MersV1, Pmc, Corpus, bibRecord, 000642

A53 MERS-CoV in East African dromedary camels

Identifieur interne : 000642 ( Pmc/Corpus ); précédent : 000641; suivant : 000643

A53 MERS-CoV in East African dromedary camels

Auteurs : Ziqi Zhou ; Daniel K W. Chu ; Abraham Ali ; Getnet F. Demissié ; Malik Peiris

Source :

Virus Evolution [ 2057-1577 ] ; 2019.

RBID : PMC:6736029

Abstract

Human Middle East respiratory syndrome is a zoonotic respiratory disease caused by Middle East respiratory syndrome coronavirus (MERS-CoV) originating from camels in the Arabian Peninsula. While there are a large number of camels in East Africa, often traded to the Arabian Peninsula, no autochthonous human MERS-CoV case is reported in East Africa. Furthermore, there is limited information of MERS-CoV in East Africa. In this study, MERS-CoV in dromedary camels from Ethiopia was detected using RT-qPCR. Next-generation sequencing was used to obtain the full genome of MERS-CoV. MERS-CoV antibodies were also detected through MERS-spike pseudoparticle neutralization assay. Phylogenetic analysis of full-genome sequences and spike-genome antibodies indicates that MERS-CoV in East Africa is genetically distinct from those in the Arabian Peninsula. The results from this study show that MERS-CoV circulating in dromedary camels in East Africa are genetically distinct from those in the Arabian Peninsula. Further studies are needed to evaluate the risk of zoonotic transmission in East Africa.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736029

