Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control
Identifieur interne : 000D68 ( Pmc/Checkpoint ); précédent : 000D67; suivant : 000D69Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control
Auteurs : Prasannavenkatesh Durai ; Maria Batool ; Masaud Shah ; Sangdun ChoiSource :
- Experimental & Molecular Medicine [ 1226-3613 ] ; 2015.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) causes high fever, cough, acute respiratory tract infection and multiorgan dysfunction that may eventually lead to the death of the infected individuals. MERS-CoV is thought to be transmitted to humans through dromedary camels. The occurrence of the virus was first reported in the Middle East and it subsequently spread to several parts of the world. Since 2012, about 1368 infections, including ~487 deaths, have been reported worldwide. Notably, the recent human-to-human ‘superspreading’ of MERS-CoV in hospitals in South Korea has raised a major global health concern. The fatality rate in MERS-CoV infection is four times higher compared with that of the closely related severe acute respiratory syndrome coronavirus infection. Currently, no drug has been clinically approved to control MERS-CoV infection. In this study, we highlight the potential drug targets that can be used to develop anti-MERS-CoV therapeutics.
Url:
DOI: 10.1038/emm.2015.76
PubMed: 26315600
PubMed Central: 4558490
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control</title><author><name sortKey="Durai, Prasannavenkatesh" sort="Durai, Prasannavenkatesh" uniqKey="Durai P" first="Prasannavenkatesh" last="Durai">Prasannavenkatesh Durai</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Batool, Maria" sort="Batool, Maria" uniqKey="Batool M" first="Maria" last="Batool">Maria Batool</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Shah, Masaud" sort="Shah, Masaud" uniqKey="Shah M" first="Masaud" last="Shah">Masaud Shah</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Choi, Sangdun" sort="Choi, Sangdun" uniqKey="Choi S" first="Sangdun" last="Choi">Sangdun Choi</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26315600</idno><idno type="pmc">4558490</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558490</idno><idno type="RBID">PMC:4558490</idno><idno type="doi">10.1038/emm.2015.76</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000512</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000512</idno><idno type="wicri:Area/Pmc/Curation">000512</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000512</idno><idno type="wicri:Area/Pmc/Checkpoint">000D68</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D68</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control</title><author><name sortKey="Durai, Prasannavenkatesh" sort="Durai, Prasannavenkatesh" uniqKey="Durai P" first="Prasannavenkatesh" last="Durai">Prasannavenkatesh Durai</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Batool, Maria" sort="Batool, Maria" uniqKey="Batool M" first="Maria" last="Batool">Maria Batool</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Shah, Masaud" sort="Shah, Masaud" uniqKey="Shah M" first="Masaud" last="Shah">Masaud Shah</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Choi, Sangdun" sort="Choi, Sangdun" uniqKey="Choi S" first="Sangdun" last="Choi">Sangdun Choi</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Experimental & Molecular Medicine</title><idno type="ISSN">1226-3613</idno><idno type="eISSN">2092-6413</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Middle East respiratory syndrome coronavirus (MERS-CoV) causes high fever, cough, acute respiratory tract infection and multiorgan dysfunction that may eventually lead to the death of the infected individuals. MERS-CoV is thought to be transmitted to humans through dromedary camels. The occurrence of the virus was first reported in the Middle East and it subsequently spread to several parts of the world. Since 2012, about 1368 infections, including ~487 deaths, have been reported worldwide. Notably, the recent human-to-human ‘superspreading’ of MERS-CoV in hospitals in South Korea has raised a major global health concern. The fatality rate in MERS-CoV infection is four times higher compared with that of the closely related severe acute respiratory syndrome coronavirus infection. Currently, no drug has been clinically approved to control MERS-CoV infection. In this study, we highlight the potential drug targets that can be used to develop anti-MERS-CoV therapeutics.