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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical imaging research of the first Middle East respiratory syndrome in China</title><author><name sortKey="Lan, Bowen" sort="Lan, Bowen" uniqKey="Lan B" first="Bowen" last="Lan">Bowen Lan</name><affiliation><nlm:aff id="aff1">Huizhou Central Hospital, China</nlm:aff></affiliation></author><author><name sortKey="Lu, Puxuan" sort="Lu, Puxuan" uniqKey="Lu P" first="Puxuan" last="Lu">Puxuan Lu</name><affiliation><nlm:aff id="aff2">Shenzhen Third People's Hospital Affiliated to Guangdong Medical College, 518112, China</nlm:aff></affiliation></author><author><name sortKey="Zeng, Yujing" sort="Zeng, Yujing" uniqKey="Zeng Y" first="Yujing" last="Zeng">Yujing Zeng</name><affiliation><nlm:aff id="aff1">Huizhou Central Hospital, China</nlm:aff></affiliation></author><author><name sortKey="Li, Xin" sort="Li, Xin" uniqKey="Li X" first="Xin" last="Li">Xin Li</name><affiliation><nlm:aff id="aff1">Huizhou Central Hospital, China</nlm:aff></affiliation></author><author><name sortKey="Ou, Xiaxing" sort="Ou, Xiaxing" uniqKey="Ou X" first="Xiaxing" last="Ou">Xiaxing Ou</name><affiliation><nlm:aff id="aff3">General Hospital of Guangzhou Military Region, China</nlm:aff></affiliation></author><author><name sortKey="Li, Jingjing" sort="Li, Jingjing" uniqKey="Li J" first="Jingjing" last="Li">Jingjing Li</name><affiliation><nlm:aff id="aff2">Shenzhen Third People's Hospital Affiliated to Guangdong Medical College, 518112, China</nlm:aff></affiliation></author><author><name sortKey="Li, Hongjun" sort="Li, Hongjun" uniqKey="Li H" first="Hongjun" last="Li">Hongjun Li</name><affiliation><nlm:aff id="aff4">Beijing You An Hospital Affiliated to Capital Medical University, China</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7103924</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103924</idno><idno type="RBID">PMC:7103924</idno><idno type="doi">10.1016/j.jrid.2015.11.004</idno><idno type="pmid">NONE</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001133</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001133</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinical imaging research of the first Middle East respiratory syndrome in China</title><author><name sortKey="Lan, Bowen" sort="Lan, Bowen" uniqKey="Lan B" first="Bowen" last="Lan">Bowen Lan</name><affiliation><nlm:aff id="aff1">Huizhou Central Hospital, China</nlm:aff></affiliation></author><author><name sortKey="Lu, Puxuan" sort="Lu, Puxuan" uniqKey="Lu P" first="Puxuan" last="Lu">Puxuan Lu</name><affiliation><nlm:aff id="aff2">Shenzhen Third People's Hospital Affiliated to Guangdong Medical College, 518112, China</nlm:aff></affiliation></author><author><name sortKey="Zeng, Yujing" sort="Zeng, Yujing" uniqKey="Zeng Y" first="Yujing" last="Zeng">Yujing Zeng</name><affiliation><nlm:aff id="aff1">Huizhou Central Hospital, China</nlm:aff></affiliation></author><author><name sortKey="Li, Xin" sort="Li, Xin" uniqKey="Li X" first="Xin" last="Li">Xin Li</name><affiliation><nlm:aff id="aff1">Huizhou Central Hospital, China</nlm:aff></affiliation></author><author><name sortKey="Ou, Xiaxing" sort="Ou, Xiaxing" uniqKey="Ou X" first="Xiaxing" last="Ou">Xiaxing Ou</name><affiliation><nlm:aff id="aff3">General Hospital of Guangzhou Military Region, China</nlm:aff></affiliation></author><author><name sortKey="Li, Jingjing" sort="Li, Jingjing" uniqKey="Li J" first="Jingjing" last="Li">Jingjing Li</name><affiliation><nlm:aff id="aff2">Shenzhen Third People's Hospital Affiliated to Guangdong Medical College, 518112, China</nlm:aff></affiliation></author><author><name sortKey="Li, Hongjun" sort="Li, Hongjun" uniqKey="Li H" first="Hongjun" last="Li">Hongjun Li</name><affiliation><nlm:aff id="aff4">Beijing You An Hospital Affiliated to Capital Medical University, China</nlm:aff></affiliation></author></analytic><series><title level="j">Radiology of Infectious Diseases (Beijing, China)</title><idno type="ISSN">2352-6211</idno><idno type="eISSN">2352-622X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome is a viral respiratory illness caused by a novel human beta-coronavirus. Based on the first case of Middle East respiratory syndrome found in China, a clinical research in combination with radiological findings was studied. Fever was the main clinical manifestation of this patient, and the primary imaging findings were basically the same as viral pneumonia. Differential imaging diagnosis on the basis of epidemiological and experimental pathogen detection is helpful for clinical diagnosis of MERS, even in distinguishing from SARS and pneumonia caused by H7N9 avian influenza.