A family cluster of Middle East Respiratory Syndrome Coronavirus infections related to a likely unrecognized asymptomatic or mild case
Identifieur interne : 001269 ( Pmc/Checkpoint ); précédent : 001268; suivant : 001270A family cluster of Middle East Respiratory Syndrome Coronavirus infections related to a likely unrecognized asymptomatic or mild case
Auteurs : Ali S. Omrani [Arabie saoudite] ; Mohammad Abdul Matin [Arabie saoudite] ; Qais Haddad [Arabie saoudite] ; Daifullah Al-Nakhli [Arabie saoudite] ; Ziad A. Memish ; Ali M. Albarrak [Arabie saoudite]Source :
- International Journal of Infectious Diseases [ 1201-9712 ] ; 2013.
Abstract
Ninety confirmed cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) have been reported to the World Health Organization. We report the details of a second family cluster of MERS-CoV infections from Riyadh, Saudi Arabia.
We present the clinical, laboratory and epidemiological details of 3 patients from a family cluster of MERS-CoV infections.
The first patient developed respiratory symptoms and fever 14 days after admission to hospital for an unrelated reason. He died 11 days later with multi-organ failure. Two of his brothers presented later to another hospital with respiratory symptoms and fever. MERS-CoV infection in the latter 2 patients was confirmed by reverse transcriptase polymerase chain reaction testing. All 3 patients had fever, cough, shortness of breath, bilateral infiltrates on chest x-ray, thrombocytopenia, lymphopenia and rises in serum creatinine kinase and alanine transaminase. No hospital or other social contacts are known to have acquired the infection. It appears that the index patient in this cluster acquired MERS-CoV infection whilst in hospital from an unrecognized mild or asymptomatic case.
MERS-CoV acquisition from unrecognized mild or asymptomatic cases may be a more important contributor to ongoing transmission than previously appreciated.
Url:
DOI: 10.1016/j.ijid.2013.07.001
PubMed: 23916548
PubMed Central: 7110537
Affiliations:
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A family cluster of Middle East Respiratory Syndrome Coronavirus infections related to a likely unrecognized asymptomatic or mild case</title>
<author><name sortKey="Omrani, Ali S" sort="Omrani, Ali S" uniqKey="Omrani A" first="Ali S." last="Omrani">Ali S. Omrani</name>
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<author><name sortKey="Matin, Mohammad Abdul" sort="Matin, Mohammad Abdul" uniqKey="Matin M" first="Mohammad Abdul" last="Matin">Mohammad Abdul Matin</name>
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<author><name sortKey="Haddad, Qais" sort="Haddad, Qais" uniqKey="Haddad Q" first="Qais" last="Haddad">Qais Haddad</name>
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<author><name sortKey="Albarrak, Ali M" sort="Albarrak, Ali M" uniqKey="Albarrak A" first="Ali M." last="Albarrak">Ali M. Albarrak</name>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Ninety confirmed cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) have been reported to the World Health Organization. We report the details of a second family cluster of MERS-CoV infections from Riyadh, Saudi Arabia.</p>
</sec>
<sec><title>Methods</title>
<p>We present the clinical, laboratory and epidemiological details of 3 patients from a family cluster of MERS-CoV infections.</p>
</sec>
<sec><title>Results</title>
<p>The first patient developed respiratory symptoms and fever 14 days after admission to hospital for an unrelated reason. He died 11 days later with multi-organ failure. Two of his brothers presented later to another hospital with respiratory symptoms and fever. MERS-CoV infection in the latter 2 patients was confirmed by reverse transcriptase polymerase chain reaction testing. All 3 patients had fever, cough, shortness of breath, bilateral infiltrates on chest x-ray, thrombocytopenia, lymphopenia and rises in serum creatinine kinase and alanine transaminase. No hospital or other social contacts are known to have acquired the infection. It appears that the index patient in this cluster acquired MERS-CoV infection whilst in hospital from an unrecognized mild or asymptomatic case.</p>
</sec>
<sec><title>Conclusion</title>
<p>MERS-CoV acquisition from unrecognized mild or asymptomatic cases may be a more important contributor to ongoing transmission than previously appreciated.</p>
</sec>
</div>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Infect Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">Int. J. Infect. Dis</journal-id>
<journal-title-group><journal-title>International Journal of Infectious Diseases</journal-title>
</journal-title-group>
<issn pub-type="ppub">1201-9712</issn>
<issn pub-type="epub">1878-3511</issn>
<publisher><publisher-name>International Society for Infectious Diseases. Published by Elsevier Ltd.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23916548</article-id>
<article-id pub-id-type="pmc">7110537</article-id>
<article-id pub-id-type="publisher-id">S1201-9712(13)00225-7</article-id>
<article-id pub-id-type="doi">10.1016/j.ijid.2013.07.001</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>A family cluster of Middle East Respiratory Syndrome Coronavirus infections related to a likely unrecognized asymptomatic or mild case</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Omrani</surname>
<given-names>Ali S.</given-names>
</name>
<email>asomrani@gmail.com</email>
<xref rid="aff0005" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author" id="aut0010"><name><surname>Matin</surname>
