Middle East respiratory syndrome coronavirus: Implications for health care facilities
Identifieur interne : 001014 ( Pmc/Checkpoint ); précédent : 001013; suivant : 001015Middle East respiratory syndrome coronavirus: Implications for health care facilities
Auteurs : Helena C. Maltezou [Grèce] ; Sotirios Tsiodras [Grèce]Source :
- American Journal of Infection Control [ 0196-6553 ] ; 2014.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel coronavirus that causes a severe respiratory disease with high case fatality rate. Starting in March 2014, a dramatic increase of cases has occurred in the Arabian Peninsula, many of which were acquired in health care settings. As of May 9, 2014, 536 laboratory-confirmed cases and 145 deaths have been reported globally.
Review of publicly available data about MERS-CoV health care–associated transmission.
We identified 11 events of possible or confirmed health care–associated transmission with high morbidity and mortality, mainly among patients with comorbidities. Health care workers are also frequently affected; however, they tend to have milder symptoms and better prognosis. Gaps in infection control were noted in all events. Currently, health care–associated outbreaks are playing a pivotal role in the evolution of the MERS-CoV epidemic in countries in the Arabian Peninsula.
There is a need to increase infection control capacity in affected areas and areas at increased risk of being affected to prevent transmission in health care settings. Vaccines and antiviral agents are urgently needed. Overall, our knowledge about the epidemiologic characteristics of MERS-CoV that impact health care transmission is very limited. As the MERS-CoV epidemic continues to evolve, issues concerning best infection control measures will arise, and studies to better define their effectiveness in real life are needed.
Url:
DOI: 10.1016/j.ajic.2014.06.019
PubMed: 25465253
PubMed Central: 7132773
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Middle East respiratory syndrome coronavirus: Implications for health care facilities</title><author><name sortKey="Maltezou, Helena C" sort="Maltezou, Helena C" uniqKey="Maltezou H" first="Helena C." last="Maltezou">Helena C. Maltezou</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department for Interventions in Health-Care Facilities, Hellenic Center for Disease Control and Prevention, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department for Interventions in Health-Care Facilities, Hellenic Center for Disease Control and Prevention, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Tsiodras, Sotirios" sort="Tsiodras, Sotirios" uniqKey="Tsiodras S" first="Sotirios" last="Tsiodras">Sotirios Tsiodras</name><affiliation wicri:level="3"><nlm:aff id="aff2">Fourth Department of Internal Medicine, University of Athens Medical School, Attikon University Hospital, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Fourth Department of Internal Medicine, University of Athens Medical School, Attikon University Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25465253</idno><idno type="pmc">7132773</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132773</idno><idno type="RBID">PMC:7132773</idno><idno type="doi">10.1016/j.ajic.2014.06.019</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001266</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001266</idno><idno type="wicri:Area/Pmc/Curation">001266</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001266</idno><idno type="wicri:Area/Pmc/Checkpoint">001014</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001014</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Middle East respiratory syndrome coronavirus: Implications for health care facilities</title><author><name sortKey="Maltezou, Helena C" sort="Maltezou, Helena C" uniqKey="Maltezou H" first="Helena C." last="Maltezou">Helena C. Maltezou</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department for Interventions in Health-Care Facilities, Hellenic Center for Disease Control and Prevention, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department for Interventions in Health-Care Facilities, Hellenic Center for Disease Control and Prevention, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Tsiodras, Sotirios" sort="Tsiodras, Sotirios" uniqKey="Tsiodras S" first="Sotirios" last="Tsiodras">Sotirios Tsiodras</name><affiliation wicri:level="3"><nlm:aff id="aff2">Fourth Department of Internal Medicine, University of Athens Medical School, Attikon University Hospital, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Fourth Department of Internal Medicine, University of Athens Medical School, Attikon University Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author></analytic><series><title level="j">American Journal of Infection Control</title><idno type="ISSN">0196-6553</idno><idno type="eISSN">1527-3296</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel coronavirus that causes a severe respiratory disease with high case fatality rate. Starting in March 2014, a dramatic increase of cases has occurred in the Arabian Peninsula, many of which were acquired in health care settings. As of May 9, 2014, 536 laboratory-confirmed cases and 145 deaths have been reported globally.</p></sec><sec><title>Methods</title><p>Review of publicly available data about MERS-CoV health care–associated transmission.</p></sec><sec><title>Results</title><p>We identified 11 events of possible or confirmed health care–associated transmission with high morbidity and mortality, mainly among patients with comorbidities. Health care workers are also frequently affected; however, they tend to have milder symptoms and better prognosis. Gaps in infection control were noted in all events. Currently, health care–associated outbreaks are playing a pivotal role in the evolution of the MERS-CoV epidemic in countries in the Arabian Peninsula.</p></sec><sec><title>Conclusion</title><p>There is a need to increase infection control capacity in affected areas and areas at increased risk of being affected to prevent transmission in health care settings. Vaccines and antiviral agents are urgently needed. Overall, our knowledge about the epidemiologic characteristics of MERS-CoV that impact health care transmission is very limited. As the MERS-CoV epidemic continues to evolve, issues concerning best infection control measures will arise, and studies to better define their effectiveness in real life are needed.