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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">MP747<break></break>EFFECTS OF ISOLATION ON HEMODIALYSIS PATIENTS WITH MERS-COV EXPOSURE IN KOREA: A COHORT STUDY</title><author><name sortKey="Lee, Young Ki" sort="Lee, Young Ki" uniqKey="Lee Y" first="Young-Ki" last="Lee">Young-Ki Lee</name><affiliation><nlm:aff id="MP747_3">Internal Medicine Hallym University College of Medicine Seoul Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Lee, Sang Ho" sort="Lee, Sang Ho" uniqKey="Lee S" first="Sang-Ho" last="Lee">Sang-Ho Lee</name><affiliation><nlm:aff id="MP747_4">Internal Medicine Kyung Hee University at Kangdong Seoul Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Cho, Ajin" sort="Cho, Ajin" uniqKey="Cho A" first="Ajin" last="Cho">Ajin Cho</name><affiliation><nlm:aff id="MP747_3">Internal Medicine Hallym University College of Medicine Seoul Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Yoon, Jong Woo" sort="Yoon, Jong Woo" uniqKey="Yoon J" first="Jong-Woo" last="Yoon">Jong-Woo Yoon</name><affiliation><nlm:aff id="MP747_3">Internal Medicine Hallym University College of Medicine Seoul Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Jeon, Hee Jung" sort="Jeon, Hee Jung" uniqKey="Jeon H" first="Hee Jung" last="Jeon">Hee Jung Jeon</name><affiliation><nlm:aff id="MP747_3">Internal Medicine Hallym University College of Medicine Seoul Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Noh, Jung Woo" sort="Noh, Jung Woo" uniqKey="Noh J" first="Jung-Woo" last="Noh">Jung-Woo Noh</name><affiliation><nlm:aff id="MP747_3">Internal Medicine Hallym University College of Medicine Seoul Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Choi, Yoo Jin" sort="Choi, Yoo Jin" uniqKey="Choi Y" first="Yoo Jin" last="Choi">Yoo Jin Choi</name><affiliation><nlm:aff id="MP747_3">Internal Medicine Hallym University College of Medicine Seoul Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Bae, Eun Ji" sort="Bae, Eun Ji" uniqKey="Bae E" first="Eun Ji" last="Bae">Eun Ji Bae</name><affiliation><nlm:aff id="MP747_3">Internal Medicine Hallym University College of Medicine Seoul Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Kim, Eun Yi" sort="Kim, Eun Yi" uniqKey="Kim E" first="Eun Yi" last="Kim">Eun Yi Kim</name><affiliation><nlm:aff id="MP747_3">Internal Medicine Hallym University College of Medicine Seoul Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Jeong, Da Wun" sort="Jeong, Da Wun" uniqKey="Jeong D" first="Da-Wun" last="Jeong">Da-Wun Jeong</name><affiliation><nlm:aff id="MP747_4">Internal Medicine Kyung Hee University at Kangdong Seoul Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Kim, Yang Gyun" sort="Kim, Yang Gyun" uniqKey="Kim Y" first="Yang-Gyun" last="Kim">Yang-Gyun Kim</name><affiliation><nlm:aff id="MP747_4">Internal Medicine Kyung Hee University at Kangdong Seoul Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Lee, Chang Hee" sort="Lee, Chang Hee" uniqKey="Lee C" first="Chang-Hee" last="Lee">Chang-Hee Lee</name><affiliation><nlm:aff id="MP747_2">Anesthesiology Gangeung Medical Center Gangeung Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Yoo, Kyung Don" sort="Yoo, Kyung Don" uniqKey="Yoo K" first="Kyung Don" last="Yoo">Kyung Don Yoo</name><affiliation><nlm:aff id="MP747_1">Internal Medicine Dongguk University Medical Center Gyeongju Korea, Republic of</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7107960</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7107960</idno><idno type="RBID">PMC:7107960</idno><idno type="doi">10.1093/ndt/gfx180.MP747</idno><idno type="pmid">NONE</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000622</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000622</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">MP747<break></break>EFFECTS OF ISOLATION ON HEMODIALYSIS PATIENTS WITH MERS-COV EXPOSURE IN KOREA: A COHORT STUDY</title><author><name sortKey="Lee, Young Ki" sort="Lee, Young Ki" uniqKey="Lee Y" first="Young-Ki" last="Lee">Young-Ki Lee</name><affiliation><nlm:aff id="MP747_3">Internal Medicine Hallym University College of Medicine Seoul Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Lee, Sang Ho" sort="Lee, Sang Ho" uniqKey="Lee S" first="Sang-Ho" last="Lee">Sang-Ho Lee</name><affiliation><nlm:aff id="MP747_4">Internal Medicine Kyung Hee University at Kangdong Seoul Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Cho, Ajin" sort="Cho, Ajin" uniqKey="Cho A" first="Ajin" last="Cho">Ajin Cho</name><affiliation><nlm:aff id="MP747_3">Internal Medicine Hallym University College of Medicine Seoul Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Yoon, Jong