Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases
Identifieur interne : 001051 ( Pmc/Checkpoint ); précédent : 001050; suivant : 001052Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases
Auteurs : J. Poissy [France] ; A. Goffard [France] ; E. Parmentier-Decrucq [France] ; R. Favory [France] ; M. Kauv [France] ; E. Kipnis [France] ; D. Mathieu [France] ; B. Guery [France]Source :
- Journal of Clinical Virology [ 1386-6532 ] ; 2014.
Abstract
Lower respiratory tract excretion of MERS-CoV can be observed for more than one month. Viral excretion in multiple organs is possible, including viraemia. Prolonged infection prevention and control measures are necessary. Prolonged monitoring of respiratory excretion seems necessary.
Url:
DOI: 10.1016/j.jcv.2014.07.002
PubMed: 25073585
PubMed Central: 7106432
Affiliations:
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Goffard</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Laboratoire de Virologie, Centre de Biologie Pathologie, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Virologie, Centre de Biologie Pathologie, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex</wicri:regionArea><wicri:noRegion>Lille Cedex</wicri:noRegion><wicri:noRegion>Lille Cedex</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0015">Molecular & Cellular Virology of Hepatitis C, Center for Infection & Immunity of Lille (CIIL), Inserm U1019, CNRS UMR8204, Université Lille Nord de France, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Molecular & Cellular Virology of Hepatitis C, Center for Infection & Immunity of Lille (CIIL), Inserm U1019, CNRS UMR8204, Université Lille Nord de France, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Parmentier Decrucq, E" sort="Parmentier Decrucq, E" uniqKey="Parmentier Decrucq E" first="E." last="Parmentier-Decrucq">E. 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Poissy</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Pôle de Réanimation, Hôpital Roger Salengro, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Pôle de Réanimation, Hôpital Roger Salengro, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex</wicri:regionArea><wicri:noRegion>Lille Cedex</wicri:noRegion><wicri:noRegion>Lille Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Goffard, A" sort="Goffard, A" uniqKey="Goffard A" first="A." last="Goffard">A. Goffard</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Laboratoire de Virologie, Centre de Biologie Pathologie, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Virologie, Centre de Biologie Pathologie, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex</wicri:regionArea><wicri:noRegion>Lille Cedex</wicri:noRegion><wicri:noRegion>Lille Cedex</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0015">Molecular & Cellular Virology of Hepatitis C, Center for Infection & Immunity of Lille (CIIL), Inserm U1019, CNRS UMR8204, Université Lille Nord de France, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Molecular & Cellular Virology of Hepatitis C, Center for Infection & Immunity of Lille (CIIL), Inserm U1019, CNRS UMR8204, Université Lille Nord de France, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Parmentier Decrucq, E" sort="Parmentier Decrucq, E" uniqKey="Parmentier Decrucq E" first="E." last="Parmentier-Decrucq">E. Parmentier-Decrucq</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Pôle de Réanimation, Hôpital Roger Salengro, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Pôle de Réanimation, Hôpital Roger Salengro, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex</wicri:regionArea><wicri:noRegion>Lille Cedex</wicri:noRegion><wicri:noRegion>Lille Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Favory, R" sort="Favory, R" uniqKey="Favory R" first="R." last="Favory">R. Favory</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Pôle de Réanimation, Hôpital Roger Salengro, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Pôle de Réanimation, Hôpital Roger Salengro, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex</wicri:regionArea><wicri:noRegion>Lille Cedex</wicri:noRegion><wicri:noRegion>Lille Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Kauv, M" sort="Kauv, M" uniqKey="Kauv M" first="M." last="Kauv">M. Kauv</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Pôle de Réanimation, Hôpital Roger Salengro, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Pôle de Réanimation, Hôpital Roger Salengro, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex</wicri:regionArea><wicri:noRegion>Lille