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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV): challenges in identifying its source and controlling its spread</title><author><name sortKey="Lu, Lu" sort="Lu, Lu" uniqKey="Lu L" first="Lu" last="Lu">Lu Lu</name><affiliation><nlm:aff id="aff1">Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College, Fudan University, Shanghai 200032, China</nlm:aff></affiliation></author><author><name sortKey="Liu, Qi" sort="Liu, Qi" uniqKey="Liu Q" first="Qi" last="Liu">Qi Liu</name><affiliation><nlm:aff id="aff1">Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College, Fudan University, Shanghai 200032, China</nlm:aff></affiliation></author><author><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name><affiliation><nlm:aff id="aff2">Lindsley F. Kimball Research Institute, New York Blood Center, 310 East 67th Street, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><affiliation><nlm:aff id="aff1">Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College, Fudan University, Shanghai 200032, China</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Lindsley F. Kimball Research Institute, New York Blood Center, 310 East 67th Street, New York, NY, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23791956</idno><idno type="pmc">7110483</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110483</idno><idno type="RBID">PMC:7110483</idno><idno type="doi">10.1016/j.micinf.2013.06.003</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001388</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001388</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Middle East respiratory syndrome coronavirus (MERS-CoV): challenges in identifying its source and controlling its spread</title><author><name sortKey="Lu, Lu" sort="Lu, Lu" uniqKey="Lu L" first="Lu" last="Lu">Lu Lu</name><affiliation><nlm:aff id="aff1">Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College, Fudan University, Shanghai 200032, China</nlm:aff></affiliation></author><author><name sortKey="Liu, Qi" sort="Liu, Qi" uniqKey="Liu Q" first="Qi" last="Liu">Qi Liu</name><affiliation><nlm:aff id="aff1">Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College, Fudan University, Shanghai 200032, China</nlm:aff></affiliation></author><author><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name><affiliation><nlm:aff id="aff2">Lindsley F. Kimball Research Institute, New York Blood Center, 310 East 67th Street, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><affiliation><nlm:aff id="aff1">Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College, Fudan University, Shanghai 200032, China</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Lindsley F. Kimball Research Institute, New York Blood Center, 310 East 67th Street, New York, NY, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Microbes and Infection</title><idno type="ISSN">1286-4579</idno><idno type="eISSN">1769-714X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome coronavirus (MERS-CoV), a novel human coronavirus that caused outbreaks of a SARS-like illness in the Middle East, is now considered a threat to global public health. This review discusses the challenges in identifying the source of this fatal virus and developing effective and safe anti-MERS-CoV vaccines and therapeutics in order to control its spread and to combat any future pandemic.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S. van Boheemen</name></author><author><name sortKey="Bestebroer, T M" uniqKey="Bestebroer T">T.M. Bestebroer</name></author><author><name sortKey="Osterhaus, A D M E" uniqKey="Osterhaus A">A.D.M.E. Osterhaus</name></author><author><name sortKey="Fouchier, R A M" uniqKey="Fouchier R">R.A.M. Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, R J" uniqKey="De Groot R">R.J. de Groot</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author><author><name sortKey="Brown, C S" uniqKey="Brown C">C.S. Brown</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L. Enjuanes</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author><author><name sortKey="Galiano, M" uniqKey="Galiano M">M. Galiano</name></author><author><name sortKey="Gorbalenya, A E" uniqKey="Gorbalenya A">A.E. Gorbalenya</name></author><author><name sortKey="Memish, Z" uniqKey="Memish Z">Z. Memish</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S. Perlman</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author><author><name sortKey="Snijder, E J" uniqKey="Snijder E">E.J. Snijder</name></author><author><name sortKey="Stephens, G M" uniqKey="Stephens G">G.M. Stephens</name></author><author><name sortKey="Woo, P C" uniqKey="Woo P">P.C. Woo</name></author><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. Zaki</name></author><author><name sortKey="Zambon, M" uniqKey="Zambon M">M. Zambon</name></author><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J. Ziebuhr</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, J S M" uniqKey="Peiris J">J.S.M. Peiris</name></author><author><name sortKey="Lai, S T" uniqKey="Lai S">S.T. Lai</name></author><author><name sortKey="Poon, L L M" uniqKey="Poon L">L.L.M. Poon</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author><author><name sortKey="Yam, L Y C" uniqKey="Yam L">L.Y.C. Yam</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W. Lim</name></author><author><name sortKey="Nicholls, J" uniqKey="Nicholls J">J. Nicholls</name></author><author><name sortKey="Yee, W K S" uniqKey="Yee W">W.K.S. Yee</name></author><author><name sortKey="Yan, W W" uniqKey="Yan W">W.W. Yan</name></author><author><name sortKey="Cheung, M T" uniqKey="Cheung M">M.T. Cheung</name></author><author><name sortKey="Cheng, V C C" uniqKey="Cheng V">V.C.C. Cheng</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Tsang, D N C" uniqKey="Tsang D">D.N.C. Tsang</name></author><author><name sortKey="Yung, R W H" uniqKey="Yung R">R.W.H. Yung</name></author><author><name sortKey="Ng, T K" uniqKey="Ng T">T.K. Ng</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhong, N S" uniqKey="Zhong N">N.S. Zhong</name></author><author><name sortKey="Zheng, B J" uniqKey="Zheng B">B.J. Zheng</name></author><author><name sortKey="Li, Y M" uniqKey="Li Y">Y.M. Li</name></author><author><name sortKey="Poon, L L M" uniqKey="Poon L">L.L.M. Poon</name></author><author><name sortKey="Xie, Z H" uniqKey="Xie Z">Z.H. Xie</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Li, P H" uniqKey="Li P">P.H. Li</name></author><author><name sortKey="Tan, S Y" uniqKey="Tan S">S.Y. Tan</name></author><author><name sortKey="Chang, Q" uniqKey="Chang Q">Q. Chang</name></author><author><name sortKey="Xie, J P" uniqKey="Xie J">J.P. Xie</name></author><author><name sortKey="Liu, X Q" uniqKey="Liu X">X.Q. Liu</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J. Xu</name></author><author><name sortKey="Li, D X" uniqKey="Li D">D.X. Li</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author><author><name sortKey="Peiris, J S M" uniqKey="Peiris J">J.S.M. Peiris</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S. Gunther</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W. Preiser</name></author><author><name sortKey="Van Der, W S" uniqKey="Van Der W">W.S. van der</name></author><author><name sortKey="Brodt, H R" uniqKey="Brodt H">H.R. Brodt</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S. Becker</name></author><author><name sortKey="Rabenau, H" uniqKey="Rabenau H">H. Rabenau</name></author><author><name sortKey="Panning, M" uniqKey="Panning M">M. Panning</name></author><author><name sortKey="Kolesnikova, L" uniqKey="Kolesnikova L">L. Kolesnikova</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author><author><name sortKey="Berger, A" uniqKey="Berger A">A. Berger</name></author><author><name sortKey="Burguiere, A M" uniqKey="Burguiere A">A.M. Burguiere</name></author><author><name sortKey="Cinatl, J" uniqKey="Cinatl J">J. Cinatl</name></author><author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M. Eickmann</name></author><author><name sortKey="Escriou, N" uniqKey="Escriou N">N. Escriou</name></author><author><name sortKey="Grywna, K" uniqKey="Grywna K">K. Grywna</name></author><author><name sortKey="Kramme, S" uniqKey="Kramme S">S. Kramme</name></author><author><name sortKey="Manuguerra, J C" uniqKey="Manuguerra J">J.C. Manuguerra</name></author><author><name sortKey="Muller, S" uniqKey="Muller S">S. Muller</name></author><author><name sortKey="Rickerts, V" uniqKey="Rickerts V">V. Rickerts</name></author><author><name sortKey="Sturmer, M" uniqKey="Sturmer M">M. Sturmer</name></author><author><name sortKey="Vieth, S" uniqKey="Vieth S">S. Vieth</name></author><author><name sortKey="Klenk, H D" uniqKey="Klenk H">H.D. Klenk</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author><author><name sortKey="Schmitz, H" uniqKey="Schmitz H">H. Schmitz</name></author><author><name sortKey="Doerr, H W" uniqKey="Doerr H">H.W. Doerr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rota, P A" uniqKey="Rota P">P.A. Rota</name></author><author><name sortKey="Oberste, M S" uniqKey="Oberste M">M.S. Oberste</name></author><author><name sortKey="Monroe, S S" uniqKey="Monroe S">S.S. Monroe</name></author><author><name sortKey="Nix, W A" uniqKey="Nix W">W.A. Nix</name></author><author><name sortKey="Campagnoli, R" uniqKey="Campagnoli R">R. Campagnoli</name></author><author><name sortKey="Icenogle, J P" uniqKey="Icenogle J">J.P. Icenogle</name></author><author><name sortKey="Penaranda, S" uniqKey="Penaranda S">S. Penaranda</name></author><author><name sortKey="Bankamp, B" uniqKey="Bankamp B">B. Bankamp</name></author><author><name sortKey="Maher, K" uniqKey="Maher K">K. Maher</name></author><author><name sortKey="Chen, M H" uniqKey="Chen M">M.H. Chen</name></author><author><name sortKey="Tong, S X" uniqKey="Tong S">S.X. Tong</name></author><author><name sortKey="Tamin, A" uniqKey="Tamin A">A. Tamin</name></author><author><name sortKey="Lowe, L" uniqKey="Lowe L">L. Lowe</name></author><author><name sortKey="Frace, M" uniqKey="Frace M">M. Frace</name></author><author><name sortKey="Derisi, J L" uniqKey="Derisi J">J.L. Derisi</name></author><author><name sortKey="Chen, Q" uniqKey="Chen Q">Q. Chen</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name></author><author><name sortKey="Erdman, D D" uniqKey="Erdman D">D.D. Erdman</name></author><author><name sortKey="Peret, T C T" uniqKey="Peret T">T.C.T. Peret</name></author><author><name sortKey="Burns, C" uniqKey="Burns C">C. Burns</name></author><author><name sortKey="Ksiazek, T G" uniqKey="Ksiazek T">T.G. Ksiazek</name></author><author><name sortKey="Rollin, P E" uniqKey="Rollin P">P.E. Rollin</name></author><author><name sortKey="Sanchez, A" uniqKey="Sanchez A">A. Sanchez</name></author><author><name sortKey="Liffick, S" uniqKey="Liffick S">S. Liffick</name></author><author><name sortKey="Holloway, B" uniqKey="Holloway B">B. Holloway</name></author><author><name sortKey="Limor, J" uniqKey="Limor J">J. Limor</name></author><author><name sortKey="Mccaustland, K" uniqKey="Mccaustland K">K. McCaustland</name></author><author><name sortKey="Olsen Rasmussen, M" uniqKey="Olsen Rasmussen M">M. Olsen-Rasmussen</name></author><author><name sortKey="Fouchier, R" uniqKey="Fouchier R">R. Fouchier</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S. Gunther</name></author><author><name sortKey="Osterhaus, A D M E" uniqKey="Osterhaus A">A.D.M.E. Osterhaus</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Pallansch, M A" uniqKey="Pallansch