Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus
Identifieur interne : 000B38 ( Pmc/Checkpoint ); précédent : 000B37; suivant : 000B39Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus
Auteurs : Anurodh Shankar Agrawal [États-Unis] ; Xinrong Tao [États-Unis] ; Abdullah Algaissi [États-Unis, Arabie saoudite] ; Tania Garron [États-Unis] ; Krishna Narayanan [États-Unis] ; Bi-Hung Peng [États-Unis] ; Robert B. Couch [États-Unis] ; Chien-Te K. Tseng [États-Unis]Source :
- Human Vaccines & Immunotherapeutics [ 2164-5515 ] ; 2016.
Abstract
To determine if a hypersensitive-type lung pathology might occur when mice were given an inactivated MERS-CoV vaccine and challenged with infectious virus as was seen with SARS-CoV vaccines, we prepared and vaccinated mice with an inactivated MERS-CoV vaccine. Neutralizing antibody was induced by vaccine with and without adjuvant and lung virus was reduced in vaccinated mice after challenge. Lung mononuclear infiltrates occurred in all groups after virus challenge but with increased infiltrates that contained eosinophils and increases in the eosinophil promoting IL-5 and IL-13 cytokines only in the vaccine groups. Inactivated MERS-CoV vaccine appears to carry a hypersensitive-type lung pathology risk from MERS-CoV infection that is similar to that found with inactivated SARS-CoV vaccines from SARS-CoV infection.
Url:
DOI: 10.1080/21645515.2016.1177688
PubMed: 27269431
PubMed Central: 5027702
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus</title><author><name sortKey="Agrawal, Anurodh Shankar" sort="Agrawal, Anurodh Shankar" uniqKey="Agrawal A" first="Anurodh Shankar" last="Agrawal">Anurodh Shankar Agrawal</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Departments of Microbiology and Immunology, University of Texas Medical Branch</institution>, Galveston, TX,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tao, Xinrong" sort="Tao, Xinrong" uniqKey="Tao X" first="Xinrong" last="Tao">Xinrong Tao</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Departments of Microbiology and Immunology, University of Texas Medical Branch</institution>, Galveston, TX,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Algaissi, Abdullah" sort="Algaissi, Abdullah" uniqKey="Algaissi A" first="Abdullah" last="Algaissi">Abdullah Algaissi</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Departments of Microbiology and Immunology, University of Texas Medical Branch</institution>, Galveston, TX,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0005"><institution>Department of Medical Laboratories Technology, College of Applied Medical Sciences, Jazan University</institution>, Jazan,<country>Saudi Arabia</country></nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Garron, Tania" sort="Garron, Tania" uniqKey="Garron T" first="Tania" last="Garron">Tania Garron</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Departments of Microbiology and Immunology, University of Texas Medical Branch</institution>, Galveston, TX,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Narayanan, Krishna" sort="Narayanan, Krishna" uniqKey="Narayanan K" first="Krishna" last="Narayanan">Krishna Narayanan</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Departments of Microbiology and Immunology, University of Texas Medical Branch</institution>, Galveston, TX,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peng, Bi Hung" sort="Peng, Bi Hung" uniqKey="Peng B" first="Bi-Hung" last="Peng">Bi-Hung Peng</name><affiliation wicri:level="1"><nlm:aff id="af0002"><institution>Pathology, University of Texas Medical Branch</institution>, Galveston, TX,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Couch, Robert B" sort="Couch, Robert B" uniqKey="Couch R" first="Robert B." last="Couch">Robert B. 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Couch</name><affiliation wicri:level="1"><nlm:aff id="af0003"><institution>Internal Medicine, Division of Infectious Disease, University of Texas Medical Branch</institution>, Galveston, TX,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tseng, Chien Te K" sort="Tseng, Chien Te K" uniqKey="Tseng C" first="Chien-Te K." last="Tseng">Chien-Te K. Tseng</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Departments of Microbiology and Immunology, University of Texas Medical Branch</institution>, Galveston, TX,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0004"><institution>Center for Biodefense and Emerging Infectious Disease, University of Texas Medical