Prior and Novel Coronaviruses, COVID-19, and Human Reproduction: What Is Known?
Identifieur interne : 000691 ( Pmc/Corpus ); précédent : 000690; suivant : 000692Prior and Novel Coronaviruses, COVID-19, and Human Reproduction: What Is Known?
Auteurs : James Segars ; Quinton Katler ; Dana B. Mcqueen ; Alexander Kotlyar ; Tanya Glenn ; Zac Knight ; Eve C. Feinberg ; Hugh S. Taylor ; James P. Toner ; Jennifer F. KawwassSource :
- Fertility and Sterility [ 0015-0282 ] ; 2020.
Abstract
To summarize current understanding of the effects of novel and prior coronaviruses on human reproduction, specifically male and female gametes, and in pregnancy.
Review of English publications in PubMed and Embase to April 6, 2020.
Manuscripts were screened for reports including coronavirus, reproduction, including pathophysiology and pregnancy.
None.
Reproductive outcomes; effects on gametes; pregnancy outcomes; neonatal complications.
Seventy-nine reports formed the basis of the review. Coronavirus binding to cells involves the S1 domain of the spike protein to receptors present in reproductive tissues, including angiotensin converting enzyme-2 (ACE2), CD26, Ezrin, and cyclophilins. SARS-CoV-1 may cause severe orchitis leading to germ cell destruction in males. Reports indicate decreased sperm concentration and motility for 72-90 days following COVID-19 infection. Gonadotropin-dependent expression of ACE2 was found in human ovaries, but it is unclear whether SARS-CoV-2 adversely affects female gametogenesis. Evidence suggests that COVID-19 infection has a lower maternal case fatality rate than SARS or MERS, but anecdotal reports suggest that infected, asymptomatic women may develop respiratory symptoms postpartum. COVID-19 infections in pregnancy are associated with preterm delivery. Postpartum neonatal transmission from mother to child has been reported.
COVID-19 infection may adversely affect some pregnant women and their offspring. Additional studies are needed to assess effects of SARS-CoV-2 infection on male and female fertility.
Url:
DOI: 10.1016/j.fertnstert.2020.04.025
PubMed: 32106972
PubMed Central: 7161522
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PMC:7161522Le document en format XML
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Mcqueen</name><affiliation><nlm:aff id="aff3">Division of Reproductive Endocrinology &, Infertility, Department of Obstetrics & Gynecology, Northwestern University, Chicago, Illinois</nlm:aff></affiliation></author><author><name sortKey="Kotlyar, Alexander" sort="Kotlyar, Alexander" uniqKey="Kotlyar A" first="Alexander" last="Kotlyar">Alexander Kotlyar</name><affiliation><nlm:aff id="aff4">Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut</nlm:aff></affiliation></author><author><name sortKey="Glenn, Tanya" sort="Glenn, Tanya" uniqKey="Glenn T" first="Tanya" last="Glenn">Tanya Glenn</name><affiliation><nlm:aff id="aff4">Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut</nlm:aff></affiliation></author><author><name sortKey="Knight, Zac" sort="Knight, Zac" uniqKey="Knight Z" first="Zac" last="Knight">Zac Knight</name><affiliation><nlm:aff id="aff5">American Society of Reproductive Medicine, Birmingham, Alabama</nlm:aff></affiliation></author><author><name sortKey="Feinberg, Eve C" sort="Feinberg, Eve C" uniqKey="Feinberg E" first="Eve C." last="Feinberg">Eve C. Feinberg</name><affiliation><nlm:aff id="aff3">Division of Reproductive Endocrinology &, Infertility, Department of Obstetrics & Gynecology, Northwestern University, Chicago, Illinois</nlm:aff></affiliation></author><author><name sortKey="Taylor, Hugh S" sort="Taylor, Hugh S" uniqKey="Taylor H" first="Hugh S." last="Taylor">Hugh S. Taylor</name><affiliation><nlm:aff id="aff4">Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut</nlm:aff></affiliation></author><author><name sortKey="Toner, James P" sort="Toner, James P" uniqKey="Toner J" first="James P." last="Toner">James P. Toner</name><affiliation><nlm:aff id="aff2">Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia</nlm:aff></affiliation></author><author><name sortKey="Kawwass, Jennifer F" sort="Kawwass, Jennifer F" uniqKey="Kawwass J" first="Jennifer F." last="Kawwass">Jennifer F. Kawwass</name><affiliation><nlm:aff id="aff2">Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia</nlm:aff></affiliation></author></analytic><series><title level="j">Fertility and Sterility</title><idno type="ISSN">0015-0282</idno><idno type="eISSN">1556-5653</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Structured Abstract</title><sec><title>Objective</title><p>To summarize current understanding of the effects of novel and prior coronaviruses on human reproduction, specifically male and female gametes, and in pregnancy.