<given-names>Mohammad Abdul</given-names>
</name>
<email>mmatin64@yahoo.com</email>
<xref rid="aff0010" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author" id="aut0015"><name><surname>Haddad</surname>
<given-names>Qais</given-names>
</name>
<email>qaishaddad@yahoo.com</email>
<xref rid="aff0015" ref-type="aff">c</xref>
</contrib>
<contrib contrib-type="author" id="aut0020"><name><surname>Al-Nakhli</surname>
<given-names>Daifullah</given-names>
</name>
<email>dralfardjh@gmail.com</email>
<xref rid="aff0020" ref-type="aff">d</xref>
</contrib>
<contrib contrib-type="author" id="aut0025"><name><surname>Memish</surname>
<given-names>Ziad A.</given-names>
</name>
<email>zmemish@yahoo.com</email>
<xref rid="aff0025" ref-type="aff">e</xref>
<xref rid="cor0005" ref-type="corresp">⁎</xref>
</contrib>
<contrib contrib-type="author" id="aut0030"><name><surname>Albarrak</surname>
<given-names>Ali M.</given-names>
</name>
<email>draalbarrak@yahoo.com</email>
<xref rid="aff0005" ref-type="aff">a</xref>
</contrib>
</contrib-group>
<aff id="aff0005"><label>a</label>
Consultant Infectious Diseases Physician, Division of Infectious Diseases, Department of Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia</aff>
<aff id="aff0010"><label>b</label>
Consultant Physician, Division of Internal Medicine, Department of Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia</aff>
<aff id="aff0015"><label>c</label>
Consultant Infectious Diseases Physician, Department of Infection Control, Security Forces Hospital, Riyadh, Saudi Arabia</aff>
<aff id="aff0020"><label>d</label>
Director of Infection Prevention and Control, Department of Infection Prevention and Control, Prince Sultan Military Medical City, Riyadh, Saudi Arabia</aff>
<aff id="aff0025"><label>e</label>
Deputy Minister of Health for Public Health, Ministry of Health, Director WHO Collaborating Center for Mass Gathering Medicine, Professor, College of Medicine, Alfaisal University, Riyadh 11176, Kingdom of Saudi Arabia</aff>
<author-notes><corresp id="cor0005"><label>⁎</label>
Corresponding author. Tel.: +9661-2124052; fax: +9661-2125052; Mobile:+966-5-05483515. <email>zmemish@yahoo.com</email>
</corresp>
</author-notes>
<pub-date pub-type="pmc-release"><day>2</day>
<month>8</month>
<year>2013</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>9</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub"><day>2</day>
<month>8</month>
<year>2013</year>
</pub-date>
<volume>17</volume>
<issue>9</issue>
<fpage>e668</fpage>
<lpage>e672</lpage>
<permissions><copyright-statement>Copyright © 2013 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.</copyright-statement>
<copyright-year>2013</copyright-year>
<copyright-holder>International Society for Infectious Diseases</copyright-holder>
<license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract id="abs0005"><sec><title>Background</title>
<p>Ninety confirmed cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) have been reported to the World Health Organization. We report the details of a second family cluster of MERS-CoV infections from Riyadh, Saudi Arabia.</p>
</sec>
<sec><title>Methods</title>
<p>We present the clinical, laboratory and epidemiological details of 3 patients from a family cluster of MERS-CoV infections.</p>
</sec>
<sec><title>Results</title>
<p>The first patient developed respiratory symptoms and fever 14 days after admission to hospital for an unrelated reason. He died 11 days later with multi-organ failure. Two of his brothers presented later to another hospital with respiratory symptoms and fever. MERS-CoV infection in the latter 2 patients was confirmed by reverse transcriptase polymerase chain reaction testing. All 3 patients had fever, cough, shortness of breath, bilateral infiltrates on chest x-ray, thrombocytopenia, lymphopenia and rises in serum creatinine kinase and alanine transaminase. No hospital or other social contacts are known to have acquired the infection. It appears that the index patient in this cluster acquired MERS-CoV infection whilst in hospital from an unrecognized mild or asymptomatic case.</p>
</sec>
<sec><title>Conclusion</title>
<p>MERS-CoV acquisition from unrecognized mild or asymptomatic cases may be a more important contributor to ongoing transmission than previously appreciated.</p>
</sec>
</abstract>
<kwd-group id="kwd0005"><title>Keywords</title>
<kwd>Middle East Respiratory Syndrome Coronavirus</kwd>
<kwd>MERS-CoV</kwd>
<kwd>Viral pneumonia</kwd>
<kwd>Cluster</kwd>
<kwd>Saudi Arabia</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Arabie saoudite</li>
</country>
</list>
<tree><noCountry><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name>
</noCountry>
<country name="Arabie saoudite"><noRegion><name sortKey="Omrani, Ali S" sort="Omrani, Ali S" uniqKey="Omrani A" first="Ali S." last="Omrani">Ali S. Omrani</name>
</noRegion>
<name sortKey="Al Nakhli, Daifullah" sort="Al Nakhli, Daifullah" uniqKey="Al Nakhli D" first="Daifullah" last="Al-Nakhli">Daifullah Al-Nakhli</name>
<name sortKey="Albarrak, Ali M" sort="Albarrak, Ali M" uniqKey="Albarrak A" first="Ali M." last="Albarrak">Ali M. Albarrak</name>
<name sortKey="Haddad, Qais" sort="Haddad, Qais" uniqKey="Haddad Q" first="Qais" last="Haddad">Qais Haddad</name>
<name sortKey="Matin, Mohammad Abdul" sort="Matin, Mohammad Abdul" uniqKey="Matin M" first="Mohammad Abdul" last="Matin">Mohammad Abdul Matin</name>
</country>
</tree>
</affiliations>
</record>
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