Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia, 2014
Identifieur interne : 000F09 ( Pmc/Checkpoint ); précédent : 000F08; suivant : 000F10Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia, 2014
Auteurs : Daniel R. Feikin ; Basem Alraddadi ; Mohammed Qutub ; Omaima Shabouni ; Aaron Curns ; Ikwo K. Oboho ; Sara M. Tomczyk ; Bernard Wolff ; John T. Watson ; Tariq A. MadaniSource :
- Emerging Infectious Diseases [ 1080-6040 ] ; 2015.
Abstract
More data are needed to determine whether modulation of virus load by therapeutic agents affects clinical outcomes.
Url:
DOI: 10.3201/eid2111.150764
PubMed: 26488195
PubMed Central: 4622256
Affiliations:
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Oboho</name></author><author><name sortKey="Tomczyk, Sara M" sort="Tomczyk, Sara M" uniqKey="Tomczyk S" first="Sara M." last="Tomczyk">Sara M. Tomczyk</name></author><author><name sortKey="Wolff, Bernard" sort="Wolff, Bernard" uniqKey="Wolff B" first="Bernard" last="Wolff">Bernard Wolff</name></author><author><name sortKey="Watson, John T" sort="Watson, John T" uniqKey="Watson J" first="John T." last="Watson">John T. Watson</name></author><author><name sortKey="Madani, Tariq A" sort="Madani, Tariq A" uniqKey="Madani T" first="Tariq A." last="Madani">Tariq A. 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Feikin</name></author><author><name sortKey="Alraddadi, Basem" sort="Alraddadi, Basem" uniqKey="Alraddadi B" first="Basem" last="Alraddadi">Basem Alraddadi</name></author><author><name sortKey="Qutub, Mohammed" sort="Qutub, Mohammed" uniqKey="Qutub M" first="Mohammed" last="Qutub">Mohammed Qutub</name></author><author><name sortKey="Shabouni, Omaima" sort="Shabouni, Omaima" uniqKey="Shabouni O" first="Omaima" last="Shabouni">Omaima Shabouni</name></author><author><name sortKey="Curns, Aaron" sort="Curns, Aaron" uniqKey="Curns A" first="Aaron" last="Curns">Aaron Curns</name></author><author><name sortKey="Oboho, Ikwo K" sort="Oboho, Ikwo K" uniqKey="Oboho I" first="Ikwo K." last="Oboho">Ikwo K. Oboho</name></author><author><name sortKey="Tomczyk, Sara M" sort="Tomczyk, Sara M" uniqKey="Tomczyk S" first="Sara M." last="Tomczyk">Sara M. Tomczyk</name></author><author><name sortKey="Wolff, Bernard" sort="Wolff, Bernard" uniqKey="Wolff B" first="Bernard" last="Wolff">Bernard Wolff</name></author><author><name sortKey="Watson, John T" sort="Watson, John T" uniqKey="Watson J" first="John T." last="Watson">John T. Watson</name></author><author><name sortKey="Madani, Tariq A" sort="Madani, Tariq A" uniqKey="Madani T" first="Tariq A." last="Madani">Tariq A. Madani</name></author></analytic><series><title level="j">Emerging Infectious Diseases</title><idno type="ISSN">1080-6040</idno><idno type="eISSN">1080-6059</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>More data are needed to determine whether modulation of virus load by therapeutic agents affects clinical outcomes.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Emerg Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Emerging Infect. Dis</journal-id><journal-id journal-id-type="publisher-id">EID</journal-id><journal-title-group><journal-title>Emerging Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">1080-6040</issn><issn pub-type="epub">1080-6059</issn><publisher><publisher-name>Centers for Disease Control and Prevention</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26488195</article-id><article-id pub-id-type="pmc">4622256</article-id><article-id pub-id-type="publisher-id">15-0764</article-id><article-id pub-id-type="doi">10.3201/eid2111.150764</article-id><article-categories><subj-group subj-group-type="second-type"><subject>Expedited</subject></subj-group><subj-group subj-group-type="heading"><subject>Research</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research</subject></subj-group><subj-group subj-group-type="TOC-title"><subject>Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia, 2014</subject></subj-group></article-categories><title-group><article-title>Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia, 2014</article-title><alt-title alt-title-type="running-head">MERS-CoV Virus Load</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Feikin</surname><given-names>Daniel R.