M">M.A. Pallansch</name></author><author><name sortKey="Anderson, L J" uniqKey="Anderson L">L.J. Anderson</name></author><author><name sortKey="Bellini, W J" uniqKey="Bellini W">W.J. Bellini</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Tanquintic Misa, E" uniqKey="Tanquintic Misa E">E. Tanquintic-Misa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, S K" uniqKey="Lau S">S.K. Lau</name></author><author><name sortKey="Li, K S" uniqKey="Li K">K.S. Li</name></author><author><name sortKey="Tsang, A K" uniqKey="Tsang A">A.K. Tsang</name></author><author><name sortKey="Lam, C S" uniqKey="Lam C">C.S. Lam</name></author><author><name sortKey="Ahmed, S" uniqKey="Ahmed S">S. Ahmed</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H. Chen</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Woo, P C" uniqKey="Woo P">P.C. Woo</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, V S" uniqKey="Raj V">V.S. Raj</name></author><author><name sortKey="Mou, H" uniqKey="Mou H">H. Mou</name></author><author><name sortKey="Smits, S L" uniqKey="Smits S">S.L. Smits</name></author><author><name sortKey="Dekkers, D H" uniqKey="Dekkers D">D.H. Dekkers</name></author><author><name sortKey="Muller, M A" uniqKey="Muller M">M.A. Muller</name></author><author><name sortKey="Dijkman, R" uniqKey="Dijkman R">R. Dijkman</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D. Muth</name></author><author><name sortKey="Demmers, J A" uniqKey="Demmers J">J.A. Demmers</name></author><author><name sortKey="Zaki, A" uniqKey="Zaki A">A. Zaki</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V. Thiel</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Rottier, P J" uniqKey="Rottier P">P.J. Rottier</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B.J. Bosch</name></author><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B.L. Haagmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author><author><name sortKey="He, Y" uniqKey="He Y">Y. He</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y. Zhou</name></author><author><name sortKey="Liu, S" uniqKey="Liu S">S. Liu</name></author><author><name sortKey="Zheng, B J" uniqKey="Zheng B">B.J. Zheng</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, J F" uniqKey="Chan J">J.F. Chan</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Choi, G K" uniqKey="Choi G">G.K. Choi</name></author><author><name sortKey="To, K K" uniqKey="To K">K.K. To</name></author><author><name sortKey="Tse, H" uniqKey="Tse H">H. Tse</name></author><author><name sortKey="Cai, J P" uniqKey="Cai J">J.P. Cai</name></author><author><name sortKey="Yeung, M L" uniqKey="Yeung M">M.L. Yeung</name></author><author><name sortKey="Cheng, V C" uniqKey="Cheng V">V.C. Cheng</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H. Chen</name></author><author><name sortKey="Che, X Y" uniqKey="Che X">X.Y. Che</name></author><author><name sortKey="Lau, S K" uniqKey="Lau S">S.K. Lau</name></author><author><name sortKey="Woo, P C" uniqKey="Woo P">P.C. Woo</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buchholz, U" uniqKey="Buchholz U">U. Buchholz</name></author><author><name sortKey="Muller, M A" uniqKey="Muller M">M.A. Muller</name></author><author><name sortKey="Nitsche, A" uniqKey="Nitsche A">A. Nitsche</name></author><author><name sortKey="Sanewski, A" uniqKey="Sanewski A">A. Sanewski</name></author><author><name sortKey="Wevering, N" uniqKey="Wevering N">N. Wevering</name></author><author><name sortKey="Bauer Balci, T" uniqKey="Bauer Balci T">T. Bauer-Balci</name></author><author><name sortKey="Bonin, F" uniqKey="Bonin F">F. Bonin</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Schweiger, B" uniqKey="Schweiger B">B. Schweiger</name></author><author><name sortKey="Wolff, T" uniqKey="Wolff T">T. Wolff</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D. Muth</name></author><author><name sortKey="Meyer, B" uniqKey="Meyer B">B. Meyer</name></author><author><name sortKey="Buda, S" uniqKey="Buda S">S. Buda</name></author><author><name sortKey="Krause, G" uniqKey="Krause G">G. Krause</name></author><author><name sortKey="Schaade, L" uniqKey="Schaade L">L. Schaade</name></author><author><name sortKey="Haas, W" uniqKey="Haas W">W. Haas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deming, D" uniqKey="Deming D">D. Deming</name></author><author><name sortKey="Sheahan, T" uniqKey="Sheahan T">T. Sheahan</name></author><author><name sortKey="Heise, M" uniqKey="Heise M">M. Heise</name></author><author><name sortKey="Yount, B" uniqKey="Yount B">B. Yount</name></author><author><name sortKey="Davis, N" uniqKey="Davis N">N. Davis</name></author><author><name sortKey="Sims, A" uniqKey="Sims A">A. Sims</name></author><author><name sortKey="Suthar, M" uniqKey="Suthar M">M. Suthar</name></author><author><name sortKey="Harkema, J" uniqKey="Harkema J">J. Harkema</name></author><author><name sortKey="Whitmore, A" uniqKey="Whitmore A">A. Whitmore</name></author><author><name sortKey="Pickles, R" uniqKey="Pickles R">R. Pickles</name></author><author><name sortKey="West, A" uniqKey="West A">A. West</name></author><author><name sortKey="Donaldson, E" uniqKey="Donaldson E">E. Donaldson</name></author><author><name sortKey="Curtis, K" uniqKey="Curtis K">K. Curtis</name></author><author><name sortKey="Johnston, R" uniqKey="Johnston R">R. Johnston</name></author><author><name sortKey="Baric, R" uniqKey="Baric R">R. Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yasui, F" uniqKey="Yasui F">F. Yasui</name></author><author><name sortKey="Kai, C" uniqKey="Kai C">C. Kai</name></author><author><name sortKey="Kitabatake, M" uniqKey="Kitabatake M">M. Kitabatake</name></author><author><name sortKey="Inoue, S" uniqKey="Inoue S">S. Inoue</name></author><author><name sortKey="Yoneda, M" uniqKey="Yoneda M">M. Yoneda</name></author><author><name sortKey="Yokochi, S" uniqKey="Yokochi S">S. Yokochi</name></author><author><name sortKey="Kase, R" uniqKey="Kase R">R. Kase</name></author><author><name sortKey="Sekiguchi, S" uniqKey="Sekiguchi S">S. Sekiguchi</name></author><author><name sortKey="Morita, K" uniqKey="Morita K">K. Morita</name></author><author><name sortKey="Hishima, T" uniqKey="Hishima T">T. Hishima</name></author><author><name sortKey="Suzuki, H" uniqKey="Suzuki H">H. Suzuki</name></author><author><name sortKey="Karamatsu, K" uniqKey="Karamatsu K">K. Karamatsu</name></author><author><name sortKey="Yasutomi, Y" uniqKey="Yasutomi Y">Y. Yasutomi</name></author><author><name sortKey="Shida, H" uniqKey="Shida H">H. Shida</name></author><author><name sortKey="Kidokoro, M" uniqKey="Kidokoro M">M. Kidokoro</name></author><author><name sortKey="Mizuno, K" uniqKey="Mizuno K">K. Mizuno</name></author><author><name sortKey="Matsushima, K" uniqKey="Matsushima K">K. Matsushima</name></author><author><name sortKey="Kohara, M" uniqKey="Kohara M">M. Kohara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bolles, M" uniqKey="Bolles M">M. Bolles</name></author><author><name sortKey="Deming, D" uniqKey="Deming D">D. Deming</name></author><author><name sortKey="Long, K" uniqKey="Long K">K. Long</name></author><author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S. Agnihothram</name></author><author><name sortKey="Whitmore, A" uniqKey="Whitmore A">A. Whitmore</name></author><author><name sortKey="Ferris, M" uniqKey="Ferris M">M. Ferris</name></author><author><name sortKey="Funkhouser, W" uniqKey="Funkhouser W">W. Funkhouser</name></author><author><name sortKey="Gralinski, L" uniqKey="Gralinski L">L. Gralinski</name></author><author><name sortKey="Totura, A" uniqKey="Totura A">A. Totura</name></author><author><name sortKey="Heise, M" uniqKey="Heise M">M. Heise</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tseng, C T" uniqKey="Tseng C">C.T. Tseng</name></author><author><name sortKey="Sbrana, E" uniqKey="Sbrana E">E. Sbrana</name></author><author><name sortKey="Iwata Yoshikawa, N" uniqKey="Iwata Yoshikawa N">N. Iwata-Yoshikawa</name></author><author><name sortKey="Newman, P C" uniqKey="Newman P">P.C. Newman</name></author><author><name sortKey="Garron, T" uniqKey="Garron T">T. Garron</name></author><author><name sortKey="Atmar, R L" uniqKey="Atmar R">R.L. Atmar</name></author><author><name sortKey="Peters, C J" uniqKey="Peters C">C.J. Peters</name></author><author><name sortKey="Couch, R B" uniqKey="Couch R">R.B. Couch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jaume, M" uniqKey="Jaume M">M. Jaume</name></author><author><name sortKey="Yip, M S" uniqKey="Yip M">M.S. Yip</name></author><author><name sortKey="Kam, Y W" uniqKey="Kam Y">Y.W. Kam</name></author><author><name sortKey="Cheung, C Y" uniqKey="Cheung C">C.Y. Cheung</name></author><author><name sortKey="Kien, F" uniqKey="Kien F">F. Kien</name></author><author><name sortKey="Roberts, A" uniqKey="Roberts A">A. Roberts</name></author><author><name sortKey="Li, P H" uniqKey="Li P">P.H. Li</name></author><author><name sortKey="Dutry, I" uniqKey="Dutry I">I. Dutry</name></author><author><name sortKey="Escriou, N" uniqKey="Escriou N">N. Escriou</name></author><author><name sortKey="Daeron, M" uniqKey="Daeron M">M. Daeron</name></author><author><name sortKey="Bruzzone, R" uniqKey="Bruzzone R">R. Bruzzone</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name></author><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Nal, B" uniqKey="Nal B">B. Nal</name></author><author><name sortKey="Altmeyer, R" uniqKey="Altmeyer R">R. Altmeyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y. He</name></author><author><name sortKey="Lu, H" uniqKey="Lu H">H. Lu</name></author><author><name sortKey="Siddiqui, P" uniqKey="Siddiqui P">P. Siddiqui</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y. Zhou</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author><author><name sortKey="Bottazzi, M E" uniqKey="Bottazzi M">M.E. Bottazzi</name></author><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author><author><name sortKey="Lustigman, S" uniqKey="Lustigman S">S. Lustigman</name></author><author><name sortKey="Tseng, C T" uniqKey="Tseng C">C.T. Tseng</name></author><author><name sortKey="Curti, E" uniqKey="Curti E">E. Curti</name></author><author><name sortKey="Jones, K" uniqKey="Jones K">K. Jones</name></author><author><name sortKey="Zhan, B" uniqKey="Zhan B">B. Zhan</name></author><author><name sortKey="Hotez, P J" uniqKey="Hotez P">P.J. Hotez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L. Lu</name></author><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author><author><name sortKey="Debnath, A K" uniqKey="Debnath A">A.K. Debnath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Chan, J F" uniqKey="Chan J">J.F. Chan</name></author><author><name sortKey="Tse, H" uniqKey="Tse H">H. Tse</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H. Chen</name></author><author><name sortKey="Lau, C C" uniqKey="Lau C">C.C. Lau</name></author><author><name sortKey="Cai, J P" uniqKey="Cai J">J.P. Cai</name></author><author><name sortKey="Tsang, A K" uniqKey="Tsang A">A.K. Tsang</name></author><author><name sortKey="Xiao, X" uniqKey="Xiao X">X. Xiao</name></author><author><name sortKey="To, K K" uniqKey="To K">K.K. To</name></author><author><name sortKey="Lau, S K" uniqKey="Lau S">S.K. Lau</name></author><author><name sortKey="Woo, P C" uniqKey="Woo P">P.C. Woo</name></author><author><name sortKey="Zheng, B J" uniqKey="Zheng B">B.J. Zheng</name></author><author><name sortKey="Wang, M" uniqKey="Wang M">M. Wang</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author><author><name sortKey="Ma, C" uniqKey="Ma