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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pediatric Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection – UAE</title><author><name sortKey="Kindi, F Al" sort="Kindi, F Al" uniqKey="Kindi F" first="F. Al" last="Kindi">F. Al Kindi</name><affiliation><nlm:aff id="aff0005">Internal Medicine, Tawam Hospital</nlm:aff></affiliation></author><author><name sortKey="Nair, S Chandrasekhar" sort="Nair, S Chandrasekhar" uniqKey="Nair S" first="S. Chandrasekhar" last="Nair">S. Chandrasekhar Nair</name><affiliation><nlm:aff id="aff0010">Academic Affairs, Tawam Hospital</nlm:aff></affiliation></author><author><name sortKey="Hashmey, R" sort="Hashmey, R" uniqKey="Hashmey R" first="R." last="Hashmey">R. Hashmey</name><affiliation><nlm:aff id="aff0015">Infectious Disease, Tawam Hospital</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7128627</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128627</idno><idno type="RBID">PMC:7128627</idno><idno type="doi">10.1016/j.jiph.2020.01.181</idno><idno type="pmid">NONE</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000611</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000611</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Pediatric Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection – UAE</title><author><name sortKey="Kindi, F Al" sort="Kindi, F Al" uniqKey="Kindi F" first="F. Al" last="Kindi">F. Al Kindi</name><affiliation><nlm:aff id="aff0005">Internal Medicine, Tawam Hospital</nlm:aff></affiliation></author><author><name sortKey="Nair, S Chandrasekhar" sort="Nair, S Chandrasekhar" uniqKey="Nair S" first="S. Chandrasekhar" last="Nair">S. Chandrasekhar Nair</name><affiliation><nlm:aff id="aff0010">Academic Affairs, Tawam Hospital</nlm:aff></affiliation></author><author><name sortKey="Hashmey, R" sort="Hashmey, R" uniqKey="Hashmey R" first="R." last="Hashmey">R. Hashmey</name><affiliation><nlm:aff id="aff0015">Infectious Disease, Tawam Hospital</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Infection and Public Health</title><idno type="ISSN">1876-0341</idno><idno type="eISSN">1876-035X</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pmc article-type="abstract"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Infect Public Health</journal-id><journal-id journal-id-type="iso-abbrev">J Infect Public Health</journal-id><journal-title-group><journal-title>Journal of Infection and Public Health</journal-title></journal-title-group><issn pub-type="ppub">1876-0341</issn><issn pub-type="epub">1876-035X</issn><publisher><publisher-name>Published by Elsevier Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7128627</article-id><article-id pub-id-type="publisher-id">S1876-0341(20)30182-9</article-id><article-id pub-id-type="doi">10.1016/j.jiph.2020.01.181</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Pediatric Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection – UAE</article-title></title-group><contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Kindi</surname><given-names>F. Al</given-names></name><xref rid="aff0005" ref-type="aff">1</xref></contrib><contrib contrib-type="author" id="aut0010"><name><surname>Nair</surname><given-names>S. Chandrasekhar</given-names></name><xref rid="aff0010" ref-type="aff">2</xref></contrib><contrib contrib-type="author" id="aut0015"><name><surname>Hashmey</surname><given-names>R.</given-names></name><xref rid="aff0015" ref-type="aff">3</xref></contrib></contrib-group><aff id="aff0005"><label>1</label>Internal Medicine, Tawam Hospital</aff><aff id="aff0010"><label>2</label>Academic Affairs, Tawam Hospital</aff><aff id="aff0015"><label>3</label>Infectious Disease, Tawam Hospital</aff><pub-date pub-type="pmc-release"><day>5</day><month>2</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>2</month><year>2020</year></pub-date><pub-date pub-type="epub"><day>5</day><month>2</month><year>2020</year></pub-date><volume>13</volume><issue>2</issue><fpage>372</fpage><lpage>372</lpage><permissions><copyright-statement>Copyright © 2020 Published by Elsevier Ltd.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions></article-meta></front><body><p id="par0005"><bold>Introduction</bold> In 2012, MERS-CoV was identified in Saudi Arabia and resulted in more than 2442 confirmed cases worldwide by May 2019. MERS-CoV infection in children is less common. A review of MERS-CoV in children from 2012 to April 2016 summarized the clinical manifestation of 31 reported cases. Most children were asymptomatic or had mild respiratory symptoms, and severe infection reported in patients with comorbid conditions. We aimed to study the clinical characteristics of pediatric MERS CoV infected cases in UAE supported by literature review.</p><p id="par0010"><bold>Method</bold> A retrospective multicenter chart review study was conducted for MERS-CoV cases in Abu Dhabi Emirate (May 2012 – May 2019). Demographic, clinical and laboratory data were analyzed. We reviewed WHO outbreak surveillance reports published online to identify pediatric MERS-CoV cases from April 2016 to June 2019.</p><p id="par0015"><bold>Results</bold> We describe favorable outcomes of MERS-CoV infection in three children identified in UAE. Two patients had household contact with MERS-CoV infected family members and another patient travelled to Saudi Arabia. MERS-CoV was confirmed by PCR from nasopharyngeal aspirates and duration of viral shedding ranged from 4 to 11 days. One patient was asymptomatic and other two had mild respiratory symptoms. Laboratory data and chest X rays were normal.</p><p id="par0020">We reviewed WHO surveillance data and identified 11 pediatric MERS-CoV cases from April 2016 to June 2019. Mean age of 14.9 years (6 females, 5 males). The majority of pediatric outbreak was in year 2017 (8 cases) and most cases identified in Saudi Arabia. The main risk factor was household infection. Two patients died due to severe MERS-CoV infection. There are an estimated 42 pediatric MERS-CoV cases reported globally, with a mortality rate of 9.5 % (4 cases).</p><p id="par0025"><bold>Conclusion</bold> Pediatric MERS-CoV infection is acquired mainly through household contact. It has favorable outcomes and the mortality rate in children remains lower than adults.</p></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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