Branch</institution>, Galveston, TX,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Human Vaccines & Immunotherapeutics</title><idno type="ISSN">2164-5515</idno><idno type="eISSN">2164-554X</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><p>To determine if a hypersensitive-type lung pathology might occur when mice were given an inactivated MERS-CoV vaccine and challenged with infectious virus as was seen with SARS-CoV vaccines, we prepared and vaccinated mice with an inactivated MERS-CoV vaccine. Neutralizing antibody was induced by vaccine with and without adjuvant and lung virus was reduced in vaccinated mice after challenge. Lung mononuclear infiltrates occurred in all groups after virus challenge but with increased infiltrates that contained eosinophils and increases in the eosinophil promoting IL-5 and IL-13 cytokines only in the vaccine groups. Inactivated MERS-CoV vaccine appears to carry a hypersensitive-type lung pathology risk from MERS-CoV infection that is similar to that found with inactivated SARS-CoV vaccines from SARS-CoV infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Tseng, Ct" uniqKey="Tseng C">CT Tseng</name></author><author><name sortKey="Sbrana, E" uniqKey="Sbrana E">E Sbrana</name></author><author><name sortKey="Iwata Yoshikawa, N" uniqKey="Iwata Yoshikawa N">N Iwata-Yoshikawa</name></author><author><name sortKey="Newman, Pc" uniqKey="Newman P">PC Newman</name></author><author><name sortKey="Garron, T" uniqKey="Garron T">T Garron</name></author><author><name sortKey="Atmar, Rl" uniqKey="Atmar R">RL Atmar</name></author><author><name sortKey="Peters, Cj" uniqKey="Peters C">CJ Peters</name></author><author><name sortKey="Couch, Rb" uniqKey="Couch R">RB 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Hum Vaccin Immunother</journal-id><journal-id journal-id-type="iso-abbrev">Hum Vaccin Immunother</journal-id><journal-id journal-id-type="publisher-id">KHVI</journal-id><journal-id journal-id-type="publisher-id">khvi20</journal-id><journal-title-group><journal-title>Human Vaccines & Immunotherapeutics</journal-title></journal-title-group><issn pub-type="ppub">2164-5515</issn><issn pub-type="epub">2164-554X</issn><publisher><publisher-name>Taylor & Francis</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27269431</article-id><article-id pub-id-type="pmc">5027702</article-id><article-id pub-id-type="publisher-id">1177688</article-id><article-id pub-id-type="doi">10.1080/21645515.2016.1177688</article-id><article-categories><subj-group subj-group-type="heading"><subject>Short Report</subject></subj-group></article-categories><title-group><article-title>Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus</article-title><alt-title alt-title-type="running-authors">A. S. AGRAWAL ET AL.</alt-title><alt-title alt-title-type="running-title">HUMAN VACCINES & IMMUNOTHERAPEUTICS</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Agrawal</surname><given-names>Anurodh Shankar</given-names></name><xref ref-type="aff" rid="af0001"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tao</surname><given-names>Xinrong</given-names></name><xref ref-type="aff" rid="af0001"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Algaissi</surname><given-names>Abdullah</given-names></name><xref ref-type="aff" rid="af0001"><sup>a</sup></xref><xref ref-type="aff" rid="af0005"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>Garron</surname><given-names>Tania</given-names></name><xref ref-type="aff" rid="af0001"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Narayanan</surname><given-names>Krishna</given-names></name><xref ref-type="aff" rid="af0001"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Peng</surname><given-names>Bi-Hung</given-names></name><xref ref-type="aff" rid="af0002"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Couch</surname><given-names>Robert B.</given-names></name><xref ref-type="aff" rid="af0003"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tseng</surname><given-names>Chien-Te K.