C">C. Ma</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brogan, T V" uniqKey="Brogan T">T.V. Brogan</name></author><author><name sortKey="Thiagarajan, R R" uniqKey="Thiagarajan R">R.R. Thiagarajan</name></author><author><name sortKey="Rycus, P T" uniqKey="Rycus P">P.T. Rycus</name></author><author><name sortKey="Bartlett, R H" uniqKey="Bartlett R">R.H. Bartlett</name></author><author><name sortKey="Bratton, S L" uniqKey="Bratton S">S.L. Bratton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stockman, L J" uniqKey="Stockman L">L.J. Stockman</name></author><author><name sortKey="Bellamy, R" uniqKey="Bellamy R">R. Bellamy</name></author><author><name sortKey="Garner, P" uniqKey="Garner P">P. Garner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, V C" uniqKey="Cheng V">V.C. Cheng</name></author><author><name sortKey="Lau, S K" uniqKey="Lau S">S.K. Lau</name></author><author><name sortKey="Woo, P C" uniqKey="Woo P">P.C. Woo</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kindler, E" uniqKey="Kindler E">E. Kindler</name></author><author><name sortKey="Jonsdottir, H R" uniqKey="Jonsdottir H">H.R. Jonsdottir</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D. Muth</name></author><author><name sortKey="Hamming, O J" uniqKey="Hamming O">O.J. Hamming</name></author><author><name sortKey="Hartmann, R" uniqKey="Hartmann R">R. Hartmann</name></author><author><name sortKey="Rodriguez, R" uniqKey="Rodriguez R">R. Rodriguez</name></author><author><name sortKey="Geffers, R" uniqKey="Geffers R">R. Geffers</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Muller, M A" uniqKey="Muller M">M.A. Muller</name></author><author><name sortKey="Dijkman, R" uniqKey="Dijkman R">R. Dijkman</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V. Thiel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Osterholm, M T" uniqKey="Osterholm M">M.T. Osterholm</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, K J" uniqKey="Huang K">K.J. Huang</name></author><author><name sortKey="Su, I J" uniqKey="Su I">I.J. Su</name></author><author><name sortKey="Theron, M" uniqKey="Theron M">M. Theron</name></author><author><name sortKey="Wu, Y C" uniqKey="Wu Y">Y.C. Wu</name></author><author><name sortKey="Lai, S K" uniqKey="Lai S">S.K. Lai</name></author><author><name sortKey="Liu, C C" uniqKey="Liu C">C.C. Liu</name></author><author><name sortKey="Lei, H Y" uniqKey="Lei H">H.Y. Lei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tisoncik, J R" uniqKey="Tisoncik J">J.R. Tisoncik</name></author><author><name sortKey="Korth, M J" uniqKey="Korth M">M.J. Korth</name></author><author><name sortKey="Simmons, C P" uniqKey="Simmons C">C.P. Simmons</name></author><author><name sortKey="Farrar, J" uniqKey="Farrar J">J. Farrar</name></author><author><name sortKey="Martin, T R" uniqKey="Martin T">T.R. Martin</name></author><author><name sortKey="Katze, M G" uniqKey="Katze M">M.G. Katze</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Josset, L" uniqKey="Josset L">L. Josset</name></author><author><name sortKey="Menachery, V D" uniqKey="Menachery V">V.D. Menachery</name></author><author><name sortKey="Gralinski, L E" uniqKey="Gralinski L">L.E. Gralinski</name></author><author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S. Agnihothram</name></author><author><name sortKey="Sova, P" uniqKey="Sova P">P. Sova</name></author><author><name sortKey="Carter, V S" uniqKey="Carter V">V.S. Carter</name></author><author><name sortKey="Yount, B L" uniqKey="Yount B">B.L. Yount</name></author><author><name sortKey="Graham, R L" uniqKey="Graham R">R.L. Graham</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author><author><name sortKey="Katze, M G" uniqKey="Katze M">M.G. Katze</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, J F" uniqKey="Chan J">J.F. Chan</name></author><author><name sortKey="Li, K S" uniqKey="Li K">K.S. Li</name></author><author><name sortKey="To, K K" uniqKey="To K">K.K. To</name></author><author><name sortKey="Cheng, V C" uniqKey="Cheng V">V.C. Cheng</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H. Chen</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author><author><name sortKey="Lin, K" uniqKey="Lin K">K. Lin</name></author><author><name sortKey="Strick, N" uniqKey="Strick N">N. Strick</name></author><author><name sortKey="Neurath, A R" uniqKey="Neurath A">A.R. Neurath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wild, C T" uniqKey="Wild C">C.T. Wild</name></author><author><name sortKey="Shugars, D C" uniqKey="Shugars D">D.C. Shugars</name></author><author><name sortKey="Greenwell, T K" uniqKey="Greenwell T">T.K. Greenwell</name></author><author><name sortKey="Mcdanal, C B" uniqKey="Mcdanal C">C.B. McDanal</name></author><author><name sortKey="Matthews, T J" uniqKey="Matthews T">T.J. Matthews</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kilby, J M" uniqKey="Kilby J">J.M. Kilby</name></author><author><name sortKey="Eron, J J" uniqKey="Eron J">J.J. Eron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lalezari, J P" uniqKey="Lalezari J">J.P. Lalezari</name></author><author><name sortKey="Henry, K" uniqKey="Henry K">K. Henry</name></author><author><name sortKey="O Hearn, M" uniqKey="O Hearn M">M. O'Hearn</name></author><author><name sortKey="Montaner, J S" uniqKey="Montaner J">J.S. Montaner</name></author><author><name sortKey="Piliero, P J" uniqKey="Piliero P">P.J. Piliero</name></author><author><name sortKey="Trottier, B" uniqKey="Trottier B">B. Trottier</name></author><author><name sortKey="Walmsley, S" uniqKey="Walmsley S">S. Walmsley</name></author><author><name sortKey="Cohen, C" uniqKey="Cohen C">C. Cohen</name></author><author><name sortKey="Kuritzkes, D R" uniqKey="Kuritzkes D">D.R. Kuritzkes</name></author><author><name sortKey="Eron, J J" uniqKey="Eron J">J.J. Eron</name></author><author><name sortKey="Chung, J" uniqKey="Chung J">J. Chung</name></author><author><name sortKey="Demasi, R" uniqKey="Demasi R">R. DeMasi</name></author><author><name sortKey="Donatacci, L" uniqKey="Donatacci L">L. Donatacci</name></author><author><name sortKey="Drobnes, C" uniqKey="Drobnes C">C. Drobnes</name></author><author><name sortKey="Delehanty, J" uniqKey="Delehanty J">J. Delehanty</name></author><author><name sortKey="Salgo, M" uniqKey="Salgo M">M. Salgo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, S" uniqKey="Liu S">S. Liu</name></author><author><name sortKey="Xiao, G" uniqKey="Xiao G">G. Xiao</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author><author><name sortKey="He, Y" uniqKey="He Y">Y. He</name></author><author><name sortKey="Niu, J" uniqKey="Niu J">J. Niu</name></author><author><name sortKey="Escalante, C R" uniqKey="Escalante C">C.R. Escalante</name></author><author><name sortKey="Xiong, H" uniqKey="Xiong H">H. Xiong</name></author><author><name sortKey="Farmar, J" uniqKey="Farmar J">J. Farmar</name></author><author><name sortKey="Debnath, A K" uniqKey="Debnath A">A.K. Debnath</name></author><author><name sortKey="Tien, P" uniqKey="Tien P">P. Tien</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, S" uniqKey="Liu S">S. Liu</name></author><author><name sortKey="Wu, S" uniqKey="Wu S">S. Wu</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Microbes Infect</journal-id><journal-id journal-id-type="iso-abbrev">Microbes Infect</journal-id><journal-title-group><journal-title>Microbes and Infection</journal-title></journal-title-group><issn pub-type="ppub">1286-4579</issn><issn pub-type="epub">1769-714X</issn><publisher><publisher-name>Institut Pasteur. Published by Elsevier Masson SAS</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23791956</article-id><article-id pub-id-type="pmc">7110483</article-id><article-id pub-id-type="publisher-id">S1286-4579(13)00118-4</article-id><article-id pub-id-type="doi">10.1016/j.micinf.2013.06.003</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Middle East respiratory syndrome coronavirus (MERS-CoV): challenges in identifying its source and controlling its spread</article-title></title-group><contrib-group><contrib contrib-type="author" id="au1"><name><surname>Lu</surname><given-names>Lu</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au2"><name><surname>Liu</surname><given-names>Qi</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au3"><name><surname>Du</surname><given-names>Lanying</given-names></name><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="au4"><name><surname>Jiang</surname><given-names>Shibo</given-names></name><email>shibojiang@fudan.edu.cn</email><xref rid="aff1" ref-type="aff">a</xref><xref rid="aff2" ref-type="aff">b</xref><xref rid="cor1" ref-type="corresp">∗</xref></contrib></contrib-group><aff id="aff1"><label>a</label>Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College, Fudan University, Shanghai 200032, China</aff><aff id="aff2"><label>b</label>Lindsley F. Kimball Research Institute, New York Blood Center, 310 East 67th Street, New York, NY, USA</aff><author-notes><corresp id="cor1"><label>∗</label>Corresponding author. Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College, Fudan University, Shanghai 200032, China. Tel.: +86 21 54237673; fax: +86 21 54237465. <email>shibojiang@fudan.edu.cn</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>19</day><month>6</month><year>2013</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub" iso-8601-date="2013-08-01"><season>July-August</season><year>2013</year></pub-date><pub-date pub-type="epub"><day>19</day><month>6</month><year>2013</year></pub-date><volume>15</volume><issue>8</issue><fpage>625</fpage><lpage>629</lpage><history><date date-type="received"><day>9</day><month>6</month><year>2013</year></date></history><permissions><copyright-statement>Copyright © 2013 Institut Pasteur. Published by Elsevier Masson SAS All rights reserved.</copyright-statement><copyright-year>2013</copyright-year><copyright-holder>Institut Pasteur</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="abs0010"><p>Middle East respiratory syndrome coronavirus (MERS-CoV), a novel human coronavirus that caused outbreaks of a SARS-like illness in the Middle East, is now considered a threat to global public health. This review discusses the challenges in identifying the source of this fatal virus and developing effective and safe anti-MERS-CoV vaccines and therapeutics in order to control its spread and to combat any future pandemic.</p></abstract><kwd-group id="kwrds0010"><title>Keywords</title><kwd>Coronavirus</kwd><kwd>MERS-CoV</kwd><kwd>SARS-CoV</kwd><kwd>Source</kwd><kwd>Vaccine</kwd><kwd>Therapeutics</kwd></kwd-group></article-meta></front><body><sec id="sec1"><label>1</label><title>Introduction</title><p id="p0010">On 20 September 2012, Dr. Ali Moh Zaki, a virologist at Dr. Fakeeh Hospital, Jeddah, Saudi Arabia, first reported on the Program for Monitoring Emerging Diseases (ProMED-mail) that a novel coronavirus (nCoV) had been isolated from the lungs of a 60-year-old male patient with acute pneumonia and acute renal failure <xref rid="bib1" ref-type="bibr">[1]</xref>. On 23 September 2012, the World Health Organization (WHO) was informed by the United Kingdom (UK) of a 49-year-old male Qatari national who had a travel history to Saudi Arabia and Qatar and showed symptoms of nCoV infection <xref rid="bib2" ref-type="bibr">[2]</xref>. In November 2012, the virus was identified as a novel betacoronavirus, the closest relative of the bat coronaviruses HKU4 and HKU5, by Dr. Ron Fouchier's group at the Erasmus Medical Center in Rotterdam, the Netherlands, and thus termed “hCoV-EMC” <xref rid="bib3" ref-type="bibr">[3]</xref>. In May 2013, this virus was renamed as the Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) by the Coronavirus Study Group of the International Committee on Taxonomy of Viruses <xref rid="bib4" ref-type="bibr">[4]</xref>, and the term was then adopted by WHO <xref rid="bib5" ref-type="bibr">[5]</xref>.