</p></sec><sec><title>Design</title><p>Review of English publications in PubMed and Embase to April 6, 2020.</p></sec><sec><title>Methods</title><p>Manuscripts were screened for reports including coronavirus, reproduction, including pathophysiology and pregnancy.</p></sec><sec><title>Intervention(s)</title><p>None.</p></sec><sec><title>Main Outcome Measure(s)</title><p>Reproductive outcomes; effects on gametes; pregnancy outcomes; neonatal complications.</p></sec><sec><title>Results</title><p>Seventy-nine reports formed the basis of the review. Coronavirus binding to cells involves the S1 domain of the spike protein to receptors present in reproductive tissues, including angiotensin converting enzyme-2 (ACE2), CD26, Ezrin, and cyclophilins. SARS-CoV-1 may cause severe orchitis leading to germ cell destruction in males. Reports indicate decreased sperm concentration and motility for 72-90 days following COVID-19 infection. Gonadotropin-dependent expression of ACE2 was found in human ovaries, but it is unclear whether SARS-CoV-2 adversely affects female gametogenesis. Evidence suggests that COVID-19 infection has a lower maternal case fatality rate than SARS or MERS, but anecdotal reports suggest that infected, asymptomatic women may develop respiratory symptoms postpartum. COVID-19 infections in pregnancy are associated with preterm delivery. Postpartum neonatal transmission from mother to child has been reported.</p></sec><sec><title>Conclusion</title><p>COVID-19 infection may adversely affect some pregnant women and their offspring. Additional studies are needed to assess effects of SARS-CoV-2 infection on male and female fertility.</p></sec></div></front></TEI><pmc article-type="brief-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Fertil Steril</journal-id><journal-id journal-id-type="iso-abbrev">Fertil. Steril</journal-id><journal-title-group><journal-title>Fertility and Sterility</journal-title></journal-title-group><issn pub-type="ppub">0015-0282</issn><issn pub-type="epub">1556-5653</issn><publisher><publisher-name>Published by Elsevier Inc. on behalf of the American Society for Reproductive Medicine</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32106972</article-id><article-id pub-id-type="pmc">7161522</article-id><article-id pub-id-type="publisher-id">S0015-0282(20)30385-X</article-id><article-id pub-id-type="doi">10.1016/j.fertnstert.2020.04.025</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Prior and Novel Coronaviruses, COVID-19, and Human Reproduction: What Is Known?</article-title></title-group><contrib-group><contrib contrib-type="author" id="au1"><name><surname>Segars</surname><given-names>James</given-names></name><degrees>MD</degrees><xref rid="aff1" ref-type="aff">1</xref></contrib><contrib contrib-type="author" id="au2"><name><surname>Katler</surname><given-names>Quinton</given-names></name><degrees>MD, MS</degrees><xref rid="aff2" ref-type="aff">2</xref></contrib><contrib contrib-type="author" id="au3"><name><surname>McQueen</surname><given-names>Dana B.</given-names></name><degrees>MD</degrees><xref rid="aff3" ref-type="aff">3</xref></contrib><contrib contrib-type="author" id="au4"><name><surname>Kotlyar</surname><given-names>Alexander</given-names></name><degrees>MD</degrees><xref rid="aff4" ref-type="aff">4</xref></contrib><contrib contrib-type="author" id="au5"><name><surname>Glenn</surname><given-names>Tanya</given-names></name><degrees>MD</degrees><xref rid="aff4" ref-type="aff">4</xref></contrib><contrib contrib-type="author" id="au6"><name><surname>Knight</surname><given-names>Zac</given-names></name><degrees>PhD</degrees><xref rid="aff5" ref-type="aff">5</xref></contrib><contrib contrib-type="author" id="au7"><name><surname>Feinberg</surname><given-names>Eve C.</given-names></name><xref rid="aff3" ref-type="aff">3</xref></contrib><contrib contrib-type="author" id="au8"><name><surname>Taylor</surname><given-names>Hugh S.</given-names></name><degrees>MD</degrees><xref rid="aff4" ref-type="aff">4</xref></contrib><contrib contrib-type="author" id="au9"><name><surname>Toner</surname><given-names>James P.