Cedex</wicri:noRegion><wicri:noRegion>Lille Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Kipnis, E" sort="Kipnis, E" uniqKey="Kipnis E" first="E." last="Kipnis">E. Kipnis</name><affiliation wicri:level="1"><nlm:aff id="aff0020">Host-Pathogen Translational Research Group, Université de Lille 2, Lille Cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Host-Pathogen Translational Research Group, Université de Lille 2, Lille Cedex</wicri:regionArea><wicri:noRegion>Lille Cedex</wicri:noRegion><wicri:noRegion>Lille Cedex</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0025">Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8204, F-59021 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8204, F-59021 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0030">Institut National de la Santé et de la Recherche Médicale, U1019, F-59019 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, U1019, F-59019 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0035">Département d’anesthésie-réanimation, Centre Hospitalier Régional et Universitaire de Lille, Lille Cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département d’anesthésie-réanimation, Centre Hospitalier Régional et Universitaire de Lille, Lille Cedex</wicri:regionArea><wicri:noRegion>Lille Cedex</wicri:noRegion><wicri:noRegion>Lille Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Mathieu, D" sort="Mathieu, D" uniqKey="Mathieu D" first="D." last="Mathieu">D. Mathieu</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Pôle de Réanimation, Hôpital Roger Salengro, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Pôle de Réanimation, Hôpital Roger Salengro, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex</wicri:regionArea><wicri:noRegion>Lille Cedex</wicri:noRegion><wicri:noRegion>Lille Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Guery, B" sort="Guery, B" uniqKey="Guery B" first="B." last="Guery">B. Guery</name><affiliation wicri:level="1"><nlm:aff id="aff0020">Host-Pathogen Translational Research Group, Université de Lille 2, Lille Cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Host-Pathogen Translational Research Group, Université de Lille 2, Lille Cedex</wicri:regionArea><wicri:noRegion>Lille Cedex</wicri:noRegion><wicri:noRegion>Lille Cedex</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0025">Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8204, F-59021 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8204, F-59021 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0030">Institut National de la Santé et de la Recherche Médicale, U1019, F-59019 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, U1019, F-59019 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0035">Département d’anesthésie-réanimation, Centre Hospitalier Régional et Universitaire de Lille, Lille Cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département d’anesthésie-réanimation, Centre Hospitalier Régional et Universitaire de Lille, Lille Cedex</wicri:regionArea><wicri:noRegion>Lille Cedex</wicri:noRegion><wicri:noRegion>Lille Cedex</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0040">Service de maladies infectieuses, Centre Hospitalier Régional et Universitaire de Lille, Lille Cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de maladies infectieuses, Centre Hospitalier Régional et Universitaire de Lille, Lille Cedex</wicri:regionArea><wicri:noRegion>Lille Cedex</wicri:noRegion><wicri:noRegion>Lille Cedex</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Clinical Virology</title><idno type="ISSN">1386-6532</idno><idno type="eISSN">1873-5967</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Lower respiratory tract excretion of MERS-CoV can be observed for more than one month.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Viral excretion in multiple organs is possible, including viraemia.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Prolonged infection prevention and control measures are necessary.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">Prolonged monitoring of respiratory excretion seems necessary.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Virol</journal-id><journal-id journal-id-type="iso-abbrev">J. Clin. Virol</journal-id><journal-title-group><journal-title>Journal of Clinical Virology</journal-title></journal-title-group><issn pub-type="ppub">1386-6532</issn><issn pub-type="epub">1873-5967</issn><publisher><publisher-name>Elsevier B.V.