Microbiological evaluation of respiratory tract infections in pilgrims returning from countries affected by Middle East respiratory syndrome coronavirus (MERS-CoV)
Identifieur interne : 000599 ( Pmc/Corpus ); précédent : 000598; suivant : 000600Microbiological evaluation of respiratory tract infections in pilgrims returning from countries affected by Middle East respiratory syndrome coronavirus (MERS-CoV)
Auteurs : S. Burrel ; S. Jaureguiberry ; E. Caumes ; A. Aubry ; H. Agut ; D. BoutolleauSource :
- Journal of Clinical Virology [ 1386-6532 ] ; 2016.
Url:
DOI: 10.1016/j.jcv.2016.08.106
PubMed: NONE
PubMed Central: 7130068
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Microbiological evaluation of respiratory tract infections in pilgrims returning from countries affected by Middle East respiratory syndrome coronavirus (MERS-CoV)</title><author><name sortKey="Burrel, S" sort="Burrel, S" uniqKey="Burrel S" first="S." last="Burrel">S. Burrel</name><affiliation><nlm:aff id="aff0005">Sorbonne Université, UPMC Univ Paris 06, CR7, CIMI-Paris, INSERM U1135, and AP-HP, Hôpitaux Universitaires La Pitié-Salpêtrière – Charles Foix, Service de Virologie, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Jaureguiberry, S" sort="Jaureguiberry, S" uniqKey="Jaureguiberry S" first="S." last="Jaureguiberry">S. Jaureguiberry</name><affiliation><nlm:aff id="aff0010">Sorbonne Université, UPMC Univ Paris 06, CR7, CIMI-Paris, INSERM U1135, and AP-HP, Hôpitaux Universitaires La Pitié-Salpêtrière – Charles Foix, Service de Maladies Infectieuses et Médecine Tropicale, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Caumes, E" sort="Caumes, E" uniqKey="Caumes E" first="E." last="Caumes">E. Caumes</name><affiliation><nlm:aff id="aff0010">Sorbonne Université, UPMC Univ Paris 06, CR7, CIMI-Paris, INSERM U1135, and AP-HP, Hôpitaux Universitaires La Pitié-Salpêtrière – Charles Foix, Service de Maladies Infectieuses et Médecine Tropicale, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Aubry, A" sort="Aubry, A" uniqKey="Aubry A" first="A." last="Aubry">A. Aubry</name><affiliation><nlm:aff id="aff0015">Sorbonne Université, UPMC Univ Paris 06, CR7, CIMI-Paris, INSERM U1135, and AP-HP, Hôpitaux Universitaires La Pitié-Salpêtrière - Charles Foix, Service de Bactériologie-Hygiène, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Agut, H" sort="Agut, H" uniqKey="Agut H" first="H." last="Agut">H. Agut</name><affiliation><nlm:aff id="aff0005">Sorbonne Université, UPMC Univ Paris 06, CR7, CIMI-Paris, INSERM U1135, and AP-HP, Hôpitaux Universitaires La Pitié-Salpêtrière – Charles Foix, Service de Virologie, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Boutolleau, D" sort="Boutolleau, D" uniqKey="Boutolleau D" first="D." last="Boutolleau">D. Boutolleau</name><affiliation><nlm:aff id="aff0005">Sorbonne Université, UPMC Univ Paris 06, CR7, CIMI-Paris, INSERM U1135, and AP-HP, Hôpitaux Universitaires La Pitié-Salpêtrière – Charles Foix, Service de Virologie, Paris, France</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7130068</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7130068</idno><idno type="RBID">PMC:7130068</idno><idno type="doi">10.1016/j.jcv.2016.08.106</idno><idno type="pmid">NONE</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000599</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000599</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Microbiological evaluation of respiratory tract infections in pilgrims returning from countries affected by Middle East respiratory syndrome coronavirus (MERS-CoV)</title><author><name sortKey="Burrel, S" sort="Burrel, S" uniqKey="Burrel S" first="S." last="Burrel">S. Burrel</name><affiliation><nlm:aff id="aff0005">Sorbonne Université, UPMC Univ Paris 06, CR7, CIMI-Paris, INSERM U1135, and AP-HP, Hôpitaux Universitaires La Pitié-Salpêtrière – Charles Foix, Service de Virologie, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Jaureguiberry, S" sort="Jaureguiberry, S" uniqKey="Jaureguiberry S" first="S." last="Jaureguiberry">S. Jaureguiberry</name><affiliation><nlm:aff id="aff0010">Sorbonne Université, UPMC Univ Paris 06, CR7, CIMI-Paris, INSERM U1135, and AP-HP, Hôpitaux Universitaires La Pitié-Salpêtrière – Charles Foix, Service de Maladies