</p><p id="p0015">By 7 June 2013, WHO had been informed of 55 confirmed cases, including 31 deaths (a case fatality rate of 56%), from four countries in the Middle East (Saudi Arabia, Jordan, Qatar, and the United Arab Emirates), three countries in Europe (France, Italy, and the United Kingdom), and one country in Africa (Tunisia) (<xref rid="tbl1" ref-type="table">Table 1</xref>) <xref rid="bib5" ref-type="bibr">[5]</xref>. Some of the patients reported in Europe were originally infected during their travel in the Middle East and became ill after their return to Europe, while others who had not been to the Middle East, but had been in close contact with laboratory-confirmed or probable cases, became infected because of limited person-to-person transmission. So far, eight MERS-CoV clusters have been reported. The largest cluster was linked to one healthcare facility in Al-Ahsa, Saudi Arabia, consisting of 25 patients and including 14 deaths. Two of these patients are healthcare providers who were infected after caring for patients with MERS-CoV infection <xref rid="bib5" ref-type="bibr">[5]</xref>, <xref rid="bib6" ref-type="bibr">[6]</xref>. This evidence strongly suggests human-to-human transmission involving different modes, such as droplet and contact transmission, although the efficiency of human-to-human transmission of MERS-CoV is lower than severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) <xref rid="bib6" ref-type="bibr">[6]</xref>. However, MERS-CoV may gain increased human-to-human transmissibility after its further adaptation and evolution in humans or as-yet unknown intermediate hosts, eventually causing a global pandemic like the one caused by SARS-CoV in 2003 <xref rid="bib7" ref-type="bibr">[7]</xref>, <xref rid="bib8" ref-type="bibr">[8]</xref>, <xref rid="bib9" ref-type="bibr">[9]</xref>, <xref rid="bib10" ref-type="bibr">[10]</xref>.<table-wrap position="float" id="tbl1"><label>Table 1</label><caption><p>The cumulative number of MERS cases and deaths as of 6 June 2013 <xref rid="bib5" ref-type="bibr">[5]</xref>.</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Countries</th><th>Cases</th><th>Deaths</th></tr></thead><tbody><tr><td>Middle East</td><td align="char">45</td><td align="char">28</td></tr><tr><td> Saudi Arabia</td><td align="char">40</td><td align="char">25</td></tr><tr><td> Jordan</td><td align="char">2</td><td align="char">2</td></tr><tr><td> Qatar</td><td align="char">2</td><td align="char">0</td></tr><tr><td> United Arab Emirates (UAE)</td><td align="char">1</td><td align="char">1</td></tr><tr><td>Europe</td><td align="char">8</td><td align="char">3</td></tr><tr><td> United Kingdom (UK)</td><td align="char">3</td><td align="char">2</td></tr><tr><td> France</td><td align="char">2</td><td align="char">1</td></tr><tr><td> Italy</td><td align="char">3</td><td align="char">0</td></tr><tr><td>Africa</td><td align="char">2</td><td align="char">0</td></tr><tr><td> Tunisia</td><td align="char">2</td><td align="char">0</td></tr><tr><td>Total</td><td align="char">55</td><td align="char">31</td></tr></tbody></table></table-wrap></p><p id="p0020">On 27 May 2013 at the Sixty-sixth World Health Assembly, Geneva, Switzerland, Dr. Margaret Chan, the Director-General of WHO, pointed out that “the novel coronavirus is a threat to the entire world” because we still do not know where the virus hides in nature or how people become infected <xref rid="bib11" ref-type="bibr">[11]</xref>.</p><p id="p0025">On 5 June 2013, the Obama administration designated MERS-CoV a threat to public health and national security and gave officials the authority to fast-track the approval of tests and treatments for MERS-CoV <xref rid="bib12" ref-type="bibr">[12]</xref>. Dr. Kathleen Sebelius, the Secretary of the Department of Health and Human Services of the United States, made the designation, allowing the U.S. Food and Drug Administration (FDA) to quickly approve products after accepting an “emergency use application (EUA)” <xref rid="bib13" ref-type="bibr">[13]</xref>.</p><p id="p0030">In mid-October of this year, more than two million Muslims will undertake the Hajj, an annual pilgrimage to Mecca, and they will remain in a confined geographical area over a five-day period. Medical authorities in Saudi Arabia have taken immediate steps to implement control measures over fears of a potential MERS-CoV pandemic resulting from this event, including the advisement to wear face masks in overcrowded areas <xref rid="bib14" ref-type="bibr">[14]</xref>.</p><p id="p0035">Therefore, while researchers need to take appropriate steps now to identify the source of MERS-CoV, track down its intermediate host(s), and develop strategies for controlling its spread, these goals also bring a number of challenges.</p></sec><sec id="sec2"><label>2</label><title>Challenge in identifying the source of MERS-CoV</title><p id="p0040">The first challenge confronting researchers is identifying the source of MERS-CoV. Genetically, we know that this virus is closely related to <italic>Tylonycteris</italic> bat CoV HKU4 (Ty-BatCoV HKU4) and <italic>Pipistrellus</italic> bat CoV HKU5 (Pi-BatCoV HKU5) in bats from Hong Kong. However, the molecular clock analysis suggests that these bat viruses are unlikely the direct ancestor of MERS-CoV <xref rid="bib15" ref-type="bibr">[15]</xref>.</p><p id="p0045">MERS-CoV uses the evolutionarily conserved dipeptidyl peptidase 4 (DPP4) as its functional receptor <xref rid="bib16" ref-type="bibr">[16]</xref>, enters into the target cell via plasma or endosomal membrane fusion, and replicates in the host cell in a similar way as SARS-CoV does <xref rid="bib17" ref-type="bibr">[17]</xref> (<xref rid="fig1" ref-type="fig">Fig. 1</xref>). It can infect various mammalian cell lines, such as primate, porcine, bat and rabbit cells <xref rid="bib18" ref-type="bibr">[18]</xref>, suggesting that MERS-CoV may have broad species tropism. It was reported that some MERS-CoV cases, as noted above, had a history of contact with animals, such as camels and goats <xref rid="bib19" ref-type="bibr">[19]</xref>, suggesting that MERS-CoV may have jumped from bats to these animals before infecting humans. However, its animal reservoir and intermediate hosts still have not been identified, which has significantly hindered the development of strategies to control this emerging infectious disease and combat the potential pandemic of MERS.<fig id="fig1"><label>Fig. 1</label><caption><p>The life cycle of MERS-CoV. MERS-CoV first binds, via its S protein, to the receptor DPP4 on the target cell <xref rid="bib16" ref-type="bibr">[16]</xref>, and then releases its RNA genome, through plasma or endosomal membrane fusion, into the target cell. After transcription and translation, the new genomic RNA and viral proteins are then assembled into virions, which are transported via vesicles and released out of the host cell, in a way similar to SARS-CoV <xref rid="bib17" ref-type="bibr">[17]</xref>.</p></caption><graphic xlink:href="gr1"></graphic></fig></p></sec><sec id="sec3"><label>3</label><title>Challenge in designing MERS vaccines</title><p id="p0050">To control MERS, we must develop an effective and safe vaccine, which constitutes a second challenge to researchers. However, the problems encountered in the development of SARS vaccines should be revisited before the MERS vaccines are designed. Some of the inactivated virus-based, DNA-based and viral vector-based vaccine candidates could induce Th2-mediated immunopathology or immunoenhancing pathology <xref rid="bib20" ref-type="bibr">[20]</xref>, <xref rid="bib21" ref-type="bibr">[21]</xref>, <xref rid="bib22" ref-type="bibr">[22]</xref>, <xref rid="bib23" ref-type="bibr">[23]</xref>, <xref rid="bib24" ref-type="bibr">[24]</xref>, raising concerns about the safety of the SARS vaccines.</p><p id="p0055">Our previous studies have shown that the SARS vaccine candidates based on the receptor-binding domain (RBD) in the S1 subunit of the SARS-CoV spike protein is more effective and safer than the above-mentioned vaccine candidates <xref rid="bib17" ref-type="bibr">[17]</xref>, <xref rid="bib25" ref-type="bibr">[25]</xref>, <xref rid="bib26" ref-type="bibr">[26]</xref>. By comparing the sequences of spike proteins of SARS-CoV and MERS-CoV, we predicted that a 286-amino acid fragment (residues 377–662) in the S1 subunit of MERS-CoV contains its RBD <xref rid="bib27" ref-type="bibr">[27]</xref>. We strongly believe that the RBD in the MERS-CoV spike protein is therefore an important target for developing MERS vaccines.</p><p id="p0060">Most recently, Chan et al. reported that the sera of some convalescent SARS patients contained antibodies that could cross-react or cross-neutralize MERS-CoV <xref rid="bib28" ref-type="bibr">[28]</xref>. This raises a hope that people with histories of SARS-CoV infection might not be susceptible to MERS-CoV infection. However, our study demonstrated that the epitopes eliciting the cross-reactive antibodies may not be located in the RBD of SARS-CoV S protein <xref rid="bib29" ref-type="bibr">[29]</xref>. Thus, it is doubtful whether these antibodies really have a role in cross-protection against MERS-CoV.</p></sec><sec id="sec4"><label>4</label><title>Challenge in developing anti-MERS therapy</title><p id="p0065">To date, no effective antiviral therapeutics against MERS-CoV have been discovered. Clinical management is mainly supportive, placing emphasis on organ support for respiratory and renal failure. In cases of acute respiratory failure, the use of extracorporeal membrane oxygenation (ECMO) is expected to improve survival rates significantly <xref rid="bib30" ref-type="bibr">[30]</xref>.</p><p id="p0070">Several nonspecific antiviral drugs, such as ribavirin, lopinavir, and type I IFN, have been used for treating SARS, although their actual efficacy in these patients is still unclear <xref rid="bib31" ref-type="bibr">[31]</xref>, <xref rid="bib32" ref-type="bibr">[32]</xref>. IFN-α was shown to inhibit <italic>in vitro</italic> MERS-CoV replication in cells <xref rid="bib33" ref-type="bibr">[33]</xref>, but it is unknown whether it works <italic>in vivo</italic>.</p><p id="p0075">It has been thought that cytokine storm, a potentially fatal immune reaction characterized by the massive release of proinflammatory cytokines, is responsible for the deaths of patients infected by highly pathogenic avian influenza A (H5N1) virus or SARS-CoV <xref rid="bib34" ref-type="bibr">[34]</xref>, <xref rid="bib35" ref-type="bibr">[35]</xref>. Therefore, immunosuppressant or immunomodulatory drugs, which diminish inflammation during infection, are expected to have therapeutic benefit <xref rid="bib36" ref-type="bibr">[36]</xref>. However, whether or not the immunosuppressant drugs should be used for treating MERS patients is debatable. First, no report has yet shown that cytokine storms are indeed responsible for the deaths of MERS patients. Second, cell host response to infection with MERS-CoV is much different from that to SARS-CoV infection <xref rid="bib37" ref-type="bibr">[37]</xref>. Yuen and colleagues believed that corticosteroid should not be considered for treating MERS, particularly since patients with severe pneumonia and respiratory failure could be supported by ECMO until the cytokine storm is over <xref rid="bib38" ref-type="bibr">[38]</xref>.