Research needed to prevent MERS coronavirus outbreaks
Identifieur interne : 000918 ( Pmc/Corpus ); précédent : 000917; suivant : 000919Research needed to prevent MERS coronavirus outbreaks
Auteurs : Sharmila DeviSource :
- Lancet (London, England) [ 0140-6736 ] ; 2017.
Url:
DOI: 10.1016/S0140-6736(17)30998-4
PubMed: 28422017
PubMed Central: 7134710
Links to Exploration step
PMC:7134710Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Research needed to prevent MERS coronavirus outbreaks</title><author><name sortKey="Devi, Sharmila" sort="Devi, Sharmila" uniqKey="Devi S" first="Sharmila" last="Devi">Sharmila Devi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28422017</idno><idno type="pmc">7134710</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134710</idno><idno type="RBID">PMC:7134710</idno><idno type="doi">10.1016/S0140-6736(17)30998-4</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000918</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000918</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Research needed to prevent MERS coronavirus outbreaks</title><author><name sortKey="Devi, Sharmila" sort="Devi, Sharmila" uniqKey="Devi S" first="Sharmila" last="Devi">Sharmila Devi</name></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="ISSN">0140-6736</idno><idno type="eISSN">1474-547X</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pmc article-type="other"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Lancet</journal-id><journal-id journal-id-type="iso-abbrev">Lancet</journal-id><journal-title-group><journal-title>Lancet (London, England)</journal-title></journal-title-group><issn pub-type="ppub">0140-6736</issn><issn pub-type="epub">1474-547X</issn><publisher><publisher-name>Elsevier Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28422017</article-id><article-id pub-id-type="pmc">7134710</article-id><article-id pub-id-type="publisher-id">S0140-6736(17)30998-4</article-id><article-id pub-id-type="doi">10.1016/S0140-6736(17)30998-4</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Research needed to prevent MERS coronavirus outbreaks</article-title></title-group><contrib-group><contrib contrib-type="author" id="au10"><name><surname>Devi</surname><given-names>Sharmila</given-names></name></contrib></contrib-group><pub-date pub-type="pmc-release"><day>13</day><month>4</month><year>2017</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub" iso-8601-date="2017-04-21"><season>15-21 April</season><year>2017</year></pub-date><pub-date pub-type="epub"><day>13</day><month>4</month><year>2017</year></pub-date><volume>389</volume><issue>10078</issue><fpage>1502</fpage><lpage>1502</lpage><permissions><copyright-statement>© 2017 Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2017</copyright-year><copyright-holder>Elsevier Ltd</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions></article-meta></front><body><p id="para10">After a recent outbreak of MERS coronavirus was contained in Saudi Arabia, WHO calls for more research for a better control of the disease. Sharmila Devi reports.</p><p id="para20">An outbreak of the Middle East respiratory syndrome coronavirus (MERS-CoV) in a hospital in Saudi Arabia that began at the end of February and affected ten people has been contained, with all patients recovered or in recovery, WHO said. Since MERS-CoV was first identified in Saudi Arabia in 2012, there have been at least 690 deaths and 1935 cases confirmed.</p><p id="para30">MERS-CoV is thought to be carried by camels and spread by droplet infection of the airways. It kills about 36% of those infected. No vaccine exists for MERS-CoV, but vaccine studies in camels are being conducted, including at the UK's Jenner Institute.</p><p id="para40">In the past, WHO has criticised Riyadh for allowing infections to spread in hospitals where most of the known human-to-human transmission has occurred. Stringent precautions and hygiene protocols are required to prevent the disease's spread. Failure to spot MERS-CoV in a patient in a vascular surgery ward in Saudi Arabia last year led to more than 49 other people being exposed. Several patients infected with MERS-CoV contracted it in the Middle East before travelling to other countries. It takes days for symptoms to develop, so their infection was only discovered in their destination country. In mid-2015, an outbreak in South Korea started by a man who had travelled in the Gulf caused 186 cases within 2 months. Cases similar to this were to be expected.</p><p id="para50">Saudi officials contacted by <italic>The Lancet</italic> for comment did not respond but Maria Van Kerkhove, WHO's technical lead for MERS-CoV, said the kingdom had made much progress in the past 2 years. She expected to see further improvement in the “early identification of hospital clusters and in the prevention of zoonotic transmission” across the entire country and medical system.</p><p id="para60">There had been a reduction in sharp peaks of cases, but “we know they are caused by delayed identification and isolation of the initial patient and suboptimal infection prevention and control measures”, she said. “What we hope for is that initial patients entering health-care facilities are suspected and isolated earlier. Some hospitals in Saudi Arabia, for example, have physically modified emergency departments where patients with respiratory symptoms have separate waiting rooms, treatment facilities, and patient rooms for non-respiratory patients.”</p><p id="para70">Saudi Arabia is one of the wealthier countries in the region and there is more concern about countries with fewer resources and less resilience to tackle the disease. “We expect more cases to be identified in the Middle East and every one of these cases has the potential to start an outbreak in the country where they are identified or, if they travel to another country, anywhere else in the world”, Van Kerkhove told <italic>The Lancet.</italic> “MERS-CoV is widespread in dromedary camels in the Middle East, large parts of Africa and possibly into South Asia where dromedaries are present”, she said. “This entire region presents an opportunity for spillover events, that is, where humans can become infected from contact with infected camels.”</p><p id="para80">Qatar has now reported 19 cases of MERS-CoV. This was the first outbreak since June, 2016. WHO investigators were still trying to determine how a man became exposed to the virus, the agency said in a statement on April 4. An investigation revealed the patient had not travelled outside of Qatar in the past 7 months and had no contact with camels or people infected with MERS-CoV.</p><p id="para90">Further outbreaks were likely in the absence of better regional surveillance and scientific research, said WHO. “The global community has been slow to implement fundamental research studies and while collaborative research has greatly improved in the last 2 years, we still lack answers to address key unknowns about this virus”, said Van Kerkhove.</p><p id="para100">WHO has recommended that until more is understood about MERS-CoV, people at high risk of developing severe disease should take precautions when visiting farms or markets where dromedary camels are present. This includes people who are older, have diabetes, renal failure, chronic lung disease, or are immunocompromised. Precautions include avoiding contact with camels, not drinking raw camel milk, and not eating camel meat that has not been thoroughly cooked.</p><p id="para110">“One of the major challenges in identifying MERS-CoV patients quickly is that signs and symptoms of MERS-CoV are non-specific—they are similar to other respiratory diseases and early disease can be mild”, said Van Kerkhove. “What we aim to accomplish with surveillance and training is to reduce the time to isolate suspected MERS-CoV patients and to improve standard infection prevention and control measures in hospitals.”</p><p id="para120"><fig id="f10"><graphic xlink:href="fx1_lrg"></graphic><permissions><copyright-statement>© 2017 Fayez Nureldine/Staff</copyright-statement><copyright-year>2017</copyright-year><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions></fig></p></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000918 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000918 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé= PMC:7134710
|texte= Research needed to prevent MERS coronavirus outbreaks
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:28422017" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |