Extensive Viable Middle East Respiratory Syndrome (MERS) Coronavirus Contamination in Air and Surrounding Environment in MERS Isolation Wards
Identifieur interne : 000B69 ( Pmc/Checkpoint ); précédent : 000B68; suivant : 000B70Extensive Viable Middle East Respiratory Syndrome (MERS) Coronavirus Contamination in Air and Surrounding Environment in MERS Isolation Wards
Auteurs : Sung-Han Kim ; So Young Chang ; Minki Sung ; Ji Hoon Park ; Hong Bin Kim ; Heeyoung Lee ; Jae-Phil Choi ; Won Suk Choi ; Ji-Young MinSource :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America [ 1058-4838 ] ; 2016.
Abstract
Middle East respiratory syndrome (MERS) coronavirus was found by reverse-transcription polymerase-chain-reaction from viral cultures of 4 of 7 air samples and 15 of 68 surface swabs from 3 MERS patients' rooms, calling for epidemiologic investigation for contact and airborne transmission.
Url:
DOI: 10.1093/cid/ciw239
PubMed: 27090992
PubMed Central: 7108054
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Extensive Viable Middle East Respiratory Syndrome (MERS) Coronavirus Contamination in Air and Surrounding Environment in MERS Isolation Wards</title><author><name sortKey="Kim, Sung Han" sort="Kim, Sung Han" uniqKey="Kim S" first="Sung-Han" last="Kim">Sung-Han Kim</name></author><author><name sortKey="Chang, So Young" sort="Chang, So Young" uniqKey="Chang S" first="So Young" last="Chang">So Young Chang</name></author><author><name sortKey="Sung, Minki" sort="Sung, Minki" uniqKey="Sung M" first="Minki" last="Sung">Minki Sung</name></author><author><name sortKey="Park, Ji Hoon" sort="Park, Ji Hoon" uniqKey="Park J" first="Ji Hoon" last="Park">Ji Hoon Park</name></author><author><name sortKey="Bin Kim, Hong" sort="Bin Kim, Hong" uniqKey="Bin Kim H" first="Hong" last="Bin Kim">Hong Bin Kim</name></author><author><name sortKey="Lee, Heeyoung" sort="Lee, Heeyoung" uniqKey="Lee H" first="Heeyoung" last="Lee">Heeyoung Lee</name></author><author><name sortKey="Choi, Jae Phil" sort="Choi, Jae Phil" uniqKey="Choi J" first="Jae-Phil" last="Choi">Jae-Phil Choi</name></author><author><name sortKey="Choi, Won Suk" sort="Choi, Won Suk" uniqKey="Choi W" first="Won Suk" last="Choi">Won Suk Choi</name></author><author><name sortKey="Min, Ji Young" sort="Min, Ji Young" uniqKey="Min J" first="Ji-Young" last="Min">Ji-Young Min</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27090992</idno><idno type="pmc">7108054</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108054</idno><idno type="RBID">PMC:7108054</idno><idno type="doi">10.1093/cid/ciw239</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000B76</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B76</idno><idno type="wicri:Area/Pmc/Curation">000B76</idno><idno type="wicri:explorRef" wicri:stream="Pmc" 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Hong" uniqKey="Bin Kim H" first="Hong" last="Bin Kim">Hong Bin Kim</name></author><author><name sortKey="Lee, Heeyoung" sort="Lee, Heeyoung" uniqKey="Lee H" first="Heeyoung" last="Lee">Heeyoung Lee</name></author><author><name sortKey="Choi, Jae Phil" sort="Choi, Jae Phil" uniqKey="Choi J" first="Jae-Phil" last="Choi">Jae-Phil Choi</name></author><author><name sortKey="Choi, Won Suk" sort="Choi, Won Suk" uniqKey="Choi W" first="Won Suk" last="Choi">Won Suk Choi</name></author><author><name sortKey="Min, Ji Young" sort="Min, Ji Young" uniqKey="Min J" first="Ji-Young" last="Min">Ji-Young Min</name></author></analytic><series><title level="j">Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome (MERS) coronavirus was found by reverse-transcription polymerase-chain-reaction from viral cultures of 4 of 7 air samples and 15 of 68 surface swabs from 3 MERS patients' rooms, calling for epidemiologic investigation for contact and airborne transmission.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ki, M" uniqKey="Ki M">M Ki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Jf" uniqKey="Chan J">JF Chan</name></author><author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name></author><author><name sortKey="To, Kk" uniqKey="To K">KK To</name></author><author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name></author><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Park, Ys" uniqKey="Park Y">YS Park</name></author><author><name sortKey="Lee, C" uniqKey="Lee C">C Lee</name></author><author><name sortKey="Kim, Km" uniqKey="Kim K">KM Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oh, Md" uniqKey="Oh M">MD Oh</name></author><author><name sortKey="Choe, Pg" uniqKey="Choe P">PG Choe</name></author><author><name sortKey="Oh, Hs" uniqKey="Oh H">HS Oh</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Bin, Sy" uniqKey="Bin S">SY Bin</name></author><author><name sortKey="Heo, Jy" uniqKey="Heo J">JY Heo</name></author><author><name sortKey="Song, Ms" uniqKey="Song M">MS Song</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Braden, Cr" uniqKey="Braden C">CR Braden</name></author><author><name sortKey="Dwell, Sf" uniqKey="Dwell S">SF Dwell</name></author><author><name sortKey="Jernigan, Db" uniqKey="Jernigan D">DB Jernigan</name></author><author><name sortKey="Hughes, Jm" uniqKey="Hughes J">JM Hughes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, It" uniqKey="Yu I">IT Yu</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Wong, Tw" uniqKey="Wong T">TW Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Olsen, Sj" uniqKey="Olsen S">SJ Olsen</name></author><author><name sortKey="Chang, Hl" uniqKey="Chang H">HL Chang</name></author><author><name sortKey="Cheung, Ty" uniqKey="Cheung T">TY Cheung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Tw" uniqKey="Wong T">TW Wong</name></author><author><name sortKey="Lee, Ck" uniqKey="Lee C">CK Lee</name></author><author><name sortKey="Tam, W" uniqKey="Tam W">W Tam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roy, Cj" uniqKey="Roy C">CJ Roy</name></author><author><name sortKey="Milton, D" uniqKey="Milton D">D Milton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name></author><author><name sortKey="Bushmaker, T" uniqKey="Bushmaker T">T Bushmaker</name></author><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Azhar, Ei" uniqKey="Azhar E">EI Azhar</name></author><author><name sortKey="Hashem, Am" uniqKey="Hashem A">AM Hashem</name></author><author><name sortKey="El Kafrawy, Sa" uniqKey="El Kafrawy S">SA El-Kafrawy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meyerholz, Dk" uniqKey="Meyerholz D">DK Meyerholz</name></author><author><name sortKey="Lambertz, Am" uniqKey="Lambertz A">AM Lambertz</name></author><author><name sortKey="Mccray, Pb" uniqKey="Mccray P">PB McCray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duan, Sm" uniqKey="Duan S">SM Duan</name></author><author><name sortKey="Zhao, Xs" uniqKey="Zhao X">XS Zhao</name></author><author><name sortKey="Wen, Rf" uniqKey="Wen R">RF Wen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ijaz, Mk" uniqKey="Ijaz M">MK Ijaz</name></author><author><name sortKey="Brunner, Ah" uniqKey="Brunner A">AH Brunner</name></author><author><name sortKey="Sattar, Sa" uniqKey="Sattar S">SA Sattar</name></author><author><name sortKey="Nair, R" uniqKey="Nair R">R Nair</name></author><author><name sortKey="Johnson Lussenburg, Cm" uniqKey="Johnson Lussenburg C">CM Johnson-Lussenburg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Da Guan, W" uniqKey="Da Guan W">W Da Guan</name></author><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Clin. Infect. Dis</journal-id><journal-id journal-id-type="publisher-id">cid</journal-id><journal-title-group><journal-title>Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</journal-title></journal-title-group><issn pub-type="ppub">1058-4838</issn><issn pub-type="epub">1537-6591</issn><publisher><publisher-name>Infectious Diseases Society of America</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27090992</article-id><article-id pub-id-type="pmc">7108054</article-id><article-id pub-id-type="doi">10.1093/cid/ciw239</article-id><article-id pub-id-type="publisher-id">ciw239</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Extensive Viable Middle East Respiratory Syndrome (MERS) Coronavirus Contamination in Air and Surrounding Environment in MERS Isolation Wards</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Kim</surname><given-names>Sung-Han</given-names></name><pmc-comment>jiyoung.min@ip-korea.org </pmc-comment>
</contrib><contrib contrib-type="author"><name><surname>Chang</surname><given-names>So Young</given-names></name></contrib><contrib contrib-type="author"><name><surname>Sung</surname><given-names>Minki</given-names></name></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>Ji Hoon</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bin Kim</surname><given-names>Hong</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Heeyoung</given-names></name></contrib><contrib contrib-type="author"><name><surname>Choi</surname><given-names>Jae-Phil</given-names></name></contrib><contrib contrib-type="author"><name><surname>Choi</surname><given-names>Won Suk</given-names></name></contrib><contrib contrib-type="author"><name><surname>Min</surname><given-names>Ji-Young</given-names></name></contrib></contrib-group><aff id="af1"><label>1</label><addr-line>Department of Infectious Diseases</addr-line> ,<institution>Asan Medical Center, University of Ulsan College of Medicine</institution> ,<addr-line>Seoul</addr-line></aff><aff id="af2"><label>2</label><addr-line>Respiratory Viruses Research Laboratory</addr-line> ,<institution>Institut Pasteur Korea, Seongnam-si</institution> ,<addr-line>Gyeonggi Province</addr-line></aff><aff id="af3"><label>3</label><addr-line>Department of Architectural Engineering</addr-line> ,<institution>Sejong University</institution> ,<addr-line>Seoul</addr-line></aff><aff id="af4"><label>4</label><addr-line>Division of Infectious Diseases, Department of Internal Medicine</addr-line></aff><aff id="af5"><label>5</label><institution>Center for Preventive Medicine and Public Health, Seoul National University Bundang Hospital, Seongnam-si</institution> ,<addr-line>Gyeonggi Province</addr-line></aff><aff id="af6"><label>6</label><addr-line>Division of Infectious Diseases, Department of Internal Medicine</addr-line> ,<institution>Seoul Medical Center</institution></aff><aff id="af7"><label>7</label><addr-line>Division of Infectious Diseases, Department of Internal Medicine</addr-line> ,<institution>Korea University College of Medicine</institution> ,<addr-line>Seoul</addr-line> ,<country>Republic of Korea</country></aff><author-notes><fn fn-type="con" id="AN1"><label>a</label><p>S.-H. K., S. Y. C., and M. S. contributed equally to this work.</p></fn><fn fn-type="con" id="AN2"><label>b</label><p>S.-H. K. and J.-Y. M. contributed equally to this work.</p></fn><corresp id="d422e193"> Correspondence: J.-Y. Min, Respiratory Viruses Research Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi Province, 13448, Republic of Korea ( <email>jiyoung.min@ip-korea.org</email> ). </corresp></author-notes><pub-date pub-type="ppub"><day>01</day><month>8</month><year>2016</year></pub-date><pub-date iso-8601-date="2016-04-18" pub-type="epub"><day>18</day><month>4</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>18</day><month>4</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>63</volume><issue>3</issue><fpage>363</fpage><lpage>369</lpage><history><date date-type="received"><day>4</day><month>1</month><year>2016</year></date><date