang, Wen" uniqKey="Wang W" first="Wen" last="Wang">Wen Wang</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Key Laboratory of Medical Virology, Ministry of Health; National Institute for Viral Disease Control and Prevention, China CDC</institution><addr-line>Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Zou, Xiaohui" sort="Zou, Xiaohui" uniqKey="Zou X" first="Xiaohui" last="Zou">Xiaohui Zou</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Key Laboratory of Medical Virology, Ministry of Health; National Institute for Viral Disease Control and Prevention, China CDC</institution><addr-line>Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Hung, Tao" sort="Hung, Tao" uniqKey="Hung T" first="Tao" last="Hung">Tao Hung</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Key Laboratory of Medical Virology, Ministry of Health; National Institute for Viral Disease Control and Prevention, China CDC</institution><addr-line>Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Lu, Zhuozhuang" sort="Lu, Zhuozhuang" uniqKey="Lu Z" first="Zhuozhuang" last="Lu">Zhuozhuang Lu</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Key Laboratory of Medical Virology, Ministry of Health; National Institute for Viral Disease Control and Prevention, China CDC</institution><addr-line>Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Wenjie" sort="Tan, Wenjie" uniqKey="Tan W" first="Wenjie" last="Tan">Wenjie Tan</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Key Laboratory of Medical Virology, Ministry of Health; National Institute for Viral Disease Control and Prevention, China CDC</institution><addr-line>Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25762305</idno><idno type="pmc">4515128</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515128</idno><idno type="RBID">PMC:4515128</idno><idno type="doi">10.1111/imm.12462</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000041</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000041</idno><idno type="wicri:Area/Pmc/Curation">000041</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000041</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus</title><author><name sortKey="Guo, Xiaojuan" sort="Guo, Xiaojuan" uniqKey="Guo X" first="Xiaojuan" last="Guo">Xiaojuan Guo</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Key Laboratory of Medical Virology, Ministry of Health; National Institute for Viral Disease Control and Prevention, China CDC</institution><addr-line>Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Deng, Yao" sort="Deng, Yao" uniqKey="Deng Y" first="Yao" last="Deng">Yao Deng</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Key Laboratory of Medical Virology, Ministry of Health; National Institute for Viral Disease Control and Prevention, China CDC</institution><addr-line>Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Hong" sort="Chen, Hong" uniqKey="Chen H" first="Hong" last="Chen">Hong Chen</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Key Laboratory of Medical Virology, Ministry of Health; National Institute for Viral Disease Control and Prevention, China CDC</institution><addr-line>Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Lan, Jiaming" sort="Lan, Jiaming" uniqKey="Lan J" first="Jiaming" last="Lan">Jiaming Lan</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Key Laboratory of Medical Virology, Ministry of Health; National Institute for Viral Disease Control and Prevention, China CDC</institution><addr-line>Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pathogenic Biology, Hebei Medical University</institution><addr-line>Shijiazhuang, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shijiazhuang</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Wen" sort="Wang, Wen" uniqKey="Wang W" first="Wen" last="Wang">Wen Wang</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Key Laboratory of Medical Virology, Ministry of Health; National Institute for Viral Disease Control and Prevention, China CDC</institution><addr-line>Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Zou, Xiaohui" sort="Zou, Xiaohui" uniqKey="Zou X" first="Xiaohui" last="Zou">Xiaohui Zou</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Key Laboratory of Medical Virology, Ministry of Health; National Institute for Viral Disease Control and Prevention, China