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Neutralizing activity of Echinacea purpurea on Coronaviruses including highly pathogenic Middle-East-Respiratory Syndrome Virus (MERS-CoV)

Identifieur interne : 000000 ( Pmc/Corpus ); suivant : 000001

Neutralizing activity of Echinacea purpurea on Coronaviruses including highly pathogenic Middle-East-Respiratory Syndrome Virus (MERS-CoV)

Auteurs : O. Engler ; M. Strasser ; J. Signer ; R. Schoop

Source :

RBID : PMC:7147923
Url:
DOI: 10.1055/s-0037-1608557
PubMed: NONE
PubMed Central: 7147923

Links to Exploration step

PMC:7147923

Le document en format XML

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<title xml:lang="en">Neutralizing activity of Echinacea purpurea on Coronaviruses including highly pathogenic Middle-East-Respiratory Syndrome Virus (MERS-CoV)</title>
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<name sortKey="Engler, O" sort="Engler, O" uniqKey="Engler O" first="O" last="Engler">O. Engler</name>
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<name sortKey="Strasser, M" sort="Strasser, M" uniqKey="Strasser M" first="M" last="Strasser">M. Strasser</name>
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<institution>SPIEZ LABORATORY, Federal Office for Civil Protection, Spiez, Switzerland</institution>
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<author>
<name sortKey="Schoop, R" sort="Schoop, R" uniqKey="Schoop R" first="R" last="Schoop">R. Schoop</name>
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<date when="2017">2017</date>
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<title xml:lang="en" level="a" type="main">Neutralizing activity of Echinacea purpurea on Coronaviruses including highly pathogenic Middle-East-Respiratory Syndrome Virus (MERS-CoV)</title>
<author>
<name sortKey="Engler, O" sort="Engler, O" uniqKey="Engler O" first="O" last="Engler">O. Engler</name>
<affiliation>
<nlm:aff id="AFTu_PosterSession2_PO_241_1">
<institution>SPIEZ LABORATORY, Federal Office for Civil Protection, Spiez, Switzerland</institution>
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<author>
<name sortKey="Strasser, M" sort="Strasser, M" uniqKey="Strasser M" first="M" last="Strasser">M. Strasser</name>
<affiliation>
<nlm:aff id="AFTu_PosterSession2_PO_241_1">
<institution>SPIEZ LABORATORY, Federal Office for Civil Protection, Spiez, Switzerland</institution>
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<author>
<name sortKey="Signer, J" sort="Signer, J" uniqKey="Signer J" first="J" last="Signer">J. Signer</name>
<affiliation>
<nlm:aff id="AFTu_PosterSession2_PO_241_1">
<institution>SPIEZ LABORATORY, Federal Office for Civil Protection, Spiez, Switzerland</institution>
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</author>
<author>
<name sortKey="Schoop, R" sort="Schoop, R" uniqKey="Schoop R" first="R" last="Schoop">R. Schoop</name>
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<nlm:aff id="AFTu_PosterSession2_PO_241_2">
<institution>A. Vogel Bioforce AG, Roggwil TG, Switzerland</institution>
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<series>
<title level="j">Planta Medica International Open</title>
<idno type="ISSN">2509-9264</idno>
<idno type="eISSN">2509-6656</idno>
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<journal-id journal-id-type="doi">10.1055/s-00032099</journal-id>
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<journal-title>Planta Medica International Open</journal-title>
</journal-title-group>
<issn pub-type="ppub">2509-9264</issn>
<issn pub-type="epub">2509-6656</issn>
<publisher>
<publisher-name>Georg Thieme Verlag KG</publisher-name>
<publisher-loc>Stuttgart · New York</publisher-loc>
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<article-id pub-id-type="pmc">7147923</article-id>
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<article-id pub-id-type="doi">10.1055/s-0037-1608557</article-id>
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<subject>Poster Session</subject>