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A. Assiri</name></author><author><name sortKey="Al Tawfiq, J A" uniqKey="Al Tawfiq J">J.A. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Infect Control</journal-id><journal-id journal-id-type="iso-abbrev">Am J Infect Control</journal-id><journal-title-group><journal-title>American Journal of Infection Control</journal-title></journal-title-group><issn pub-type="ppub">0196-6553</issn><issn pub-type="epub">1527-3296</issn><publisher><publisher-name>Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25465253</article-id><article-id pub-id-type="pmc">7132773</article-id><article-id pub-id-type="publisher-id">S0196-6553(14)00931-6</article-id><article-id pub-id-type="doi">10.1016/j.ajic.2014.06.019</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Middle East respiratory syndrome coronavirus: Implications for health care facilities</article-title></title-group><contrib-group><contrib contrib-type="author" id="au1"><name><surname>Maltezou</surname><given-names>Helena C.</given-names></name><degrees>MD, PhD</degrees><email>helen-maltezou@ath.forthnet.gr</email><xref rid="aff1" ref-type="aff">a</xref><xref rid="cor1" ref-type="corresp">∗</xref></contrib><contrib contrib-type="author" id="au2"><name><surname>Tsiodras</surname><given-names>Sotirios</given-names></name><degrees>MD, PhD</degrees><xref rid="aff2" ref-type="aff">b</xref></contrib></contrib-group><aff id="aff1"><label>a</label>Department for Interventions in Health-Care Facilities, Hellenic Center for Disease Control and Prevention, Athens, Greece</aff><aff id="aff2"><label>b</label>Fourth Department of Internal Medicine, University of Athens Medical School, Attikon University Hospital, Athens, Greece</aff><author-notes><corresp id="cor1"><label>∗</label>Address correspondence to Helena C. Maltezou, MD, PhD, Department for Interventions in Health-Care Facilities, Hellenic Center for Disease Control and Prevention, 3-5 Agrafon St, Athens, 15123 Greece. <email>helen-maltezou@ath.forthnet.gr</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>25</day><month>11</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>12</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>25</day><month>11</month><year>2014</year></pub-date><volume>42</volume><issue>12</issue><fpage>1261</fpage><lpage>1265</lpage><permissions><copyright-statement>Copyright © 2014 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights reserved.</copyright-statement><copyright-year>2014</copyright-year><copyright-holder>Association for Professionals in Infection Control and Epidemiology, Inc.</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="abs0010"><sec><title>Background</title><p>Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel coronavirus that causes a severe respiratory disease with high case fatality rate. Starting in March 2014, a dramatic increase of cases has occurred in the Arabian Peninsula, many of which were acquired in health care settings. As of May 9, 2014, 536 laboratory-confirmed cases and 145 deaths have been reported globally.</p></sec><sec><title>Methods</title><p>Review of publicly available data about MERS-CoV health care–associated transmission.</p></sec><sec><title>Results</title><p>We identified 11 events of possible or confirmed health care–associated transmission with high morbidity and mortality, mainly among patients with comorbidities. Health care workers are also frequently affected; however, they tend to have milder symptoms and better prognosis. Gaps in infection control were noted in all events. Currently, health care–associated outbreaks are playing a pivotal role in the evolution of the MERS-CoV epidemic in countries in the Arabian Peninsula.</p></sec><sec><title>Conclusion</title><p>There is a need to increase infection control capacity in affected areas and areas at increased risk of being affected to prevent transmission in health care settings. Vaccines and antiviral agents are urgently needed. Overall, our knowledge about the epidemiologic characteristics of MERS-CoV that impact health care transmission is very limited. As the MERS-CoV epidemic continues to evolve, issues concerning best infection control measures will arise, and studies to better define their effectiveness in real life are needed.</p></sec></abstract><abstract abstract-type="author-highlights" id="abs0015"><title>Highlights</title><p><list list-type="simple" id="ulist0010"><list-item id="u0010"><label>•</label><p id="p0010">Health care–associated transmission plays a pivotal role in the Middle East respiratory syndrome coronavirus epidemic.</p></list-item><list-item id="u0015"><label>•</label><p id="p0015">Gaps in infection control were noted in all health care–associated events.</p></list-item><list-item id="u0020"><label>•</label><p id="p0020">There is a need to increase infection control capacity.</p></list-item><list-item id="u0025"><label>•</label><p id="p0025">Studies about the effectiveness of infection control measures are needed.</p></list-item><list-item id="u0030"><label>•</label><p id="p0030">Vaccines and antiviral agents against Middle East respiratory syndrome coronavirus are urgently needed.</p></list-item></list></p></abstract><kwd-group id="kwrds0010"><title>Key Words</title><kwd>Middle East respiratory syndrome coronavirus</kwd><kwd>Middle East respiratory syndrome</kwd><kwd>Hospital</kwd><kwd>Health care associated</kwd><kwd>Outbreak</kwd><kwd>Health care workers</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Grèce</li></country><region><li>Attique (région)</li></region><settlement><li>Athènes</li></settlement></list><tree><country name="Grèce"><region name="Attique (région)"><name sortKey="Maltezou, Helena C" sort="Maltezou, Helena C" uniqKey="Maltezou H" first="Helena C." last="Maltezou">Helena C. Maltezou</name></region><name sortKey="Tsiodras, Sotirios" sort="Tsiodras, Sotirios" uniqKey="Tsiodras S" first="Sotirios" last="Tsiodras">Sotirios Tsiodras</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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