Coronavirus non-structural protein 16: Evasion, attenuation, and possible treatments
Identifieur interne : 001118 ( Pmc/Checkpoint ); précédent : 001117; suivant : 001119Coronavirus non-structural protein 16: Evasion, attenuation, and possible treatments
Auteurs : Vineet D. Menachery [États-Unis] ; Kari Debbink [États-Unis] ; Ralph S. Baric [États-Unis]Source :
- Virus Research [ 0168-1702 ] ; 2014.
Abstract
Identifies components required for CoV 2′O-MTase activity including structural motifs and interaction partners. Demonstrates attenuation of NSP16 mutants in multiple CoV strains. Defines innate immune components including MDA5 and IFIT proteins that mediate the attenuation of 2′O-MTase CoV mutants. Provides approaches to exploit 2′O-MTase pathways for antiviral treatment of CoVs and other viruses.
Url:
DOI: 10.1016/j.virusres.2014.09.009
PubMed: 25278144
PubMed Central: 4260984
Affiliations:
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Menachery</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Debbink, Kari" sort="Debbink, Kari" uniqKey="Debbink K" first="Kari" last="Debbink">Kari Debbink</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0010">Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0010">Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author></analytic><series><title level="j">Virus Research</title><idno type="ISSN">0168-1702</idno><idno type="eISSN">1872-7492</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Identifies components required for CoV 2′O-MTase activity including structural motifs and interaction partners.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Demonstrates attenuation of NSP16 mutants in multiple CoV strains.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Defines innate immune components including MDA5 and IFIT proteins that mediate the attenuation of 2′O-MTase CoV mutants.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">Provides approaches to exploit 2′O-MTase pathways for antiviral treatment of CoVs and other viruses.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Almazan, F" uniqKey="Almazan F">F. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Virus Res</journal-id><journal-id journal-id-type="iso-abbrev">Virus Res</journal-id><journal-title-group><journal-title>Virus Research</journal-title></journal-title-group><issn pub-type="ppub">0168-1702</issn><issn pub-type="epub">1872-7492</issn><publisher><publisher-name>Published by Elsevier B.V.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25278144</article-id><article-id pub-id-type="pmc">4260984</article-id><article-id pub-id-type="publisher-id">S0168-1702(14)00396-7</article-id><article-id pub-id-type="doi">10.1016/j.virusres.2014.09.009</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Coronavirus non-structural protein 16: Evasion, attenuation, and possible treatments</article-title></title-group><contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Menachery</surname><given-names>Vineet D.</given-names></name><email>vineet@email.unc.edu</email><email>Vineet.Menachery@gmail.com</email><xref rid="aff0005" ref-type="aff">a</xref><xref rid="cor0005" ref-type="corresp">⁎</xref></contrib><contrib contrib-type="author" id="aut0010"><name><surname>Debbink</surname><given-names>Kari</given-names></name><xref rid="aff0005" ref-type="aff">a</xref><xref rid="aff0010" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="aut0015"><name><surname>Baric</surname><given-names>Ralph S.</given-names></name><xref rid="aff0005" ref-type="aff">a</xref><xref rid="aff0010" ref-type="aff">b</xref></contrib></contrib-group><aff id="aff0005"><label>a</label>Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA</aff><aff id="aff0010"><label>b</label>Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA</aff><author-notes><corresp id="cor0005"><label>⁎</label>Corresponding author at: Department of Microbiology and Immunology, 3304 Michael Hooker Research Building, Campus Box 7435, Chapel Hill, NC 27599-7435, United States. Tel.: +1 919 966 3895. <email>vineet@email.unc.edu</email><email>Vineet.Menachery@gmail.com</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>30</day><month>9</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><day>19</day><month>12</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>30</day><month>9</month><year>2014</year></pub-date><volume>194</volume><fpage>191</fpage><lpage>199</lpage><history><date date-type="received"><day>14</day><month>8</month><year>2014</year></date><date date-type="rev-recd"><day>18</day><month>9</month><year>2014</year></date><date date-type="accepted"><day>19</day><month>9</month><year>2014</year></date></history><permissions><copyright-statement>Copyright © 2014 Published by Elsevier B.V.</copyright-statement><copyright-year>2014</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract abstract-type="author-highlights" id="abs0005"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Identifies components required for CoV 2′O-MTase activity including structural motifs and interaction partners.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Demonstrates attenuation of NSP16 mutants in multiple CoV strains.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Defines innate immune components including MDA5 and IFIT proteins that mediate the attenuation of 2′O-MTase CoV mutants.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">Provides approaches to exploit 2′O-MTase pathways for antiviral treatment of CoVs and other viruses.</p></list-item></list></p></abstract><abstract id="abs0010"><p>The recent emergence of Middle East Respiratory Syndrome Coronavirus (MERS-CoV), nearly a decade after the Severe Acute Respiratory Syndrome (SARS) CoV, highlights the importance of understanding and developing therapeutic treatment for current and emergent CoVs. This manuscript explores the role of NSP16, a 2′O-methyl-transferase (2′O-MTase), in CoV infection and the host immune response. The review highlights conserved motifs, required interaction partners, as well as the attenuation of NSP16 mutants, and restoration of these mutants in specific immune knockouts. Importantly, the work also identifies a number of approaches to exploit this understanding for therapeutic treatment and the data clearly illustrate the importance of NSP16 2′O-MTase activity for CoV infection and pathogenesis.</p></abstract><kwd-group id="kwd0005"><title>Keywords</title><kwd>CoV</kwd><kwd>SARS-CoV</kwd><kwd>2′O-Methyl-transferase</kwd><kwd>2′O-MTase</kwd><kwd>NSP16</kwd><kwd>MDA5</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li></region></list><tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Menachery, Vineet D" sort="Menachery, Vineet D" uniqKey="Menachery V" first="Vineet D." last="Menachery">Vineet D. Menachery</name></region><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name><name sortKey="Debbink, Kari" sort="Debbink, Kari" uniqKey="Debbink K" first="Kari" last="Debbink">Kari Debbink</name><name sortKey="Debbink, Kari" sort="Debbink, Kari" uniqKey="Debbink K" first="Kari" last="Debbink">Kari Debbink</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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