DOI: 10.1093/ve/vez002.052
PubMed: NONE
PubMed Central: 6736029

Links to Exploration step

PMC:6736029

Le document en format XML

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<author><name sortKey="Zhou, Ziqi" sort="Zhou, Ziqi" uniqKey="Zhou Z" first="Ziqi" last="Zhou">Ziqi Zhou</name>
<affiliation><nlm:aff id="vez002.052-AFF1">School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chu, Daniel K W" sort="Chu, Daniel K W" uniqKey="Chu D" first="Daniel K W" last="Chu">Daniel K W. Chu</name>
<affiliation><nlm:aff id="vez002.052-AFF1">School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ali, Abraham" sort="Ali, Abraham" uniqKey="Ali A" first="Abraham" last="Ali">Abraham Ali</name>
<affiliation><nlm:aff id="vez002.052-AFF2">Bacterial, Parasitic and Zoonotic Diseases Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Demissie, Getnet F" sort="Demissie, Getnet F" uniqKey="Demissie G" first="Getnet F" last="Demissié">Getnet F. Demissié</name>
<affiliation><nlm:aff id="vez002.052-AFF3">College of Veterinary Medecine, Haramaya University, Dire Dawa, Ethiopia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name>
<affiliation><nlm:aff id="vez002.052-AFF3">College of Veterinary Medecine, Haramaya University, Dire Dawa, Ethiopia</nlm:aff>
</affiliation>
</author>
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<idno type="doi">10.1093/ve/vez002.052</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A53 MERS-CoV in East African dromedary camels</title>
<author><name sortKey="Zhou, Ziqi" sort="Zhou, Ziqi" uniqKey="Zhou Z" first="Ziqi" last="Zhou">Ziqi Zhou</name>
<affiliation><nlm:aff id="vez002.052-AFF1">School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chu, Daniel K W" sort="Chu, Daniel K W" uniqKey="Chu D" first="Daniel K W" last="Chu">Daniel K W. Chu</name>
<affiliation><nlm:aff id="vez002.052-AFF1">School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ali, Abraham" sort="Ali, Abraham" uniqKey="Ali A" first="Abraham" last="Ali">Abraham Ali</name>
<affiliation><nlm:aff id="vez002.052-AFF2">Bacterial, Parasitic and Zoonotic Diseases Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Demissie, Getnet F" sort="Demissie, Getnet F" uniqKey="Demissie G" first="Getnet F" last="Demissié">Getnet F. Demissié</name>
<affiliation><nlm:aff id="vez002.052-AFF3">College of Veterinary Medecine, Haramaya University, Dire Dawa, Ethiopia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name>
<affiliation><nlm:aff id="vez002.052-AFF3">College of Veterinary Medecine, Haramaya University, Dire Dawa, Ethiopia</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Virus Evolution</title>
<idno type="eISSN">2057-1577</idno>
<imprint><date when="2019">2019</date>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>Human Middle East respiratory syndrome is a zoonotic respiratory disease caused by Middle East respiratory syndrome coronavirus (MERS-CoV) originating from camels in the Arabian Peninsula. While there are a large number of camels in East Africa, often traded to the Arabian Peninsula, no autochthonous human MERS-CoV case is reported in East Africa. Furthermore, there is limited information of MERS-CoV in East Africa. In this study, MERS-CoV in dromedary camels from Ethiopia was detected using RT-qPCR. Next-generation sequencing was used to obtain the full genome of MERS-CoV. MERS-CoV antibodies were also detected through MERS-spike pseudoparticle neutralization assay. Phylogenetic analysis of full-genome sequences and spike-genome antibodies indicates that MERS-CoV in East Africa is genetically distinct from those in the Arabian Peninsula. The results from this study show that MERS-CoV circulating in dromedary camels in East Africa are genetically distinct from those in the Arabian Peninsula. Further studies are needed to evaluate the risk of zoonotic transmission in East Africa.</p>
</div>
</front>
</TEI>
<pmc article-type="abstract"><pmc-dir>properties open_access</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Virus Evol</journal-id>
<journal-id journal-id-type="iso-abbrev">Virus Evol</journal-id>
<journal-id journal-id-type="publisher-id">vevolu</journal-id>
<journal-title-group><journal-title>Virus Evolution</journal-title>
</journal-title-group>
<issn pub-type="epub">2057-1577</issn>
<publisher><publisher-name>Oxford University Press</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmc">6736029</article-id>
<article-id pub-id-type="doi">10.1093/ve/vez002.052</article-id>
<article-id pub-id-type="publisher-id">vez002.052</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Abstract Overview</subject>
</subj-group>
</article-categories>
<title-group><article-title>A53 MERS-CoV in East African dromedary camels</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Zhou</surname>
<given-names>Ziqi</given-names>
</name>
<xref ref-type="aff" rid="vez002.052-AFF1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chu</surname>
<given-names>Daniel K W</given-names>
</name>
<xref ref-type="aff" rid="vez002.052-AFF1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ali</surname>
<given-names>Abraham</given-names>
</name>
<xref ref-type="aff" rid="vez002.052-AFF2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Demissié</surname>
<given-names>Getnet F</given-names>
</name>
<xref ref-type="aff" rid="vez002.052-AFF3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peiris</surname>
<given-names>Malik</given-names>
</name>
<xref ref-type="aff" rid="vez002.052-AFF3">3</xref>
</contrib>
</contrib-group>
<aff id="vez002.052-AFF1"><label>1</label>
School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China</aff>
<aff id="vez002.052-AFF2"><label>2</label>
Bacterial, Parasitic and Zoonotic Diseases Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia</aff>
<aff id="vez002.052-AFF3"><label>3</label>
College of Veterinary Medecine, Haramaya University, Dire Dawa, Ethiopia</aff>
<pub-date pub-type="collection"><month>8</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub" iso-8601-date="2019-08-22"><day>22</day>
<month>8</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>22</day>
<month>8</month>
<year>2019</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on the . </pmc-comment>
      <volume>5</volume>
<issue>Suppl 1</issue>
<issue-title>23rd International BioInformatics Workshop on Virus Evolution and Molecular Epidemiology</issue-title>
<elocation-id>vez002.052</elocation-id>
<permissions><copyright-statement>© Published by Oxford University Press.</copyright-statement>
<copyright-year>2019</copyright-year>
<license license-type="cc-by-nc" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/"><license-p>This is an Open Access publication distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>
), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com</license-p>
</license>
</permissions>
<self-uri xlink:href="vez002.052.pdf"></self-uri>
<abstract><title>Abstract</title>
<p>Human Middle East respiratory syndrome is a zoonotic respiratory disease caused by Middle East respiratory syndrome coronavirus (MERS-CoV) originating from camels in the Arabian Peninsula. While there are a large number of camels in East Africa, often traded to the Arabian Peninsula, no autochthonous human MERS-CoV case is reported in East Africa. Furthermore, there is limited information of MERS-CoV in East Africa. In this study, MERS-CoV in dromedary camels from Ethiopia was detected using RT-qPCR. Next-generation sequencing was used to obtain the full genome of MERS-CoV. MERS-CoV antibodies were also detected through MERS-spike pseudoparticle neutralization assay. Phylogenetic analysis of full-genome sequences and spike-genome antibodies indicates that MERS-CoV in East Africa is genetically distinct from those in the Arabian Peninsula. The results from this study show that MERS-CoV circulating in dromedary camels in East Africa are genetically distinct from those in the Arabian Peninsula. Further studies are needed to evaluate the risk of zoonotic transmission in East Africa.</p>
</abstract>
<counts><page-count count="1"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>

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A53 MERS-CoV in East African dromedary camels

A53 MERS-CoV in East African dromedary camels

Source :

Abstract

Links to Exploration step

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