Woo" sort="Yoon, Jong Woo" uniqKey="Yoon J" first="Jong-Woo" last="Yoon">Jong-Woo Yoon</name><affiliation><nlm:aff id="MP747_3">Internal Medicine Hallym University College of Medicine Seoul Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Jeon, Hee Jung" sort="Jeon, Hee Jung" uniqKey="Jeon H" first="Hee Jung" last="Jeon">Hee Jung Jeon</name><affiliation><nlm:aff id="MP747_3">Internal Medicine Hallym University College of Medicine Seoul Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Noh, Jung Woo" sort="Noh, Jung Woo" uniqKey="Noh J" first="Jung-Woo" last="Noh">Jung-Woo Noh</name><affiliation><nlm:aff id="MP747_3">Internal Medicine Hallym University College of Medicine Seoul Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Choi, Yoo Jin" sort="Choi, Yoo Jin" uniqKey="Choi Y" first="Yoo Jin" last="Choi">Yoo Jin Choi</name><affiliation><nlm:aff id="MP747_3">Internal Medicine Hallym University College of Medicine Seoul Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Bae, Eun Ji" sort="Bae, Eun Ji" uniqKey="Bae E" first="Eun Ji" last="Bae">Eun Ji Bae</name><affiliation><nlm:aff id="MP747_3">Internal Medicine Hallym University College of Medicine Seoul Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Kim, Eun Yi" sort="Kim, Eun Yi" uniqKey="Kim E" first="Eun Yi" last="Kim">Eun Yi Kim</name><affiliation><nlm:aff id="MP747_3">Internal Medicine Hallym University College of Medicine Seoul Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Jeong, Da Wun" sort="Jeong, Da Wun" uniqKey="Jeong D" first="Da-Wun" last="Jeong">Da-Wun Jeong</name><affiliation><nlm:aff id="MP747_4">Internal Medicine Kyung Hee University at Kangdong Seoul Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Kim, Yang Gyun" sort="Kim, Yang Gyun" uniqKey="Kim Y" first="Yang-Gyun" last="Kim">Yang-Gyun Kim</name><affiliation><nlm:aff id="MP747_4">Internal Medicine Kyung Hee University at Kangdong Seoul Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Lee, Chang Hee" sort="Lee, Chang Hee" uniqKey="Lee C" first="Chang-Hee" last="Lee">Chang-Hee Lee</name><affiliation><nlm:aff id="MP747_2">Anesthesiology Gangeung Medical Center Gangeung Korea, Republic of</nlm:aff></affiliation></author><author><name sortKey="Yoo, Kyung Don" sort="Yoo, Kyung Don" uniqKey="Yoo K" first="Kyung Don" last="Yoo">Kyung Don Yoo</name><affiliation><nlm:aff id="MP747_1">Internal Medicine Dongguk University Medical Center Gyeongju Korea, Republic of</nlm:aff></affiliation></author></analytic><series><title level="j">Nephrology Dialysis Transplantation</title><idno type="ISSN">0931-0509</idno><idno type="eISSN">1460-2385</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pmc article-type="abstract"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Nephrol Dial Transplant</journal-id><journal-id journal-id-type="iso-abbrev">Nephrol. Dial. Transplant</journal-id><journal-id journal-id-type="publisher-id">ndt</journal-id><journal-title-group><journal-title>Nephrology Dialysis Transplantation</journal-title></journal-title-group><issn pub-type="ppub">0931-0509</issn><issn pub-type="epub">1460-2385</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7107960</article-id><article-id pub-id-type="doi">10.1093/ndt/gfx180.MP747</article-id><article-id pub-id-type="publisher-id">gfx180.MP747</article-id><article-categories><subj-group subj-group-type="heading"><subject>POSTER SESSION</subject><subj-group subj-group-type="category-toc-heading"><subject>Dialysis - Epidemiology and outcome II</subject></subj-group></subj-group></article-categories><title-group><article-title>MP747<break></break>EFFECTS OF ISOLATION ON HEMODIALYSIS PATIENTS WITH MERS-COV EXPOSURE IN KOREA: A COHORT STUDY</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Young-Ki</given-names></name><xref ref-type="aff" rid="MP747_3">3</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Sang-Ho</given-names></name><xref ref-type="aff" rid="MP747_4">4</xref></contrib><contrib contrib-type="author"><name><surname>Cho</surname><given-names>Ajin</given-names></name><xref ref-type="aff" rid="MP747_3">3</xref></contrib><contrib contrib-type="author"><name><surname>Yoon</surname><given-names>Jong-Woo</given-names></name><xref ref-type="aff" rid="MP747_3">3</xref></contrib><contrib contrib-type="author"><name><surname>Jeon</surname><given-names>Hee Jung</given-names></name><xref ref-type="aff" rid="MP747_3">3</xref></contrib><contrib contrib-type="author"><name><surname>Noh</surname><given-names>Jung-Woo</given-names></name><xref ref-type="aff" rid="MP747_3">3</xref></contrib><contrib contrib-type="author"><name><surname>Choi</surname><given-names>Yoo Jin</given-names></name><xref