</p><p id="p0080">Similar to HIV and SARS-CoV, MERS-CoV enters the target cells through its S2 protein-mediated membrane fusion (<xref rid="fig1" ref-type="fig">Fig. 1</xref>). Therefore, the S2 subunit of the MERS-CoV S protein may serve as a target for developing MERS-CoV fusion inhibitors. In the early 1990s, Jiang et al. <xref rid="bib39" ref-type="bibr">[39]</xref> and Wild et al. <xref rid="bib40" ref-type="bibr">[40]</xref> found that the peptides SJ-2176 and T20 derived from the HIV-1 gp41 HR2 domain had potent anti-HIV-1 activity. In 2003, T20 was approved by the U.S. FDA for treatment of HIV-infected patients who fail to respond to the current antiretroviral drugs <xref rid="bib41" ref-type="bibr">[41]</xref>, <xref rid="bib42" ref-type="bibr">[42]</xref>. In 2004, Jiang and colleagues identified an anti-SARS-CoV peptide (CP-1) from the SARS-CoV S protein S2 subunit of the HR2 domain <xref rid="bib43" ref-type="bibr">[43]</xref>. Similar approaches could also be used to identify anti-MERS-CoV peptides. Different from the T20-based HIV/AIDS treatment regimen, which needs long-term injection <xref rid="bib44" ref-type="bibr">[44]</xref>, the MERS-CoV fusion inhibitor-based therapy would only require a regimen of a few days at the onset of MERS-CoV infection to save patients' lives.</p></sec><sec id="sec5"><label>5</label><title>Conclusion</title><p id="p0085">In conclusion, MERS-CoV, which originally caused outbreaks of a SARS-like illness in the Middle East, is now considered a threat to global public health. While its human-to-human transmission is so far limited, serious concerns over its pandemic potential have been raised. Therefore, researchers must take immediate steps to identify the source of this fatal virus and develop effective and safe anti-MERS-CoV vaccines and therapeutics in order to control its spread and to combat any future pandemic.</p></sec></body><back><ref-list id="cebib0010"><title>References</title><ref id="bib1"><label>1</label><mixed-citation publication-type="other" id="oref1">A.M. Zaki, Novel Cornavirus – Saudi Arabia: Human Isolate, <ext-link ext-link-type="uri" xlink:href="http://www.promedmail.org/direct.php%3fid%3d20120920.1302733" id="intref0010">http://www.promedmail.org/direct.php?id=20120920.1302733</ext-link> (accessed 09.06.13).</mixed-citation></ref><ref id="bib2"><label>2</label><mixed-citation publication-type="other" id="oref2">WHO, Novel Coronavirus Infection in the United Kingdom, <ext-link ext-link-type="uri" xlink:href="http://www.who.int/csr/don/2012_09_23/en/index.html" id="intref0015">http://www.who.int/csr/don/2012_09_23/en/index.html</ext-link> (accessed 09.06.13).</mixed-citation></ref><ref id="bib3"><label>3</label><element-citation publication-type="journal" id="sref1"><person-group person-group-type="author"><name><surname>Zaki</surname><given-names>A.M.</given-names></name><name><surname>van Boheemen</surname><given-names>S.</given-names></name><name><surname>Bestebroer</surname><given-names>T.M.</given-names></name><name><surname>Osterhaus</surname><given-names>A.D.M.E.</given-names></name><name><surname>Fouchier</surname><given-names>R.A.M.</given-names></name></person-group><article-title>Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia</article-title><source>N. Engl. J. Med.</source><volume>367</volume><year>2012</year><fpage>1814</fpage><lpage>1820</lpage><pub-id pub-id-type="pmid">23075143</pub-id></element-citation></ref><ref id="bib4"><label>4</label><element-citation publication-type="journal" id="sref2"><person-group person-group-type="author"><name><surname>de Groot</surname><given-names>R.J.</given-names></name><name><surname>Baker</surname><given-names>S.C.</given-names></name><name><surname>Baric</surname><given-names>R.S.</given-names></name><name><surname>Brown</surname><given-names>C.S.</given-names></name><name><surname>Drosten</surname><given-names>C.</given-names></name><name><surname>Enjuanes</surname><given-names>L.</given-names></name><name><surname>Fouchier</surname><given-names>R.A.</given-names></name><name><surname>Galiano</surname><given-names>M.</given-names></name><name><surname>Gorbalenya</surname><given-names>A.E.</given-names></name><name><surname>Memish</surname><given-names>Z.</given-names></name><name><surname>Perlman</surname><given-names>S.</given-names></name><name><surname>Poon</surname><given-names>L.L.</given-names></name><name><surname>Snijder</surname><given-names>E.J.</given-names></name><name><surname>Stephens</surname><given-names>G.M.</given-names></name><name><surname>Woo</surname><given-names>P.C.</given-names></name><name><surname>Zaki</surname><given-names>A.M.</given-names></name><name><surname>Zambon</surname><given-names>M.</given-names></name><name><surname>Ziebuhr</surname><given-names>J.</given-names></name></person-group><article-title>Middle East respiratory syndrome coronavirus (MERS-CoV); announcement of the coronavirus study group</article-title><source>J. Virol.</source><year>15 May 2013</year><comment>(Epub ahead of print)</comment></element-citation></ref><ref id="bib5"><label>5</label><mixed-citation publication-type="other" id="oref3">WHO, Novel Coronavirus Infection – Update (Middle East Respiratory Syndrome-coronavirus), <ext-link ext-link-type="uri" xlink:href="http://www.who.int/csr/don/2013_06_07/en/index.html" id="intref0020">http://www.who.int/csr/don/2013_06_07/en/index.html</ext-link> (accessed 09.06.13).</mixed-citation></ref><ref id="bib6"><label>6</label><mixed-citation publication-type="other" id="oref4">Centers for Disease Control and Prevention, Update, Case Definitions, and Guidance – MERS Update, <ext-link ext-link-type="uri" xlink:href="http://www.cdc.gov/coronavirus/mers/case-def.html" id="intref0025">http://www.cdc.gov/coronavirus/mers/case-def.html</ext-link> (accessed 09.06.13).</mixed-citation></ref><ref id="bib7"><label>7</label><element-citation publication-type="journal" id="sref3"><person-group person-group-type="author"><name><surname>Peiris</surname><given-names>J.S.M.</given-names></name><name><surname>Lai</surname><given-names>S.T.</given-names></name><name><surname>Poon</surname><given-names>L.L.M.</given-names></name><name><surname>Guan</surname><given-names>Y.</given-names></name><name><surname>Yam</surname><given-names>L.Y.C.</given-names></name><name><surname>Lim</surname><given-names>W.</given-names></name><name><surname>Nicholls</surname><given-names>J.</given-names></name><name><surname>Yee</surname><given-names>W.K.S.</given-names></name><name><surname>Yan</surname><given-names>W.W.</given-names></name><name><surname>Cheung</surname><given-names>M.T.</given-names></name><name><surname>Cheng</surname><given-names>V.C.C.</given-names></name><name><surname>Chan</surname><given-names>K.H.</given-names></name><name><surname>Tsang</surname><given-names>D.N.C.</given-names></name><name><surname>Yung</surname><given-names>R.W.H.</given-names></name><name><surname>Ng</surname><given-names>T.K.</given-names></name><name><surname>Yuen</surname><given-names>K.Y.</given-names></name></person-group><article-title>Coronavirus as a possible cause of severe acute respiratory syndrome</article-title><source>Lancet</source><volume>361</volume><year>2003</year><fpage>1319</fpage><lpage>1325</lpage><pub-id pub-id-type="pmid">12711465</pub-id></element-citation></ref><ref id="bib8"><label>8</label><element-citation publication-type="journal" id="sref4"><person-group person-group-type="author"><name><surname>Zhong</surname><given-names>N.S.</given-names></name><name><surname>Zheng</surname><given-names>B.J.</given-names></name><name><surname>Li</surname><given-names>Y.M.</given-names></name><name><surname>Poon</surname><given-names>L.L.M.</given-names></name><name><surname>Xie</surname><given-names>Z.H.</given-names></name><name><surname>Chan</surname><given-names>K.H.</given-names></name><name><surname>Li</surname><given-names>P.H.</given-names></name><name><surname>Tan</surname><given-names>S.Y.</given-names></name><name><surname>Chang</surname><given-names>Q.</given-names></name><name><surname>Xie</surname><given-names>J.P.</given-names></name><name><surname>Liu</surname><given-names>X.Q.</given-names></name><name><surname>Xu</surname><given-names>J.</given-names></name><name><surname>Li</surname><given-names>D.X.</given-names></name><name><surname>Yuen</surname><given-names>K.Y.</given-names></name><name><surname>Peiris</surname><given-names>J.S.M.</given-names></name><name><surname>Guan</surname><given-names>Y.</given-names></name></person-group><article-title>Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003</article-title><source>Lancet</source><volume>362</volume><year>2003</year><fpage>1353</fpage><lpage>1358</lpage><pub-id pub-id-type="pmid">14585636</pub-id></element-citation></ref><ref id="bib9"><label>9</label><element-citation publication-type="journal" id="sref5"><person-group person-group-type="author"><name><surname>Drosten</surname><given-names>C.</given-names></name><name><surname>Gunther</surname><given-names>S.</given-names></name><name><surname>Preiser</surname><given-names>W.</given-names></name><name><surname>van der</surname><given-names>W.S.</given-names></name><name><surname>Brodt</surname><given-names>H.R.</given-names></name><name><surname>Becker</surname><given-names>S.</given-names></name><name><surname>Rabenau</surname><given-names>H.</given-names></name><name><surname>Panning</surname><given-names>M.</given-names></name><name><surname>Kolesnikova</surname><given-names>L.</given-names></name><name><surname>Fouchier</surname><given-names>R.A.</given-names></name><name><surname>Berger</surname><given-names>A.</given-names></name><name><surname>Burguiere</surname><given-names>A.M.</given-names></name><name><surname>Cinatl</surname><given-names>J.</given-names></name><name><surname>Eickmann</surname><given-names>M.</given-names></name><name><surname>Escriou</surname><given-names>N.</given-names></name><name><surname>Grywna</surname><given-names>K.</given-names></name><name><surname>Kramme</surname><given-names>S.</given-names></name><name><surname>Manuguerra</surname><given-names>J.C.</given-names></name><name><surname>Muller</surname><given-names>S.</given-names></name><name><surname>Rickerts</surname><given-names>V.</given-names></name><name><surname>Sturmer</surname><given-names>M.</given-names></name><name><surname>Vieth</surname><given-names>S.</given-names></name><name><surname>Klenk</surname><given-names>H.D.</given-names></name><name><surname>Osterhaus</surname><given-names>A.D.</given-names></name><name><surname>Schmitz</surname><given-names>H.</given-names></name><name><surname>Doerr</surname><given-names>H.W.</given-names></name></person-group><article-title>Identification of a novel coronavirus in patients with severe acute respiratory syndrome</article-title><source>N. Engl. J. Med.</source><volume>348</volume><year>2003</year><fpage>1967</fpage><lpage>1976</lpage><pub-id pub-id-type="pmid">12690091</pub-id></element-citation></ref><ref id="bib10"><label>10</label><element-citation publication-type="journal" id="sref6"><person-group person-group-type="author"><name><surname>Rota</surname><given-names>P.A.</given-names></name><name><surname>Oberste</surname><given-names>M.S.</given-names></name><name><surname>Monroe</surname><given-names>S.S.</given-names></name><name><surname>Nix</surname><given-names>W.A.