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hijawi, B" uniqKey="Hijawi B">B. Hijawi</name></author><author><name sortKey="Abdallat, M" uniqKey="Abdallat M">M. Abdallat</name></author><author><name sortKey="Sayaydeh, A" uniqKey="Sayaydeh A">A. Sayaydeh</name></author><author><name sortKey="Alqasrawi, S" uniqKey="Alqasrawi S">S. Alqasrawi</name></author><author><name sortKey="Haddadin, A" uniqKey="Haddadin A">A. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Radiol Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Radiol Infect Dis</journal-id><journal-title-group><journal-title>Radiology of Infectious Diseases (Beijing, China)</journal-title></journal-title-group><issn pub-type="ppub">2352-6211</issn><issn pub-type="epub">2352-622X</issn><publisher><publisher-name>Beijing You'an Hospital affiliated to Capital Medical University. Production and hosting by Elsevier B.V</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7103924</article-id><article-id pub-id-type="publisher-id">S2352-6211(15)00085-6</article-id><article-id pub-id-type="doi">10.1016/j.jrid.2015.11.004</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Clinical imaging research of the first Middle East respiratory syndrome in China</article-title></title-group><contrib-group><contrib contrib-type="author" id="au1"><name><surname>Lan</surname><given-names>Bowen</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au2"><name><surname>Lu</surname><given-names>Puxuan</given-names></name><email>lupuxuan@126.com</email><xref rid="aff2" ref-type="aff">b</xref><xref rid="cor1" ref-type="corresp">∗</xref></contrib><contrib contrib-type="author" id="au3"><name><surname>Zeng</surname><given-names>Yujing</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au4"><name><surname>Li</surname><given-names>Xin</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au5"><name><surname>Ou</surname><given-names>Xiaxing</given-names></name><xref rid="aff3" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au6"><name><surname>Li</surname><given-names>Jingjing</given-names></name><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="au7"><name><surname>Li</surname><given-names>Hongjun</given-names></name><xref rid="aff4" ref-type="aff">d</xref></contrib></contrib-group><aff id="aff1"><label>a</label>Huizhou Central Hospital, China</aff><aff id="aff2"><label>b</label>Shenzhen Third People's Hospital Affiliated to Guangdong Medical College, 518112, China</aff><aff id="aff3"><label>c</label>General Hospital of Guangzhou Military Region, China</aff><aff id="aff4"><label>d</label>Beijing You An Hospital Affiliated to Capital Medical University, China</aff><author-notes><corresp id="cor1"><label>∗</label>Corresponding author. <email>lupuxuan@126.com</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>23</day><month>11</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>12</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>23</day><month>11</month><year>2015</year></pub-date><volume>2</volume><issue>4</issue><fpage>173</fpage><lpage>176</lpage><history><date date-type="received"><day>10</day><month>8</month><year>2015</year></date><date date-type="rev-recd"><day>1</day><month>9</month><year>2015</year></date><date date-type="accepted"><day>23</day><month>9</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 The Authors</copyright-statement><copyright-year>2015</copyright-year><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="abs0010"><p>Middle East respiratory syndrome is a viral respiratory illness caused by a novel human beta-coronavirus. Based on the first case of Middle East respiratory syndrome found in China, a clinical research in combination with radiological findings was studied. Fever was the main clinical manifestation of this patient, and the primary imaging findings were basically the same as viral pneumonia. Differential imaging diagnosis on the basis of epidemiological and experimental pathogen detection is helpful for clinical diagnosis of MERS, even in distinguishing from SARS and pneumonia caused by H7N9 avian influenza.