date-type="accepted"><day>7</day><month>4</month><year>2016</year></date></history><permissions><copyright-statement> © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail <email>journals.permissions@oup.com</email> . </copyright-statement><copyright-year>2016</copyright-year><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p></license></permissions><self-uri xlink:href="ciw239.pdf"></self-uri><abstract abstract-type="teaser"><p>Middle East respiratory syndrome (MERS) coronavirus was found by reverse-transcription polymerase-chain-reaction from viral cultures of 4 of 7 air samples and 15 of 68 surface swabs from 3 MERS patients' rooms, calling for epidemiologic investigation for contact and airborne transmission.</p></abstract><abstract><title>Abstract</title><p><bold><italic>Background.</italic></bold> The largest outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) outside the Middle East occurred in South Korea in 2015 and resulted in 186 laboratory-confirmed infections, including 36 (19%) deaths. Some hospitals were considered epicenters of infection and voluntarily shut down most of their operations after nearly half of all transmissions occurred in hospital settings. However, the ways that MERS-CoV is transmitted in healthcare settings are not well defined. </p><p><bold><italic>Methods.</italic></bold> We explored the possible contribution of contaminated hospital air and surfaces to MERS transmission by collecting air and swabbing environmental surfaces in 2 hospitals treating MERS-CoV patients. The samples were tested by viral culture with reverse transcription polymerase chain reaction (RT-PCR) and immunofluorescence assay (IFA) using MERS-CoV Spike antibody, and electron microscopy (EM). </p><p><bold><italic>Results.</italic></bold> The presence of MERS-CoV was confirmed by RT-PCR of viral cultures of 4 of 7 air samples from 2 patients' rooms, 1 patient's restroom, and 1 common corridor. In addition, MERS-CoV was detected in 15 of 68 surface swabs by viral cultures. IFA on the cultures of the air and swab samples revealed the presence of MERS-CoV. EM images also revealed intact particles of MERS-CoV in viral cultures of the air and swab samples. </p><p><bold><italic>Conclusions.</italic></bold> These data provide experimental evidence for extensive viable MERS-CoV contamination of the air and surrounding materials in MERS outbreak units. Thus, our findings call for epidemiologic investigation of the possible scenarios for contact and airborne transmission, and raise concern regarding the adequacy of current infection control procedures. </p></abstract><kwd-group><kwd>MERS</kwd><kwd>transmission</kwd><kwd>contamination</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Bin Kim, Hong" sort="Bin Kim, Hong" uniqKey="Bin Kim H" first="Hong" last="Bin Kim">Hong Bin Kim</name><name sortKey="Chang, So Young" sort="Chang, So Young" uniqKey="Chang S" first="So Young" last="Chang">So Young Chang</name><name sortKey="Choi, Jae Phil" sort="Choi, Jae Phil" uniqKey="Choi J" first="Jae-Phil" last="Choi">Jae-Phil Choi</name><name sortKey="Choi, Won Suk" sort="Choi, Won Suk" uniqKey="Choi W" first="Won Suk" last="Choi">Won Suk Choi</name><name sortKey="Kim, Sung Han" sort="Kim, Sung Han" uniqKey="Kim S" first="Sung-Han" last="Kim">Sung-Han Kim</name><name sortKey="Lee, Heeyoung" sort="Lee, Heeyoung" uniqKey="Lee H" first="Heeyoung" last="Lee">Heeyoung Lee</name><name sortKey="Min, Ji Young" sort="Min, Ji Young" uniqKey="Min J" first="Ji-Young" last="Min">Ji-Young Min</name><name sortKey="Park, Ji Hoon" sort="Park, Ji Hoon" uniqKey="Park J" first="Ji Hoon" last="Park">Ji Hoon Park</name><name sortKey="Sung, Minki" sort="Sung, Minki" uniqKey="Sung M" first="Minki" last="Sung">Minki Sung</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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