CDC</institution><addr-line>Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Hung, Tao" sort="Hung, Tao" uniqKey="Hung T" first="Tao" last="Hung">Tao Hung</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Key Laboratory of Medical Virology, Ministry of Health; National Institute for Viral Disease Control and Prevention, China CDC</institution><addr-line>Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Lu, Zhuozhuang" sort="Lu, Zhuozhuang" uniqKey="Lu Z" first="Zhuozhuang" last="Lu">Zhuozhuang Lu</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Key Laboratory of Medical Virology, Ministry of Health; National Institute for Viral Disease Control and Prevention, China CDC</institution><addr-line>Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Wenjie" sort="Tan, Wenjie" uniqKey="Tan W" first="Wenjie" last="Tan">Wenjie Tan</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Key Laboratory of Medical Virology, Ministry of Health; National Institute for Viral Disease Control and Prevention, China CDC</institution><addr-line>Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author></analytic><series><title level="j">Immunology</title><idno type="ISSN">0019-2805</idno><idno type="eISSN">1365-2567</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>An ideal vaccine against mucosal pathogens such as Middle East respiratory syndrome coronavirus (MERS-CoV) should confer sustained, protective immunity at both systemic and mucosal levels. Here, we evaluated the <italic>in vivo</italic> systemic and mucosal antigen-specific immune responses induced by a single intramuscular or intragastric administration of recombinant adenoviral type 5 (Ad5) or type 41 (Ad41) -based vaccines expressing the MERS-CoV spike (S) protein. Intragastric administration of either Ad5-S or Ad41-S induced antigen-specific IgG and neutralizing antibody in serum; however, antigen-specific T-cell responses were not detected. In contrast, after a single intramuscular dose of Ad5-S or Ad41-S, functional antigen-specific T-cell responses were elicited in the spleen and pulmonary lymphocytes of the mice, which persisted for several months. Both rAd-based vaccines administered intramuscularly induced systemic humoral immune responses (neutralizing IgG antibodies). Our results show that a single dose of Ad5-S- or Ad41-S-based vaccines represents an appealing strategy for the control of MERS-CoV infection and transmission.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bermingham, A" uniqKey="Bermingham A">A Bermingham</name></author><author><name sortKey="Chand, Ma" uniqKey="Chand M">MA Chand</name></author><author><name sortKey="Brown, Cs" uniqKey="Brown C">CS Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name></author><author><name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="De Graaf, M" uniqKey="De Graaf M">M de Graaf</name></author><author><name sortKey="Lauber, C" uniqKey="Lauber C">C Lauber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Mou, H" uniqKey="Mou H">H Mou</name></author><author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, Ly" uniqKey="Du L">LY Du</name></author><author><name sortKey="Zhou, Ys" uniqKey="Zhou Y">YS Zhou</name></author><author><name sortKey="Liu, Sw" uniqKey="Liu S">SW Liu</name></author><author><name sortKey="Zheng, Bj" uniqKey="Zheng B">BJ Zheng</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, F" uniqKey="Song F">F Song</name></author><author><name sortKey="Fux, R" uniqKey="Fux R">R Fux</name></author><author><name sortKey="Provacia, Lb" uniqKey="Provacia L">LB Provacia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gierer, S" uniqKey="Gierer S">S Gierer</name></author><author><name sortKey="Bertram, S" uniqKey="Bertram S">S Bertram</name></author><author><name sortKey="Kaup, F" uniqKey="Kaup F">F Kaup</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shiver, Jw" uniqKey="Shiver J">JW Shiver</name></author><author><name sortKey="Emini, Ea" uniqKey="Emini E">EA Emini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sullivan, Nj" uniqKey="Sullivan N">NJ Sullivan</name></author><author><name sortKey="Sanchez, A" uniqKey="Sanchez A">A Sanchez</name></author><author><name sortKey="Rollin, Pe" uniqKey="Rollin P">PE Rollin</name></author><author><name sortKey="Yang, Zy" uniqKey="Yang Z">ZY Yang</name></author><author><name