</p></abstract><kwd-group id="kwrds0010"><title>Keywords</title><kwd>Middle East respiratory syndrome</kwd><kwd>Imaging</kwd><kwd>Infection</kwd></kwd-group></article-meta></front><body><sec id="sec1"><label>1</label><title>Introduction</title><p id="p0010c">Middle East respiratory syndrome (MERS), also known as camel flu, is a viral respiratory illness caused by a novel human beta-coronavirus (CoV) <xref rid="bib1" ref-type="bibr">[1]</xref>, <xref rid="bib2" ref-type="bibr">[2]</xref>, <xref rid="bib3" ref-type="bibr">[3]</xref>. Since it was firstly reported by Saudi Arabia in September 2012, till June 2015, more than 1200 patients have been detected worldwide, with at least 427 cases of patients died <xref rid="bib4" ref-type="bibr">[4]</xref>, <xref rid="bib5" ref-type="bibr">[5]</xref>. Until June 2015, most of the cases of MERS-CoV infectors occurred in the Middle East, and recently, it is reported that South Korea has been sufferring from MERS. Symptoms may range from mild to severe, including fever, cough, diarrhea, and shortness of breath. Although the exact route of transmission is still unclear, the respiratory droplet route is currently most likely <xref rid="bib6" ref-type="bibr">[6]</xref>. Although a few cases were reported in other countries, one was found in China in May 2015. A clinical research in combination with radiological findings was studied.</p></sec><sec id="sec2"><label>2</label><title>Materials and methods</title><sec id="sec2.1"><label>2.1</label><title>Case history</title><p id="p0015">A male Korean patient, born in 1971, had a close contact with his father who was diagnosed as the Middle East respiratory syndrome. He began to appear back pain on May 21, 2015, without fever, cough and sputum. No special treatment was given. He had a fever on May 25, 2015, with body temperature up to 39.7 °C, no chills, no cough, sputum, no shortness of breath, no abdominal pain, no diarrhea, and no sore throat. Cold medications were ineffective. On June 26 of 2015, he arrived in Hong Kong from South Korea by flight at 12:50, and then arrived in Huizhou City from Shenzhen. At 2:00 pm, May 28 of 2015, isolation and treatment was given for him in Huizhou designated hospital. During his whole journey in China, there were about 75 close contactors, who were all confirmed to be healthy after the isolated ward.</p></sec><sec id="sec2.2"><label>2.2</label><title>Physical examination</title><p id="p0020">Body temperature was 39.0 °C, blood pressure was 126/78 mm Hg, heart rate was 98 beats/min, and breathing was 21 times/min. Breath sounds were ruder for the two lungs without coarse rales, heart rate was regular, abdomen was soft, and bowel sounded normal.</p></sec><sec id="sec2.3"><label>2.3</label><title>Laboratory tests after hospitalization</title><p id="p0025">The blood gas analysis, Biochemistry, and Blood routine examination after hospitalization were shown in <xref rid="tbl1" ref-type="table">Table 1</xref>and <xref rid="tbl2" ref-type="table">Table 2</xref>. Pathogenic examination (sputum virological detection) showed that MERS-COV was positive on June 1 of 2015, and the result changed to negative the second day.<table-wrap position="float" id="tbl1"><label>Table 1</label><caption><p>The blood gas analysis after hospitalization.</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Items</th><th>Results</th><th>Items</th><th>Results</th></tr></thead><tbody><tr><td>Lactic acid</td><td>1.8 mmol/L</td><td>Bicarbonate</td><td>21.4 mmol/L</td></tr><tr><td>PH</td><td>7.41</td><td>Extracellular base excess</td><td>−2.5 mmol/L</td></tr><tr><td>Partial pressure of carbon dioxide</td><td>34.4 mm Hg</td><td>Alveolar blood oxygen partial pressure</td><td>171 mm Hg</td></tr><tr><td>Oxygen partial pressure</td><td>72 mm Hg</td><td>BB</td><td>−2.2 mmol/L</td></tr><tr><td>Hematocrit</td><td>44%</td><td>Difference of alveolar-arterial oxygen pressure</td><td>99 mm Hg</td></tr><tr><td>Base excess</td><td>−2.0 mmol/L</td><td>a/AO2</td><td>41.9</td></tr><tr><td>SO<sub>2</sub> (c)</td><td>94.5%</td><td>K<sup>+</sup></td><td>4.21 mmol/L</td></tr><tr><td>Cl<sup>−</sup></td><td>97 mmol/L</td><td>Na<sup>+</sup></td><td>132 mmol/L</td></tr></tbody></table></table-wrap><table-wrap position="float" id="tbl2"><label>Table 2</label><caption><p>The biochemistry, and blood routine examination after hospitalization.