</given-names></name><name><surname>Campagnoli</surname><given-names>R.</given-names></name><name><surname>Icenogle</surname><given-names>J.P.</given-names></name><name><surname>Penaranda</surname><given-names>S.</given-names></name><name><surname>Bankamp</surname><given-names>B.</given-names></name><name><surname>Maher</surname><given-names>K.</given-names></name><name><surname>Chen</surname><given-names>M.H.</given-names></name><name><surname>Tong</surname><given-names>S.X.</given-names></name><name><surname>Tamin</surname><given-names>A.</given-names></name><name><surname>Lowe</surname><given-names>L.</given-names></name><name><surname>Frace</surname><given-names>M.</given-names></name><name><surname>Derisi</surname><given-names>J.L.</given-names></name><name><surname>Chen</surname><given-names>Q.</given-names></name><name><surname>Wang</surname><given-names>D.</given-names></name><name><surname>Erdman</surname><given-names>D.D.</given-names></name><name><surname>Peret</surname><given-names>T.C.T.</given-names></name><name><surname>Burns</surname><given-names>C.</given-names></name><name><surname>Ksiazek</surname><given-names>T.G.</given-names></name><name><surname>Rollin</surname><given-names>P.E.</given-names></name><name><surname>Sanchez</surname><given-names>A.</given-names></name><name><surname>Liffick</surname><given-names>S.</given-names></name><name><surname>Holloway</surname><given-names>B.</given-names></name><name><surname>Limor</surname><given-names>J.</given-names></name><name><surname>McCaustland</surname><given-names>K.</given-names></name><name><surname>Olsen-Rasmussen</surname><given-names>M.</given-names></name><name><surname>Fouchier</surname><given-names>R.</given-names></name><name><surname>Gunther</surname><given-names>S.</given-names></name><name><surname>Osterhaus</surname><given-names>A.D.M.E.</given-names></name><name><surname>Drosten</surname><given-names>C.</given-names></name><name><surname>Pallansch</surname><given-names>M.A.</given-names></name><name><surname>Anderson</surname><given-names>L.J.</given-names></name><name><surname>Bellini</surname><given-names>W.J.</given-names></name></person-group><article-title>Characterization of a novel coronavirus associated with severe acute respiratory syndrome</article-title><source>Science</source><volume>300</volume><year>2003</year><fpage>1394</fpage><lpage>1399</lpage><pub-id pub-id-type="pmid">12730500</pub-id></element-citation></ref><ref id="bib11"><label>11</label><mixed-citation publication-type="other" id="oref5">M. Chan, WHO Director-General Praises the World Health Assembly for its Work, <ext-link ext-link-type="uri" xlink:href="http://www.who.int/dg/speeches/2013/world_health_assembly_20130527/en/index.html" id="intref0030">http://www.who.int/dg/speeches/2013/world_health_assembly_20130527/en/index.html</ext-link> (accessed 09.06.13).</mixed-citation></ref><ref id="bib12"><label>12</label><mixed-citation publication-type="other" id="oref6">M.R. Wilson, Administration Declares Mideast Flu a Potential Public Health Emergency, <ext-link ext-link-type="uri" xlink:href="http://thehill.com/blogs/healthwatch/public-global-health/303441-administration-declares-mideast-flu-a-public-health-emergency#ixzz2VLnzfH16" id="intref0035">http://thehill.com/blogs/healthwatch/public-global-health/303441-administration-declares-mideast-flu-a-public-health-emergency#ixzz2VLnzfH16</ext-link> (accessed 09.06.13).</mixed-citation></ref><ref id="bib13"><label>13</label><mixed-citation publication-type="other" id="oref7">Department of Health and Human Services, Determination and Declaration Regarding emergency Use of in Vitro Diagnostics for Detection of Middle East Respiratory Syndrome Coronavirus (MERS-CoV), <ext-link ext-link-type="uri" xlink:href="http://www.gpo.gov/fdsys/pkg/FR-2013-06-05/html/2013-13333.htm" id="intref0040">http://www.gpo.gov/fdsys/pkg/FR-2013-06-05/html/2013-13333.htm</ext-link> (accessed 09.06.13).</mixed-citation></ref><ref id="bib14"><label>14</label><element-citation publication-type="book" id="sref7"><person-group person-group-type="author"><name><surname>Tanquintic-Misa</surname><given-names>E.</given-names></name></person-group><chapter-title>Saudi Arabia Moves to Control MERS-CoV before Mecca Hajj Pilgrimage Season</chapter-title><year>6 June 2013</year><comment>(Ref Type: Report)</comment><ext-link ext-link-type="uri" xlink:href="http://www.ibtimes.co.uk/articles/475277/20130606/saudi-mers-cov-mecca-hajj.htm" id="intref0045">http://www.ibtimes.co.uk/articles/475277/20130606/saudi-mers-cov-mecca-hajj.htm</ext-link></element-citation></ref><ref id="bib15"><label>15</label><element-citation publication-type="journal" id="sref8"><person-group person-group-type="author"><name><surname>Lau</surname><given-names>S.K.</given-names></name><name><surname>Li</surname><given-names>K.S.</given-names></name><name><surname>Tsang</surname><given-names>A.K.</given-names></name><name><surname>Lam</surname><given-names>C.S.</given-names></name><name><surname>Ahmed</surname><given-names>S.</given-names></name><name><surname>Chen</surname><given-names>H.</given-names></name><name><surname>Chan</surname><given-names>K.H.</given-names></name><name><surname>Woo</surname><given-names>P.C.</given-names></name><name><surname>Yuen</surname><given-names>K.Y.</given-names></name></person-group><article-title>Genetic characterization of betacoronavirus lineage C viruses in bats revealed marked sequence divergence in the spike protein of Pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: implications on the origin of the novel Middle East respiratory syndrome coronavirus</article-title><source>J. Virol.</source><year>29 May 2013</year><comment>(Epub ahead of print)</comment></element-citation></ref><ref id="bib16"><label>16</label><element-citation publication-type="journal" id="sref9"><person-group person-group-type="author"><name><surname>Raj</surname><given-names>V.S.</given-names></name><name><surname>Mou</surname><given-names>H.</given-names></name><name><surname>Smits</surname><given-names>S.L.</given-names></name><name><surname>Dekkers</surname><given-names>D.H.</given-names></name><name><surname>Muller</surname><given-names>M.A.</given-names></name><name><surname>Dijkman</surname><given-names>R.</given-names></name><name><surname>Muth</surname><given-names>D.</given-names></name><name><surname>Demmers</surname><given-names>J.A.</given-names></name><name><surname>Zaki</surname><given-names>A.</given-names></name><name><surname>Fouchier</surname><given-names>R.A.</given-names></name><name><surname>Thiel</surname><given-names>V.</given-names></name><name><surname>Drosten</surname><given-names>C.</given-names></name><name><surname>Rottier</surname><given-names>P.J.</given-names></name><name><surname>Osterhaus</surname><given-names>A.D.</given-names></name><name><surname>Bosch</surname><given-names>B.J.</given-names></name><name><surname>Haagmans</surname><given-names>B.L.</given-names></name></person-group><article-title>Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC</article-title><source>Nature</source><volume>495</volume><year>2013</year><fpage>251</fpage><lpage>254</lpage><pub-id pub-id-type="pmid">23486063</pub-id></element-citation></ref><ref id="bib17"><label>17</label><element-citation publication-type="journal" id="sref10"><person-group person-group-type="author"><name><surname>Du</surname><given-names>L.</given-names></name><name><surname>He</surname><given-names>Y.</given-names></name><name><surname>Zhou</surname><given-names>Y.</given-names></name><name><surname>Liu</surname><given-names>S.</given-names></name><name><surname>Zheng</surname><given-names>B.J.</given-names></name><name><surname>Jiang</surname><given-names>S.</given-names></name></person-group><article-title>The spike protein of SARS-CoV: a target for vaccine and therapeutic development</article-title><source>Nat. Rev. Microbiol.</source><volume>7</volume><year>2009</year><fpage>226</fpage><lpage>236</lpage><pub-id pub-id-type="pmid">19198616</pub-id></element-citation></ref><ref id="bib18"><label>18</label><element-citation publication-type="journal" id="sref11"><person-group person-group-type="author"><name><surname>Chan</surname><given-names>J.F.</given-names></name><name><surname>Chan</surname><given-names>K.H.</given-names></name><name><surname>Choi</surname><given-names>G.K.</given-names></name><name><surname>To</surname><given-names>K.K.</given-names></name><name><surname>Tse</surname><given-names>H.</given-names></name><name><surname>Cai</surname><given-names>J.P.</given-names></name><name><surname>Yeung</surname><given-names>M.L.</given-names></name><name><surname>Cheng</surname><given-names>V.C.</given-names></name><name><surname>Chen</surname><given-names>H.</given-names></name><name><surname>Che</surname><given-names>X.Y.</given-names></name><name><surname>Lau</surname><given-names>S.K.</given-names></name><name><surname>Woo</surname><given-names>P.C.</given-names></name><name><surname>Yuen</surname><given-names>K.Y.</given-names></name></person-group><article-title>Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012: implications for disease pathogenesis and clinical manifestation</article-title><source>J. Infect. Dis.</source><volume>207</volume><year>2013</year><fpage>1743</fpage><lpage>1752</lpage><pub-id pub-id-type="pmid">23532101</pub-id></element-citation></ref><ref id="bib19"><label>19</label><element-citation publication-type="journal" id="sref12"><person-group person-group-type="author"><name><surname>Buchholz</surname><given-names>U.</given-names></name><name><surname>Muller</surname><given-names>M.A.</given-names></name><name><surname>Nitsche</surname><given-names>A.</given-names></name><name><surname>Sanewski</surname><given-names>A.</given-names></name><name><surname>Wevering</surname><given-names>N.</given-names></name><name><surname>Bauer-Balci</surname><given-names>T.</given-names></name><name><surname>Bonin</surname><given-names>F.</given-names></name><name><surname>Drosten</surname><given-names>C.</given-names></name><name><surname>Schweiger</surname><given-names>B.</given-names></name><name><surname>Wolff</surname><given-names>T.</given-names></name><name><surname>Muth</surname><given-names>D.</given-names></name><name><surname>Meyer</surname><given-names>B.</given-names></name><name><surname>Buda</surname><given-names>S.</given-names></name><name><surname>Krause</surname><given-names>G.</given-names></name><name><surname>Schaade</surname><given-names>L.</given-names></name><name><surname>Haas</surname><given-names>W.</given-names></name></person-group><article-title>Contact investigation of a case of human novel coronavirus infection treated in a German hospital, October–November 2012</article-title><source>Euro. Surveill.</source><volume>18</volume><year>2013</year><comment>pii: 20406</comment></element-citation></ref><ref id="bib20"><label>20</label><element-citation publication-type="journal" id="sref13"><person-group person-group-type="author"><name><surname>Deming</surname><given-names>D.</given-names></name><name><surname>Sheahan</surname><given-names>T.</given-names></name><name><surname>Heise</surname><given-names>M.</given-names></name><name><surname>Yount</surname><given-names>B.</given-names></name><name><surname>Davis</surname><given-names>N.</given-names></name><name><surname>Sims</surname><given-names>A.</given-names></name><name><surname>Suthar</surname><given-names>M.</given-names></name><name><surname>Harkema</surname><given-names>J.</given-names></name><name><surname>Whitmore</surname><given-names>A.