</given-names></name><degrees>MD, PhD</degrees><xref rid="aff2" ref-type="aff">2</xref></contrib><contrib contrib-type="author" id="au10"><name><surname>Kawwass</surname><given-names>Jennifer F.</given-names></name><degrees>MD</degrees><email>jennifer.kawwass@emory.edu</email><xref rid="aff2" ref-type="aff">2</xref><xref rid="cor1" ref-type="corresp">∗</xref></contrib><on-behalf-of>for the ASRM Coronavirus/COVID-19 Task Force</on-behalf-of></contrib-group><aff id="aff1"><label>1</label>Division of Reproductive Sciences, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA</aff><aff id="aff2"><label>2</label>Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia</aff><aff id="aff3"><label>3</label>Division of Reproductive Endocrinology &, Infertility, Department of Obstetrics & Gynecology, Northwestern University, Chicago, Illinois</aff><aff id="aff4"><label>4</label>Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut</aff><aff id="aff5"><label>5</label>American Society of Reproductive Medicine, Birmingham, Alabama</aff><author-notes><corresp id="cor1"><label>∗</label>Corresponding Author: Jennifer F. Kawwass, MD , Division of Reproductive Endocrinology and Infertility, Emory University School of Medicine, 550 W Peachtree, Atlanta, Georgia 30308 , <email>jennifer.kawwass@emory.edu</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>16</day><month>4</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="epub"><day>16</day><month>4</month><year>2020</year></pub-date><history><date date-type="received"><day>10</day><month>4</month><year>2020</year></date><date date-type="rev-recd"><day>13</day><month>4</month><year>2020</year></date><date date-type="accepted"><day>13</day><month>4</month><year>2020</year></date></history><permissions><copyright-statement>©2020 Published by Elsevier Inc. on behalf of the American Society for Reproductive Medicine.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="abs0010"><title>Structured Abstract</title><sec><title>Objective</title><p>To summarize current understanding of the effects of novel and prior coronaviruses on human reproduction, specifically male and female gametes, and in pregnancy.</p></sec><sec><title>Design</title><p>Review of English publications in PubMed and Embase to April 6, 2020.</p></sec><sec><title>Methods</title><p>Manuscripts were screened for reports including coronavirus, reproduction, including pathophysiology and pregnancy.</p></sec><sec><title>Intervention(s)</title><p>None.</p></sec><sec><title>Main Outcome Measure(s)</title><p>Reproductive outcomes; effects on gametes; pregnancy outcomes; neonatal complications.</p></sec><sec><title>Results</title><p>Seventy-nine reports formed the basis of the review. Coronavirus binding to cells involves the S1 domain of the spike protein to receptors present in reproductive tissues, including angiotensin converting enzyme-2 (ACE2), CD26, Ezrin, and cyclophilins. SARS-CoV-1 may cause severe orchitis leading to germ cell destruction in males. Reports indicate decreased sperm concentration and motility for 72-90 days following COVID-19 infection. Gonadotropin-dependent expression of ACE2 was found in human ovaries, but it is unclear whether SARS-CoV-2 adversely affects female gametogenesis. Evidence suggests that COVID-19 infection has a lower maternal case fatality rate than SARS or MERS, but anecdotal reports suggest that infected, asymptomatic women may develop respiratory symptoms postpartum. COVID-19 infections in pregnancy are associated with preterm delivery. Postpartum neonatal transmission from mother to child has been reported.</p></sec><sec><title>Conclusion</title><p>COVID-19 infection may adversely affect some pregnant women and their offspring. Additional studies are needed to assess effects of SARS-CoV-2 infection on male and female fertility.</p></sec></abstract><abstract abstract-type="teaser" id="abs0015"><p>A review of prior and the novel coronaviruses and their impact on human reproduction, specifically male and female gametes, pregnancy, and postpartum suggests that much remains unknown.</p></abstract><kwd-group id="kwrds0010"><title>Keywords</title><kwd>Novel coronavirus</kwd><kwd>COVID-19</kwd><kwd>reproduction</kwd><kwd>pregnancy</kwd><kwd>review</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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