sortKey="Nabel, Gj" uniqKey="Nabel G">GJ Nabel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sullivan, Nj" uniqKey="Sullivan N">NJ Sullivan</name></author><author><name sortKey="Geisbert, Tw" uniqKey="Geisbert T">TW Geisbert</name></author><author><name sortKey="Geisbert, Jb" uniqKey="Geisbert J">JB Geisbert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arnberg, N" uniqKey="Arnberg N">N Arnberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lemiale, F" uniqKey="Lemiale F">F Lemiale</name></author><author><name sortKey="Kong, Wp" uniqKey="Kong W">WP Kong</name></author><author><name sortKey="Akyurek, Lm" uniqKey="Akyurek L">LM Akyurek</name></author><author><name sortKey="Ling, X" uniqKey="Ling X">X Ling</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name></author><author><name sortKey="Chakrabarti, Bk" uniqKey="Chakrabarti B">BK Chakrabarti</name></author><author><name sortKey="Eckhaus, M" uniqKey="Eckhaus M">M Eckhaus</name></author><author><name sortKey="Nabel, Gj" uniqKey="Nabel G">GJ Nabel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, Zz" uniqKey="Lu Z">ZZ Lu</name></author><author><name sortKey="Zou, Xh" uniqKey="Zou X">XH Zou</name></author><author><name sortKey="Dong, Lx" uniqKey="Dong L">LX Dong</name></author><author><name sortKey="Qu, Jg" uniqKey="Qu J">JG Qu</name></author><author><name sortKey="Song, Jd" uniqKey="Song J">JD Song</name></author><author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name></author><author><name sortKey="Guo, L" uniqKey="Guo L">L Guo</name></author><author><name sortKey="Hung, T" uniqKey="Hung T">T Hung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Catanzaro, At" uniqKey="Catanzaro A">AT Catanzaro</name></author><author><name sortKey="Koup, Ra" uniqKey="Koup R">RA Koup</name></author><author><name sortKey="Roederer, M" uniqKey="Roederer M">M Roederer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neutra, Mr" uniqKey="Neutra M">MR Neutra</name></author><author><name sortKey="Kozlowski, Pa" uniqKey="Kozlowski P">PA Kozlowski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ko, Sy" uniqKey="Ko S">SY Ko</name></author><author><name sortKey="Cheng, C" uniqKey="Cheng C">C Cheng</name></author><author><name sortKey="Kong, Wp" uniqKey="Kong W">WP Kong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaufman, Dr" uniqKey="Kaufman D">DR Kaufman</name></author><author><name sortKey="Bivas Benita, M" uniqKey="Bivas Benita M">M Bivas-Benita</name></author><author><name sortKey="Simmons, Nl" uniqKey="Simmons N">NL Simmons</name></author><author><name sortKey="Miller, D" uniqKey="Miller D">D Miller</name></author><author><name sortKey="Barouch, Dh" uniqKey="Barouch D">DH Barouch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, Zz" uniqKey="Lu Z">ZZ Lu</name></author><author><name sortKey="Zou, Xh" uniqKey="Zou X">XH Zou</name></author><author><name sortKey="Lastinger, K" uniqKey="Lastinger K">K Lastinger</name></author><author><name sortKey="Williams, A" uniqKey="Williams A">A Williams</name></author><author><name sortKey="Qu, Jg" uniqKey="Qu J">JG Qu</name></author><author><name sortKey="Estes, Dm" uniqKey="Estes D">DM Estes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author><author><name sortKey="Hu, Y" uniqKey="Hu Y">Y Hu</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name></author><author><name sortKey="Ma, C" uniqKey="Ma C">C Ma</name></author><author><name sortKey="Li, D" uniqKey="Li D">D Li</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Vincent, Km" uniqKey="Vincent K">KM Vincent</name></author><author><name sortKey="Poon, Wl" uniqKey="Poon W">WL Poon</name></author><author><name sortKey="Yu, F" uniqKey="Yu F">F Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, J" uniqKey="Gao J">J Gao</name></author><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author><author><name sortKey="Qi, J" uniqKey="Qi J">J Qi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chuai, X" uniqKey="Chuai X">X Chuai</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Deng, Y" uniqKey="Deng Y">Y Deng</name></author><author><name sortKey="Wen, B" uniqKey="Wen B">B Wen</name></author><author><name sortKey="Tan, W" uniqKey="Tan W">W Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author><author><name sortKey="Tricoche, N" uniqKey="Tricoche N">N