</given-names></name><xref ref-type="aff" rid="af0001"><sup>a</sup></xref><xref ref-type="aff" rid="af0004"><sup>d</sup></xref><xref ref-type="corresp" rid="an0001"></xref></contrib><aff id="af0001"><label>a</label><institution>Departments of Microbiology and Immunology, University of Texas Medical Branch</institution>, Galveston, TX,<country>USA</country></aff><aff id="af0002"><label>b</label><institution>Pathology, University of Texas Medical Branch</institution>, Galveston, TX,<country>USA</country></aff><aff id="af0003"><label>c</label><institution>Internal Medicine, Division of Infectious Disease, University of Texas Medical Branch</institution>, Galveston, TX,<country>USA</country></aff><aff id="af0004"><label>d</label><institution>Center for Biodefense and Emerging Infectious Disease, University of Texas Medical Branch</institution>, Galveston, TX,<country>USA</country></aff><aff id="af0005"><label>e</label><institution>Department of Medical Laboratories Technology, College of Applied Medical Sciences, Jazan University</institution>, Jazan,<country>Saudi Arabia</country></aff></contrib-group><author-notes><corresp id="an0001"><bold>CONTACT</bold> Chien-Te K. Tseng <email xlink:href="sktseng@utmb.edu">sktseng@utmb.edu</email><institution>Department of Microbiology and Immunology, University of Texas Medical Branch</institution>, <addr-line>301 University Boulevard, Galveston National Laboratory 5.200Q</addr-line>, Galveston, TX 77555-0609, <country>USA</country>.</corresp><fn><p>Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/khvi.</p></fn></author-notes><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>07</day><month>6</month><year>2016</year></pub-date><volume>12</volume><issue>9</issue><fpage seq="20">2351</fpage><lpage>2356</lpage><history><date date-type="received"><day>08</day><month>2</month><year>2016</year></date><date date-type="rev-recd"><day>24</day><month>3</month><year>2016</year></date><date date-type="accepted"><day>07</day><month>4</month><year>2016</year></date></history><permissions><copyright-statement>© 2016 Taylor & Francis</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>Taylor & Francis</copyright-holder><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="KHVI_12_1177688.pdf"></self-uri><abstract><title>ABSTRACT</title><p>To determine if a hypersensitive-type lung pathology might occur when mice were given an inactivated MERS-CoV vaccine and challenged with infectious virus as was seen with SARS-CoV vaccines, we prepared and vaccinated mice with an inactivated MERS-CoV vaccine. Neutralizing antibody was induced by vaccine with and without adjuvant and lung virus was reduced in vaccinated mice after challenge. Lung mononuclear infiltrates occurred in all groups after virus challenge but with increased infiltrates that contained eosinophils and increases in the eosinophil promoting IL-5 and IL-13 cytokines only in the vaccine groups. Inactivated MERS-CoV vaccine appears to carry a hypersensitive-type lung pathology risk from MERS-CoV infection that is similar to that found with inactivated SARS-CoV vaccines from SARS-CoV infection.</p></abstract><kwd-group kwd-group-type="author"><title>Keywords</title><kwd>coronavirus; Eosinophils; immunopathology; Middle East Respiratory Syndrome; vaccination</kwd></kwd-group><counts><fig-count count="4"></fig-count><table-count count="1"></table-count><ref-count count="22"></ref-count><page-count count="6"></page-count></counts></article-meta></front></pmc><affiliations><list><country><li>Arabie saoudite</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Agrawal, Anurodh Shankar" sort="Agrawal, Anurodh Shankar" uniqKey="Agrawal A" first="Anurodh Shankar" last="Agrawal">Anurodh Shankar Agrawal</name></noRegion><name sortKey="Algaissi, Abdullah" sort="Algaissi, Abdullah" uniqKey="Algaissi A" first="Abdullah" last="Algaissi">Abdullah Algaissi</name><name sortKey="Couch, Robert B" sort="Couch, Robert B" uniqKey="Couch R" first="Robert B." last="Couch">Robert B. Couch</name><name sortKey="Garron, Tania" sort="Garron, Tania" uniqKey="Garron T" first="Tania" last="Garron">Tania Garron</name><name sortKey="Narayanan, Krishna" sort="Narayanan, Krishna" uniqKey="Narayanan K" first="Krishna" last="Narayanan">Krishna Narayanan</name><name sortKey="Peng, Bi Hung" sort="Peng, Bi Hung" uniqKey="Peng B" first="Bi-Hung" last="Peng">Bi-Hung Peng</name><name sortKey="Tao, Xinrong" sort="Tao, Xinrong" uniqKey="Tao X" first="Xinrong" last="Tao">Xinrong Tao</name><name sortKey="Tseng, Chien Te K" sort="Tseng, Chien Te K" uniqKey="Tseng C" first="Chien-Te K." last="Tseng">Chien-Te K. Tseng</name><name sortKey="Tseng, Chien Te K" sort="Tseng, Chien Te K" uniqKey="Tseng C" first="Chien-Te K." last="Tseng">Chien-Te K. Tseng</name></country><country name="Arabie saoudite"><noRegion><name sortKey="Algaissi, Abdullah" sort="Algaissi, Abdullah" uniqKey="Algaissi A" first="Abdullah" last="Algaissi">Abdullah Algaissi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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