</p></caption><table frame="hsides" rules="groups"><thead><tr><th colspan="2">Biochemistry</th><th colspan="2">Blood routine examination</th></tr></thead><tbody><tr><td>ALT</td><td>24 U/L</td><td>WRC</td><td>3.22 × 10ˆ9/L</td></tr><tr><td>AST</td><td>57U/L</td><td>NE</td><td>2.35</td></tr><tr><td>AST/ALT</td><td>2.38</td><td>PLT</td><td>81 × 10ˆ9/L</td></tr><tr><td>CK-MB</td><td>8 U/L</td><td>RBC</td><td>4.7 × 10ˆ12/L</td></tr><tr><td>GLU</td><td>5.7 mmol/L</td><td>/</td><td>/</td></tr><tr><td>Urea</td><td>5.4 mmol/L</td><td>/</td><td>/</td></tr><tr><td>UA</td><td>308umol/L</td><td>/</td><td>/</td></tr><tr><td>Cr</td><td>54umol/L</td><td>/</td><td>/</td></tr></tbody></table></table-wrap></p></sec><sec id="sec2.4"><label>2.4</label><title>Imaging examination and diagnosis</title><p id="p0030">Mobile DR was implemented by employing the chest semi-recumbent on May 28 of 2015 after hospitalization, followed by May 30th, June 1st, June 3rd, June 4th, June 6th and June 8th. Obviously, pneumonia of the lower lungs was the primary finding (<xref rid="fig1" ref-type="fig">Fig. 1</xref>).<fig id="fig1"><label>Fig. 1</label><caption><p>Chest radiograph of a 44-year male patient with the Middle East respiratory syndrome. <bold>A</bold>. On the 7th day after hospitalization, the chest radiograph revealed the little patchy increased density shadow in the two lower lungs near the edge of heart. <bold>B</bold>. On the 10th day after hospitalization, the chest radiograph revealed two obviously increased patchy shadows in the two lower lungs, the degree of lower right lung was more serious. <bold>C</bold>. On the 13th day, the patchy lesions progressed to be large patchy consolidation shadows. <bold>D</bold>. On the 32nd day, chest radiograph showed two obvious absorptions in the lower lung lesions, only small pieces of the grid shadow could be observed.</p></caption><graphic xlink:href="gr1"></graphic></fig></p></sec></sec><sec id="sec3"><label>3</label><title>Results</title><p id="p0035">Patients was in fever after May 28, 2015 hospitalized, lasting about a week between 38.0 °C and 39.5 °C (<xref rid="fig2" ref-type="fig">Fig. 2</xref>). Then with Tamiflu and ribavirin antiviral therapy, broad-spectrum antibiotic anti-infective therapy, oxygen therapy and improve immune function with gamma globulin, the virus was negative on June 2. Low white blood cell count had been gradually increased to normal in two days after the virus was negative (<xref rid="fig3" ref-type="fig">Fig. 3</xref>). According to ‘cases of diagnosis and treatment of Middle East Respiratory Syndrome (2015 edition)’ by the National Health Development Planning Commission, he was discharged on June 26, 2015.<fig id="fig2"><label>Fig. 2</label><caption><p>The relationship of temperature changes and viral negative.</p></caption><graphic xlink:href="gr2"></graphic></fig><fig id="fig3"><label>Fig. 3</label><caption><p>Relationship of peripheral blood leukocyte counts and viral negative.</p></caption><graphic xlink:href="gr3"></graphic></fig></p></sec><sec id="sec4"><label>4</label><title>Discussion and conclusion</title><p id="p0040">It is well-known that incubation period of MERS is 2–14 days. Clinically, acute respiratory infection is the primary performance of MERS, accompanying with high fever (even reach to 39–40 °C), and sometimes with chills, shiver, cough, chest pain, headache, muscle and joint aches, fatigue, loss of appetite and so on. On the basis of pneumonia, the MERS rapidly developed into respiratory failure, acute respiratory distress syndrome (ARDS) or acute renal failure. Diarrhea and other atypical clinical manifestations might occur to individual cases (such as immunodeficiency cases). In this study, the patient suffered from fever (up to 39.5 °C) and back pain firstly. After hospitalization for one week, his body temperature returned to normal (Fig. 2), but still being in cough with a small amount of yellow phlegm and a little bloodshot; and there is no shortness of breath at rest and oxygen therapy. On the sixth day after his hospitalization, MERS-COV was negative via the virological