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<title-group>
<article-title xml:lang="en">Neutralizing activity of Echinacea purpurea on Coronaviruses including highly pathogenic Middle-East-Respiratory Syndrome Virus (MERS-CoV)</article-title>
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<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Engler</surname>
<given-names>O</given-names>
</name>
<xref rid="AFTu_PosterSession2_PO_241_1" ref-type="aff">1</xref>
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<contrib contrib-type="author">
<name>
<surname>Strasser</surname>
<given-names>M</given-names>
</name>
<xref rid="AFTu_PosterSession2_PO_241_1" ref-type="aff">1</xref>
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<contrib contrib-type="author">
<name>
<surname>Signer</surname>
<given-names>J</given-names>
</name>
<xref rid="AFTu_PosterSession2_PO_241_1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Schoop</surname>
<given-names>R</given-names>
</name>
<xref rid="AFTu_PosterSession2_PO_241_2" ref-type="aff">2</xref>
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<aff id="AFTu_PosterSession2_PO_241_1">
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<institution>SPIEZ LABORATORY, Federal Office for Civil Protection, Spiez, Switzerland</institution>
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<aff id="AFTu_PosterSession2_PO_241_2">
<label>2</label>
<institution>A. Vogel Bioforce AG, Roggwil TG, Switzerland</institution>
</aff>
<pub-date pub-type="ppub">
<month>10</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>24</day>
<month>10</month>
<year>2017</year>
</pub-date>
<volume>4</volume>
<issue>Suppl 1</issue>
<fpage>S1</fpage>
<lpage>S202</lpage>
<history></history>
<permissions>
<license license-type="open-access">
<license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p>
</license>
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</front>
<body>
<p>Coronaviruses (CoV) are able to infect the human respiratory tract and subtypes 229E, NL63, HKU-1 or OC43 are frequently detected during common colds. Other CoV strains infect animals but recent history has seen two cases of animal-to-human transitions, leading to the epidemic of Severe Acute Respiratory Syndrom (SARS) in 2003 and in recent years to outbreaks of Middle-East-Respiratory-Syndrome (MERS).</p>
<p>We tested the antiviral hydroalcoholic extract (65% V/V) of freshly harvested
<italic>Echinacea purpurea</italic>
herb and roots (Echinaforce®, EF) on Coronavirus 229E and also the highly pathogenic MERS-type. CoV 229E (10
<sup>5</sup>
tissue culture infectious dose, TCID
<sub>50</sub>
) and MERS-CoV (1.6 × 10
<sup>4</sup>
TCID
<sub>50</sub>
) were incubated with 0, 1, 10 and 50 µg/ml EF for 1h and remaining infectivity assessed by determining TCID
<sub>50</sub>
on HuH-7 and Vero cells. EF showed a dose dependent reduction of CoV 229E infectivity with an IC50 = 9+/-3 µg/ml. Complete neutralization was achieved with 50 µg/ml. Similar inhibition was observed for MERS-CoV, where 10 µg/ml EF reduced > 99.9% and 50 µg/ml fully blocked infectivity. Interestingly, virus inhibition was only seen upon direct exposition of virus to the extract. Corresponding tests with other viruses showed that membranous RNA-viruses such as Influenza, Yellow fever virus were also neutralized by EF, while infectivity of DNA-viruses such as Parvo- and Vaccinia virus were not altered by EF. </p>
<p>In summary, pre- and post-incubation experiments show that EF has the potential of inhibiting infection rather than the dissemination of Coronaviruses. Our data are in agreement with the results of a placebo controlled study, where 4-months Echinaforce® prevention significantly reduced membranous virus infections overall (p = 0.0114), and Coronavirus infections in particular: 33 infections in N = 362 with placebo i.c. to 21 infections in N = 355 with EF [1].</p>
<p>[1] Jawad M, et al. ECAM. 2012: 841315. Epub 2012 Sep 16.</p>
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