Serveur d'exploration MERS

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Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012

Identifieur interne : 000F71 ( Pmc/Checkpoint ); précédent : 000F70; suivant : 000F72

Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012

Auteurs : Ziad A. Memish [Arabie saoudite] ; Ahmad Alsahly [Arabie saoudite] ; Malak Al Masri [Arabie saoudite] ; Gary L. Heil [États-Unis] ; Benjamin D. Anderson [États-Unis] ; Malik Peiris [Hong Kong] ; Salah Uddin Khan [États-Unis, Bangladesh] ; Gregory C. Gray [États-Unis]

Source :

RBID : PMC:4353318

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that primarily causes respiratory illness. We conducted a seroprevalence study of banked human serum samples collected in 2012 from Southern Saudi Arabia. Sera from 300 animal workers (17% with daily camel exposure) and 50 non-animal-exposed controls were examined for serological evidence of MERS-CoV infection by a pseudoparticle MERS-CoV spike protein neutralization assay. None of the sera reproducibly neutralized the MERS-CoV-pseudotyped lentiviral vector. These data suggest that serological evidence of zoonotic transmission of MERS-CoV was not common among animal workers in Southern Saudi Arabia during July 2012.


Url:
DOI: 10.1111/irv.12287
PubMed: 25470665
PubMed Central: 4353318


Affiliations:


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PMC:4353318

Le document en format XML

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<p>Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that primarily causes respiratory illness. We conducted a seroprevalence study of banked human serum samples collected in 2012 from Southern Saudi Arabia. Sera from 300 animal workers (17% with daily camel exposure) and 50 non-animal-exposed controls were examined for serological evidence of MERS-CoV infection by a pseudoparticle MERS-CoV spike protein neutralization assay. None of the sera reproducibly neutralized the MERS-CoV-pseudotyped lentiviral vector. These data suggest that serological evidence of zoonotic transmission of MERS-CoV was not common among animal workers in Southern Saudi Arabia during July 2012.</p>
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<name>
<surname>Memish</surname>
<given-names>Ziad A</given-names>
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<xref ref-type="aff" rid="au2">b</xref>
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<name>
<surname>Alsahly</surname>
<given-names>Ahmad</given-names>
</name>
<xref ref-type="aff" rid="au3">c</xref>
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<name>
<surname>Masri</surname>
<given-names>Malak al</given-names>
</name>
<xref ref-type="aff" rid="au1">a</xref>
</contrib>
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<name>
<surname>Heil</surname>
<given-names>Gary L</given-names>
</name>
<xref ref-type="aff" rid="au4">d</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Anderson</surname>
<given-names>Benjamin D</given-names>
</name>
<xref ref-type="aff" rid="au4">d</xref>
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<name>
<surname>Peiris</surname>
<given-names>Malik</given-names>
</name>
<xref ref-type="aff" rid="au5">e</xref>
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<contrib contrib-type="author">
<name>
<surname>Khan</surname>
<given-names>Salah Uddin</given-names>
</name>
<xref ref-type="aff" rid="au4">d</xref>
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<surname>Gray</surname>
<given-names>Gregory C</given-names>
</name>
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<aff id="au1">
<label>a</label>
<institution>Ministry of Health</institution>
<addr-line>Riyadh, Saudi Arabia</addr-line>
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<aff id="au2">
<label>b</label>
<institution>College of Medicine, Alfaisal University</institution>
<addr-line>Riyadh, KSA</addr-line>
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<aff id="au3">
<label>c</label>
<institution>Regional Health Directorate</institution>
<addr-line>Jazan, Saudi Arabia</addr-line>
</aff>
<aff id="au4">
<label>d</label>
<institution>College of Public Health and Health Professions, Emerging Pathogens Institute, University of Florida</institution>
<addr-line>Gainesville, FL, USA</addr-line>
</aff>
<aff id="au5">
<label>e</label>
<institution>School of Public Health and the HKU-Pasteur Research Pole, The University of Hong Kong</institution>
<addr-line>Hong Kong, Hong Kong</addr-line>
</aff>
<aff id="au6">
<label>f</label>
<institution>Center for Communicable Diseases, ICDDR, B</institution>
<addr-line>Dhaka, Bangladesh</addr-line>
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<author-notes>
<corresp id="cor1">
<italic>Correspondence</italic>
: Gregory C. Gray, Division of Infectious Diseases, Duke Global Health Institute, Hanes House, Rm 254, DUMC Box 102359, Durham, NC 27710, USA., E-mail:
<email>gregory.gray@duke.edu</email>
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<pub-date pub-type="ppub">
<month>3</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub">
<day>03</day>
<month>12</month>
<year>2014</year>
</pub-date>
<volume>9</volume>
<issue>2</issue>
<fpage>64</fpage>
<lpage>67</lpage>
<history>
<date date-type="accepted">
<day>03</day>
<month>9</month>
<year>2014</year>
</date>
</history>
<permissions>
<copyright-statement>© 2014 The Authors.
<italic>Influenza and Other Respiratory Viruses</italic>
Published by John Wiley & Sons Ltd.</copyright-statement>
<copyright-year>2014</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0/">
<license-p>This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
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<abstract>
<p>Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that primarily causes respiratory illness. We conducted a seroprevalence study of banked human serum samples collected in 2012 from Southern Saudi Arabia. Sera from 300 animal workers (17% with daily camel exposure) and 50 non-animal-exposed controls were examined for serological evidence of MERS-CoV infection by a pseudoparticle MERS-CoV spike protein neutralization assay. None of the sera reproducibly neutralized the MERS-CoV-pseudotyped lentiviral vector. These data suggest that serological evidence of zoonotic transmission of MERS-CoV was not common among animal workers in Southern Saudi Arabia during July 2012.</p>
</abstract>
<kwd-group>
<kwd>antibody</kwd>
<kwd>Kingdom of Saudi Arabia</kwd>
<kwd>MERS-CoV</kwd>
<kwd>pseudoparticle virus neutralization assays</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations>
<list>
<country>
<li>Arabie saoudite</li>
<li>Bangladesh</li>
<li>Hong Kong</li>
<li>États-Unis</li>
</country>
<region>
<li>Floride</li>
</region>
</list>
<tree>
<country name="Arabie saoudite">
<noRegion>
<name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A" last="Memish">Ziad A. Memish</name>
</noRegion>
<name sortKey="Alsahly, Ahmad" sort="Alsahly, Ahmad" uniqKey="Alsahly A" first="Ahmad" last="Alsahly">Ahmad Alsahly</name>
<name sortKey="Masri, Malak Al" sort="Masri, Malak Al" uniqKey="Masri M" first="Malak Al" last="Masri">Malak Al Masri</name>
</country>
<country name="États-Unis">
<region name="Floride">
<name sortKey="Heil, Gary L" sort="Heil, Gary L" uniqKey="Heil G" first="Gary L" last="Heil">Gary L. Heil</name>
</region>
<name sortKey="Anderson, Benjamin D" sort="Anderson, Benjamin D" uniqKey="Anderson B" first="Benjamin D" last="Anderson">Benjamin D. Anderson</name>
<name sortKey="Gray, Gregory C" sort="Gray, Gregory C" uniqKey="Gray G" first="Gregory C" last="Gray">Gregory C. Gray</name>
<name sortKey="Khan, Salah Uddin" sort="Khan, Salah Uddin" uniqKey="Khan S" first="Salah Uddin" last="Khan">Salah Uddin Khan</name>
</country>
<country name="Hong Kong">
<noRegion>
<name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name>
</noRegion>
</country>
<country name="Bangladesh">
<noRegion>
<name sortKey="Khan, Salah Uddin" sort="Khan, Salah Uddin" uniqKey="Khan S" first="Salah Uddin" last="Khan">Salah Uddin Khan</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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