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25073585</article-id><article-id pub-id-type="pmc">7106432</article-id><article-id pub-id-type="publisher-id">S1386-6532(14)00265-0</article-id><article-id pub-id-type="doi">10.1016/j.jcv.2014.07.002</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases</article-title></title-group><contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Poissy</surname><given-names>J.</given-names></name><email>julien_poissy@hotmail.fr</email><xref rid="aff0005" ref-type="aff">a</xref><xref rid="cor0005" ref-type="corresp">⁎</xref></contrib><contrib contrib-type="author" id="aut0010"><name><surname>Goffard</surname><given-names>A.</given-names></name><xref rid="aff0010" ref-type="aff">b</xref><xref rid="aff0015" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="aut0015"><name><surname>Parmentier-Decrucq</surname><given-names>E.</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="aut0020"><name><surname>Favory</surname><given-names>R.</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="aut0025"><name><surname>Kauv</surname><given-names>M.</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="aut0030"><name><surname>Kipnis</surname><given-names>E.</given-names></name><xref rid="aff0020" ref-type="aff">d</xref><xref rid="aff0025" ref-type="aff">e</xref><xref rid="aff0030" ref-type="aff">f</xref><xref rid="aff0035" ref-type="aff">g</xref></contrib><contrib contrib-type="author" id="aut0035"><name><surname>Mathieu</surname><given-names>D.</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="aut0040"><name><surname>Guery</surname><given-names>B.</given-names></name><xref rid="aff0020" ref-type="aff">d</xref><xref rid="aff0025" ref-type="aff">e</xref><xref rid="aff0030" ref-type="aff">f</xref><xref rid="aff0035" ref-type="aff">g</xref><xref rid="aff0040" ref-type="aff">h</xref></contrib><contrib contrib-type="author"><collab>The MERS-CoV Biology Group</collab><xref rid="fn1" ref-type="fn">1</xref></contrib></contrib-group><aff id="aff0005"><label>a</label>Pôle de Réanimation, Hôpital Roger Salengro, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex, France</aff><aff id="aff0010"><label>b</label>Laboratoire de Virologie, Centre de Biologie Pathologie, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex, France</aff><aff id="aff0015"><label>c</label>Molecular & Cellular Virology of Hepatitis C, Center for Infection & Immunity of Lille (CIIL), Inserm U1019, CNRS UMR8204, Université Lille Nord de France, F-59000 Lille, France</aff><aff id="aff0020"><label>d</label>Host-Pathogen Translational Research Group, Université de Lille 2, Lille Cedex, France</aff><aff id="aff0025"><label>e</label>Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8204, F-59021 Lille, France</aff><aff id="aff0030"><label>f</label>Institut National de la Santé et de la Recherche Médicale, U1019, F-59019 Lille, France</aff><aff id="aff0035"><label>g</label>Département d’anesthésie-réanimation, Centre Hospitalier Régional et Universitaire de Lille, Lille Cedex, France</aff><aff id="aff0040"><label>h</label>Service de maladies infectieuses, Centre Hospitalier Régional et Universitaire de Lille, Lille Cedex, France</aff><author-notes><corresp id="cor0005"><label>⁎</label>Corresponding author. Tel.: +33 650862354. <email>julien_poissy@hotmail.fr</email></corresp><fn id="fn1"><label>1</label><p id="npar0005">MERS-CoV Biology Group: K. Alidjinou, L. Bocket, A. Dewilde, I. Engelmann, D. Hober, M. Lazrek, B. Prévost (Virology, Lille); S. Behillil, V. Enouf, S. Van der Werf (Institut Pasteur, National Reference Center for Influenza Viruses and Unit of Molecular Genetics of RNA Viruses, Paris).</p></fn></author-notes><pub-date pub-type="pmc-release"><day>12</day><month>7</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>10</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>12</day><month>7</month><year>2014</year></pub-date><volume>61</volume><issue>2</issue><fpage>275</fpage><lpage>278</lpage><history><date date-type="received"><day>19</day><month>4</month><year>2014</year></date><date date-type="rev-recd"><day>25</day><month>6</month><year>2014</year></date><date date-type="accepted"><day>4</day><month>7</month><year>2014</year></date></history><permissions><copyright-statement>Copyright © 2014 Elsevier B.V. All rights reserved.</copyright-statement><copyright-year>2014</copyright-year><copyright-holder>Elsevier B.V.</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract abstract-type="author-highlights" id="abs0005"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Lower respiratory tract excretion of MERS-CoV can be observed for more than one month.