Infectieuses et Médecine Tropicale, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Caumes, E" sort="Caumes, E" uniqKey="Caumes E" first="E." last="Caumes">E. Caumes</name><affiliation><nlm:aff id="aff0010">Sorbonne Université, UPMC Univ Paris 06, CR7, CIMI-Paris, INSERM U1135, and AP-HP, Hôpitaux Universitaires La Pitié-Salpêtrière – Charles Foix, Service de Maladies Infectieuses et Médecine Tropicale, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Aubry, A" sort="Aubry, A" uniqKey="Aubry A" first="A." last="Aubry">A. Aubry</name><affiliation><nlm:aff id="aff0015">Sorbonne Université, UPMC Univ Paris 06, CR7, CIMI-Paris, INSERM U1135, and AP-HP, Hôpitaux Universitaires La Pitié-Salpêtrière - Charles Foix, Service de Bactériologie-Hygiène, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Agut, H" sort="Agut, H" uniqKey="Agut H" first="H." last="Agut">H. Agut</name><affiliation><nlm:aff id="aff0005">Sorbonne Université, UPMC Univ Paris 06, CR7, CIMI-Paris, INSERM U1135, and AP-HP, Hôpitaux Universitaires La Pitié-Salpêtrière – Charles Foix, Service de Virologie, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Boutolleau, D" sort="Boutolleau, D" uniqKey="Boutolleau D" first="D." last="Boutolleau">D. Boutolleau</name><affiliation><nlm:aff id="aff0005">Sorbonne Université, UPMC Univ Paris 06, CR7, CIMI-Paris, INSERM U1135, and AP-HP, Hôpitaux Universitaires La Pitié-Salpêtrière – Charles Foix, Service de Virologie, Paris, France</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Clinical Virology</title><idno type="ISSN">1386-6532</idno><idno type="eISSN">1873-5967</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pmc article-type="abstract"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Virol</journal-id><journal-id journal-id-type="iso-abbrev">J. Clin. Virol</journal-id><journal-title-group><journal-title>Journal of Clinical Virology</journal-title></journal-title-group><issn pub-type="ppub">1386-6532</issn><issn pub-type="epub">1873-5967</issn><publisher><publisher-name>Published by Elsevier B.V.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7130068</article-id><article-id pub-id-type="publisher-id">S1386-6532(16)30298-0</article-id><article-id pub-id-type="doi">10.1016/j.jcv.2016.08.106</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Microbiological evaluation of respiratory tract infections in pilgrims returning from countries affected by Middle East respiratory syndrome coronavirus (MERS-CoV)</article-title></title-group><contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Burrel</surname><given-names>S.</given-names></name><xref rid="aff0005" ref-type="aff">1</xref><xref rid="cor0005" ref-type="corresp">⁎</xref></contrib><contrib contrib-type="author" id="aut0010"><name><surname>Jaureguiberry</surname><given-names>S.</given-names></name><xref rid="aff0010" ref-type="aff">2</xref></contrib><contrib contrib-type="author" id="aut0015"><name><surname>Caumes</surname><given-names>E.</given-names></name><xref rid="aff0010" ref-type="aff">2</xref></contrib><contrib contrib-type="author" id="aut0020"><name><surname>Aubry</surname><given-names>A.</given-names></name><xref rid="aff0015" ref-type="aff">3</xref></contrib><contrib contrib-type="author" id="aut0025"><name><surname>Agut</surname><given-names>H.</given-names></name><xref rid="aff0005" ref-type="aff">1</xref></contrib><contrib contrib-type="author" id="aut0030"><name><surname>Boutolleau</surname><given-names>D.</given-names></name><xref rid="aff0005" ref-type="aff">1</xref></contrib></contrib-group><aff id="aff0005"><label>1</label>Sorbonne Université, UPMC Univ Paris 06, CR7, CIMI-Paris, INSERM U1135, and AP-HP, Hôpitaux Universitaires La Pitié-Salpêtrière – Charles Foix, Service de Virologie, Paris, France</aff><aff id="aff0010"><label>2</label>Sorbonne Université, UPMC Univ Paris 06, CR7, CIMI-Paris, INSERM U1135, and AP-HP, Hôpitaux Universitaires La Pitié-Salpêtrière – Charles Foix, Service de Maladies Infectieuses et Médecine Tropicale, Paris, France</aff><aff id="aff0015"><label>3</label>Sorbonne Université, UPMC Univ Paris 06, CR7, CIMI-Paris, INSERM U1135, and AP-HP, Hôpitaux Universitaires La Pitié-Salpêtrière - Charles Foix, Service de Bactériologie-Hygiène, Paris, France</aff><author-notes><corresp id="cor0005"><label>⁎</label>Corresponding author.