</given-names></name><name><surname>Pickles</surname><given-names>R.</given-names></name><name><surname>West</surname><given-names>A.</given-names></name><name><surname>Donaldson</surname><given-names>E.</given-names></name><name><surname>Curtis</surname><given-names>K.</given-names></name><name><surname>Johnston</surname><given-names>R.</given-names></name><name><surname>Baric</surname><given-names>R.</given-names></name></person-group><article-title>Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants</article-title><source>PLoS Med.</source><volume>3</volume><year>2006</year><fpage>e525</fpage><pub-id pub-id-type="pmid">17194199</pub-id></element-citation></ref><ref id="bib21"><label>21</label><element-citation publication-type="journal" id="sref14"><person-group person-group-type="author"><name><surname>Yasui</surname><given-names>F.</given-names></name><name><surname>Kai</surname><given-names>C.</given-names></name><name><surname>Kitabatake</surname><given-names>M.</given-names></name><name><surname>Inoue</surname><given-names>S.</given-names></name><name><surname>Yoneda</surname><given-names>M.</given-names></name><name><surname>Yokochi</surname><given-names>S.</given-names></name><name><surname>Kase</surname><given-names>R.</given-names></name><name><surname>Sekiguchi</surname><given-names>S.</given-names></name><name><surname>Morita</surname><given-names>K.</given-names></name><name><surname>Hishima</surname><given-names>T.</given-names></name><name><surname>Suzuki</surname><given-names>H.</given-names></name><name><surname>Karamatsu</surname><given-names>K.</given-names></name><name><surname>Yasutomi</surname><given-names>Y.</given-names></name><name><surname>Shida</surname><given-names>H.</given-names></name><name><surname>Kidokoro</surname><given-names>M.</given-names></name><name><surname>Mizuno</surname><given-names>K.</given-names></name><name><surname>Matsushima</surname><given-names>K.</given-names></name><name><surname>Kohara</surname><given-names>M.</given-names></name></person-group><article-title>Prior immunization with severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) nucleocapsid protein causes severe pneumonia in mice infected with SARS-CoV</article-title><source>J. Immunol.</source><volume>181</volume><year>2008</year><fpage>6337</fpage><lpage>6348</lpage><pub-id pub-id-type="pmid">18941225</pub-id></element-citation></ref><ref id="bib22"><label>22</label><element-citation publication-type="journal" id="sref15"><person-group person-group-type="author"><name><surname>Bolles</surname><given-names>M.</given-names></name><name><surname>Deming</surname><given-names>D.</given-names></name><name><surname>Long</surname><given-names>K.</given-names></name><name><surname>Agnihothram</surname><given-names>S.</given-names></name><name><surname>Whitmore</surname><given-names>A.</given-names></name><name><surname>Ferris</surname><given-names>M.</given-names></name><name><surname>Funkhouser</surname><given-names>W.</given-names></name><name><surname>Gralinski</surname><given-names>L.</given-names></name><name><surname>Totura</surname><given-names>A.</given-names></name><name><surname>Heise</surname><given-names>M.</given-names></name><name><surname>Baric</surname><given-names>R.S.</given-names></name></person-group><article-title>A double-inactivated SARS-CoV vaccine provides incomplete protection in mice and induces increased eosinophilic pro-inflammatory pulmonary response upon challenge</article-title><source>J. Virol.</source><volume>85</volume><issue>23</issue><year>2011</year><fpage>12201</fpage><lpage>12215</lpage><pub-id pub-id-type="pmid">21937658</pub-id></element-citation></ref><ref id="bib23"><label>23</label><element-citation publication-type="journal" id="sref16"><person-group person-group-type="author"><name><surname>Tseng</surname><given-names>C.T.</given-names></name><name><surname>Sbrana</surname><given-names>E.</given-names></name><name><surname>Iwata-Yoshikawa</surname><given-names>N.</given-names></name><name><surname>Newman</surname><given-names>P.C.</given-names></name><name><surname>Garron</surname><given-names>T.</given-names></name><name><surname>Atmar</surname><given-names>R.L.</given-names></name><name><surname>Peters</surname><given-names>C.J.</given-names></name><name><surname>Couch</surname><given-names>R.B.</given-names></name></person-group><article-title>Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus</article-title><source>PLoS One</source><volume>7</volume><year>2012</year><fpage>e35421</fpage><pub-id pub-id-type="pmid">22536382</pub-id></element-citation></ref><ref id="bib24"><label>24</label><element-citation publication-type="journal" id="sref17"><person-group person-group-type="author"><name><surname>Jaume</surname><given-names>M.</given-names></name><name><surname>Yip</surname><given-names>M.S.</given-names></name><name><surname>Kam</surname><given-names>Y.W.</given-names></name><name><surname>Cheung</surname><given-names>C.Y.</given-names></name><name><surname>Kien</surname><given-names>F.</given-names></name><name><surname>Roberts</surname><given-names>A.</given-names></name><name><surname>Li</surname><given-names>P.H.</given-names></name><name><surname>Dutry</surname><given-names>I.</given-names></name><name><surname>Escriou</surname><given-names>N.</given-names></name><name><surname>Daeron</surname><given-names>M.</given-names></name><name><surname>Bruzzone</surname><given-names>R.</given-names></name><name><surname>Subbarao</surname><given-names>K.</given-names></name><name><surname>Peiris</surname><given-names>J.S.</given-names></name><name><surname>Nal</surname><given-names>B.</given-names></name><name><surname>Altmeyer</surname><given-names>R.</given-names></name></person-group><article-title>SARS CoV subunit vaccine: antibody-mediated neutralisation and enhancement</article-title><source>Hong Kong Med. J.</source><volume>18</volume><issue>Suppl. 2</issue><year>2012</year><fpage>31</fpage><lpage>36</lpage></element-citation></ref><ref id="bib25"><label>25</label><element-citation publication-type="journal" id="sref18"><person-group person-group-type="author"><name><surname>He</surname><given-names>Y.</given-names></name><name><surname>Lu</surname><given-names>H.</given-names></name><name><surname>Siddiqui</surname><given-names>P.</given-names></name><name><surname>Zhou</surname><given-names>Y.</given-names></name><name><surname>Jiang</surname><given-names>S.</given-names></name></person-group><article-title>Receptor-binding domain of severe acute respiratory syndrome coronavirus spike protein contains multiple conformation-dependent epitopes that induce highly potent neutralizing antibodies</article-title><source>J. Immunol.</source><volume>174</volume><year>2005</year><fpage>4908</fpage><lpage>4915</lpage><pub-id pub-id-type="pmid">15814718</pub-id></element-citation></ref><ref id="bib26"><label>26</label><element-citation publication-type="journal" id="sref19"><person-group person-group-type="author"><name><surname>Jiang</surname><given-names>S.</given-names></name><name><surname>Bottazzi</surname><given-names>M.E.</given-names></name><name><surname>Du</surname><given-names>L.</given-names></name><name><surname>Lustigman</surname><given-names>S.</given-names></name><name><surname>Tseng</surname><given-names>C.T.</given-names></name><name><surname>Curti</surname><given-names>E.</given-names></name><name><surname>Jones</surname><given-names>K.</given-names></name><name><surname>Zhan</surname><given-names>B.</given-names></name><name><surname>Hotez</surname><given-names>P.J.</given-names></name></person-group><article-title>Roadmap to developing a recombinant coronavirus S protein receptor-binding domain vaccine for severe acute respiratory syndrome</article-title><source>Expert Rev. Vaccines</source><volume>11</volume><year>2012</year><fpage>1405</fpage><lpage>1413</lpage><pub-id pub-id-type="pmid">23252385</pub-id></element-citation></ref><ref id="bib27"><label>27</label><element-citation publication-type="journal" id="sref20"><person-group person-group-type="author"><name><surname>Jiang</surname><given-names>S.</given-names></name><name><surname>Lu</surname><given-names>L.</given-names></name><name><surname>Du</surname><given-names>L.</given-names></name><name><surname>Debnath</surname><given-names>A.K.</given-names></name></person-group><article-title>A predicted receptor-binding and critical neutralizing domain in S protein of the novel human coronavirus HCoV-EMC</article-title><source>J. Infect.</source><volume>66</volume><year>2013</year><fpage>464</fpage><lpage>466</lpage><pub-id pub-id-type="pmid">23266463</pub-id></element-citation></ref><ref id="bib28"><label>28</label><element-citation publication-type="journal" id="sref21"><person-group person-group-type="author"><name><surname>Chan</surname><given-names>K.H.</given-names></name><name><surname>Chan</surname><given-names>J.F.</given-names></name><name><surname>Tse</surname><given-names>H.</given-names></name><name><surname>Chen</surname><given-names>H.</given-names></name><name><surname>Lau</surname><given-names>C.C.</given-names></name><name><surname>Cai</surname><given-names>J.P.</given-names></name><name><surname>Tsang</surname><given-names>A.K.</given-names></name><name><surname>Xiao</surname><given-names>X.</given-names></name><name><surname>To</surname><given-names>K.K.</given-names></name><name><surname>Lau</surname><given-names>S.K.</given-names></name><name><surname>Woo</surname><given-names>P.C.</given-names></name><name><surname>Zheng</surname><given-names>B.J.</given-names></name><name><surname>Wang</surname><given-names>M.</given-names></name><name><surname>Yuen</surname><given-names>K.Y.</given-names></name></person-group><article-title>Cross-reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests</article-title><source>J. Infect.</source><year>10 Apr 2013</year><comment>(Epub ahead of print), pii: S0163-4453(13)00071-6</comment></element-citation></ref><ref id="bib29"><label>29</label><element-citation publication-type="journal" id="sref22"><person-group person-group-type="author"><name><surname>Du</surname><given-names>L.</given-names></name><name><surname>Ma</surname><given-names>C.</given-names></name><name><surname>Jiang</surname><given-names>S.</given-names></name></person-group><article-title>Antibodies induced by receptor-binding domain in spike protein of SARS-CoV do not cross-neutralize the novel human coronavirus hCoV-EMC</article-title><source>J. Infect.</source><year>16 May 2013</year><comment>(Epub ahead of print)</comment></element-citation></ref><ref id="bib30"><label>30</label><element-citation publication-type="journal" id="sref23"><person-group person-group-type="author"><name><surname>Brogan</surname><given-names>T.V.</given-names></name><name><surname>Thiagarajan</surname><given-names>R.R.</given-names></name><name><surname>Rycus</surname><given-names>P.T.</given-names></name><name><surname>Bartlett</surname><given-names>R.H.</given-names></name><name><surname>Bratton</surname><given-names>S.L.</given-names></name></person-group><article-title>Extracorporeal membrane oxygenation in adults with severe respiratory failure: a multi-center database</article-title><source>Intensive Care Med.</source><volume>35</volume><year>2009</year><fpage>2105</fpage><lpage>2114</lpage><pub-id pub-id-type="pmid">19768656</pub-id></element-citation></ref><ref id="bib31"><label>31</label><element-citation publication-type="journal" id="sref24"><person-group person-group-type="author"><name><surname>Stockman</surname><given-names>L.J.