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Baez Santos, Ym" uniqKey="Baez Santos Y">YM Baez-Santos</name></author><author><name sortKey="Mielech, Am" uniqKey="Mielech A">AM Mielech</name></author><author><name sortKey="Deng, X" uniqKey="Deng X">X Deng</name></author><author><name sortKey="Baker, S" uniqKey="Baker S">S Baker</name></author><author><name sortKey="Mesecar, Ad" uniqKey="Mesecar A">AD Mesecar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Banik, Gr" uniqKey="Banik G">GR Banik</name></author><author><name sortKey="Khandaker, G" uniqKey="Khandaker G">G Khandaker</name></author><author><name sortKey="Rashid, H" uniqKey="Rashid H">H Rashid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kayali, G" uniqKey="Kayali G">G 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Exp Mol Med</journal-id><journal-id journal-id-type="iso-abbrev">Exp. Mol. Med</journal-id><journal-title-group><journal-title>Experimental & Molecular Medicine</journal-title></journal-title-group><issn pub-type="ppub">1226-3613</issn><issn pub-type="epub">2092-6413</issn><publisher><publisher-name>Nature Publishing Group UK</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26315600</article-id><article-id pub-id-type="pmc">4558490</article-id><article-id pub-id-type="publisher-id">BFemm201576</article-id><article-id pub-id-type="doi">10.1038/emm.2015.76</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Durai</surname><given-names>Prasannavenkatesh</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Batool</surname><given-names>Maria</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Shah</surname><given-names>Masaud</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Choi</surname><given-names>Sangdun</given-names></name><address><email>sangdunchoi@ajou.ac.kr</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.251916.8</institution-id><institution-id institution-id-type="ISNI">0000 0004 0532 3933</institution-id><institution>Department of Molecular Science and Technology,</institution><institution>Ajou University,</institution></institution-wrap>Suwon, Korea</aff></contrib-group><pub-date pub-type="epub"><day>28</day><month>8</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>28</day><month>8</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>8</month><year>2015</year></pub-date><volume>47</volume><issue>8</issue><fpage>e181</fpage><lpage>e181</lpage><history><date date-type="received"><day>12</day><month>7</month><year>2015</year></date><date date-type="accepted"><day>5</day><month>8</month><year>2015</year></date></history><permissions><copyright-statement>© The Author(s) 2015</copyright-statement><license license-type="OpenAccess"><license-p>This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link></license-p></license></permissions><abstract id="Abs1"><p id="Par1">Middle East respiratory syndrome coronavirus (MERS-CoV) causes high fever, cough, acute respiratory tract infection and multiorgan dysfunction that may eventually lead to the death of the infected individuals. MERS-CoV is thought to be transmitted to humans through dromedary camels. The occurrence of the virus was first reported in the Middle East and it subsequently spread to several parts of the world. Since 2012, about 1368 infections, including ~487 deaths, have been reported worldwide. Notably, the recent human-to-human ‘superspreading’ of MERS-CoV in hospitals in South Korea has raised a major global health concern. The fatality rate in MERS-CoV infection is four times higher compared with that of the closely related severe acute respiratory syndrome coronavirus infection. Currently, no drug has been clinically approved to control MERS-CoV infection. In this study, we highlight the potential drug targets that can be used to develop anti-MERS-CoV therapeutics.</p></abstract><abstract id="Abs2" abstract-type="ResearchSummary"><title>Middle East respiratory syndrome: Potential therapeutic targets</title><p id="Par2">Urgent research into anti-viral drugs to tackle Middle East respiratory syndrome coronavirus (MERS-CoV) is vital to avoid a future pandemic. MERS-CoV has a fatality rate four times that of similar acute respiratory infections, yet no clinically approved drugs are available. Scientists believe MERS-CoV originates from dromedary camels, though there may be unidentified intermediate hosts. Concerned by the recent human-to-human spread of MERS-CoV in South Korean hospitals, Sangdun Choi and co-workers at Ajou University in Suwon, South Korea, reviewed current understanding of MERS-CoV, the proteins involved in viral entry and replication, and potential therapeutic targets. Three such vital targets are spike protein and proteases, PLpro and 3CLpro, involved in viral entry or replication, respectively. Host receptor DPP4 and viral accessory protein 4a could be other promising targets. Multiple compounds against viral proteases and two antibodies directed against the viral protein to prevent binding showed promise, but further research is needed.</p></abstract><kwd-group kwd-group-type="npg-subject"><title>Subject terms</title><kwd>Viral infection</kwd><kwd>Viral infection</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2015</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Batool, Maria" sort="Batool, Maria" uniqKey="Batool M" first="Maria" last="Batool">Maria Batool</name><name sortKey="Choi, Sangdun" sort="Choi, Sangdun" uniqKey="Choi S" first="Sangdun" last="Choi">Sangdun Choi</name><name sortKey="Durai, Prasannavenkatesh" sort="Durai, Prasannavenkatesh" uniqKey="Durai P" first="Prasannavenkatesh" last="Durai">Prasannavenkatesh Durai</name><name sortKey="Shah, Masaud" sort="Shah, Masaud" uniqKey="Shah M" first="Masaud" last="Shah">Masaud Shah</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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