Tissue Distribution of the Mers-Coronavirus Receptor in Bats
Identifieur interne : 000601 ( Pmc/Corpus ); précédent : 000600; suivant : 000602Tissue Distribution of the Mers-Coronavirus Receptor in Bats
Auteurs : A. Widagdo ; L. Begeman ; D. Schipper ; P. R. Van Run ; A. A. Cunningham ; N. Kley ; C. B. Reusken ; B. L. Haagmans ; J. M. A. Van Den BrandSource :
- Journal of Comparative Pathology [ 0021-9975 ] ; 2018.
Url:
DOI: 10.1016/j.jcpa.2017.10.024
PubMed: NONE
PubMed Central: 7130339
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Tissue Distribution of the Mers-Coronavirus Receptor in Bats</title><author><name sortKey="Widagdo, A" sort="Widagdo, A" uniqKey="Widagdo A" first="A." last="Widagdo">A. Widagdo</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Begeman, L" sort="Begeman, L" uniqKey="Begeman L" first="L." last="Begeman">L. Begeman</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Schipper, D" sort="Schipper, D" uniqKey="Schipper D" first="D." last="Schipper">D. Schipper</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Run, P R" sort="Van Run, P R" uniqKey="Van Run P" first="P. R." last="Van Run">P. R. Van Run</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Cunningham, A A" sort="Cunningham, A A" uniqKey="Cunningham A" first="A. A." last="Cunningham">A. A. Cunningham</name><affiliation><nlm:aff id="aff2">Institute of Zoology, Zoological Society of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kley, N" sort="Kley, N" uniqKey="Kley N" first="N." last="Kley">N. Kley</name><affiliation><nlm:aff id="aff3">Institute for Novel and Emerging Infectious Diseases, Friedrich Loeffler Institute, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Reusken, C B" sort="Reusken, C B" uniqKey="Reusken C" first="C. B." last="Reusken">C. B. Reusken</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Haagmans, B L" sort="Haagmans, B L" uniqKey="Haagmans B" first="B. L." last="Haagmans">B. L. Haagmans</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Den Brand, J M A" sort="Van Den Brand, J M A" uniqKey="Van Den Brand J" first="J. M. A." last="Van Den Brand">J. M. A. Van Den Brand</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7130339</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7130339</idno><idno type="RBID">PMC:7130339</idno><idno type="doi">10.1016/j.jcpa.2017.10.024</idno><idno type="pmid">NONE</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000601</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000601</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Tissue Distribution of the Mers-Coronavirus Receptor in Bats</title><author><name sortKey="Widagdo, A" sort="Widagdo, A" uniqKey="Widagdo A" first="A." last="Widagdo">A. Widagdo</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Begeman, L" sort="Begeman, L" uniqKey="Begeman L" first="L." last="Begeman">L. Begeman</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Schipper, D" sort="Schipper, D" uniqKey="Schipper D" first="D." last="Schipper">D. Schipper</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Run, P R" sort="Van Run, P R" uniqKey="Van Run P" first="P. R." last="Van Run">P. R. Van Run</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Cunningham, A A" sort="Cunningham, A A" uniqKey="Cunningham A" first="A. A." last="Cunningham">A. A. Cunningham</name><affiliation><nlm:aff id="aff2">Institute of Zoology, Zoological Society of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kley, N" sort="Kley, N" uniqKey="Kley N" first="N." last="Kley">N. Kley</name><affiliation><nlm:aff id="aff3">Institute for Novel and Emerging Infectious Diseases, Friedrich Loeffler Institute, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Reusken, C B" sort="Reusken, C B" uniqKey="Reusken C" first="C. B." last="Reusken">C. B. Reusken</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Haagmans, B L" sort="Haagmans, B L" uniqKey="Haagmans B" first="B. L." last="Haagmans">B. L. Haagmans</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Den Brand, J M A" sort="Van Den Brand, J M A" uniqKey="Van Den Brand J" first="J. M. A." last="Van Den Brand">J. M. A. Van Den Brand</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Comparative Pathology</title><idno type="ISSN">0021-9975</idno><idno type="eISSN">1532-3129</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pmc article-type="abstract"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Comp Pathol</journal-id><journal-id journal-id-type="iso-abbrev">J. Comp. Pathol</journal-id><journal-title-group><journal-title>Journal of Comparative Pathology</journal-title></journal-title-group><issn pub-type="ppub">0021-9975</issn><issn pub-type="epub">1532-3129</issn><publisher><publisher-name>Published by Elsevier Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7130339</article-id><article-id pub-id-type="publisher-id">S0021-9975(17)30384-5</article-id><article-id pub-id-type="doi">10.1016/j.jcpa.2017.10.024</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Tissue Distribution of the Mers-Coronavirus Receptor in Bats</article-title></title-group><contrib-group><contrib contrib-type="author" id="au1"><name><surname>Widagdo</surname><given-names>A.