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Viral excretion in multiple organs is possible, including viraemia.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Prolonged infection prevention and control measures are necessary.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">Prolonged monitoring of respiratory excretion seems necessary.</p></list-item></list></p></abstract><abstract id="abs0010"><sec><title>Background</title><p>Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging coronavirus involved in severe acute respiratory distress syndrome (ARDS) and rapid renal failure. Hospital outbreak and nosocomial transmission were reported, however, several issues remain on the viral excretion course.</p></sec><sec><title>Objectives</title><p>Describe the kinetics and pattern of viral excretion in two infected patients.</p></sec><sec><title>Study design</title><p>After the initial diagnosis, blood, urine, rectal and respiratory samples were collected regularly, aliquoted and stored at −80 °C. Real-time reverse transcriptase polymerase chain reaction assay targeted the UpE and Orf1a regions of the MERS-CoV genome.</p></sec><sec><title>Results</title><p>In patient 1, who died of refractory ARDS and renal failure, MERS-CoV RNA was detected in pharyngeal and tracheal swabs, as well blood samples and urine samples until the 30th day. Rectal swabs were negative. Patient 2 also developed multiple-organ failure, but survived, with persisting renal insufficiency (creatinine clearance at 30 mL/min) and persistent interstitial syndrome albeit weaned off mechanical ventilation and no longer requiring oxygen. Tracheal aspirations were positive until the 33rd day, while nasopharyngeal swabs were negative. All other biological samples were negative.</p></sec><sec><title>Discussion</title><p>Lower respiratory tract excretion of MERS-CoV could be observed for more than one month. The most severely ill patient presented an expression of the virus in blood and urine, consistent with a type-1 interferon mediated immunological response impaired in patient 1, but developed by patient 2. These results suggest that infection control precautions must be adequately evaluated in clinical wards and laboratories exposed to MERS-CoV.</p></sec></abstract><kwd-group id="kwd0005"><title>Keywords</title><kwd>Coronavirus</kwd><kwd>MERS-CoV</kwd><kwd>RNA detection</kwd><kwd>Kinetic</kwd><kwd>Respiratory tract infection</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>France</li></country><region><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li></region><settlement><li>Lille</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Poissy, J" sort="Poissy, J" uniqKey="Poissy J" first="J." last="Poissy">J. Poissy</name></noRegion><name sortKey="Favory, R" sort="Favory, R" uniqKey="Favory R" first="R." last="Favory">R. Favory</name><name sortKey="Goffard, A" sort="Goffard, A" uniqKey="Goffard A" first="A." last="Goffard">A. Goffard</name><name sortKey="Goffard, A" sort="Goffard, A" uniqKey="Goffard A" first="A." last="Goffard">A. Goffard</name><name sortKey="Guery, B" sort="Guery, B" uniqKey="Guery B" first="B." last="Guery">B. Guery</name><name sortKey="Guery, B" sort="Guery, B" uniqKey="Guery B" first="B." last="Guery">B. Guery</name><name sortKey="Guery, B" sort="Guery, B" uniqKey="Guery B" first="B." last="Guery">B. Guery</name><name sortKey="Guery, B" sort="Guery, B" uniqKey="Guery B" first="B." last="Guery">B. Guery</name><name sortKey="Guery, B" sort="Guery, B" uniqKey="Guery B" first="B." last="Guery">B. Guery</name><name sortKey="Kauv, M" sort="Kauv, M" uniqKey="Kauv M" first="M." last="Kauv">M. Kauv</name><name sortKey="Kipnis, E" sort="Kipnis, E" uniqKey="Kipnis E" first="E." last="Kipnis">E. Kipnis</name><name sortKey="Kipnis, E" sort="Kipnis, E" uniqKey="Kipnis E" first="E." last="Kipnis">E. Kipnis</name><name sortKey="Kipnis, E" sort="Kipnis, E" uniqKey="Kipnis E" first="E." last="Kipnis">E. Kipnis</name><name sortKey="Kipnis, E" sort="Kipnis, E" uniqKey="Kipnis E" first="E." last="Kipnis">E. Kipnis</name><name sortKey="Mathieu, D" sort="Mathieu, D" uniqKey="Mathieu D" first="D." last="Mathieu">D. Mathieu</name><name sortKey="Parmentier Decrucq, E" sort="Parmentier Decrucq, E" uniqKey="Parmentier Decrucq E" first="E." last="Parmentier-Decrucq">E. Parmentier-Decrucq</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases
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