</given-names></name><name><surname>Bellamy</surname><given-names>R.</given-names></name><name><surname>Garner</surname><given-names>P.</given-names></name></person-group><article-title>SARS: systematic review of treatment effects</article-title><source>PLoS Med.</source><volume>3</volume><year>2006</year><fpage>e343</fpage><pub-id pub-id-type="pmid">16968120</pub-id></element-citation></ref><ref id="bib32"><label>32</label><element-citation publication-type="journal" id="sref25"><person-group person-group-type="author"><name><surname>Cheng</surname><given-names>V.C.</given-names></name><name><surname>Lau</surname><given-names>S.K.</given-names></name><name><surname>Woo</surname><given-names>P.C.</given-names></name><name><surname>Yuen</surname><given-names>K.Y.</given-names></name></person-group><article-title>Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection</article-title><source>Clin. Microbiol. Rev.</source><volume>20</volume><year>2007</year><fpage>660</fpage><lpage>694</lpage><pub-id pub-id-type="pmid">17934078</pub-id></element-citation></ref><ref id="bib33"><label>33</label><element-citation publication-type="journal" id="sref26"><person-group person-group-type="author"><name><surname>Kindler</surname><given-names>E.</given-names></name><name><surname>Jonsdottir</surname><given-names>H.R.</given-names></name><name><surname>Muth</surname><given-names>D.</given-names></name><name><surname>Hamming</surname><given-names>O.J.</given-names></name><name><surname>Hartmann</surname><given-names>R.</given-names></name><name><surname>Rodriguez</surname><given-names>R.</given-names></name><name><surname>Geffers</surname><given-names>R.</given-names></name><name><surname>Fouchier</surname><given-names>R.A.</given-names></name><name><surname>Drosten</surname><given-names>C.</given-names></name><name><surname>Muller</surname><given-names>M.A.</given-names></name><name><surname>Dijkman</surname><given-names>R.</given-names></name><name><surname>Thiel</surname><given-names>V.</given-names></name></person-group><article-title>Efficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potential</article-title><source>mBio</source><volume>4</volume><year>2013</year><fpage>e00611</fpage><lpage>e00612</lpage></element-citation></ref><ref id="bib34"><label>34</label><element-citation publication-type="journal" id="sref27"><person-group person-group-type="author"><name><surname>Osterholm</surname><given-names>M.T.</given-names></name></person-group><article-title>Preparing for the next pandemic</article-title><source>N. Engl. J. Med.</source><volume>352</volume><year>2005</year><fpage>1839</fpage><lpage>1842</lpage><pub-id pub-id-type="pmid">15872196</pub-id></element-citation></ref><ref id="bib35"><label>35</label><element-citation publication-type="journal" id="sref28"><person-group person-group-type="author"><name><surname>Huang</surname><given-names>K.J.</given-names></name><name><surname>Su</surname><given-names>I.J.</given-names></name><name><surname>Theron</surname><given-names>M.</given-names></name><name><surname>Wu</surname><given-names>Y.C.</given-names></name><name><surname>Lai</surname><given-names>S.K.</given-names></name><name><surname>Liu</surname><given-names>C.C.</given-names></name><name><surname>Lei</surname><given-names>H.Y.</given-names></name></person-group><article-title>An interferon-gamma-related cytokine storm in SARS patients</article-title><source>J. Med. Virol.</source><volume>75</volume><year>2005</year><fpage>185</fpage><lpage>194</lpage><pub-id pub-id-type="pmid">15602737</pub-id></element-citation></ref><ref id="bib36"><label>36</label><element-citation publication-type="journal" id="sref29"><person-group person-group-type="author"><name><surname>Tisoncik</surname><given-names>J.R.</given-names></name><name><surname>Korth</surname><given-names>M.J.</given-names></name><name><surname>Simmons</surname><given-names>C.P.</given-names></name><name><surname>Farrar</surname><given-names>J.</given-names></name><name><surname>Martin</surname><given-names>T.R.</given-names></name><name><surname>Katze</surname><given-names>M.G.</given-names></name></person-group><article-title>Into the eye of the cytokine storm</article-title><source>Microbiol. Mol. Biol. Rev.</source><volume>76</volume><year>2012</year><fpage>16</fpage><lpage>32</lpage><pub-id pub-id-type="pmid">22390970</pub-id></element-citation></ref><ref id="bib37"><label>37</label><element-citation publication-type="journal" id="sref30"><person-group person-group-type="author"><name><surname>Josset</surname><given-names>L.</given-names></name><name><surname>Menachery</surname><given-names>V.D.</given-names></name><name><surname>Gralinski</surname><given-names>L.E.</given-names></name><name><surname>Agnihothram</surname><given-names>S.</given-names></name><name><surname>Sova</surname><given-names>P.</given-names></name><name><surname>Carter</surname><given-names>V.S.</given-names></name><name><surname>Yount</surname><given-names>B.L.</given-names></name><name><surname>Graham</surname><given-names>R.L.</given-names></name><name><surname>Baric</surname><given-names>R.S.</given-names></name><name><surname>Katze</surname><given-names>M.G.</given-names></name></person-group><article-title>Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus</article-title><source>mBio</source><volume>4</volume><year>2013</year></element-citation></ref><ref id="bib38"><label>38</label><element-citation publication-type="journal" id="sref31"><person-group person-group-type="author"><name><surname>Chan</surname><given-names>J.F.</given-names></name><name><surname>Li</surname><given-names>K.S.</given-names></name><name><surname>To</surname><given-names>K.K.</given-names></name><name><surname>Cheng</surname><given-names>V.C.</given-names></name><name><surname>Chen</surname><given-names>H.</given-names></name><name><surname>Yuen</surname><given-names>K.Y.</given-names></name></person-group><article-title>Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?</article-title><source>J. Infect.</source><volume>65</volume><year>2012</year><fpage>477</fpage><lpage>489</lpage><pub-id pub-id-type="pmid">23072791</pub-id></element-citation></ref><ref id="bib39"><label>39</label><element-citation publication-type="journal" id="sref32"><person-group person-group-type="author"><name><surname>Jiang</surname><given-names>S.</given-names></name><name><surname>Lin</surname><given-names>K.</given-names></name><name><surname>Strick</surname><given-names>N.</given-names></name><name><surname>Neurath</surname><given-names>A.R.</given-names></name></person-group><article-title>HIV-1 inhibition by a peptide</article-title><source>Nature</source><volume>365</volume><year>1993</year><fpage>113</fpage><pub-id pub-id-type="pmid">8371754</pub-id></element-citation></ref><ref id="bib40"><label>40</label><element-citation publication-type="journal" id="sref33"><person-group person-group-type="author"><name><surname>Wild</surname><given-names>C.T.</given-names></name><name><surname>Shugars</surname><given-names>D.C.</given-names></name><name><surname>Greenwell</surname><given-names>T.K.</given-names></name><name><surname>McDanal</surname><given-names>C.B.</given-names></name><name><surname>Matthews</surname><given-names>T.J.</given-names></name></person-group><article-title>Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection</article-title><source>Proc. Natl. Acad. Sci. U. S. A.</source><volume>91</volume><year>1994</year><fpage>9770</fpage><lpage>9774</lpage><pub-id pub-id-type="pmid">7937889</pub-id></element-citation></ref><ref id="bib41"><label>41</label><element-citation publication-type="journal" id="sref34"><person-group person-group-type="author"><name><surname>Kilby</surname><given-names>J.M.</given-names></name><name><surname>Eron</surname><given-names>J.J.</given-names></name></person-group><article-title>Novel therapies based on mechanisms of HIV-1 cell entry</article-title><source>N. Engl. J. Med.</source><volume>348</volume><year>2003</year><fpage>2228</fpage><lpage>2238</lpage><pub-id pub-id-type="pmid">12773651</pub-id></element-citation></ref><ref id="bib42"><label>42</label><element-citation publication-type="journal" id="sref35"><person-group person-group-type="author"><name><surname>Lalezari</surname><given-names>J.P.</given-names></name><name><surname>Henry</surname><given-names>K.</given-names></name><name><surname>O'Hearn</surname><given-names>M.</given-names></name><name><surname>Montaner</surname><given-names>J.S.</given-names></name><name><surname>Piliero</surname><given-names>P.J.</given-names></name><name><surname>Trottier</surname><given-names>B.</given-names></name><name><surname>Walmsley</surname><given-names>S.</given-names></name><name><surname>Cohen</surname><given-names>C.</given-names></name><name><surname>Kuritzkes</surname><given-names>D.R.</given-names></name><name><surname>Eron</surname><given-names>J.J.</given-names><suffix>Jr.</suffix></name><name><surname>Chung</surname><given-names>J.</given-names></name><name><surname>DeMasi</surname><given-names>R.</given-names></name><name><surname>Donatacci</surname><given-names>L.</given-names></name><name><surname>Drobnes</surname><given-names>C.</given-names></name><name><surname>Delehanty</surname><given-names>J.</given-names></name><name><surname>Salgo</surname><given-names>M.</given-names></name></person-group><article-title>Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV infection in North and South America</article-title><source>N. Engl. J. Med.</source><volume>348</volume><year>2003</year><fpage>2175</fpage><lpage>2185</lpage><pub-id pub-id-type="pmid">12637625</pub-id></element-citation></ref><ref id="bib43"><label>43</label><element-citation publication-type="journal" id="sref36"><person-group person-group-type="author"><name><surname>Liu</surname><given-names>S.</given-names></name><name><surname>Xiao</surname><given-names>G.</given-names></name><name><surname>Chen</surname><given-names>Y.</given-names></name><name><surname>He</surname><given-names>Y.</given-names></name><name><surname>Niu</surname><given-names>J.</given-names></name><name><surname>Escalante</surname><given-names>C.R.</given-names></name><name><surname>Xiong</surname><given-names>H.</given-names></name><name><surname>Farmar</surname><given-names>J.</given-names></name><name><surname>Debnath</surname><given-names>A.K.</given-names></name><name><surname>Tien</surname><given-names>P.</given-names></name><name><surname>Jiang</surname><given-names>S.</given-names></name></person-group><article-title>Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors</article-title><source>Lancet</source><volume>363</volume><year>2004</year><fpage>938</fpage><lpage>947</lpage><pub-id pub-id-type="pmid">15043961</pub-id></element-citation></ref><ref id="bib44"><label>44</label><element-citation publication-type="journal" id="sref37"><person-group person-group-type="author"><name><surname>Liu</surname><given-names>S.</given-names></name><name><surname>Wu</surname><given-names>S.</given-names></name><name><surname>Jiang</surname><given-names>S.</given-names></name></person-group><article-title>HIV entry inhibitors targeting gp41: from polypeptides to small-molecule compounds</article-title><source>Curr. Pharm. Des.</source><volume>13</volume><year>2007</year><fpage>143</fpage><lpage>162</lpage><pub-id pub-id-type="pmid">17269924</pub-id></element-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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