ref-type="aff" rid="MP747_3">3</xref></contrib><contrib contrib-type="author"><name><surname>Bae</surname><given-names>Eun Ji</given-names></name><xref ref-type="aff" rid="MP747_3">3</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Eun Yi</given-names></name><xref ref-type="aff" rid="MP747_3">3</xref></contrib><contrib contrib-type="author"><name><surname>Jeong</surname><given-names>Da-Wun</given-names></name><xref ref-type="aff" rid="MP747_4">4</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Yang-Gyun</given-names></name><xref ref-type="aff" rid="MP747_4">4</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Chang-Hee</given-names></name><xref ref-type="aff" rid="MP747_2">2</xref></contrib><contrib contrib-type="author"><name><surname>Yoo</surname><given-names>Kyung Don</given-names></name><xref ref-type="aff" rid="MP747_1">1</xref></contrib></contrib-group><aff id="MP747_1"><label>1</label>Internal Medicine Dongguk University Medical Center Gyeongju Korea, Republic of</aff><aff id="MP747_2"><label>2</label>Anesthesiology Gangeung Medical Center Gangeung Korea, Republic of</aff><aff id="MP747_3"><label>3</label>Internal Medicine Hallym University College of Medicine Seoul Korea, Republic of</aff><aff id="MP747_4"><label>4</label>Internal Medicine Kyung Hee University at Kangdong Seoul Korea, Republic of</aff><pub-date pub-type="ppub"><month>5</month><year>2017</year></pub-date><pub-date pub-type="epub" iso-8601-date="2017-05-26"><day>26</day><month>5</month><year>2017</year></pub-date><volume>32</volume><issue>Suppl 3</issue><issue-title>54th ERA-EDTA CONGRESS, Madrid, Spain June 3rd-6th 2017 ABSTRACTS</issue-title><fpage>iii707</fpage><lpage>iii708</lpage><permissions><copyright-statement>© The Author 2017. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.</copyright-statement><copyright-year>2017</copyright-year><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p></license></permissions><self-uri xlink:href="gfx180.mp747.pdf"></self-uri><counts><page-count count="2"></page-count></counts></article-meta></front><body><p><bold>INTRODUCTION AND AIMS:</bold> In 2015, the Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak imposed a huge threat to public health in Korea. A total of 186 confirmed patients with MERS-CoV infection were reported, including one case with maintenance hemodialysis (HD). Dialysis patients in three HD units were incidentally exposed to patients or health care workers with confirmed MERS-CoV infection. To interrupt the spread of MERS-CoV, they were isolated from other people during outbreak. There are very few studies evaluating the effectiveness of isolation to reduce the spread of respiratory viruses in HD unit. This study examined the influence of isolation on HD patients with MERS-CoV exposure.</p><p><bold>METHODS:</bold> We studied 116 HD subjects that were exposed to MERS-CoV and isolated. MERS-CoV serological study for asymptomatic infections was performed. The interval from exposure to the blood sampling was 2, 4 and 16 weeks. Secondary transmission were identified on the basis of reactivity on enzyme-linked immunosorbent assay (ELISA) against MERS-CoV S1 antigen, supported by reactivity on recombinant S-protein immunofluorescence (IFA) and demonstration of spike pseudoparticle neutralization assay (ppNT). Hematologic and biochemical parameters were also examined during isolation period.</p><p><bold>RESULTS:</bold> In our study population, mean age was 62.2 years; 77 (66%) were men, 52 (45%) were diabetes. Isolation period from the exposure was 15.0±3.0 days (4-22). Hospitalized quarantine care was 71 (61%), cohort isolation was 34 (29%) and self-imposed quarantine was 11 (10%). Three cases were screened in test of serum samples by anti-MERS-CoV (IgG) ELISA. But, it proved no case of secondary transmission of MERS-CoV in HD units as results for IFA and ppNT. The proportion of patients with Hb <10 g/dL was higher during isolation period than that before isolation. Other biochemical parameters during isolation period were similar to those before isolation. During the 12-month follow-up period, there were 10 deaths (8.6%) regardless of isolation.</p><p><bold>CONCLUSIONS:</bold> This study suggested that isolation itself was sufficient to prevent the spread of MERS-CoV. Although the best isolation system in HD units has not been determined, simple and low-cost intervention would be adequate for stopping the spread of virus from person to person. Further studies of cost-effectiveness of different strategies of isolation management are needed.</p></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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