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Alraddadi</surname><given-names>Basem</given-names></name></contrib><contrib contrib-type="author"><name><surname>Qutub</surname><given-names>Mohammed</given-names></name></contrib><contrib contrib-type="author"><name><surname>Shabouni</surname><given-names>Omaima</given-names></name></contrib><contrib contrib-type="author"><name><surname>Curns</surname><given-names>Aaron</given-names></name></contrib><contrib contrib-type="author"><name><surname>Oboho</surname><given-names>Ikwo K.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Tomczyk</surname><given-names>Sara M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Wolff</surname><given-names>Bernard</given-names></name></contrib><contrib contrib-type="author"><name><surname>Watson</surname><given-names>John T.</given-names></name></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Madani</surname><given-names>Tariq A.</given-names></name></contrib><aff id="aff1">Centers for Disease Control and Prevention, Atlanta, Georgia, USA (D.R. Feikin, A. Curns, I.K. Oboho, S.M. Tomczyk, B. Wolff, J.T. Watson);</aff><aff id="aff2">Ministry of Health, Jeddah, Saudi Arabia (B. Al-Raddadi, M. Qutub, O. Shabouni, T.A. Madani);</aff><aff id="aff3">King Faisal Specialist Hospital and Research Center, Jeddah (B. Al-Raddadi, M. Qutub);</aff><aff id="aff4">King Abdulaziz University, Jeddah (T.A. Madani)</aff></contrib-group><author-notes><corresp id="cor1">Address for correspondence: Tariq A. Madani, Department of Medicine, Faculty of Medicine, King Abdulaziz University, PO Box 80215, Jeddah 21589, Saudi Arabia; email: <email xlink:href="tmadani@kau.edu.sa">tmadani@kau.edu.sa</email></corresp></author-notes><pub-date pub-type="ppub"><month>11</month><year>2015</year></pub-date><volume>21</volume><issue>11</issue><fpage>2029</fpage><lpage>2035</lpage><abstract abstract-type="toc"><p>More data are needed to determine whether modulation of virus load by therapeutic agents affects clinical outcomes.</p></abstract><abstract><p>Middle East respiratory syndrome coronavirus (MERS-CoV) causes a spectrum of illness. We evaluated whether cycle threshold (C<sub>t</sub>) values (which are inversely related to virus load) were associated with clinical severity in patients from Saudi Arabia whose nasopharyngeal specimens tested positive for this virus by real-time reverse transcription PCR. Among 102 patients, median C<sub>t</sub> of 31.0 for the upstream of the E gene target for 41 (40%) patients who died was significantly lower than the median of 33.0 for 61 survivors (p = 0.0087). In multivariable regression analyses, risk factors for death were age >60 years), underlying illness, and decreasing C<sub>t</sub> for each 1-point decrease in C<sub>t</sub>). Results were similar for a composite severe outcome (death and/or intensive care unit admission). More data are needed to determine whether modulation of virus load by therapeutic agents affects clinical outcomes.</p></abstract><kwd-group kwd-group-type="author"><title>Keywords: </title><kwd>Middle East respiratory syndrome coronavirus</kwd><kwd>MERS-CoV</kwd><kwd>virus load</kwd><kwd>Saudi Arabia</kwd><kwd>viruses</kwd><kwd>zoonoses</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Alraddadi, Basem" sort="Alraddadi, Basem" uniqKey="Alraddadi B" first="Basem" last="Alraddadi">Basem Alraddadi</name><name sortKey="Curns, Aaron" sort="Curns, Aaron" uniqKey="Curns A" first="Aaron" last="Curns">Aaron Curns</name><name sortKey="Feikin, Daniel R" sort="Feikin, Daniel R" uniqKey="Feikin D" first="Daniel R." last="Feikin">Daniel R. Feikin</name><name sortKey="Madani, Tariq A" sort="Madani, Tariq A" uniqKey="Madani T" first="Tariq A." last="Madani">Tariq A. Madani</name><name sortKey="Oboho, Ikwo K" sort="Oboho, Ikwo K" uniqKey="Oboho I" first="Ikwo K." last="Oboho">Ikwo K. Oboho</name><name sortKey="Qutub, Mohammed" sort="Qutub, Mohammed" uniqKey="Qutub M" first="Mohammed" last="Qutub">Mohammed Qutub</name><name sortKey="Shabouni, Omaima" sort="Shabouni, Omaima" uniqKey="Shabouni O" first="Omaima" last="Shabouni">Omaima Shabouni</name><name sortKey="Tomczyk, Sara M" sort="Tomczyk, Sara M" uniqKey="Tomczyk S" first="Sara M." last="Tomczyk">Sara M. Tomczyk</name><name sortKey="Watson, John T" sort="Watson, John T" uniqKey="Watson J" first="John T." last="Watson">John T. Watson</name><name sortKey="Wolff, Bernard" sort="Wolff, Bernard" uniqKey="Wolff B" first="Bernard" last="Wolff">Bernard Wolff</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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