Tricoche</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mizuguchi, H" uniqKey="Mizuguchi H">H Mizuguchi</name></author><author><name sortKey="Kay, Ma" uniqKey="Kay M">MA Kay</name></author><author><name sortKey="Hayakawa, T" uniqKey="Hayakawa T">T Hayakawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Danthinne, X" uniqKey="Danthinne X">X Danthinne</name></author><author><name sortKey="Imperiale, Mj" uniqKey="Imperiale M">MJ Imperiale</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raviprakash, K" uniqKey="Raviprakash K">K Raviprakash</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Ewing, D" uniqKey="Ewing D">D Ewing</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lemiale, F" uniqKey="Lemiale F">F Lemiale</name></author><author><name sortKey="Haddada, H" uniqKey="Haddada H">H Haddada</name></author><author><name sortKey="Nabel, Gj" uniqKey="Nabel G">GJ Nabel</name></author><author><name sortKey="Brough, De" uniqKey="Brough D">DE Brough</name></author><author><name sortKey="King, Cr" uniqKey="King C">CR King</name></author><author><name sortKey="Gall, Jg" uniqKey="Gall J">JG Gall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name></author><author><name sortKey="Chen, Dl" uniqKey="Chen D">DL Chen</name></author><author><name sortKey="Song, Jd" uniqKey="Song J">JD Song</name></author><author><name sortKey="Qu, Jg" uniqKey="Qu J">JG Qu</name></author><author><name sortKey="Lu, Zz" uniqKey="Lu Z">ZZ Lu</name></author><author><name sortKey="Zhao, Wm" uniqKey="Zhao W">WM Zhao</name></author><author><name sortKey="Hong, T" uniqKey="Hong T">T Hong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, Q" uniqKey="Zhou Q">Q Zhou</name></author><author><name sortKey="Hidajat, R" uniqKey="Hidajat R">R Hidajat</name></author><author><name sortKey="Peng, B" uniqKey="Peng B">B Peng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Channappanavar, R" uniqKey="Channappanavar R">R Channappanavar</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Channappanavar, R" uniqKey="Channappanavar R">R Channappanavar</name></author><author><name sortKey="Fett, C" uniqKey="Fett C">C Fett</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Meyerholz, Dk" uniqKey="Meyerholz D">DK Meyerholz</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, E" uniqKey="Kim E">E Kim</name></author><author><name sortKey="Okada, K" uniqKey="Okada K">K Okada</name></author><author><name sortKey="Beeler, Ja" uniqKey="Beeler J">JA Beeler</name></author><author><name sortKey="Crim, Rl" uniqKey="Crim R">RL Crim</name></author><author><name sortKey="Piedra, Pa" uniqKey="Piedra P">PA Piedra</name></author><author><name sortKey="Gilbert, Be" uniqKey="Gilbert B">BE Gilbert</name></author><author><name sortKey="Gambotto, A" uniqKey="Gambotto A">A Gambotto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeng, M" uniqKey="Zeng M">M Zeng</name></author><author><name sortKey="Xu, Q" uniqKey="Xu Q">Q Xu</name></author><author><name sortKey="Elias, M" uniqKey="Elias M">M Elias</name></author><author><name sortKey="Pichichero, Me" uniqKey="Pichichero M">ME Pichichero</name></author><author><name sortKey="Simpson, Ll" uniqKey="Simpson L">LL Simpson</name></author><author><name sortKey="Smith, La" uniqKey="Smith L">LA Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ma, C" uniqKey="Ma C">C Ma</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seregin, Ss" uniqKey="Seregin S">SS Seregin</name></author><author><name sortKey="Amalfitano, A" uniqKey="Amalfitano A">A Amalfitano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Madani, Ta" uniqKey="Madani T">TA Madani</name></author><author><name sortKey="Azhar, Ei" uniqKey="Azhar E">EI Azhar</name></author><author><name sortKey="Hashem, Am" uniqKey="Hashem A">AM Hashem</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, E" uniqKey="Kim E">E Kim</name></author><author><name sortKey="Okada, K" uniqKey="Okada K">K Okada</name></author><author><name sortKey="Kenniston, T" uniqKey="Kenniston T">T Kenniston</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Immunology</journal-id><journal-id journal-id-type="iso-abbrev">Immunology</journal-id><journal-id journal-id-type="publisher-id">imm</journal-id><journal-title-group><journal-title>Immunology</journal-title></journal-title-group><issn pub-type="ppub">0019-2805</issn><issn pub-type="epub">1365-2567</issn><publisher><publisher-name>John