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref></contrib><contrib contrib-type="author" id="au2"><name><surname>Begeman</surname><given-names>L.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref></contrib><contrib contrib-type="author" id="au3"><name><surname>Schipper</surname><given-names>D.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref></contrib><contrib contrib-type="author" id="au4"><name><surname>van Run</surname><given-names>P.R.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref></contrib><contrib contrib-type="author" id="au5"><name><surname>Cunningham</surname><given-names>A.A.</given-names></name><xref rid="aff2" ref-type="aff">†</xref></contrib><contrib contrib-type="author" id="au6"><name><surname>Kley</surname><given-names>N.</given-names></name><xref rid="aff3" ref-type="aff">‡</xref></contrib><contrib contrib-type="author" id="au7"><name><surname>Reusken</surname><given-names>C.B.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref></contrib><contrib contrib-type="author" id="au8"><name><surname>Haagmans</surname><given-names>B.L.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref></contrib><contrib contrib-type="author" id="au9"><name><surname>van den Brand</surname><given-names>J.M.A.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref></contrib></contrib-group><aff id="aff1"><label>∗</label>Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</aff><aff id="aff2"><label>†</label>Institute of Zoology, Zoological Society of London, London, UK</aff><aff id="aff3"><label>‡</label>Institute for Novel and Emerging Infectious Diseases, Friedrich Loeffler Institute, Greifswald, Germany</aff><pub-date pub-type="pmc-release"><day>2</day><month>2</month><year>2018</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>1</month><year>2018</year></pub-date><pub-date pub-type="epub"><day>2</day><month>2</month><year>2018</year></pub-date><volume>158</volume><fpage>102</fpage><lpage>102</lpage><permissions><copyright-statement>Copyright © 2017 Published by Elsevier Ltd.</copyright-statement><copyright-year>2017</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions></article-meta></front><body><p id="p0010"><bold>Introduction:</bold> Middle East respiratory syndrome coronavirus (MERS-CoV) has been shown to infect both man and dromedary camels using dipeptidyl peptidase-4 (DPP4) as its receptor. The distribution of DPP4 in the respiratory tract tissues of man and camels reflects MERS-CoV tropism. Apart from dromedary camels, insectivorous bats are suggested as another natural reservoir for MERS-like-CoVs.</p><p id="p0015"><bold>Materials and Methods:</bold> In order to gain insight on the tropism of these viruses in bats, we studied the DPP4 distribution in the respiratory and extra-respiratory tissues of two frugivorous bat species (<italic>Epomophorus gambianus</italic> and <italic>Rousettus aegyptiacus</italic>) and two insectivorous bat species (<italic>Pipistrellus pipistrellus</italic> and <italic>Eptesicus serotinus</italic>).</p><p id="p0020"><bold>Results:</bold> In the frugivorous bats, DPP4 was present in epithelial cells of both the respiratory and the intestinal tract, similar to what has been reported for camels and man. In the insectivorous bats, however, DPP4 expression in epithelial cells of the respiratory tract was almost absent.</p><p id="p0025"><bold>Conclusions:</bold> The preferential expression of DPP4 in the intestinal tract of insectivorous bats suggests that transmission of MERS-like-CoVs mainly occurs via the faecal–oral route. Our results highlight differences in the distribution of DPP4 expression among MERS-CoV susceptible species, which might influence variability in virus tropism, pathogenesis and transmission route.</p></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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