detection of sputum, and his body temperature had decreased to be normal, which indicated that the virus has a direct relationship with the fever. Laboratory tests found that the leukocytes count in the peripheral blood had decreased obviously since his hospitalization, and the count was about 3.00 × 10<sup>9</sup>/L lasting for nine days, followed by increasing and till the 27th days it recovered to the normal level. This indicated that MERS-CoV mainly attacked human immune system, resulting in a significant reduce of leukocytes count; after the virus was cleared, the recovery may be a relatively slow process due to the leukocytes count recovered to the normal range for about two weeks after the virus return to be negative.</p><p id="p0045">The camel and bat are always thought to be the main infection source, but the animal to human infection process was not so clear till now. Generally, human to human infection should be paid more attention, for MERS-CoV would spread by direct contact of patients' secretions, or by aerosol and droplets. As is reported, there is an evidence of limited person-to-person transmission of MERS <xref rid="bib7" ref-type="bibr">[7]</xref>, <xref rid="bib8" ref-type="bibr">[8]</xref>. In this study, 75 people who had more or less contact with the patient were without any further infection. This limited transmissibility is consistent with the data available to date <xref rid="bib8" ref-type="bibr">[8]</xref>.</p><p id="p0050">Radiological manifestations of MERS are lungs consolidation and ground glass, due to the fact that the MERS-CoV primary lead to viral pneumonia <xref rid="bib3" ref-type="bibr">[3]</xref>. Imaging findings in this case were characteristic by the following three stages. 1) Small pieces of high density shadows in the two lower lungs near the heart edge were observed during the early period via chest X-ray examination, suggesting that it firstly progressed to pneumonia (about one week). 2) Subsequently, the lesions gradually expanded. Further chest X-ray examination showed large pieces of high density shadows in the middle right lower lung, oval pieces of high density shadows in the left lower lung field, and clear boundaries of the two upper lungs. 3) After the active antiretroviral therapy, the virus turned to be negative, the body temperature decreased to normal level (Fig. 2), and leukocyte count also began to rise (Fig. 3). Chest X-ray of deferred examination showed the gradually foci absorbed in both lungs, being consistence with clinical changes.</p><p id="p0055">Differential diagnosis of pneumonia imaging result from MERS, SARS or H7N9 avian influenza is necessary. Due to the fact that both SARS and MERS belong to the coronavirus family, their nucleotide homologies for one same PCR fragment are 70%–80%, their radiographic manifestations have in common. Both showed ground glass shadows and pulmonary opacities in the middle and lower lung lobes, accompanying with a rapid disease progression. Via High-resolution CT scans, septal thickening and bronchiectasis could be both observed. However, ground glass opacities and consolidation of SARS were relatively mild, with the lesions of a migratory change <xref rid="bib9" ref-type="bibr">[9]</xref>, <xref rid="bib10" ref-type="bibr">[10]</xref>, <xref rid="bib11" ref-type="bibr">[11]</xref>. As for MERS and H7N9 avian influenza, their common characteristics were ground glass shadows and pulmonary opacities in both lower lung lobes, except for that disease progression of H7N9 avian influenza infection might be more rapid <xref rid="bib10" ref-type="bibr">[10]</xref>, <xref rid="bib11" ref-type="bibr">[11]</xref>. 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id="ack0010"><title>Acknowledgment</title><p>Fund Project: <funding-source id="gs1">2013 Shenzhen key projects of the Knowledge Innovation Program</funding-source> (JCYJ20130401164750006), <funding-source id="gs2">2015 Shenzhen key projects of the Knowledge Innovation Program</funding-source> (JCYJ20150207181301).</p></ack><fn-group><fn id="d32e580"><p id="ntpara0010">Peer review under responsibility of Beijing You’an Hospital affiliated to Capital Medical University.</p></fn></fn-group></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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