Deadly MERS virus could hold the key to its own cure
Identifieur interne : 000925 ( Pmc/Corpus ); précédent : 000924; suivant : 000926Deadly MERS virus could hold the key to its own cure
Auteurs :Source :
- New Scientist (1971) [ 0262-4079 ] ; 2014.
Abstract
Recreating a small part of the MERS virus, which has killed 76 people so far, could block it from infecting cells and spreading disease
Url:
DOI: 10.1016/S0262-4079(14)60218-9
PubMed: NONE
PubMed Central: 7130780
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Deadly MERS virus could hold the key to its own cure</title></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7130780</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7130780</idno><idno type="RBID">PMC:7130780</idno><idno type="doi">10.1016/S0262-4079(14)60218-9</idno><idno type="pmid">NONE</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000925</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000925</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Deadly MERS virus could hold the key to its own cure</title></analytic><series><title level="j">New Scientist (1971)</title><idno type="ISSN">0262-4079</idno><idno type="eISSN">0262-4079</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Recreating a small part of the MERS virus, which has killed 76 people so far, could block it from infecting cells and spreading disease</p></div></front></TEI><pmc article-type="other"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">New Sci</journal-id><journal-id journal-id-type="iso-abbrev">New Sci</journal-id><journal-title-group><journal-title>New Scientist (1971)</journal-title></journal-title-group><issn pub-type="ppub">0262-4079</issn><issn pub-type="epub">0262-4079</issn><publisher><publisher-name>Published by Reed Business Information Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7130780</article-id><article-id pub-id-type="publisher-id">S0262-4079(14)60218-9</article-id><article-id pub-id-type="doi">10.1016/S0262-4079(14)60218-9</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Deadly MERS virus could hold the key to its own cure</article-title></title-group><pub-date pub-type="pmc-release"><day>1</day><month>2</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><day>1</day><month>2</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>1</day><month>2</month><year>2014</year></pub-date><volume>221</volume><issue>2954</issue><fpage>17</fpage><lpage>17</lpage><permissions><copyright-statement>© 2014 </copyright-statement><copyright-year>2014</copyright-year><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="ceab10"><p>Recreating a small part of the MERS virus, which has killed 76 people so far, could block it from infecting cells and spreading disease</p></abstract></article-meta></front><body><p id="para10">A PIECE of the deadly MERS virus might provide its own cure.</p><p id="para20">The virus causing Middle East respiratory syndrome emerged in 2012. It does not spread readily between people, but there are fears it could cause a pandemic if it ever starts. It has <ext-link ext-link-type="uri" xlink:href="http://www.who.int/csr/disease/coronavirus_infections/MERS_CoV_Update_20_Jan_2014.pdf" id="interrefs10">killed 76 of the 178 people known to have caught it</ext-link>, and there is no specific treatment.</p><p id="para30">Shibo Jiang at Fudan University in Shanghai and colleagues found the virus forces its way into cells using a rod-like structure made of two “fusion” proteins that bind tightly during infection.</p><p id="para40">Using X-rays to dissect this structure, they found the binding segments of these two proteins. They made one of the protein's segments in the lab, and found that it bound tightly to the other protein, blocking the binding site and preventing the rod from assembling. This protected cells in culture from becoming infected (<italic>Nature Communications</italic>, <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1038/ncomms4067" id="interrefs20">DOI: 10.1038/ncomms4067</ext-link>).</p><p id="para50">Jiang hopes this fragment could be used to treat MERS. A similar fragment of HIV is now used as the <ext-link ext-link-type="uri" xlink:href="http://www.fuzeon.com/Fuzeon/consumer-home_page.do" id="interrefs30">anti-HIV drug enfuvirtide</ext-link>. This drug can cause <ext-link ext-link-type="uri" xlink:href="http://www.fuzeon.com/Fuzeon/consumer-home_page.do" id="interrefs40">severe side effects</ext-link>, but that may not be the case with MERS, as treatment would take weeks, rather than years as for HIV. He is also working on a MERS vaccine.</p><p id="para60"><italic>This article appeared in print under the headline “MERS virus holds key to its own demise”</italic></p></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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