Wiley & Sons, Ltd</publisher-name><publisher-loc>Chichester, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25762305</article-id><article-id pub-id-type="pmc">4515128</article-id><article-id pub-id-type="doi">10.1111/imm.12462</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject></subj-group></article-categories><title-group><article-title>Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Guo</surname><given-names>Xiaojuan</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="author-notes" rid="fn1">*</xref></contrib><contrib contrib-type="author"><name><surname>Deng</surname><given-names>Yao</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="author-notes" rid="fn1">*</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Hong</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="author-notes" rid="fn1">*</xref></contrib><contrib contrib-type="author"><name><surname>Lan</surname><given-names>Jiaming</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="aff" rid="au2">2</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Wen</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zou</surname><given-names>Xiaohui</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hung</surname><given-names>Tao</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Lu</surname><given-names>Zhuozhuang</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Tan</surname><given-names>Wenjie</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="corresp" rid="cor1"></xref></contrib><aff id="au1"><label>1</label><institution>Key Laboratory of Medical Virology, Ministry of Health; National Institute for Viral Disease Control and Prevention, China CDC</institution><addr-line>Beijing, China</addr-line></aff><aff id="au2"><label>2</label><institution>Department of Pathogenic Biology, Hebei Medical University</institution><addr-line>Shijiazhuang, China</addr-line></aff></contrib-group><author-notes><corresp id="cor1">Correspondence: Wenjie Tan and Zhuozhuang Lu, Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, China CDC, 155 Changbai Road, ChangPing District, Beijing 102206, China, Emails: <email>tanwj28@163.com</email> and <email>luzz@ivdc.chinacdc.cn</email>, Senior author: Wenjie Tan
</corresp><fn id="fn1"><p>* These authors contributed equally to this article.</p></fn></author-notes><pub-date pub-type="ppub"><month>8</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>21</day><month>4</month><year>2015</year></pub-date><volume>145</volume><issue>4</issue><fpage>476</fpage><lpage>484</lpage><history><date date-type="received"><day>26</day><month>11</month><year>2014</year></date><date date-type="rev-recd"><day>02</day><month>3</month><year>2015</year></date><date date-type="accepted"><day>09</day><month>3</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 John Wiley & Sons Ltd</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract><p>An ideal vaccine against mucosal pathogens such as Middle East respiratory syndrome coronavirus (MERS-CoV) should confer sustained, protective immunity at both systemic and mucosal levels. Here, we evaluated the <italic>in vivo</italic> systemic and mucosal antigen-specific immune responses induced by a single intramuscular or intragastric administration of recombinant adenoviral type 5 (Ad5) or type 41 (Ad41) -based vaccines expressing the MERS-CoV spike (S) protein. Intragastric administration of either Ad5-S or Ad41-S induced antigen-specific IgG and neutralizing antibody in serum; however, antigen-specific T-cell responses were not detected. In contrast, after a single intramuscular dose of Ad5-S or Ad41-S, functional antigen-specific T-cell responses were elicited in the spleen and pulmonary lymphocytes of the mice, which persisted for several months. Both rAd-based vaccines administered intramuscularly induced systemic humoral immune responses (neutralizing IgG antibodies). Our results show that a single dose of Ad5-S- or Ad41-S-based vaccines represents an appealing strategy for the control of MERS-CoV infection and transmission.</p></abstract><kwd-group><kwd>adenoviral vector</kwd><kwd>immunity</kwd><kwd>Middle East respiratory syndrome coronavirus</kwd><kwd>spike protein</kwd><kwd>vaccine</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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