</corresp></author-notes><pub-date pub-type="pmc-release"><day>12</day><month>9</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>9</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>12</day><month>9</month><year>2016</year></pub-date><volume>82</volume><fpage>S54</fpage><lpage>S54</lpage><permissions><copyright-statement>Copyright © 2016 Published by Elsevier B.V.</copyright-statement><copyright-year>2016</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions></article-meta></front><body><p id="par0005">Since September 2012, the World Health Organization (WHO) has been notified of 1728 laboratory-confirmed cases of infection with Middle East respiratory syndrome coronavirus (MERS-CoV), including at least 624 related deaths (disease outbreak news of April 26, 2016). Although MERS-CoV appears to be transmitted through respiratory droplets between humans with close contact, dromedary camels are likely to be a zoonotic source of MERS-CoV infection in humans. Early detection of MERS-CoV infection among international travelers exposed to camels or healthcare facilities in the Middle East remains essential. All travelers returning from MERS-CoV-affected areas to Paris (France) are given particular attention and those with fever and/or respiratory symptoms are referred to a dedicated infectious disease unit as the Infectious Disease Department of La Pitié-Salpêtrière University Hospital in Paris. The aim of this study was to investigate the microbiological etiologies of respiratory tract infections (RTI) among these specific travellers from the beginning of the 2015 Hajj and Umrah pilgrimage period (September 2015) to April 2016.</p><p id="par0010">Upon admission, patients were isolated and nasopharyngeal swabs, sputum samples and, for persons on ventilators, bronchoalveolar lavage specimens were collected by trained nurses. We examined which etiological respiratory pathogens were identified during screening for MERS-CoV in symptomatic travellers returning to Paris during September 2015 to April 2016 period, from MERS-CoV endemic regions (published WHO bulletins). Firstly, samples were screened with a specific MERS-CoV real-time reverse transcription PCR targeting region upstream of the E gene (upE), as recommended by WHO. The second step of the etiologic diagnosis entailed an investigation for other respiratory viruses (influenza A/B viruses, respiratory syncytial virus, metapneumovirus, rhinovirus-enterovirus, parainfluenza viruses, other human coronaviruses) using Respiratory MWS r-gene<sup>®</sup> kits (bioMérieux) and for bacteria using standardized culture procedures.</p><p id="par0015">A total of 31 symptomatic travellers mainly returning from Saudi Arabia (mean age 63.1 years, range 21–92 years; 58% male) were included during the study period and overall 48 respiratory clinical specimens were collected. None of the tested specimens were positive for MERS-CoV. Since a negative result should not absolutely rule out the possibility of MERS-CoV infection, notably if specimen is collected late or very early in the illness, some patients were screened twice. The vast majority of viral RTI, sometimes associated with bacteria superinfection, in these pilgrims returning home, were due to seasonal influenza A viruses (29%), rhinoviruses (23%), and other coronaviruses (7%) distinct from the MERS-CoV. Four patients were presenting acute lobar pneumonia, none were formally diagnosed. However, all were cured with antibiotics, as the presentation suggested pneumococcal infection. One case of Q fever, another known zoonosis transmitted by dromedary camels, and one case of <italic>Legionnella pneumophilia-</italic>associated disease were diagnosed among tested pilgrims.</p><p id="par0020">Continuous surveillance should be implemented to ensure the timely detection of possible imported cases of MERS-CoV and their immediate isolation in order to avoid secondary cases. However, clinicians should be aware that influenza viruses and rhinoviruses are the most commonly identified pathogens in returning pilgrims with acute RTI.</p></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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