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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Persistent Environmental Contamination and Prolonged Viral Shedding in MERS Patients During MERS-CoV Outbreak in South Korea</title><author><name sortKey="Jeong, Hye Won" sort="Jeong, Hye Won" uniqKey="Jeong H" first="Hye Won" last="Jeong">Hye Won Jeong</name></author><author><name sortKey="Heo, Jung Yeon" sort="Heo, Jung Yeon" uniqKey="Heo J" first="Jung Yeon" last="Heo">Jung Yeon Heo</name></author><author><name sortKey="Kim, Hyung Woo" sort="Kim, Hyung Woo" uniqKey="Kim H" first="Hyung-Woo" last="Kim">Hyung-Woo Kim</name></author><author><name sortKey="Choi, Young Ki" sort="Choi, Young Ki" uniqKey="Choi Y" first="Young Ki" last="Choi">Young Ki Choi</name></author><author><name sortKey="Song, Min Sok" sort="Song, Min Sok" uniqKey="Song M" first="Min-Sok" last="Song">Min-Sok Song</name></author><author><name sortKey="Bin Seo, Yu" sort="Bin Seo, Yu" uniqKey="Bin Seo Y" first="Yu" last="Bin Seo">Yu Bin Seo</name></author><author><name sortKey="Lee, Jacob" sort="Lee, Jacob" uniqKey="Lee J" first="Jacob" last="Lee">Jacob Lee</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">4946541</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946541</idno><idno type="RBID">PMC:4946541</idno><idno type="doi">10.1093/ofid/ofv130.11</idno><idno type="pmid">NONE</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000628</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000628</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Persistent Environmental Contamination and Prolonged Viral Shedding in MERS Patients During MERS-CoV Outbreak in South Korea</title><author><name sortKey="Jeong, Hye Won" sort="Jeong, Hye Won" uniqKey="Jeong H" first="Hye Won" last="Jeong">Hye Won Jeong</name></author><author><name sortKey="Heo, Jung Yeon" sort="Heo, Jung Yeon" uniqKey="Heo J" first="Jung Yeon" last="Heo">Jung Yeon Heo</name></author><author><name sortKey="Kim, Hyung Woo" sort="Kim, Hyung Woo" uniqKey="Kim H" first="Hyung-Woo" last="Kim">Hyung-Woo Kim</name></author><author><name sortKey="Choi, Young Ki" sort="Choi, Young Ki" uniqKey="Choi Y" first="Young Ki" last="Choi">Young Ki Choi</name></author><author><name sortKey="Song, Min Sok" sort="Song, Min Sok" uniqKey="Song M" first="Min-Sok" last="Song">Min-Sok Song</name></author><author><name sortKey="Bin Seo, Yu" sort="Bin Seo, Yu" uniqKey="Bin Seo Y" first="Yu" last="Bin Seo">Yu Bin Seo</name></author><author><name sortKey="Lee, Jacob" sort="Lee, Jacob" uniqKey="Lee J" first="Jacob" last="Lee">Jacob Lee</name></author></analytic><series><title level="j">Open Forum Infectious Diseases</title><idno type="eISSN">2328-8957</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pmc article-type="abstract"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Open Forum Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Open Forum Infect Dis</journal-id><journal-id journal-id-type="publisher-id">ofid</journal-id><journal-title-group><journal-title>Open Forum Infectious Diseases</journal-title></journal-title-group><issn pub-type="epub">2328-8957</issn><publisher><publisher-name>Infectious Diseases Society of America</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">4946541</article-id><article-id pub-id-type="doi">10.1093/ofid/ofv130.11</article-id><article-id pub-id-type="publisher-id">ofv130</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Persistent Environmental Contamination and Prolonged Viral Shedding in MERS Patients During MERS-CoV Outbreak in South Korea</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Jeong</surname><given-names>Hye Won</given-names></name></contrib><contrib contrib-type="author"><name><surname>Heo</surname><given-names>Jung Yeon</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Hyung-Woo</given-names></name></contrib><contrib contrib-type="author"><name><surname>Choi</surname><given-names>Young Ki</given-names></name></contrib><contrib contrib-type="author"><name><surname>Song</surname><given-names>Min-Sok</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bin Seo</surname><given-names>Yu</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Jacob</given-names></name></contrib></contrib-group><aff id="sa11-af1"><label>1</label><addr-line>Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, South Korea</addr-line></aff><aff id="sa11-af2"><label>2</label><addr-line>Division of Infectious Diseases, Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, South Korea</addr-line></aff><aff id="sa11-af3"><label>3</label><addr-line>Department of Microbiology, Chungbuk National University College of Medicine, Cheongju, South Korea</addr-line></aff><aff id="sa11-af4"><label>4</label><addr-line>Department of Internal Medicine, Hallym University Medical Center, Seoul, South Korea</addr-line></aff><author-notes><fn id="TN1"><p><bold>Session:</bold> 275a. Featured Oral Abstract</p></fn><fn id="TN2"><p><italic>Saturday, October 10, 2015: 4:45 PM</italic></p></fn></author-notes><pub-date pub-type="epub" iso-8601-date="2015-12-09"><day>09</day><month>12</month><year>2015</year></pub-date><pub-date pub-type="collection"><season>Fall</season><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>09</day><month>12</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>2</volume><issue>Suppl 1</issue><elocation-id>1978a</elocation-id><permissions><copyright-statement>© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America</copyright-statement><copyright-year>2015</copyright-year><license license-type="cc-by-nc-nd" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/">http://creativecommons.org/licenses/by-nc-nd/4.0/</ext-link>), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact <email>journals.permissions@oup.com</email>.</license-p></license></permissions></article-meta></front><body><p><bold><italic>Background.</italic></bold> Although Middle East Respiratory Syndrome coronavirus (MERS-CoV) is characterized by a risk of nosocomial transmission, the detailed mode of transmission and virus shedding periods from the patients are poorly understood. The aims of this study was to investigate the potential roles of environmental contamination by MERS-CoV in health care settings and the viable virus shedding period of MERS patients.</p><p><bold><italic>Method.</italic></bold> During the South Korea outbreaks of MERS-CoV, we investigated environmental contamination in MERS-CoV units (4 airborne infection isolation rooms, AIIRs) in two hospitals. By reverse-transcription PCR and virus culture, we detected the RNA of MERS-CoV and the viability of the virus from the environmental samples of the four rooms and the respiratory specimens of the four patients in above-mentioned AIIRs.</p><p><bold><italic>Result.</italic></bold> Environmental surfaces of MERS patient's room including many points frequently touched by patients or healthcare workers were contaminated by MERS-CoV. Also in anterooms, medical devices and air-ventilating equipment, the MERS-CoV RNA was detected. In addition, we could isolate the MERS-CoV in bedsheets, bedrails, IV fluid hangers and x-ray devices. During the late clinical phase of MERS, viable virus could be isolated in 3 of the 4 enrolled patients on day 18 to day 27 after symptom onset. In environmental specimens (bed controller and thermometer), PCR positivity persisted until the 5th day from the last positive PCR of patient's respiratory specimen.</p><p><bold><italic>Conclusion.</italic></bold> Most of touchable environments in MERS units were contaminated by patients and health care workers and the viable virus could shed through respiratory secretion of patients who clinically fully recovered with conventional PCR-negative. Therefore, our results emphasize strict environment surface hygiene practices and detailed and premeditative proceeding/guideline to disinfect the health care workers.</p><p><bold><italic>Disclosures.</italic></bold> <bold>All authors:</bold> No reported disclosures.</p></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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